4 results match your criteria: "School of Engineering (FEIS)[Affiliation]"
Effect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts.
J Pharmacol Sci
January 2022
São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Science (IBILCE), Campus São José do Rio Preto, Department of Biology, SP, Brazil; São Paulo State University (UNESP), School of Engineering (FEIS), Campus Ilha Solteira, Department of Biology and Animal Science, Brazil. Electronic address:
The objective of the present study was to evaluate the action of the crude hydroalcoholic extract of Piper cubeba fruits and isolated lignans (cubebin, dihydrocubebin, ethylcubebin, hinokinin and methylcubebin) on head and neck cancer cells. We evaluated the influence of the Piper cubeba extract and isolated lignans (10, 50 e 100 μg/mL) for 4, 24, 48 and 72 h, in the larynx (Hep-2) and oral (SCC-25) squamous cell carcinoma cells and normal fibroblasts, on morphology, cell proliferation and migration, cytotoxicity, genotoxicity and gene and protein expression (PTGS2, PTGER3, PTGER4, MMP2, MMP9). The results showed that the P.
View Article and Find Full Text PDFCisplatin treatment modulates Annexin A1 and inhibitor of differentiation to DNA 1 expression in cervical cancer cells.
Biomed Pharmacother
September 2020
São Paulo State University (Unesp), Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Campus São José do Rio Preto, SP, Brazil; Universidade Federal de São Paulo - UNIFESP, Post-Graduation in Structural and Functional Biology, SP, Brazil. Electronic address:
Article Synopsis
- - Cisplatin (Cis) is an effective chemotherapy for cervical cancer, promoting DNA damage and apoptosis while influencing the expression of Annexin A1 (ANXA1) and inhibitor of DNA binding 1 (ID1) proteins in cervical cancer tissues and cells.
- - Observations from cervical tissue samples show a strong presence of ID1 in advanced Cervical Intraepithelial Neoplasia (CIN) stages, and in vitro experiments indicate that Cis treatments, alone or with ANXA1 peptide, boost ANXA1 expression while decreasing ID1 levels.
- - Treatment with ANXA1 peptide or Cis not only lowers cell growth and survival but also induces late-stage apoptosis and hinders the migration of cervical cancer
Leaching of benzimidazole antiparasitics in soil columns and in soil columns amended with sheep excreta.
Environ Sci Pollut Res Int
November 2021
Institute of Chemistry, Department of Analytical Chemistry, University of Campinas, P.O. Box 6154, Campinas, SP, 13084-971, Brazil.
Benzimidazoles are anthelmintics frequently used in sheep farming due to the high susceptibility of these animals to parasitic diseases. Sheep excreta are often disposed onto soils as a fertilizer, and they may contain benzimidazole residues that can contaminate soil and water. This work aimed to assess the leaching behavior of benzimidazole drugs (albendazole, fenbendazole, and thiabendazole) and their metabolites in two Brazilian soils of different textural classifications (sandy and clay), as well as sheep excreta-amended soils, following the OECD 312 Guidelines.
View Article and Find Full Text PDFMeat quality of Santa Inês lamb chilled-then-frozen storage up to 12 months.
Meat Sci
February 2019
School of Agrarian and Veterinary Sciences (FCAV), Department of Technology, São Paulo State University (UNESP), Jaboticabal, SP 14884-900, Brazil.
Frozen lamb meat storage is widely used to extend its shelf life. However, it is scarcely known whether this practice changes the quality of lamb meat. The aim of this study was to evaluate the meat quality at five frozen storage periods (0, 3, 6, 9, and 12 months after slaughter) of 30 Santa Inês male lambs (hair sheep) finished in feedlot.
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