1 results match your criteria: "School of Medicine University of Galway Galway Ireland.[Affiliation]"
Defining Cardiomyocyte Repolarization Response to Pharmacotherapy in Long-QT Syndrome Type 3.
J Am Heart Assoc
October 2024
Regenerative Medicine Institute, School of Medicine University of Galway Galway Ireland.
Article Synopsis
- Long-QT syndrome type 3 (LQT3) is a cardiac ion channel disorder that increases the risk of dangerous heart rhythms, and this study aimed to create a model using human induced pluripotent stem cells (hiPSCs) to better understand the disease and test potential treatments.!
- Researchers generated hiPSCs from a patient with LQT3 and a healthy individual, employing CRISPR/Cas9 to introduce the same genetic mutation into healthy cells; all hiPSC lines were then converted into heart cells for analysis.!
- Both patient-derived and engineered LQT3 heart cells exhibited longer repolarization times, but treatments like mexiletine, nifedipine, and verapamil could effectively alter these