245 results match your criteria: "School of Medicine Sydney[Affiliation]"

Patient digital self-screening tool for familial hypercholesterolaemia: A pilot study.

Aust J Gen Pract

December 2024

FRACGP, MBBS (Hons), DCH (Lon), Associate Professor, Head General Practice and Primary Care Research, School of Medicine Sydney, University of Notre Dame, Sydney, NSW; General Practitioner, Glebe Family Medical Practice, Glebe, NSW.

Background And Objectives: Familial hypercholesterolaemia (FH) is a genetic condition contributing to premature cardiovascular disease. Currently, general practitioners (GPs) do not proactively screen for the condition. This study implemented and evaluated a digital FH self-screening questionnaire administered in general practice.

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Background And Objective: Adrenal crises (AC) occur in middle aged adults with adrenal insufficiency (AI). Psychosocial difficulties may impede effective self-management in some cases. This study aimed to investigate associations between psychosocial problems and hospital admissions for AI/AC in middle aged adults.

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Background And Objectives: This study describes the prevalence of risky alcohol consumption in Australian women aged 40-45 years. It explores the relationship between demographic factors and access to and usage of primary healthcare services.

Method: Data were obtained from the Australian Longitudinal Study on Women's Health, Survey 8 (1973-78 cohort).

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Poland, Public Health, Chaplains, Clergy, Mindfulness and Prayer.

J Relig Health

December 2024

School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.

This issue commences with a bibliometric analysis of the top 100 most cited articles on religion. It then presents the first of a two-part series relating to research from Poland and progresses to examine the relevance of religion and spirituality to public health. Finally, this issue revisits the long-established and productive discipline of healthcare chaplaincy and various factors relating to parish clergy.

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Nutrition, Chronic Care, Measurement Scales and COVID-19.

J Relig Health

October 2024

School of Psychology and Public Health, La Trobe University, Melbourne, Australia.

In the year of the Olympics (Paris, 2024), this issue of JORH explores nutrition and chronic care, offers a caution regarding the use of religiosity and spiritual measurement scales, and revisits the topic of COVID-19. While the latter has been rapidly declining in terms of its global impact, each of these areas of inquiry generate a great deal of research from which humanity still has much to learn.

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Introduction: Ageing is associated with physical and cognitive declines, which may be further exacerbated by poor nutrition. Nuts are energy and nutrient dense, and their consumption is associated with better physical and cognitive functions in older adults, but data from interventional studies are limited. This 6-month randomised controlled trial is designed to investigate the effects of consuming 43 g/day of peanut butter (equivalent to 1.

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Fracture risk assessment in the presence of competing risk of death.

Osteoporos Int

November 2024

School of Biomedical Engineering, University of Technology Sydney, Level 10, Building 11, City Campus, Broadway, NSW, 2007, Australia.

Purpose: To identify the optimal statistical approach for predicting the risk of fragility fractures in the presence of competing event of death.

Methods: We used real-world data from the Dubbo Osteoporosis Epidemiology Study that has monitored 3035 elderly participants for bone health and mortality. Fragility fractures were ascertained radiologically.

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Rationale: Comorbidities are common in fracture patients, but the interaction between fracture and comorbidities remains unclear. This study aimed to define specific multimorbidity clusters in older adults and quantify the association between the multimorbidity clusters and fracture risk.

Methods: This nationwide cohort study includes 1.

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Faith and Health in Israel, Türkiye and the USA.

J Relig Health

August 2024

School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.

This issue of JORH focuses upon faith and health within three nations that have contributed a great deal in terms of religion and health research during this century-namely Israel, Türkiye and the USA.

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Article Synopsis
  • This study investigates how weight loss affects hormonal changes related to gonadal dysfunction in obese patients over three years, comparing different weight loss methods like diet and bariatric surgeries.
  • Researchers measured various hormonal parameters in 61 adults with a BMI over 30 and found that weight loss significantly influenced testosterone levels, with men experiencing increases and women showing decreases.
  • The results highlighted that women undergoing certain bariatric surgeries had notably lower testosterone levels compared to those on a diet, regardless of age or menopausal status, emphasizing the hormonal effects of different weight loss strategies.
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Objective: This study aims to determine the associations between specialty type and practice location at postgraduate year 10 (PGY10), matched with PGY5 and PGY8 work locations, and earlier rural exposure/experience.

Design And Setting: A cohort study of medicine graduates from nine Australian universities.

Participants: 1220 domestic medicine graduates from the class of 2011.

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A man with hyperparathyroidism secondary to kidney failure on peritoneal dialysis underwent a parathyroidectomy with half-gland reimplantation complicated by severe hungry bone syndrome resulting in severe hypocalcaemia, hypotension and QT prolongation on ECG. He was initially managed with oral calcium and intravenous (IV) calcium chloride. Despite standard supportive treatment, attempts to wean IV therapy were unsuccessful.

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Impact of COVID-19 on asthma management in general practice: A qualitative study.

Aust J Gen Pract

May 2024

FRACGP, MBBS (Hons), DCH (Lon), Associate Professor, Head General Practice and Primary Care Research, School of Medicine Sydney, University of Notre Dame, Sydney, NSW; General Practitioner, Glebe Family Medical Practice, Glebe, NSW.

Background And Objectives: The COVID-19 pandemic catalysed unprecedented changes to healthcare delivery in Australia, leading to a rapid transformation of asthma management, to which healthcare providers and patients have had to adapt. Understanding the impact of these changes is critical as we emerge from pandemic-affected workflows.

Method: A qualitative study using semistructured interviews was conducted with 19 general practitioners across Sydney and regional New South Wales.

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As hematopoietic cell transplantation (HCT) and cellular therapy expand to new indications and international access improves, the volume of HCT performed annually continues to rise. Parallel improvements in HCT techniques and supportive care entails more patients surviving long-term, creating further emphasis on survivorship needs. Survivors are at risk for developing late complications secondary to pre-, peri- and post-transplant exposures and other underlying risk-factors.

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International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update.

Transplant Cell Ther

April 2024

Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

As hematopoietic cell transplantation (HCT) and cellular therapy expand to new indications and international access improves, the number of HCTs performed annually continues to rise. Parallel improvements in HCT techniques and supportive care entails more patients surviving long term, creating further emphasis on survivorship needs. Survivors are at risk for developing late complications secondary to pretransplantation, peritransplantation, and post-transplantation exposures and other underlying risk factors.

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Purpose: Hypocalcaemia upon arrival (HUA) to hospital is associated with morbidity and mortality in the trauma patient. It has been hypothesised that there is an increased incidence of HUA in patients receiving prehospital transfusion as a result of citrated blood products. This research aimed to determine if there was a difference in arrival ionised calcium (iCa) levels in trauma patients who did and did not receive prehospital transfusion.

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DHDDS and NUS1: A Converging Pathway and Common Phenotype.

Mov Disord Clin Pract

January 2024

Movement Disorder Unit, Department of Neurology, Westmead Hospital, Westmead, New South Wales, Australia.

Background: Variants in dehydrodolichol diphosphate synthetase (DHDDS) and nuclear undecaprenyl pyrophosphate synthase 1 (NUS1) cause a neurodevelopmental disorder, classically with prominent epilepsy. Recent reports suggest a complex movement disorder and an overlapping phenotype has been postulated due to their combined role in dolichol synthesis.

Cases: We describe three patients with heterozygous variants in DHDDS and five with variants affecting NUS1.

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Article Synopsis
  • A meta-analysis of data from 46 cohorts found that individuals who reported falling in the past year had an increased risk of fractures, highlighting falls as an important factor for fracture risk assessment.
  • Previous falls were correlated with a significant rise in fracture risks for both men and women, with hazard ratios indicating that the risk is greater for men.
  • The study suggests that falls should be included in the FRAX® algorithm, which currently does not consider this important risk factor for osteoporotic fractures.
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Spirituality, Mental Health, and COVID-19.

J Relig Health

February 2024

School of Psychology and Public Health, La Trobe University, Melbourne, Australia.

This issue of JORH presents a broad range of articles that consider spirituality and spiritual care from various international perspectives. It also looks at a diverse range of articles relating to mental health disorders and addictions. Lastly, this issue considers the aftermath of COVID-19.

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Neurodevelopmental outcomes in a cohort of Australian families with self-limited familial epilepsy of neonatal/infantile onset.

Seizure

February 2024

Department of Neurology, Sydney Children's Hospital Network, Randwick, Australia; School of Clinical Medicine, UNSW Medicine & Health, Randwick Clinical Campus, Discipline of Paediatrics, UNSW Sydney, Australia.

Article Synopsis
  • The study aimed to investigate seizure recurrence, developmental disabilities, and risk factors in families affected by self-limited familial neonatal and/or infantile epilepsy (SeLFE).
  • Researchers analyzed data from 15 families in Sydney, finding a high genetic diagnosis rate (93%) among participants, with 73 individuals affected by seizures, including both children and adults.
  • The results revealed a 20% risk of recurrent seizures and identified predictors such as a high number of seizures and prolonged treatment; developmental delays were noted in some children, indicating the importance of ongoing developmental monitoring.
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Since the year 2000, admissions for adrenal insufficiency (AI) and adrenal crises (AC) have shown a particular increase in young adult females. We examined data on acute non-surgical hospitalisations for AI/AC from New South Wales, Australia, to determine relevant factors that may have contributed to this increase. Data were analysed to ascertain associations between various comorbid psychosocial issues, identified by relevant ICD-10-AM codes in each record, and ACs.

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