Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility.

Plasmodium malariae parasites are widely observed across the tropics and sub-tropics. This slow-growing species, known to maintain chronic asymptomatic infections, has been associated with reduced antimalarial susceptibility. We analyse 251 P.

Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance.

Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P.

Multidisciplinary team meetings: dynamic routines that (re)make palliative care.

Multidisciplinary team meetings are part of the everyday working life of palliative care staff. Based on ethnographic material from community and hospital palliative care teams in England, this article examines these meetings as dynamic routines. Although intended to have a prescribed format to review deaths and collect standardised information to monitor service performance, in practice, the content and conduct of the meetings were fluid, reflecting how this structure did not always match the concerns held by the team.

Youth With Functional Abdominal Pain Disorders Have More Sleep Disturbances. A School-Based Study.

Background: There is a bidirectional relationship between sleep and pain disturbances. Sleep disturbances increase the risk for chronic pain, while chronic pain can interfere with sleep. Hence, we assessed the subjective sleep characteristics of youth with functional abdominal pain disorders (FAPDs) compared to healthy youth and examined associations with gastrointestinal symptoms.

Frequency and antibiotic resistance pattern of spp. isolated from traditional dairies and raw milks collected in Yazd province, Iran.

Background And Objectives: Salmonellosis is among the most common food-born infections, caused by spp. bacteria. Present study has investigated the frequency and antibiotic resistance pattern of spp.

Seizing the Teachable Moment: A Pilot Study of Preventive Lifestyle Education in the Emergency Department.

Background Preventive measures are critical in avoiding and limiting the severity of diseases. Key lifestyle behaviors include sleep hygiene, habitual exercise, a healthy diet, and avoidance of risky substances, particularly the use of tobacco. The transtheoretical model (TTM) of change suggests that patients can move towards healthful changes through education.

Accountability and objectivity: Humanitarian narratives at the intersection of evidence and localisation.

In the last decade, there has been a push for greater evidence-based practice within the humanitarian sector, alongside an increasing turn towards localising humanitarian assistance. Humanitarian actors and organisations have been increasing their production and use of evidence, while also being encouraged to reflect more critically on power hierarchies and decolonise humanitarian aid. This paper explores the intersection of these two narratives, examining how the use of evidence in humanitarian decision-making fits within a localisation agenda.

Infants born during COVID-19 pandemic experience increased susceptibility to airway hyperresponsiveness.

Background: Asthma, allergic rhinitis, atopic dermatitis, and food allergy are type 2 inflammation diseases. Since the 1960s, the prevalence of those diseases has steadily increased, presumably due to the "Hygiene hypothesis" which suggests that early exposure of infants to pathogens, siblings, and environmental dust, has a protective effect against the development of allergic diseases. The COVID-19 pandemic increased environmental hygiene due to lockdowns, masks, and social distancing.

Effect of ultrasound on the physical, biochemical, antioxidant, and antimicrobial properties of industrial Iranian honey.

The aim of this study was to investigate the effects of ultrasound at two different frequencies, namely 30 kHz and 42 kHz, on various aspects of industrial Iranian honey, including its physical, biochemical, antioxidant and antimicrobial properties. Samples were subjected to ultrasound treatment at 30 kHz or 42 kHz for a duration of 1, 5 or 10 minutes at temperatures of 20 °C or 45 °C, respectively. The following parameters were then evaluated on days 1, 30, 90, and 180: HMF content, pH, acidity, proline concentration, total number of aerobic mesophilic bacteria, diastase activity, moisture content, sucrose concentration, fructose concentration, glucose concentration, fructose- glucose ratio, ABTS (antioxidant activity) content, number of osmophiles, phenol concentration, reducing sugar concentration and total sugar concentration.

Sepsis in a 9-Month-Old Female Infant: A Case Report.

Grimontia hollisae, an uncommon cause of sepsis, was identified in a 9-month-old infant in Africa without confirmed seafood consumption. Prompt diagnosis through blood culture and targeted antibiotic therapy ensured recovery, emphasizing the need for increased awareness, enhanced diagnostic tools, and active monitoring of emerging pathogens in tropical and resource-limited regions. We present a case report involving a 9-month-old infant who exhibited symptoms of acute gastroenteritis.

Insights into the biology and insecticide susceptibility of the secondary malaria vector Anopheles parensis in an area with long-term use of insecticide-treated nets in northwestern Tanzania.

Background: The Anopheles funestus group includes at least 11 sibling species, with Anopheles funestus Giles being the most studied and significant malaria vector. Other species, like Anopheles parensis, are understudied despite their potential role in transmission. This article provides insights into the biology and insecticide susceptibility of An.

Tooth loss-associated neuroplasticity of mastication-related motor cortical neurons.

Objectives: The cerebral cortex contains neurons that play a pivotal role in controlling rhythmic masticatory jaw movements. However, the population characteristics of individual cortical neuronal activity during mastication and the impact of tooth loss on these characteristics remain unclear. Thus, in this study, we aimed to determine the activity patterns of mastication-related motor cortical neurons elicited during mastication and examine the effects of tooth extraction on neuronal activity using two-photon Ca imaging in head-restrained awake mice.

High water iodine levels are associated with the prevalence of subclinical hypothyroidism, thyroid nodules and goiter among pregnant women in Shandong, China.

Background: Both iodine deficiency and iodine excess can harm the thyroid glands during pregnancy. In areas without iodine fortification, the relationship between the water iodine concentration (WIC) and thyroid disease in pregnant women requires further investigation.

Objective: The aim of this study was to evaluate the relationship between water iodine levels and the prevalence of thyroid disease in pregnant women residing in areas with high water iodine levels without access to iodized salt.

Evaluation of susceptibility to pyrazinamide and streptomycin, isoniazid, rifampin and ethambutol of Mycobacterium caprae strains isolated from European bison (Bison bonasus caucasicus) in the Bieszczady Mountains (Southern Poland).

The material for drug resistance testing was 28 strains of Mycobacterium caprae isolated from tissue collected post mortem from a free-living Bieszczady Mountain European bison (Bison bonasus caucasicus) herd. All drug susceptibility tests were carried out on an automated Bactec mycobacterial growth indicator tube (MGIT) 960 system, using Bactec MGIT 960 streptomycin, isoniazid, rifampin and ethambutol (S.I.

Case Finding and Management of Childhood Cataracts: The Role of a Child Eye Health Programme in Kaduna State, Nigeria.

Objective: To evaluate the output of a child eye health programme in terms of identification, referral, and volume of paediatric cataract surgeries in Kaduna State, Nigeria.

Materials And Methods: This was a retrospective review of the North-West Nigeria Child Eye Health Initiative programme referral registers at primary, secondary and tertiary hospitals in Kaduna State. Theatre registers of children 0-16 years who had cataract surgery at National Eye Centre Kaduna between 2016 and 2019 were also reviewed.

Relationship Between Early-Life Factors and Self-Reported Age at Myopia Onset: A Study Based on a Sample of Chinese Adults.

Aim: To investigate the influence of early-life factors (Season of birth, premature birth and breastfeeding) on the age at myopia onset.

Methods: A total of 331 myopic students aged 18 years or above were recruited from one medical university in Wenzhou, China. Questionnaires were administered to collect data on age at myopia onset, early-life factors, and vision hygiene habits.

Antimicrobial and Remineralization of Carboxymethyl Chitosan and Xylitol Functionalized Carbon Dots Coating on Orthodontic Brackets.

Purpose: During fixed orthodontic treatment, oral hygiene is difficult to ensure and can easily lead to an imbalance in the oral micro-ecological balance. In this study, based on the adhesive properties of polydopamine (PDA) and the good antimicrobial and remineralization properties of carboxymethyl chitosan (CMC) and xylitol (Xy), new nanocomposites with both antimicrobial and remineralization capabilities were prepared to coat on orthodontic brackets.

Methods: Composite carbon dots (CDs) were synthesized using carboxymethyl chitosan and xylitol, we characterized them and the antimicrobial properties of the CMC-Xy-CDs were investigated by co-cultivation with S.

The Effects of Different Hygiene Instrumentations on Titanium Implant Fixture Surfaces.

Background and objective Applying different hygiene tools for implant maintenance alters surface configurations, impacting bacterial adhesion on titanium implant surfaces and potentially leading to peri-implant diseases. This study aimed to assess the alterations in surface topography of titanium implant fixtures after utilizing hygiene instruments such as airflow; erbium, chromium-doped: yttrium, scandium, gallium, and garnet (Er, Cr: YSGG) laser; and titanium brush, under scanning electron microscope (SEM) observation. Materials and methods We employed an experimental laboratory study design for this research, involving 20 MegaGen ST titanium implant fixtures (MegaGen Implant Co.

Right Ventricular Myxoma Involving the Chordae Tendineae: A Case Report and Literature Review.

This case report describes a rare instance of massive right ventricular myxoma (RVM). A 36-year-old woman initially presented with progressive breathlessness and chest heaviness. Imaging revealed a large mass in the mediastinum, which was initially thought to be a pericardial cyst, and it was unclear whether the mass was intracardiac or extracardiac.

Managing Early Childhood Caries: A Comparative Review of Preventive and Restorative Approaches.

Early childhood caries (ECC), one of the most common health problems among children aged six years and below, is considered present when one or more surfaces of a tooth are decayed, missing, or filled. Not only does ECC cause pain for a long time, but it also has short- and long-term health consequences in children. In order to treat ECC, holistic management that includes preventive, restorative, and prosthetic intervention is necessary.

Knowledge, perceptions, and management of symptoms of hormonal imbalance among adolescent girls in selected schools in Ghana: a qualitative exploratory study.

Introduction: Adolescent girls are more sensitive to hormonal imbalance with major impact on their nutritional, reproductive, physical, psychosocial, and academic wellbeing. This study explored adolescent girls' knowledge and perceptions of causes and management of symptoms of hormonal imbalance.

Materials And Methods: Using a qualitative approach, focus group discussions were conducted with 116 assented in-school adolescent girls aged 10-19 years between 3rd and 19th October 2022.

The impact of an integrated intervention program combining drug therapy with water, sanitation, and hygiene (WASH) education on reinfection with intestinal parasitic infections among the Karen hill tribe in northern Thailand.

Background: Intestinal parasitic infections (IPIs) are a major health problem among the Karen hill tribe in Thailand. This study aimed to evaluate the effect of an integrated intervention program of drug therapy combined with water, sanitation, and hygiene (WASH) education on reinfection with IPIs among the Karen hill tribe in an endemic area of northern Thailand.

Methods: A quasi-experimental study was conducted in two Karen villages, involving 691 residents, in Omkoi District, Chiang Mai Province; one village was designated as the intervention group and the other as the control group.

Respiratory Morbidity Before and During the COVID-19 Pandemic from Birth to 18 Months in a Swedish Birth Cohort.

Background: Respiratory infections in early life is one identified risk factor for asthma. We hypothesized that infection preventive measures during the COVID-19 pandemic influenced the risk of respiratory morbidity and aeroallergen sensitization in early childhood.

Objective: To compare respiratory morbidity and aeroallergen sensitization in children born before and during the pandemic.