Enhancing physical activity during pregnancy using a multi-theory model: a study protocol for a randomised controlled trial in China.

Background: Physical inactivity is a global concern and poses serious health risks. Physical inactivity is exacerbated and affects the health of both generations during the special period of pregnancy. Appropriate physical activity (PA) intervention programmes based on health behaviour change theory are lacking.

Sorafenib promotes Treg cell differentiation to compromise its efficacy via VEGFR/AKT/Foxo1 signaling in hepatocellular carcinoma.

Unlabelled: Our study revealed that sorafenib (Sora) induced the formation of an immunosuppressive tumor microenvironment in hepatocellular carcinoma (HCC) by promoting the differentiation of regulatory T (Treg) cells through VEGFR/AKT/Foxo1 signaling, leading to compromised Sora efficacy. Importantly, combination treatment with an anti-CD25 antibody or the Foxo1 inhibitor AS1842856 inhibited Treg cell differentiation and increased the therapeutic efficacy of Sora in HCC.

Background & Aims: Sora is the first-line drug for advanced HCC.

Health-promoting lifestyles and influencing factors among pregnant women with urinary incontinence: a multicentre cross-sectional study.

Objective: Lifestyle modification is an important part of non-surgical treatment for urinary incontinence (UI) and is strongly recommended. This study aims to explore the status and influencing factors of health-promoting lifestyle among pregnant women with UI.

Design: A multicentre cross-sectional study.

Innovative public strategies in response to COVID-19: A review of practices from China.

The COVID-19 pandemic presented unparalleled challenges to prompt and adaptive responses from nations worldwide. This review examines China's multifaceted approach to the crisis, focusing on five key areas of response: infrastructure and system design, medical care and treatment, disease prevention and control, economic and social resilience, and China's engagement in global health. This review demonstrates the effectiveness of a top-down command system at the national level, intersectoral coordination, a legal framework, and public social governance.

Ozone concentration, physical activity, and emotional and behavioral problems in children and adolescents.

Background: No prior study has examined the mutual association of long-term outdoor ozone (O) concentration and physical activity (PA) with emotional and behavioral problems (EBPs) in children and adolescents. This study aims to investigate the association between long-term outdoor O concentration and the risk of EBPs in children and adolescents and further explore whether increased PA levels modify this association.

Methods: Data were obtained from the 2020 wave follow-up examination of an ongoing prospective cohort study (COHERENCE project) in Guangzhou, China.

Enhanced therapeutic potential of a self-healing hyaluronic acid hydrogel for early intervention in osteoarthritis.

Osteoarthritis (OA) is characterized by symptoms such as abnormal lubrication function of synovial fluid and heightened friction on the cartilage surface in its early stages, prior to evident cartilage damage. Current early intervention strategies employing lubricated hydrogels to shield cartilage from friction often overlook the significance of hydrogel-cartilage adhesion and enhancement of the cartilage extracellular matrix (ECM). Herein, we constructed a hydrogel based on dihydrazide-modified hyaluronic acid (HA) (AHA) and catechol-conjugated aldehyde-modified HA (CHA), which not only adheres to the cartilage surface as an effective lubricant but also improves the extracellular environment of chondrocytes in OA.

Prevention of Intrauterine Adhesion with Platelet-Rich Plasma Double-Network Hydrogel.

Intrauterine adhesion (IUA) can negatively impact on pregnancy outcomes, leading to reduced pregnancy rates, secondary infertility, and an increased risk of pregnancy complications. Studies have shown that the application of platelet-rich plasma (PRP) in IUA patients is effective. However, the clinical readhesive rate of IUA after treatment is still high, especially in severe cases.

Development and validation of a nomogram for predicting outcomes in ovarian cancer patients with liver metastases.

Purpose: To develop and validate a nomogram for predicting the overall survival (OS) of ovarian cancer patients with liver metastases (OCLM).

Methods: This study identified 821 patients in the Surveillance, Epidemiology, and End Results (SEER) database. All patients were randomly divided in a ratio of 7:3 into a training cohort (n = 574) and a validation cohort (n = 247).

An improved low-rank plus sparse unrolling network method for dynamic magnetic resonance imaging.

Background: Recent advances in deep learning have sparked new research interests in dynamic magnetic resonance imaging (MRI) reconstruction. However, existing deep learning-based approaches suffer from insufficient reconstruction efficiency and accuracy due to the lack of time correlation modeling during the reconstruction procedure.

Purpose: Inappropriate tensor processing steps and deep learning models may lead to not only a lack of modeling in the time dimension but also an increase in the overall size of the network.

Serum urea concentration and risk of 16 site-specific cancers, overall cancer, and cancer mortality in individuals with metabolic syndrome: a cohort study.

Background: The relationship between serum urea concentration and cancer in patients with metabolic syndrome (MetS) remains unclear. This study aimed to investigate the association between serum urea concentration and 16 site-specific cancers, overall cancer incidence, and cancer mortality in individuals with MetS.

Methods: We analysed the data of 108,284 individuals with MetS obtained from the UK Biobank.

Serum hsa_circ_0007534 as a diagnostic biomarker for ovarian cancer.

Objective: To investigate the implications of serum hsa_circ_0007534 levels in ovarian cancer (OC) patients.

Methods: A retrospective analysis was conducted on the clinical data of 102 OC patients, and 102 healthy controls (HCs) were included in this study. Serum levels of hsa_circ_0007534 were measured using qPCR.

Advances in the application of ultrasonographic parameters for fluid management in obstetric anesthesia.

Ultrasound provides a valuable non-invasive approach for fluid management in obstetric anesthesia. Ultrasonographic parameters assist anesthesiologists to effectively assess the fluid status of parturients and reduce related complications. In addition to conventional parameters, which have been widely validated in clinical practice, we provide new insights into arterial parameters such as peak velocity, velocity-time integral, corrected flow time, and vein-related parameters, including the internal jugular vein and its collapsibility index, the inferior vena cava and its collapsibility index, as well as subclavian vein and its collapsibility index.

Administration of a diabetes-specific formula can improve postprandial glycemic control and delay insulin use in gestational diabetes mellitus: A randomized controlled trial from two centers.

Background And Aims: There have been limited studies on the application of a diabetes-specific formula in gestational diabetes mellitus (GDM), the role of which has not been well studied. We explored the effect of a diabetes-specific formula on blood glucose levels, insulin use and pregnancy outcomes in GDM patients.

Methods: In this randomized controlled study, 112 GDM patients were randomly assigned to the intervention group (56) and the control group (56).

Impact of perceived social support on anxiety and depression in women undergoing in vitro fertilization-embryo transfer: the role of psychological resilience.

Purpose: This study aimed to analyze the current status of women's perception of social support levels, psychological resilience, anxiety, and depression levels during IVF-ET, as well as investigate the influence of perceived social support and psychological resilience on the anxiety and depression levels of women undergoing IVF-ET and the mediating role of psychological resilience in this process.

Methods: In this study, a convenience sampling method was used to administer a questionnaire survey among 433 women undergoing IVF-ET. Then, multivariate linear regression models were applied to identify factors influencing anxiety and depression.

The toxic effects of and benzo(a)pyrene in inducing atrophic gastritis and gut microbiota dysbiosis in Mongolian gerbils.

Food chemical and microbiological contamination are major global food safety issues. This study investigated the combined effects of the food-borne pathogen () and the pollutant benzo(a)pyrene (Bap) on atrophic gastritis and gut microbiota in Mongolian gerbils. The results demonstrated that simultaneous administration of and Bap caused more severe weight loss, DNA damage, and gastritis in Mongolian gerbils compared with those exposed to or Bap alone.

Ex vivo Magnetic Resonance Imaging of the Human Fetal Brain.

Background: The fetal brain undergoes a dynamic process of development during gestation, marked by well-orchestrated events such as neuronal proliferation, migration, axonal outgrowth, and dendritic arborization, mainly elucidated through histological studies. Ex vivo magnetic resonance imaging (MRI) has emerged as a useful tool for 3D visualization of the developing fetal brain, serving as a complementary tool to traditional histology.

Summary: In this review, we summarized the commonly employed ex vivo MRI techniques and their advances in fetal brain imaging, and proposed a standard protocol for postmortem fetal brain specimen collection and fixation.

The role of non-coding RNAs in fibroblast-like synoviocytes in rheumatoid arthritis.

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovial hyperplasia, and fibroblast-like synoviocytes (FLSs) constitute the majority of cells in the synovial tissue, playing a crucial role in the onset of RA. Dysregulation of FLSs function is a critical strategy in treating joint damage associated with RA. Non-coding RNAs, a class of RNA molecules that do not encode proteins, participate in the development of various diseases.

Mechanism of denervation muscle atrophy mediated by Ach/p38/MAPK pathway in rats with erectile dysfunction caused by nerve injury.

Background: Peripheral nerve injury can result in penile cavernosal denervation muscle atrophy, a primary factor in nerve injury erectile dysfunction (NED). While acetylcholine (Ach) is integral to erectile function, its role and mechanisms in NED need further exploration.

Objective: To investigate the inhibition of CCMSCs Apoptosis and Protein Degradation Pathway by Ach in NED rat model.

An Engineered Hierarchical Hydrogel with Immune Responsiveness and Targeted Mitochondrial Transfer to Augmented Bone Regeneration.

Coordinating the immune response and bioenergy metabolism in bone defect environments is essential for promoting bone regeneration. Mitochondria are important organelles that control internal balance and metabolism. Repairing dysfunctional mitochondria has been proposed as a therapeutic approach for disease intervention.