Knee-Related Patient-Reported Outcome Measures for Young Adults: A Scoping Meta-Review.

Background: There is a lack of patient-reported outcome measures (PROMs) research on young adults and knee disorders. This scoping meta-review examined a young adult population and aimed to (1) provide an overview of knee-related PROMs research and (2) evaluate the measurement properties of the five most evaluated knee-related PROMs relevant for individual care and group-level analysis.

Methods: A systematic search of the PubMed and COSMIN databases was conducted on 18 September 2023 and updated on 25 November 2024 to identify systematic reviews of knee-related PROMs in young adults.

Exploring the use of digital technology for injury prevention and self-management among recreational runners.

Objectives: Explore digital technology use among recreational runners in Wales and assess attitudes toward a proposed digital intervention for running-related injury (RRI) prevention and self-management.

Design: Exploratory survey.

Setting: Online questionnaire, closed questions distributed to runners over a 7 week period.

Impact of Mast Cell Activation on Neurodegeneration: A Potential Role for Gut-Brain Axis and Infection.

Background: The innate immune response aims to prevent pathogens from entering the organism and/or to facilitate pathogen clearance. Innate immune cells, such as macrophages, mast cells (MCs), natural killer cells and neutrophils, bear pattern recognition receptors and are thus able to recognize common molecular patterns, such as pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs), the later occurring in the context of neuroinflammation. An inflammatory component in the pathology of otherwise "primary cerebrovascular and neurodegenerative" disease has recently been recognized and targeted as a means of therapeutic intervention.

The impact of psoriatic arthritis on quality of life: a systematic review.

Background: Psoriatic arthritis (PsA) is a chronic inflammatory condition that can affect individuals of all ages. Patients may experience a range of physical and psychological issues.

Objective: To examine the impact of PsA on an individual's quality of life (QoL) and physical function.

Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis.

Background: Around one in three pregnant women undergoes induction of labour in the United Kingdom, usually preceded by in-hospital cervical ripening to soften and open the cervix.

Objectives: This study set out to determine whether cervical ripening at home is within an acceptable safety margin of cervical ripening in hospital, is effective, acceptable and cost-effective from both National Health Service and service user perspectives.

Design: The CHOICE study comprised a prospective multicentre observational cohort study using routinely collected data (CHOICE cohort), a process evaluation comprising a survey and nested case studies (qCHOICE) and a cost-effectiveness analysis.

Lessons learned from the experiences of newly qualified therapeutic radiography students who transitioned to work during the Covid-19 pandemic.

Introduction: The Covid-19 pandemic raised profound questions regarding healthcare values and responsibility for managing collective and individual needs. This context presents a unique opportunity to explore the experiences of newly qualified therapeutic radiographers transitioning to work.

Method: An interpretivist qualitative design used one-to-one, semi-structured interviews.

Psoriatic Arthritis Priority Setting Partnership: patient- and clinician-informed considerations for future UK health service delivery.

Objectives: Little is known about the ideal service delivery model and shortcomings in patient experiences in the NHS for patients with Psoriatic Arthritis (PsA). To identify unmet needs perceived within the current health service delivery model for PsA from the UK Psoriatic Arthritis Priority Setting Partnership (PsA PSP).

Methods: An online survey was conducted in 2020 and distributed to people with PsA, their carers and clinicians to identify research priorities in PsA.

Meta-analyses uncover the genetic architecture of Idiopathic Inflammatory Myopathies.

Objective: Idiopathic inflammatory myopathies (myositis, IIMs) are rare, systemic autoimmune disorders that lead to muscle inflammation, weakness, and extra-muscular manifestations, with a strong genetic component influencing disease development and progression. Previous genome-wide association studies identified loci associated with IIMs. In this study, we imputed data from two prior genome-wide myositis studies and analyzed the largest myositis dataset to date to identify novel risk loci and susceptibility genes associated with IIMs and its clinical subtypes.

Does Allostatic Load in 50-89-Year-Olds Predict the Development of Frailty? Evidence From a National Longitudinal Study Over 12 Years.

Frailty is characterised by a loss of function across several domains but is not an inevitable aspect of ageing and can be reversed with intervention. Determining those who are more likely to become frail before physical deficits become manifest will allow earlier intervention. One promising indicator of the potential for frailty is allostatic load, a physiological status associated with prolonged stress that is, characterised by multisystem dysfunction.

Defining and measuring long COVID fatigue: a scoping review.

Objective: Long COVID encompasses a range of symptoms in which fatigue is one of the most prevalents. It is clear from other conditions that the definition and measurement of fatigue can be complex, but it is not clear how fatigue is defined and measured in long COVID. To advance our understanding, this review summarises the definitions and measures of long COVID fatigue being used by researchers.

Personal and Social Transformative Learning through Community‑Based Education: Insights from Training Socially Accountable Medical Doctors at a Historically Disadvantaged University in the Eastern Cape, South Africa.

In 2014, the Faculty of Health Sciences at Walter Sisulu University introduced a 20‑week long integrated longitudinal clinical clerkship (ILCC) rotation block as part of its commitment to community‑based education and social responsiveness, with the goal of ensuring that the curriculum is updated to align with the contemporary health system challenges in South Africa. To explore whether medical student participants underwent social and personal transformative learning in understanding complex societal health needs during their integrated longitudinal community clerkship program. This was an exploratory qualitative research study conducted among 113 5 year medical students based at 8 selected hospitals during their 20‑week‑long community clerkship.

Using ultrafast angio planewave ultrasensitive and conventional doppler imaging techniques to assess intramuscular blood perfusion in older adults.

Background: Microvascular ultrasound imaging techniques such as Angio PLanewave UltraSensitive (Angio-PL.U.S.

Leadership training in emergency medicine: A national survey.

Background: Emergency medicine (EM) is a uniquely stressful environment in which leadership training could improve individual and team performance, patient outcomes, well-being, and EM career intentions. The primary aim was to evaluate EM-specific leadership training (EMLeaders) compared to no leadership training. A secondary comparison was with other forms of leadership training.

The influence of pain on community reintegration after spinal cord injury.

Background: Community reintegration is an important goal for people living with a spinal cord injury (SCI), and pain is suspected to limit reintegration due to its limitations in daily functioning, mood, and sleep.

Objectives: To determine the influence of pain on community reintegration in manual wheelchair users with SCI.

Methods: The Reintegration to Normal Living Index was used to determine community reintegration, while the DN4 and the Wheelchair User's Shoulder Pain Index were used to determine the presence of neuropathic and shoulder pain respectively.

Integrated hip surveillance pathways for pain, function and quality of life in children with Cerebral Palsy: A systematic literature review.

Aim: To determine the effectiveness of integrated hip surveillance pathways on pain, function and quality of life (QOL) in children with Cerebral Palsy (CP).

Method: A systematic literature review, designed, conducted and reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Inclusion Criteria: confirmed CP diagnosis, management under recognised international hip surveillance pathways, outcome measures of hip displacement plus at least one other relevant to pain, function or QOL.

Personalized adaptive learning in higher education: A scoping review of key characteristics and impact on academic performance and engagement.

Introduction: Higher education institutions face persistent challenges of student retention and academic progress. Personalized adaptive learning has the potential to address these issues as it leverages educational technology to tailor learning pathways according to individual student needs.

Objective: To elucidate the key characteristics of personalized adaptive learning in higher education and its impact on academic performance and engagement.

'Hidden' work and lost opportunities: nursing research and impact case studies submitted to REF2021.

Aims: (1) Identify and characterise the nursing contribution to impact case studies submitted to Research Excellence Framework (REF) 2021 across all Units of Assessment and compare this to those submitted to REF 2014; (2) Identify and characterise those impact case studies of relevance to nursing that did not include a nurse in the research team; (3) Compare the characteristics of impact case studies identified in Aim 2 with those that did include a nurse in the research team.

Design: Desk-based analysis of REF2021 published data.

Methods: We searched the REF2021 impact database with the term nurs* then sorted case studies into categories representing the involvement of nurses on the research team.

Value-based outcome evaluation methods used by occupational therapists in primary care: a scoping review.

Objective: This scoping review aimed to map how occupational therapists evaluate the outcomes of services they provide within primary care. This evidence was considered in relation to how identified outcome evaluation methods align to principles of value-based health care.

Introduction: Primary care services are experiencing unprecedented demands.

Supporting People Treated with Immune Checkpoint Inhibitors: A Qualitative Study Exploring Oncology Healthcare Professionals' Experiences.

Objectives: Immune checkpoint inhibitors have recently developed successfully in treatment for several advanced cancers, including advanced renal cancer, where options have previously been limited. However, while some are able to tolerate these treatments, others may experience unpredictable and sometimes severe immune-related adverse events. Oncology health care professionals have vital roles in optimizing safety and supporting positive outcomes for people receiving these treatments.