590 results match your criteria: "School of Life Dentistry at Niigata[Affiliation]"

The bone ring technique is applied for vertical augmentation, in which the dental implant and autogenous block bone graft are simultaneously inserted. We investigated the healing of bone around implants placed simultaneously using the bone ring technique with and without membrane placement after a 12-month healing period. Vertical bone defects were created on both sides of the mandible of Beagle dogs.

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Establishing protein expression profiles involved in tooth development using a proteomic approach.

Odontology

October 2023

Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-Ku, Niigata, 951-8514, Japan.

Various growth and transcription factors are involved in tooth development and developmental abnormalities; however, the protein dynamics do not always match the mRNA expression level. Using a proteomic approach, this study comprehensively analyzed protein expression in epithelial and mesenchymal tissues of the tooth germ during development. First molar tooth germs from embryonic day 14 and 16 Crlj:CD1 (ICR) mouse embryos were collected and separated into epithelial and mesenchymal tissues by laser microdissection.

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The effect of intentionally perforating the floor of the pulp chamber on pulpal healing after tooth replantation in mice.

J Oral Biosci

March 2023

Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address:

Objectives: Shortening the root of a mouse molar prior to tooth replantation results in early revascularization in the pulp cavity and activation of the dental pulp quiescent stem cells. This study aimed to validate the effects of pulp chamber floor perforation on pulpal healing after tooth replantation as a strategy to promote early revascularization into the pulp.

Methods: The maxillary first molars of three-week-old Crlj:CD1 mice were extracted and repositioned into the original socket: the left teeth were immediately replanted (control group: CG), whereas the floor of the pulp chamber of the right teeth was perforated with a tungsten carbide bur before tooth replantation (experimental group: EG).

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Background/aim: An undercut on the model's labial side affects the mouthguard thickness. The aim of this study was to investigate how the undercut amount on the model's labial side affects the reduction rate of laminated mouthguard thickness.

Materials And Methods: Mouthguards were thermoformed using 3.

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Purpose: To investigate the bactericidal and biofilm removal effect of super reducing water (SRW) on Streptococcus mutans (S. mutans) adhered to orthodontic brackets, in vitro.

Methods: Three types of brackets were bonded to aluminum disks.

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The medial brachial cutaneous nerve (MBC) originates from the medial cord of the brachial plexus and innervates the skin sensory in the medial posterior surface of the upper arm. Considering previous reports of the primate brachial plexus, the MBC appeared to be the sole branch in the brachial plexus that only some primates possess. However, the detailed descriptions and records regarding the morphology of the MBC and related nerves, their origins and distributions (dermatomes) in particular, were frequently lacked in the previous reports, and it remains unclear why the difference in the MBC appearance exists among primates.

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Anatomical Study of Sites and Surface Area of the Attachment Region of Tibial Posterior Tendon Attachment.

Int J Environ Res Public Health

December 2022

Department of Anatomy, School of Life Dentistry at Niigata, Nippon Dental University, Niigata 951-8151, Japan.

Background: The purpose of this study was not only to examine the attachment site but also to quantify the effect of the tibialis posterior tendon (TPT) on each attachment site by examining the surface area of the attachment region.

Methods: We examined 100 feet from 50 Japanese cadavers. The TPT attachment to the navicular bone (NB), medial cuneiform bone (MCB), and lateral cuneiform bone (LCB) were set as the main attachment sites (Type I).

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Background/aim: Polyolefin sheets are fabricated in the same manner as ethylene vinyl acetate sheets. The aim of this study was to examine the difference of vacuum-formed mouthguard thickness according to each heating condition using ethylene vinyl acetate and polyolefin sheets.

Materials And Methods: Mouthguard sheets of 3.

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Stimulation of the center of the lateral reticular nucleus suppresses the swallowing reflex in rats.

Neurosci Lett

January 2023

Clinical Examination, Field of Oral and Maxillofacial Surgery and Systemic Medicine, Course of Clinical Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan; Department of Internal Medicine, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan.

Morphological studies have demonstrated that the lateral reticular nucleus (LRt) receives fibers projected from sites that are related to control of the swallowing reflex. Although the LRt may therefore be related to control of the swallowing reflex, the functional role of the LRt in the swallowing reflex remains unknown. The present study examined whether the swallowing reflex is modulated by stimulation of the LRt.

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Purpose: Japan, with an increasing number of elderly people needing long-term care in a super-aged society, urgent needs to develop the clinical guidelines on implant maintenance for elderly people with declining independence. The purpose is to categorize the troubles encountered in the care of patients with dental implants and to indicate actual practices and points of note.

Methods: From the members of the Japanese Society of Oral Implantology, 12 expert panelists who were experienced with many problems of implant maintenance during dental visits and were familiar with their solutions were selected.

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Objectives: The objectives of the study were to investigate the relationship between caries prevalence and the Index of Orthodontic Treatment Need Dental Health Component (IOTN-DHC) in school-age children who live in the dentistless area and to consider the effective way to reduce the potential progression of malocclusion with the growth through the dental survey in Arbulag district, Khövsgöl province, Mongolia.

Materials And Methods: The 95 school-age children (49 males, 46 females) who participated in the study were born in and were residents of Arbulag district, Khövsgöl province, Mongolia. The mean ages of the participants were 8.

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Gars and bichirs develop scales and teeth with ancient actinopterygian characteristics. Their scale surface and tooth collar are covered with enamel, also known as ganoin, whereas the tooth cap is equipped with an enamel-like tissue, acrodin. Here, we investigated the formation and mineralization of the ganoin and acrodin matrices in spotted gar, and the evolution of the scpp5, ameloblastin (ambn), and enamelin (enam) genes, which encode matrix proteins of ganoin.

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How Sleep Quality Relates to Bodily and Oral Symptoms: An Analysis from Japanese National Statistics.

Healthcare (Basel)

November 2022

Department of Preventive and Community Dentistry, School of Life Dentistry at Niigata, The Nippon Dental University, Niigata 951-8151, Japan.

Background: Sleep is one of the most important health-related factors. This cross-sectional study focused on sleep quality relates to systemic symptoms, including dental symptoms. Methods: Resource data were compiled from 7995 men and women aged 30 to 69 years, which is the core of the Japanese working population.

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Article Synopsis
  • The study aimed to compare the maximum and mean standardized uptake values (SUVs) of various jaw pathologies, including medication-related osteonecrosis of the jaw (MRONJ), using bone SPECT/CT imaging.
  • Eighty-nine patients were examined, where SPECT/CT scans were performed after administering a radiotracer, and statistical analyses were conducted on the SUV values to correlate and assess their significance.
  • Results showed distinct SUV values for each jaw pathology, with MRONJ demonstrating specific differences, suggesting that maximum and mean SUVs are valuable in quantitatively evaluating jaw conditions like MRONJ.
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Molecular targets and predictive biomarkers for prognosis in salivary duct carcinoma (SDC) have not been fully identified. We conducted comprehensive molecular profiling to discover novel biomarkers for SDC. A total of 67 SDC samples were examined with DNA sequencing of 464 genes and transcriptome analysis in combination with the clinicopathological characteristics of the individuals.

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Influence of mandibular incisor agenesis and growth pattern on symphysis characteristics: A retrospective cephalometric study.

Orthod Craniofac Res

August 2023

Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Life Dentistry at Niigata, The Nippon Dental University, Niigata, Japan.

Objective: This study was performed to investigate the effects of mandibular incisor (MnI) agenesis and divergent malocclusion type on mandibular symphysis inclination and morphology.

Methods: A total of 162 selected patients were divided into two groups: one group consisted of patients with one or two congenitally missing MnIs, and another group comprised patients without tooth agenesis. Patients in each group were categorized into three divergent malocclusion groups (hypodivergent, normodivergent and hyperdivergent) according to the Frankfort mandibular plane angle, with 27 patients per group.

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Background: This study aimed to investigate parameters for medication-related osteonecrosis of jaw (MRONJ) patients using the bone SPECT/CT, especially bone mineral-based parameters.

Methods: Sixty-three patients with MRONJ (43 osteoporosis and 20 bone metastasises) underwent CT, MRI and SPECT/CT. A commercially available software automatically detected lesion area and calculated the quantitative SPECT/CT parameters as bone mineral-based standardized uptake value (SUV).

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Background/aim: The shape of the working model is one of the major factors affecting the thickness of thermoformed mouthguards. The aim of this study was to clarify the priority of model trimming to prevent thinning during mouthguard thermoforming.

Materials And Methods: Mouthguards were thermoformed using 4.

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Effects of nicotine and lipopolysaccharide stimulation on adhesion molecules in human gingival endothelial cells.

Odontology

April 2023

Field of Advanced Conservative Dentistry and Periodontology, Periodontology, Course of Clinical Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, 1-8 Hamaura-cho, chou-ku, 951-8580, Niigata, Japan.

Smoking is a risk factor for periodontitis, and the immune response of periodontal tissues in patients with periodontitis may be strongly affected by smoking. The purpose of this study was to elucidate the bioactivity and signal transduction of human gingival endothelial cells (HGECs) due to nicotinic stimulation using a cultured medium supplemented with lipopolysaccharide (LPS) as a model of periodontitis. HGECs were cultured in medium supplemented with LPS, nicotine, nicotine + LPS, and medium supplemented without nicotine or LPS (control).

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(1) Aim: To investigate the effect of synthetic bone substitutes, α-tricalcium phosphate (α-TCP) or bi-layered biphasic calcium-phosphate (BBCP) combined with deproteinized bovine bone mineral (DBBM), on bone formation. (2) Methods: Thirty critical size defects were randomly treated with the following five different treatment modalities: (1) negative control (NC, empty), (2) DBBM, (3) α-TCP + DBBM (1:1), (4) BBCP 3%HA/97%α-TCP + DBBM (1:1), and (5) BBCP 6%HA/94%α-TCP + DBBM (1:1). The samples, at four weeks post-surgery, were investigated by micro-CT and histological analysis.

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Background: Suprahyoid muscles behavior during the tongue lifting movement has not yet been elucidated.

Objective: The purpose of this study was to investigate the potential of elastography imaging to examine developmental oral dysfunction in children and oral hypofunction in older adults using sonography.

Methods: Tongue pressure was measured using a manometer with a probe.

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Effect of Systemic Administration of Amitriptyline on Oral Microbes in Rats.

In Vivo

September 2022

Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Tōbetsu, Japan;

Article Synopsis
  • Amitriptyline, a tricyclic antidepressant used for chronic orofacial pain, may alter oral microflora and innate immunity, though its specific effects were previously unclear.
  • In a study with Sprague-Dawley rats, amitriptyline was administered for two weeks, during which researchers analyzed changes in the oral microbiome and antimicrobial peptide levels through DNA sequencing and mRNA evaluation.
  • Results revealed significant shifts in oral bacteria composition and increased antimicrobial peptide expression in the amitriptyline group, indicating that this medication may influence oral health and immunity.
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Study of the Acquisition of Sensitivity to Paclitaxel Plus Cetuximab by the Addition of Low-dose Proteasome Inhibitor.

Anticancer Res

September 2022

Course of Clinical Science, Field of Oral and Maxillofacial Surgery and Systemic Medicine, Oral and Maxillofacial Surgery, Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.

Article Synopsis
  • The study investigates the effects of paclitaxel plus cetuximab, a common treatment for recurrent/metastatic oral squamous cell carcinoma (OSCC), focusing on the changes in NF-κB expression after treatment.
  • Eight OSCC cell lines were examined in a 3D culture setup, revealing a significant reduction in NF-κB expression in sensitive cell lines, while resistant ones showed an increase.
  • The addition of bortezomib, a proteasome inhibitor, enhanced the effectiveness of the drug combination in resistant cell lines, suggesting a potential strategy to overcome treatment resistance.
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Article Synopsis
  • This study examines whether local low-dose administration of anti-PD-1 antibody can provide similar antitumor effects and overall survival rates as systemic high-dose administration in treating oral cancer.
  • The research involved using a specific cancer cell line in mice and comparing the effects of local and systemic drug delivery on tumor shrinkage and immune markers.
  • Results indicated that local low-dose treatment achieved comparable effectiveness to systemic high-dose treatment and may minimize side effects and costs associated with immunotherapy in oral cancer.
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Relationship between tongue pressure and handgrip strength: A systematic review and meta-analysis.

J Oral Rehabil

November 2022

Department of Reconstructive Dentistry and Gerodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.

Objectives: Muscle strength decreases with age, causing a decline in physical and oro-facial function. However, the impact of physiological and pathophysiological factors on tongue pressure (TP) has not been clarified. The purpose of this systematic review and meta-analysis was to compare and analyse TP and handgrip strength (HGS) between individuals aged <60 and ≥60 years, gender and need for care (independent older adults (IC) and older adults receiving nursing care (NC)).

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