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Regulation of energy metabolism and mitochondrial function in skeletal muscle during lipid overfeeding in healthy men.
J Clin Endocrinol Metab
July 2014
INSERM Unité Mixte de Recherche 1060 (K.S., M.A., E.M., E.L., E.D., E.B., J.R., M.L., H.V.), Laboratoires CarMeN et Centre Européen pour la Nutrition et la Santé, Université Lyon 1, F-69600 Oullins, France; Centre de Recherche en Nutrition Humaine Rhône-Alpes (K.S., M.A., E.D., S.L.-P., E.B., M.L., H.V.), Centre Hospitalier Lyon-Sud, F-69310 Pierre Bénite, France; Institut National de la Recherche Agronomique Unité 1235 (E.M., J.R., M.L., H.V.), F-69600 Oullins, France; Institut National de la Recherche Agronomique Unité Mixte de Recherche 1019 (E.C., B.M.), Unité de Nutrition Humaine and Centre de Recherche en Nutrition Humaine Auvergne, Université d'Auvergne, F-63000 Clermont-Ferrand, France; Laboratory of Integrative and Systems Physiology (C.C.), Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences - Institute of Bioengineering, CH-1015 Lausanne, Switzerland; and Genfit (J.B.), F-59120 Loos, France.
Context/objective: The aim of this study was to evaluate the regulation of the fuel partitioning and energy metabolism in skeletal muscle during lipid overfeeding in healthy men. Design/Participants/Intervention: Thirty-nine healthy volunteers were overfed for 56 days with a high-fat diet (3180 kJ/d). Energy metabolism (indirect calorimetry) was characterized in the fasting state and during a test meal before and at the end of the diet.
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