Preictal period optimization for deep learning-based epileptic seizure prediction.

. Accurate seizure prediction could prove critical for improving patient safety and quality of life in drug-resistant epilepsy. While deep learning-based approaches have shown promising performance using scalp electroencephalogram (EEG) signals, the incomplete understanding and variability of the preictal state imposes challenges in identifying the optimal preictal period (OPP) for labeling the EEG segments.

Prospective changes in financial toxicity and health-related quality of life in patients with gynecologic cancer.

Background: Financial toxicity impacts the treatment choices, daily life, and health-related quality of life (HRQoL) of cancer patients. We investigated future variations in financial toxicity and HRQoL of patients with gynecologic cancer, evaluated using the COmprehensive Score for financial Toxicity (COST) questionnaire.

Methods: This multicenter study enrolled patients with gynecologic cancer incurring co-payments for anti-cancer drug treatment for over 2 months.

Psychometric properties of the Arabic Stress Numerical Rating Scale (SNRS-11) in adolescents.

Meta-analytic results have revealed a significant influence of stress on a wide array of psychological and behavioral markers, underscoring its considerable clinical importance. Providing a simple and cost-effective tool assessing stress for the Arabic-speaking population would be immensely beneficial. Therefore, our research objective was to examine the psychometric properties of an Arabic version of the Stress Numerical Rating Scale-11 (Arabic SNRS-11), including its reliability, and construct validity.

Corrigendum: Advances in understanding the regulation of pluripotency fate transition in embryonic stem cells.

[This corrects the article DOI: 10.3389/fcell.2024.

Menopause and Quality of Life Among Greek Women in Rural Areas.

Introduction The World Health Organization defines menopause as the permanent termination of ovarian function and the absence of menstruation for a minimum of 12 months. A woman's quality of life and health may be affected by menopause, a physiological condition that is typically accompanied by vasomotor, physical, and psychological disorders. Also, menopausal women experience a wide range of psychological symptoms, such as irritability, anxiety, sadness, and depression.

Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1.

Aerobic glycolysis is a hallmark of cancer and is regulated by growth factors, protein kinases and transcription factors. However, it remains poorly understood how these components interact to regulate aerobic glycolysis coordinately. Here, we show that sine oculis homeobox 1 (SIX1) phosphorylation integrates growth factors (e.

Effusol ameliorates ischemic stroke by targeting NLRP3 protein to regulate NLRP3 inflammasome-mediated pyroptosis.

Background: The significance of pyroptosis as an inflammatory mode of death in ischemic stroke (IS) has attracted much attention in recent years. Effusol is a dihydrophenanthrene component extracted from Juncus effusus L..

Effect of mutation of secG gene in drug resistance and physiological and biochemical activities of Xanthomonas oryzae pv. oryzae.

Background: Bacterial leaf blight caused by the bacterium Xanthomonas oryzae pv. oryzae has a substantial effect on the yield of rice crops. The secretory (Sec) pathway, essential for efflux transport in bacteria, remains insufficiently studied in X.

Neuroanatomical and neurochemical substrates mediating fear-induced antinociception: A systematic review of rodent preclinical studies.

Fear-induced antinociception (FIA), an instinctive defensive response producing pain suppression in stressful and/or dangerous situations, has been the subject of extensive research to elucidate the mechanisms involved in triggering and controlling pain during emotional disorders. In this systematic review, we synthesized pre-clinical studies that demonstrated the neural hodology and the neurochemical bases of FIA in laboratory animals. The literature search in PubMed, Web of Science, Science Direct, and Scopus, from inception up to July 2022, retrieved 797 articles from which 50 studies were included in this review.

C-like metabolism and HCO use in submerged leaves of Ottelia cordata lacking Kranz anatomy at both low and high CO concentrations.

To date, only a few submerged plants have been reported to perform C and CAM. Ottelia cordata is a heteroblastic aquatic plant developing both submerged and floating leaves throughout its life cycle. Previous research found that, besides HCO use, the submerged leaves of O.

Greater resting state functional connectivity of the medial prefrontal cortex with the thalamus, caudate, and putamen in individuals who adhere to the Mediterranean style diets.

Purpose: Healthy diets are believed to be associated with a reduced risk of experiencing common mental disorders (CMDs) and related symptomatology (such as ruminative thinking), and with healthier brain chemistry and structure, especially in the frontal regions implicated in CMDs, cognitive control, and food choice. Nevertheless, there is very limited research on the relationship between diet health/quality and brain function. In this study we assessed the associations between adherence to the Mediterranean diet and resting state functional connectivity (rs-FC) of the prefrontal cortex (PFC) with the whole brain and whether this connectivity would be associated with ruminative thinking as a transdiagnostic factor for CMDs.

Molecular insights into Dalbavancin's blockade of ACE2-spike protein interaction in SARS-CoV-2.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic and a serious impact on human life and health. The spread of this virus, coupled with the emergence of many mutants, has posed increasingly formidable challenges to the design and development of antiviral drugs. Recently, it has been discovered that dalbavancin can bind to angiotensin-converting enzyme 2 (ACE2) of host cells with high affinity, blocking the interaction between the spike protein and ACE2, thereby making it a potentially promising anti-SARS-CoV-2 drug.

[Retrospect on seventy years of Chinese stomatology history research:focusing on papers issued by ].

has issued eighty papers on Chinese stomatology history in seventy years. According to three stages of the journal,statistics of the quantity and themes of the issued papers are compiled: the number of issued papers increased while the theme shifted from Chinese stomatology history before 1912 to Chinese contemporary stomatology history. Research methods shifted from the comparatively scanty summary or induction on literature and cultural relics materials to multidisciplinary approaches.

Comprehensive genome analysis of two novel strains- sp. nov. and sp. nov. isolated from stony corals in Hainan.

Marine actinomycetes exhibit a high level of biodiversity and possess significant potential for the production of high-value secondary metabolites. During the course of investigation of marine actinobacteria from corals, two strains, namely, HNM0983 and HNM0986, were isolated from stony corals collected from the coastal area of Hainan Island. The 16S ribosomal RNA (rRNA) gene sequence analysis revealed that these two strains are putative novel taxa of the genus .

Critical assessment of nanopore sequencing for the detection of multiple forms of DNA modifications.

While nanopore sequencing is increasingly used for mapping DNA modifications, it is important to recognize false positive calls as they can mislead biological interpretations. To assist biologists and methods developers, we describe a framework for rigorous evaluation that highlights the use of false discovery rate with rationally designed negative controls capturing both general background and confounding modifications. Our critical assessment across multiple forms of DNA modifications highlights that while nanopore sequencing performs reliably for high-abundance modifications, including 5-methylcytosine (5mC) at CpG sites in mammalian cells and 5-hydroxymethylcytosine (5hmC) in mammalian brain cells, it makes a significant proportion of false positive detections for low-abundance modifications, such as 5mC at CpH sites, 5hmC and N6-methyldeoxyadenine (6mA) in most mammal cell types.