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Article Synopsis
- Fish oil (FO), known for its n-3 polyunsaturated fatty acids, shows potential in protecting against colon cancer, but concerns about contamination from persistent organic pollutants (POPs), like PCBs, complicate its efficacy.
- In a study using male Sprague-Dawley rats, those fed unmodified FO demonstrated significantly lower colon cancer risk factors, including fewer aberrant crypt foci and reduced cell proliferation compared to those fed contaminated or corn oil.
- The presence of POPs in FO diminished its protective benefits, indicating that contamination may undermine the health advantages associated with fish oil consumption.