Nutritional Profiles and Factors Associated with the Intake of Certain Food Types in Patients Undergoing Maxillofacial Prosthetic Rehabilitation: A Cross-Sectional Study.

Malnutrition is a significant concern for head and neck cancer (HNC) patients, as treatment often impairs mastication, causes dysphagia, and alters taste and smell, leading to reduced food intake and a diminished quality of life. Thus, this study aims to compare nutritional intake in HNC survivors using maxillofacial prostheses (MFPs) to healthy reference values and identify the factors influencing their dietary intake. The study included 56 patients treated for HNC undergoing rehabilitation with comfortable definitive dentures for over a month at the Maxillofacial Prosthetics Clinic of Tokyo Medical and Dental University Hospital.

Effect of geometry on clasp retention force: a finite element analysis study.

Purpose: The retention force of a realistic clasp is influenced by multiple, interrelated factors, which complicates the identification of the fundamental relationship between clasp geometry and retention force. While realistic clasps exhibit various shapes, they share basic geometric elements such as length, diameter, and curvature. Simpler geometries are often more conducive to identifying the underlying issues.

Comparative in situ characterization of erythroid cells found throughout the developing tongue tissue, circulation, and liver of fetal mice.

Background: Erythroid cells contribute to embryonic organ development and adult tissue repair supplying oxygen to tissues. During mouse development, the primitive erythroid cells produced in the extraembryonic blood islands of the yolk sac begin to circulate as immature and nucleated erythroblasts with the onset of cardiac contractions around embryonic day 9.5 (E9.

Custom Ocular Prosthesis With Intraoral Obturator for Orbital and Intraoral Defects Resulting From Mucormycosis: A Technical Case Report.

Orbital defects can result from a myriad of underlying diseases and injuries. Treatment of malignant neoplasms and maxillofacial trauma are common reasons for orbital exenteration. Recently, a growing number of cases of orbital defects have been reported due to mucormycosis in patients with COVID-19.

Enamel microcrack inspection using near-infrared light transillumination with fluorescence staining.

Enamel microcracks are often apparent in the teeth of elderly individuals. However, accurate clinical diagnosis of enamel microcracks is very difficult. The purpose of this study was to examine the utility of inspections for enamel microcracks using a near-infrared light transillumination device with fluorescence staining.

Digitization of Dentate and Edentulous Maxillectomy and Mandibulectomy Defects with Three Different Intraoral Scanners: A Comparative In Vitro Study.

: The objective of this study was to compare the trueness and precision of three intraoral scanners (IOSs) for the digitization of dentate and edentulous maxillectomy and mandibulectomy defects in artificial models. Four representative defect models-a dentate and an edentulous maxillectomy model and a dentate and an edentulous mandibulectomy model-were used for digital scanning. After a reference scan of each model, they were scanned with three IOSs: CEREC AC Omnicam, True Definition, and cara TRIOS 3.

Hyperglycemia Exacerbates Periodontal Destruction via Systemic Suppression of Regulatory T Cell Number and Function.

Aim: Diabetes is a significant risk factor that exacerbates the pathological progression of periodontal disease. In recent years, attention has focused on the effect of regulatory T cells (Tregs), which play a central role in immune tolerance, on inflammatory processes in periodontal tissue, suggesting a link with diabetes-associated periodontitis. In this study, we examined the dynamics of Tregs in periodontal tissue of mice with streptozotocin (STZ)-induced hyperglycemia.

In Vitro Assessment of Injectable Bone Marrow Aspirate Concentrates Compared to Injectable Platelet-Rich Fibrin.

Background: Injectable platelet-rich fibrin (iPRF), a liquid form of PRF that is prepared from peripheral blood without anticoagulants, promotes tissue wound healing and regeneration. The present study focused on iPRF-like bone marrow aspirate concentrate (iBMAC) prepared without anticoagulant, and the regenerative potential of iPRF and iBMAC was compared in vitro.

Methods: iPRF and iBMAC were prepared from the same New Zealand white rabbits.

Efficacy of initial conservative treatment options for temporomandibular disorders: A network meta-analysis of randomized clinical trials.

Purpose: This network meta-analysis (NMA) of randomized controlled trials (RCTs) aimed to identify effective initial conservative treatment strategies for patients with temporomandibular joint disorders (TMD).

Study Selection: RCTs comparing treatment options for TMD published between January 2000 and July 2021 were retrieved from the databases of PubMed and Embase via a comprehensive electronic search. Patients diagnosed with myalgia (muscle pain) or arthralgia (joint pain) according to pain-related Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) and the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) were eligible for inclusion.

Nisin, a Probiotic Bacteriocin, Modulates the Inflammatory and Microbiome Changes in Female Reproductive Organs Mediated by Polymicrobial Periodontal Infection.

Periodontitis-related oral microbial dysbiosis is thought to contribute to adverse pregnancy outcomes (APOs), infertility, and female reproductive inflammation. Since probiotics can modulate periodontitis and oral microbiome dysbiosis, this study examined the effects of a probiotic bacteriocin, nisin, in modulating the reproductive microbiome and inflammation triggered by periodontitis. A total of 24 eight-week-old BALB/cByJ female mice were randomly divided into four treatment groups (control, infection, nisin, and infection+nisin group), with 6 mice per group.

CAD-CAM for removable partial denture fabrication after marginal mandibulectomy based on a well-adjusted pre-existing denture.

This clinical report summarizes a workflow that introduces two approaches for fabricating a metal framework removable partial denture for a marginal mandibulectomy patient. First, the pre-existing denture was adjusted according to the piezographic technique to determine the optimal configuration for adhering to the available denture space. Second, computer-aided design-computer-aided manufacturing (CAD-CAM) technology was used to fabricate a new removable partial denture by digitally scanning the oral condition and the well-adjusted denture and then using the obtained data to design and fabricate the new denture.

Interplay of co-cultured chimeric adipose and gingival tissues exacerbates inflammatory dysfunction relevant to periodontal and metabolic conditions.

Adipose tissue dysfunction is a key feature of metabolic syndrome, which increases the risk of periodontitis, an inflammatory disease induced by bacteria that affects the gingiva and other components of periodontal tissue. Recent studies indicate that molecules from inflamed periodontal tissue contribute to adipose tissue dysfunction. However, the cellular mechanisms and interactions between adipose tissue and gingiva driving the progression of metabolic and periodontal conditions remain unclear.

Higher solubility and lower onset temperature of protein denaturation increase the osteoconductive capacity of collagen membranes: A preclinical in vivo study.

Objectives: Collagen membranes are extensively used for guided bone regeneration procedures, primarily for horizontal bone augmentation. More recently, it has been demonstrated that collagen membranes promote bone regeneration. Present study aimed at assessing if structural modifications of collagen membranes may enhance their osteoconductive capacity.

Generation of bone-specific lysyl hydroxylase 2 knockout mice and their phenotypes.

Lysyl hydroxylase 2 (LH2) catalyzes the hydroxylation of lysine residues in the telopeptides of type I collagen. This modification is critical for the formation of stable hydroxylysine-aldehyde derived collagen cross-links, thus, for the stability of collagen fibrils. Though dysfunction of LH2 causes Bruck syndrome, recessive osteogenesis imperfecta with joint contracture, the molecular mechanisms by which LH2 affects bone formation are still not well understood.

Maxillectomy patients' speech and performance of contemporary speaker-independent automatic speech recognition platforms in Japanese.

Background: Automatic speech recognition (ASR) can potentially help older adults and people with disabilities reduce their dependence on others and increase their participation in society. However, maxillectomy patients with reduced speech intelligibility may encounter some problems using such technologies.

Objectives: To investigate the accuracy of three commonly used ASR platforms when used by Japanese maxillectomy patients with and without their obturator placed.

Dental and bony changes following subtotal glossectomy for cancer: A clinical report.

The impact of tongue size and forces on surrounding tissues have been described, but clinical reports on the influence on dentoalveolar structures after glossectomy for cancer are lacking. This report describes the dental and bony changes after subtotal glossectomy for squamous cell carcinoma by comparing 3-dimensional models generated from computed tomography scans at various time points during the clinical course. Surface comparison showed lingual tipping of the teeth and areas of bone surface remodeling on the alveolar bone, basilar bone, coronoid process, and condyles.

The dimensions of preformed nickel-titanium archwires measured at the bracket positions corresponding to the central incisor, canine, and first molar.

Introduction: Variation in the thickness of commercially available preformed rectangular archwires at the bracket positions has not been thoroughly studied. Therefore, this study measured the edgewise (height) and flatwise (width) dimensions of preformed rectangular nickel-titanium (NiTi) archwires at bracket positions corresponding to the central incisor, canine, and first molar and compared them among bracket positions.

Methods: Sixty types of preformed rectangular NiTi mandibular archwires indicated as 0.

Alternated activation with relaxation of periosteum stimulates bone modeling and remodeling.

Gradual elevation of the periosteum from the original bone surface, based on the principle of distraction osteogenesis, induces endogenous hard and soft tissue formation. This study aimed to assess the impact of alternating protocols of activation with relaxation (periosteal pumping) on bone modeling and remodeling. One hundred and sixty-two adult male Wistar rats were used in this study.

Effect of Simulated Dental Pulpal Pressure Using Fetal Bovine Serum for the Bonding Performance of Contemporary Adhesive to Dentin.

This study evaluated the effect of simulated pulpal pressure (SPP) conditions and storage time on contemporary adhesive systems' microtensile bond strength (µTBS) to dentin. Extracted human molars were prepared and randomly divided into four groups according to the adhesives: Clearfil Megabond 2 (CSE), Beautibond Xtreme Universal (BXU), G2-Bond (G2B), and Scotchbond Universal Plus (SBP). Each adhesive group was further divided following the SPP conditions: control with no simulation (SPP-CTR), SPP with distilled water (SPP-DTW), and SPP with fetal bovine serum (SPP-FBS).

Predicting maximum occlusal force and tongue pressure using decision tree analysis in patients diagnosed with head and neck tumors.

Statement Of Problem: Preserving and restoring oral functions, especially mastication and swallowing, is important to the quality of life of patients being treated for head and neck tumors. Studies that help predict maximum occlusal force and tongue pressure during prosthetic treatment, necessary for providing comprehensive, appropriate treatment and encouraging patient adherence and confidence are lacking.

Purpose: The purpose of this clinical study was to develop a decision tree model for predicting maximum occlusal force and tongue pressure in patients diagnosed with head and neck tumors that could help both experienced and less experienced prosthodontists and oral surgeons optimize the treatment plan and support patient compliance and their quality of life.

Comparison of Aversion to Visual Dental Stimuli Between Patients and Dentists: A Preliminary Study.

Purpose: Fearful dental patients often cite various dental instruments or procedures as triggers for their dental fear. Thus, visual dental stimuli provoke anxiety. This preliminary study aimed to assess the level of aversion to visual stimuli in dental patients and compare it with that in dentists.

Tissue-Targeted Transcriptomics Reveals SEMA3D Control of Hypoglossal Nerve Projection to Mouse Tongue Primordia.

The mouse hypoglossal nerve originates in the occipital motor nuclei at embryonic day (E)10.5 and projects a long distance, reaching the vicinity of the tongue primordia, the lateral lingual swellings, at E11.5.

Rapid multiplex real-time PCR assay using a portable device for the detection of oral pathogens.

Colonization by several oral pathogens and the onset of oral diseases, such as dental caries and periodontal diseases, are closely related. Therefore, the analysis of pathogens in oral specimens would be helpful for the risk assessment of oral diseases. We developed a rapid multiplex real-time polymerase chain reaction (PCR) method using a portable device and newly designed probe/primer sets to detect the oral pathogens Streptococcus mutans, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia.

Spatiotemporal expression profiles of c-Mpl mRNA in the tooth germ: Comparative expression dynamics of vascularization-related genes.

Background: Vascularization is an essential event for both embryonic organ development and tissue repair in adults. During mouse tooth development, endothelial cells migrate into dental papilla during the cap stage, and form blood vessels through angiogenesis. Megakaryocytes and/or platelets, as other hematopoietic cells, express angiogenic molecules and can promote angiogenesis in adult tissues.