1,535 results match your criteria: "School of Life and Medical Sciences[Affiliation]"
Brain Sci
November 2022
Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hertfordshire AL10 9EU, UK.
Recreational drug intake may be associated with a range of medical untoward consequences, including male infertility. However, as the related evidence is still limited, the main outcome of this review is to provide a better understanding of the existence of any association between recreational drug misuse and male fertility levels' decline. Whilst searching the MEDLINE/PubMed, a comprehensive overview of the literature regarding male infertility and substances of abuse (e.
View Article and Find Full Text PDFChildren (Basel)
November 2022
School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9EU, UK.
Coaches of youth judo athletes might be under the influence of some extraordinary elite judo athletes that have won elite competitions at a relatively young age and might put youth athletes under pressure to gain as much fighting experience as fast as possible. The present study aims to present a 5-year competition structure, volume and age competition categories (ACC) range in which youth judokas competed with 10-year dropout status. Data from 46 judokas were collected (M = 24; F = 22) for four categorisation classes (National-NC; Perspective-PC; International-IC; World class-WC).
View Article and Find Full Text PDFPlant Dis
June 2023
Centre for Agriculture, Food and Environmental Management Research, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, U.K.
Cercospora leaf spot (CLS; causal agent Sacc.) is endemic in many sugar beet production regions due to the widespread distribution of and the inability of current management practices to provide complete control of the disease. Roots harvested from plants with CLS, therefore, are inevitably incorporated into sugar beet root storage piles, even though the effects of CLS on root storage properties are largely unknown.
View Article and Find Full Text PDFJ Funct Morphol Kinesiol
November 2022
Department of Coaching Education, Faculty of Sport Sciences, Selcuk University, Konya 42130, Türkiye.
The normative values of the Special Judo Fitness Test (SJFT) are used to evaluate judo athletes, and the question arises of which performance tests from crucial motor abilities best define the SJFT classification in elite judo athletes. This study aimed to investigate the relationship between elite judo athletes’ physical performance and the evaluation using SJFT index norms. Nineteen judo athletes (11 females) (22.
View Article and Find Full Text PDFFront Pharmacol
November 2022
Department of Clinical and Pharmaceutical Sciences, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
A 2021 study to determine the viewpoints among the seven member countries regarding the effectiveness (i.e., achieving the intended outcomes) and efficiency (i.
View Article and Find Full Text PDFEur J Hybrid Imaging
November 2022
Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
Background: Recent neuroimaging studies have demonstrated pathological mechanisms related to cerebral neuroplasticity in chronic low back pain (CLBP). Few studies have compared cerebral changes between patients with and without pain in the absence of an experimentally induced stimulus. We investigated the neurobiological substrates associated with chronic low back pain using [Tc]Tc-ECD brain SPECT and correlated rCBF findings with the numeric rating scale (NRS) of pain and douleur neuropathique en 4 questions (DN4).
View Article and Find Full Text PDFNoncoding RNA Res
March 2023
Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835, Cairo, Egypt.
Advances in high-throughput sequencing techniques and bioinformatic analysis have refuted the "junk" RNA hypothesis that was claimed against non-coding RNAs (ncRNAs). Circular RNAs (circRNAs); a class of single-stranded covalently closed loop RNA molecules have recently emerged as stable epigenetic regulators. Although the exact regulatory role of circRNAs is still to be clarified, it has been proven that circRNAs could exert their functions by interacting with other ncRNAs or proteins in their own physiologically authentic environment, regulating multiple cellular signaling pathways and other classes of ncRNAs.
View Article and Find Full Text PDFJ Appl Res Intellect Disabil
January 2023
Trust Headquarters, Herefordshire and Worcestershire Health and Care NHS Trust, Worcester, UK.
Background: We examined whether a series of variables were related to the number of psychiatric inpatients using publicly available data about English psychiatric bed utilisation and NHS workforce.
Method: Using linear regression, with auto-regressive errors, we examined relationships between variables over time using data from December 2013 to March 2021.
Results: Over time, the number of inpatients reduced by either 6.
BJPsych Open
November 2022
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, UK; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, UK; and NIHR CRF Human Metabolism Research Unit, University Hospitals Coventry and Warwickshire NHS Trust, UK.
Background: Psychological stress has an established bi-directional relationship with obesity. Mindfulness techniques reduce stress and improve eating behaviours, but their long-term impact remains untested. CALMPOD (Compassionate Approach to Living Mindfully for Prevention of Disease) is a psychoeducational mindfulness-based course evidenced to improve eating patterns across a 6-month period, possibly by reducing stress.
View Article and Find Full Text PDFBJPsych Open
November 2022
Adult Learning Disability Services, Hertfordshire Partnership University NHS Foundation Trust, UK.
Background: A recent government white paper sets out proposals for reforms to the Mental Health Act 1983 (MHA). Some of these proposals affect people with intellectual disabilities and/or autism.
Aims: To explore both positive and unintended negative effects of the proposed reforms by gathering the perspectives of healthcare workers from multiple disciplines, working with intellectual disability and/or autism in community and in-patient settings.
Addiction
April 2023
Pharmacology Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Aims: Impulse control disorders (ICDs) are iatrogenic and idiopathic conditions with psychosocial and economic consequences for the affected individuals and their families (e.g. bankruptcy and divorce).
View Article and Find Full Text PDFBiomolecules
October 2022
Centre for Health Services and Clinical Research, Basic and Clinical Science Unit, Department of Clinical, Pharmaceutical and Biological Science, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
Vascular smooth muscle cells (VSMCs) are the main stromal cells in the medial layer of the vascular wall. These cells produce the extracellular matrix (ECM) and are involved in many pathological changes in the vascular wall. Semicarbazide-sensitive amine oxidase (SSAO) and lysyl oxidase (LOX) are vascular enzymes associated with the development of atherosclerosis.
View Article and Find Full Text PDFCancers (Basel)
October 2022
Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
Pediatric primary brain tumors represent a real challenge in the oncology arena. Besides the psychosocial burden, brain tumors are considered one of the most difficult-to-treat malignancies due to their sophisticated cellular and molecular pathophysiology. Notwithstanding the advances in research and the substantial efforts to develop a suitable therapy, a full understanding of the molecular pathways involved in primary brain tumors is still demanded.
View Article and Find Full Text PDFPharmaceuticals (Basel)
October 2022
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
(Blume) Merr. and L.M.
View Article and Find Full Text PDFMetabolites
October 2022
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.
Hiern is a medicinal plant widely distributed in the northeast parts of South Africa. This plant has been used to treat miscarriage and to alleviate gastrointestinal problems. It can also be used externally for the treatment of ulcers and gonorrhea.
View Article and Find Full Text PDFTher Innov Regul Sci
March 2023
School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK.
Purpose: This study aimed to assess the current regulatory review process of the food and drugs authority (FDA) Ghana by identifying key milestones, target timelines, good review practices and quality decision-making practices and evaluating the overall regulatory performance from 2019 to 2021, as well as the challenges and opportunities for improvement.
Methods: The FDA Ghana representatives completed the optimising efficiencies in regulatory agencies (OpERA) questionnaire, including data identifying the milestones and overall approval times for all products registered by the FDA Ghana from 2019 to 2021.
Results: Of the new active substances approved from 2019 to 2021, 91% were biologicals processed by full or abridged reviews pathways.
Front Cardiovasc Med
October 2022
Department of Cardiology, East and North Hertfordshire NHS Trust, Stevenage, United Kingdom.
Current guidelines for patients with acute coronary syndrome (ACS) recommend dual antiplatelet therapy (DAPT) for 12 months. Since bleeding is the main Achilles' heel of DAPT, in recent years several randomized controlled trials have evaluated the safety and efficacy of de-escalation of DAPT with respect to ischaemic and bleeding endpoints. These trials can be broadly divided into studies evaluating a shorter duration of DAPT, and those studies in which DAPT that includes a potent P2Y inhibitor, such as prasugrel or ticagrelor, is compared to less intense DAPT, mainly clopidogrel or reduced-dose prasugrel.
View Article and Find Full Text PDFBiochem Biophys Res Commun
December 2022
Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan. Electronic address:
Inhibition of osteoclast differentiation is a promising approach for the treatment of osteoporosis and rheumatoid arthritis. Receptor activator of nuclear factor kappa B (NF-κB) (RANK), which is an essential molecule for osteoclast differentiation, interacts with tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) to transduce downstream signals. Both RANK and TRAF6 have homo-trimeric structures, forming a multivalent interaction between the Pro-X-Glu-X-X-(aromatic/acidic) motif of RANK and the C-terminal domain of TRAF6 (TRAF-C), that markedly increases the binding affinity.
View Article and Find Full Text PDFTohoku J Exp Med
December 2022
Laboratory for Genetic Code, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University.
Tumor tissue includes cancer cells and their associated stromal cells, such as adipocytes, myocytes, and immune cells. Obesity modulates tumor microenvironment through the secretion of several inflammatory mediators by inducing adipogenesis and myogenesis. Previously, we indicated that tumor growth is promoted by a transcription factor nuclear factor erythroid 2-related factor 3 (NRF3) in human cancer cells.
View Article and Find Full Text PDFPest Manag Sci
May 2024
Centre for Agriculture, Food and Environmental Management Research, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK.
Background: Phoma stem canker is caused by two coexisting pathogens, Leptosphaeria maculans and L. biglobosa. They coexist because of their temporal and spatial separations, which are associated with the differences in timing of their ascospore release.
View Article and Find Full Text PDFMicroPubl Biol
October 2022
Department of Cell Biology, Johns Hopkins University School of Medicine.
Opatic atrophy 1 (Opa1) is a mitochondrial GTPase that regulates mitochondrial fusion and maintenance of cristae architecture. Osteoclasts are mitochondrial rich-cells. However, the role of Opa1 in osteoclasts remains unclear.
View Article and Find Full Text PDFMolecules
October 2022
Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha University 1-3 TataraMiyakodani, Kyoto 610-0394, Japan.
The Omicron variant (B.529) of COVID-19 caused disease outbreaks worldwide because of its contagious and diverse mutations. To reduce these outbreaks, therapeutic drugs and adjuvant vaccines have been applied for the treatment of the disease.
View Article and Find Full Text PDFLife (Basel)
October 2022
Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 12622, Egypt.
COVID-19 is a recent pandemic that mandated the scientific society to provide effective evidence-based therapeutic approaches for the prevention and treatment for such a global threat, especially to those patients who hold a higher risk of infection and complications, such as patients with autoimmune diseases and cancer. Recent research has examined the role of various fat-soluble vitamins (vitamins A, D, E, and K) in reducing the severity of COVID-19 infection. Studies showed that deficiency in fat-soluble vitamins abrogates the immune system, thus rendering individuals more susceptible to COVID-19 infection.
View Article and Find Full Text PDFDiagnostics (Basel)
October 2022
Department of Biomedical Sciences and Informatics, Doshisha University, Kyoto 610-0394, Japan.
Cancers (Basel)
October 2022
Department of Medical Oncology, Mount Vernon Cancer Centre, London HA6 2RN, UK.
Background/Aim: The occurrence of germ cell tumour (GCT) in the elderly is rare, with scarce data available. The aim of this study was to understand the clinical outcomes of patients with GCT in patients aged > 45 years. Materials and Methods: A retrospective study was conducted in a large tertiary cancer centre in north-west London.
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