Hydrogel design and applications for periodontitis therapy: A review.

Periodontitis is a prevalent oral disease characterized by microbial infection, inflammation, and damage to periodontal tissues. Hydrogels have emerged as promising carriers and regenerative biomaterials in periodontitis therapy. This review provides a comprehensive overview of recent advances in hydrogel applications for treating periodontitis.

Sturgeon-derived peptide LLLE alleviates colitis via regulating gut microbiota and its metabolites.

Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease, entails chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD implicates genetic factors, gut microbiome alterations, and immune dysregulation, contributing to its increasing global prevalence. The sturgeon-derived peptide, which exhibits promising anti-inflammatory effects, provides potential therapeutic insights for managing IBD symptoms.

Glycemic impact of cereal and legume-based bakery products: Implications for chronic disease management.

This review examines the glycemic impact of cereal and legume-based bakery products and their potential role in chronic disease management, particularly in type II diabetes and cardiovascular diseases. The primary objective is to assess the glycemic index (GI) and glycemic load (GL) of bakery products made from cereals such as wheat and barley, and legumes like chickpeas, and to explore their effects on postprandial blood glucose response. Cereal-based products typically exhibit higher GIs (55-80), while legume-based bakery products demonstrate lower GIs (40-50), potentially contributing to better glycemic control.

Stabilizing effect of Leuconostoc mesenteroides Lm10 produced dextran in situ on stirred soy yogurt: Structure-function relationship.

Stirred soy yogurt as a dairy alternative is widely accepted among consumers, but its poor stability has been an urgent problem. We found that Leuconostoc mesenteroides Lm10 produced dextran reduced water mobility and improved the water holding capacity of stirred soy yogurt, especially with over 4 % sucrose added which could completely prevent whey separation. With the increase of dextran content, the particle size of stirred soy yogurt was significantly decreased, accompanied by the improvement of viscoelastic behaviors and resistance to deformation.

Mechanism underlying V-type structure formation in maize starch through glycerol-ethanol thermal substitution method.

V-type starches have been widely used in food science, agriculture, and biomedical science, but their mechanism of formation in nonaqueous solvents remains unclear. This study performed glycerol-ethanol thermal substitution to prepare V-type starch at atmospheric pressure. Scanning electron microscopy and confocal laser scanning microscopy revealed that breakage of starch particles began in the hilum region and rapidly spread to the periphery with the temperature increased from 100 °C to 130 °C.

Mussel-inspired highly adhesive carrageenan-based coatings with self-activating enhanced activity for meat preservation.

In order to solve the problem of poor adhesion of polysaccharide coatings in meat storage and inconvenient secondary spraying, which leads to poor preservation effect, this study was inspired by the property of mussels to adhere firmly to surfaces and design a bioactive composite coating. Here, curcumin-loaded zein nanoparticles (CZ NPs) were successfully prepared and incorporated into carrageenan-based biocomposite coatings for chilled meat preservation. The prepared curcumin-zein-riboflavin-carrageenan (CZRC) coating featured smooth spherical morphology and the solubility of hydrophobic substances, the adhesion and stability of the composite coating were respectively improved to 3.

Preparation of photo-crosslinked microalgae-carboxymethyl chitosan composite hydrogels for enhanced wound healing.

Integrating microalgae into wound dressings has proven effective in promoting chronic wound healing through photosynthesis-induced oxygen release. However, challenges such as high crosslinking temperatures and prolonged gel molding processes limit microalgae growth and reduce the overall therapeutic impact. In this work, inspired by cell-symbiotic photo-crosslinked hydrogels, we present a novel photo-crosslinked microalgae carboxymethyl chitosan composite hydrogel.

Exploring the dual role of anti-nutritional factors in soybeans: a comprehensive analysis of health risks and benefits.

Soybeans (Glycine max [L.] Merr.) are a globally significant crop, valued for their high protein content and nutritional versatility.

EGCG-enabled Deep Tumor Penetration of Phosphatase and Acidity Dual-responsive Nanotherapeutics for Combinatory Therapy of Breast Cancer.

The presence of dense collagen fibers is a typical characteristic of triple-negative breast cancer (TNBC). Although these fibers hinder drug penetration and reduce treatment efficacy, the depletion of the collagen matrix is associated with tumor metastasis. To address this issue, epigallocatechin-3-gallate (EGCG) is first exploited for disrupting the dense collagenous stroma and alleviate fibrosis by specifically blocking the TGF-β/Smad pathway in fibroblasts and tumor cells when intraperitoneally administrated in TNBC tumor-bearing mice.

pH-activated metal-organic layer nanozyme for ferroptosis tumor therapy.

Nanozymes have made great achievements in the research of tumor therapy. However, due to the complex tumor microenvironment, the catalytic activity and biosafety of nanozymes are limited. High catalytic efficiency is a relentless pursuit for the preparation of high-performance nanozymes.

Structural and functional optimization of egg white protein hydrogels by succinylation: Gel properties and mineral enrichment.

The development of novel gel-mineral supplements is important for improving the health of patients with dysphagia. In this study, we used natural egg white protein (NEWP) and phosphorylated egg white protein (STEWP) as controls. We modified NEWP with succinic anhydride to produce varying degrees of succinylated egg white protein (SAEWP).

Hypoglycemic activity of enzymatically extracted Eucommia ulmoides polysaccharide (EUL-w1) on IR-HepG2 cell via the AMPK/PI3K/Akt signaling pathway.

This study devised optimal conditions to extract Eucommia ulmoides leaf (EUL) polysaccharides using a cellulase and pectinase composite enzyme system based on one-way experiments and response surface methodology. Crude EUL polysaccharides (EULPs) were extracted and purified using a DEAE chromatography column. The polysaccharides EUL-w, EUL1, EUL2, and EUL3 were obtained by elution with water, 0.

Monolithic gold saturated on nanoporous gold@mirror template for highly reliable and fast surface-enhanced Raman scattering detection.

The primary challenge hindering the broad application of surface-enhanced Raman scattering (SERS) is the variability in substrate performance due to site differences, leading to unstable detection results. Thus, the current work reports the constant potential deposition of gold (Au) nanostructure on a hybrid nanoporous gold (npAu)-Au mirror template to generate highly stable monolithic Au-saturated npAu@Au-mirror substrate. By systematically adjusting electrochemical variables, different sizes, shapes, and nanogaps of Au nanostructure are generated with high-intensity electromagnetic field regions (hot junctions) for enhanced SERS response.

Curcumin-incorporated EGCG-based nano-antioxidants alleviate colon and kidney inflammation via antioxidant and anti-inflammatory therapy.

Natural remedies are gaining attention as promising approaches to alleviating inflammation, yet their full potential is often limited by challenges such as poor bioavailability and suboptimal therapeutic effects. To overcome these limitations, we have developed a novel nano-antioxidant (EK) based on epigallocatechin gallate (EGCG) aimed at enhancing the oral and systemic bioavailability, as well as the anti-inflammatory efficacy, of curcumin (Cur) in conditions such as acute colon and kidney inflammation. EK is synthesized using a straightforward Mannich reaction between EGCG and L-lysine (K), resulting in the formation of EGCG oligomers.

A new S1 subunit truncation vaccine induces effective protection against porcine deltacoronavirus in suckling piglets.

Porcine deltacoronavirus (PDCoV) is a novel porcine intestinal coronavirus that causes diarrhea in pigs of various ages, especially in suckling pigs. Developing effective treatments and vaccines is crucial to preventing PDCoV transmission and infection. This study evaluated the immune response elicited by the PDCoV S1 subunit and an inactivated PDCoV vaccine in mice.

Temporal analysis of non-targeted flavor component variation in green tea storage and rapid prediction of storage duration.

The precise changes in the flavor quality of green tea before and after the optimal consumption period remain elusive. This study used HS-SPME-GC-MS to carefully examine the volatile compounds of green tea samples from multiple storage periods and simultaneously detected changes in taste and color during tea infusion. Notably, 16 compounds with VIP > 1.

Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus.

The choroid plexus (ChP) serves as the principal origin of cerebrospinal fluid (CSF). CSF hypersecretion due to ChP inflammation has emerged as an important pathogenesis of hydrocephalus recently. Nevertheless, the precise mechanisms of ChP inflammation and the ensuing CSF hypersecretion in hydrocephalus remain ill-defined.

Recovery of protein-rich biomass from surimi rinsing wastewater by using a sustainable cold plasma treatment.

Surimi rinsing wastewater is typically discarded, causing waste of protein resources and environmental pollution. This study investigated the technology of a cold atmospheric plasma jet (CAPJ) for the recovery of protein-rich biomass (PRB), including myofibrillar proteins (MPs) and sarcoplasmic proteins (SPs), from surimi rinsing wastewater. The protein recovery yield was up to 59.

TRIM28 regulates the coagulation cascade inhibited by p72 of African swine fever virus.

In 2018, African swine fever virus (ASFV) emerged in China, causing extremely serious economic losses to the domestic pig industry. Infection with ASFV can cause disseminated coagulation, leading to the consumption of platelets and coagulation factors and severe bleeding. However, the mechanism of virus-induced coagulation has yet to be established.

Differential contribution of Cu and OH to the formation of N-carboxymethyllysine and N-carboxyethyllysine in preserved egg white during pickling.

In this study, the relationship between advanced glycosylation end products (AGEs) in preserved egg white (PEW) with protein oxidation and precursors induced by OH and Cu were performed to clarify the differential contribution of OH and Cu on the formation of AGEs during pickling. It was found that AGEs were more easily formed in PEW rather than yolk, and the accumulation of N-carboxymethyllysine (CML) could be promoted through protein oxidation related to carbonyl compounds, tryptophan induced by Cu at early stage, while carbonyl compounds were more conducive to form N-carboxyethyllysine (CEL) under synergistic action of Cu and OH. At later period, Schiff base promoted the formation of CEL and CML in the presence of Cu.

The immune responses elicited by six recombinant antigens of Mycoplasma hyopneumoniae in mice.

Mycoplasma hyopneumoniae (M. hyopneumoniae) is the causative agent of swine enzootic pneumonia, resulting in substantial economic losses in global pig farming. Although vaccination is the primary strategy for controlling M.

Electrochemical Synthesis of Quinazolines: N-H/C(sp)-H Coupling of -Carbonyl Anilines with Amino Acids and Amines.

A mild and efficient electrochemical protocol for the synthesis of quinazolines through N-H/C(sp)-H coupling of -carbonyl anilines with natural amino acids/amines has been developed. The products quinazolines can easily be isolated in moderate to excellent yields under external chemical oxidant-free conditions. Moreover, this reaction can be safely conducted on gram scale.

Physicochemical properties of bacterial cellulose from a strain of Komagataeibacter intermedius and analytical studies on its application.

A high bacterial cellulose (BC) producing Komagataeibacter intermedius (KEI6 strain) was isolated from water kefir grains in Xinjiang, China. Under optimized culture conditions, the KEI6 strain was able to produce BC (KEI6-BC) up to 7.03 g/L dry weight.