The study investigates how intestinal sweet taste receptors and glucose transporters influence glycemic control in rats with Type 2 diabetes after undergoing duodenal-jejunal bypass (DJB) surgery.
Researchers evaluated changes in gut peptide levels, glucose transporters, and sweet taste receptors in different parts of the intestines following surgery.
Results indicate that DJB surgery improved glucose tolerance and stimulated gut peptide secretion, but this effect was negated when sweet taste receptor activity was inhibited, suggesting a link between taste sensing and glucose regulation.