Brain functional alteration and cognitive performance in cardiovascular diseases: a systematic review of fMRI studies.

Background: Functional magnetic resonance imaging (fMRI) is a useful tool to evaluate brain inefficiencies secondary to cardiovascular diseases (CVDs); nevertheless, limited fMRI studies have been conducted to investigate the effect of CVDs on brain functional changes and cognitive function. This systematic review aims to explore, synthesise, and report fMRI outcomes (resting state and task-based) and cognitive performance in patients with CVDs.

Methods: Two reviewers independently searched published literature until April 2024 on ScienceDirect, PubMed, Web of Science, and ClinicalTrials.

The Assessment of White Matter Integrity Alteration Pattern in Patients with Brain Tumor Utilizing Diffusion Tensor Imaging: A Systematic Review.

Alteration in the surrounding brain tissue may occur in the presence of a brain tumor. The present study aims to assess the characteristics and criteria of the pattern of white matter tract microstructure integrity alteration in brain tumor patients. The Scopus, PubMed/Medline, and Web of Science electronic databases were searched for related articles based on the guidelines established by PRISMA.

In Vitro Cytopathogenic Activities of T3 and T4 Genotypes on HeLa Cell Monolayer.

Amoebic keratitis and encephalitis are mainly caused by free-living amoebae of the genus , which consists of both pathogenic and nonpathogenic species. The global distribution, amphizoic properties and the severity of the disease caused by species have inspired the scientific community to put more effort into the isolation of , besides exploring the direct and indirect parameters that could signify a pathogenic potential. Therefore, this study was performed to characterize the pathogenic potential of isolated from contact lens paraphernalia and water sources in Malaysia.

Magnetic Resonance Imaging and Its Clinical Correlation in Spinocerebellar Ataxia Type 3: A Systematic Review.

Background: Spinocerebellar ataxia type 3 (SCA3) is a complex cerebrocerebellar disease primarily characterized by ataxia symptoms alongside motor and cognitive impairments. The heterogeneous clinical presentation of SCA3 necessitates correlations between magnetic resonance imaging (MRI) and clinical findings in reflecting progressive disease changes. At present, an attempt to systematically examine the brain-behavior relationship in SCA3, specifically, the correlation between MRI and clinical findings, is lacking.

Acanthamoeba species isolated from marine water in Malaysia exhibit distinct genotypes and variable physiological properties.

The present study identifies the Acanthamoeba genotypes and their pathogenic potential in five marine waters in Malaysia. Fifty water samples were collected between January and May 2019. Physical parameters of water quality were measured in situ, whereas chemical and microbiological analyses were conducted in the laboratory.

Adaptation to Endophytic Lifestyle Through Genome Reduction by sp. SUK42.

Endophytic actinobacteria offer great potential as a source of novel bioactive compounds. In order to investigate the potential for the production of secondary metabolites by endophytes, we recovered a filamentous microorgansism from the tree Miq. After phenotypic analysis and whole genome sequencing we demonstrated that this organism, SUK42 was a member of the actinobacterial genus .

A systematic review of olfactory-related brain structural changes in patients with congenital or acquired anosmia.

Brain structural features of healthy individuals are associated with olfactory functions. However, due to the pathophysiological differences, congenital and acquired anosmia may exhibit different structural characteristics. A systematic review was undertaken to compare brain structural features between patients with congenital and acquired anosmia.

effects of multi-purpose contact lens disinfecting solutions towards survivability of genotype T4 in Malaysia.

The incidence of keratitis has been increasing since the previous decades, especially among contact lens users. This infection is majorly caused by the use of ineffective contact lens disinfecting solution. Thus, this study was conducted to evaluate the effects of multi-purpose disinfecting solutions (MPDS) against trophozoites and cysts.

Occurrence and molecular characterisation of Acanthamoeba isolated from recreational hot springs in Malaysia: evidence of pathogenic potential.

This study aimed to identify the Acanthamoeba genotypes and their pathogenic potential in five recreational hot springs in Peninsular Malaysia. Fifty water samples were collected between April and September 2018. Physical parameters of water quality were measured in situ while chemical and microbiological analyses were performed in the laboratory.

Modelling the Effect of a Novel Autodissemination Trap on the Spread of Dengue in Shah Alam and Malaysia.

In this paper, we will start off by introducing the classical Ross-Macdonald model for vector-borne diseases which we use to describe the transmission of dengue between humans and mosquitoes in Shah Alam, which is a city and the state capital of Selangor, Malaysia. We will focus on analysing the effect of using the Mosquito Home System (MHS), which is an example of an autodissemination trap, in reducing the number of dengue cases by changing the Ross-Macdonald model. By using the national dengue data from Malaysia, we are able to estimate , which represents the initial growth rate of the dengue epidemic, and this allows us to estimate the number of mosquitoes in Malaysia.

Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study.

Purpose: This study was aimed at determining the presence of cognitive frailty and its associated factors among community-dwelling older adults from the "LRGS-Towards Useful Aging (TUA)" longitudinal study.

Patients And Methods: The available data related to cognitive frailty among a sub-sample of older adults aged 60 years and above (n=815) from two states in Malaysia were analysed. In the LRGS-TUA study, a comprehensive interview-based questionnaire was administered to obtain the socio-demographic information of the participants, followed by assessments to examine the cognitive function, functional status, dietary intake, lifestyle, psychosocial status and biomarkers associated with cognitive frailty.

Factors associated with poor socioeconomic status among Malaysian older adults: an analysis according to urban and rural settings.

Background: Poverty at old age is associated with poor dietary habit, nutritional status and higher rates of chronic diseases and psychosocial problems. However, there is limited information about this matter according to urban and rural settings. The aim of this study was to identify dietary, nutritional, physical and cognitive factors associated with poor socioeconomic status (SES) among older adults according to urban and rural settings in Malaysia.

Rapid treatment of full-thickness skin loss using ovine tendon collagen type I scaffold with skin cells.

The full-thickness skin wound is a common skin complication affecting millions of people worldwide. Delayed treatment of this condition causes the loss of skin function and integrity that could lead to the development of chronic wounds or even death. This study was aimed to develop a rapid wound treatment modality using ovine tendon collagen type I (OTC-I) bio-scaffold with or without noncultured skin cells.

Interventions for children with dyslexia: A review on current intervention methods.

Introduction: Dyslexia is a neurobiological impairment that primarily affects reading ability. It is commonly known as a reading disorder which is likely to be present at birth and is generally identified at pre-school level. Dyslexia is manifested through difficulties with accurate word recognition and also by poor performance in reading and writing.

A Review on the Effects of Bisphenol A and Its Derivatives on Skeletal Health.

Bisphenol A (BPA) is an endocrine disruptor which can bind to the oestrogen receptor. It also possesses oestrogenic, antiandrogenic, inflammatory and oxidative properties. Since bone responds to changes in sex hormones, inflammatory and oxidative status, BPA exposure could influence bone health in humans.

Physicochemical factors and their potential sources inferred from long-term rainfall measurements at an urban and a remote rural site in tropical areas.

Air pollution can be detected through rainwater composition. In this study, long-term measurements (2000-2014) of wet deposition were made to evaluate the physicochemical interaction and the potential sources of pollution due to changes of land use. The rainwater samples were obtained from an urban site in Kuala Lumpur and a highland-rural site in the middle of Peninsular Malaysia.

Knowledge, attitude and perception regarding antimicrobial resistance and usage among ruminant farmers in Selangor, Malaysia.

The increasing public health problem of antimicrobial resistance (AMR) has been linked to the extensive antimicrobial use (AMU) in food animals. We conducted a survey among ruminant farmers in Selangor, Malaysia to assess their level of awareness on AMR, attitudes towards AMU, and determinants that influence their practices. The survey was developed in English and Malay, validated, and administered to ruminant farmers in Selangor.

Crystal structures and Hirshfeld surface analyses of bis-[,-bis-(2-meth-oxy-eth-yl)di-thio-carbamato-κ,']di--butyl-tin(IV) and [-(2-meth-oxy-eth-yl)--methyl-dithio-carbamato-κ,']tri-phenyl-tin(IV).

The crystal and mol-ecular structures of the two title organotin di-thio-carbamate compounds, [Sn(CH)(CHNOS)], (I), and [Sn(CH)(CHNOS)], (II), are described. Both structures feature asymmetrically bound di-thio-carbamate ligands leading to a skew-trapezoidal bipyramidal geometry for the metal atom in (I) and a distorted tetra-hedral geometry in (II). The complete mol-ecule of (I) is generated by a crystallographic twofold axis (Sn site symmetry 2).

The Biological Activities of Oleocanthal from a Molecular Perspective.

Oleocanthal is a minor constituent of olive oil with strong anti-inflammatory activities. Since the pathogenesis of many chronic diseases involves inflammatory and oxidative components, oleocanthal is a promising agent to prevent these conditions. This review aimed to summarise the current beneficial health effects of oleocanthal and the molecular basis of its biological actions.

Prevalence, Virulence Genes and Antimicrobial Resistance Profiles of Serovars from Retail Beef in Selangor, Malaysia.

The aim of the present study was to investigate the prevalence of spp., Enteritidis and Typhimurium in retail beef from different retail markets of Selangor area, as well as, to assess their pathogenic potential and antimicrobial resistance. A total of 240 retail beef meat samples (chuck = 60; rib = 60; round = 60; sirloin = 60) were randomly collected.

Prevalence and Antibiotic Resistance against Tetracycline in and in Cattle and Beef Meat from Selangor, Malaysia.

is a major foodborne pathogen frequently associated with human bacterial gastroenteritis in the world. This study was conducted to determine the prevalence and antibiotic resistance of spp. in the beef food system in Malaysia.

Genomic characterization of a new endophytic identifies biosynthetic pathway gene clusters for novel phenazine antibiotic production.

Background: are well known for their capability to produce many bioactive secondary metabolites with medical and industrial importance. Here we report a novel bioactive phenazine compound, 6-((2-hydroxy-4-methoxyphenoxy) carbonyl) phenazine-1-carboxylic acid (HCPCA) extracted from , an endophyte isolated from the ethnomedicinal

Methods: The HCPCA chemical structure was determined using nuclear magnetic resonance spectroscopy. We conducted whole genome sequencing for the identification of the gene cluster(s) believed to be responsible for phenazine biosynthesis in order to map its corresponding pathway, in addition to bioinformatics analysis to assess the potential of in producing other useful secondary metabolites.

Erratum to: Isolation, Purification, and Characterization of Five Active Diketopiperazine Derivatives from Endophytic SUK 25 with Antimicrobial and Cytotoxic Activities.

This erratum is being published to correct the 2nd author's name of above manuscript by Alshaibani et al. that was published in Journal of Microbiology and Biotechnology (2017, 27: 1249-1256). The 2nd author name(Noraziah MohamadZin) should appear as 'Noraziah Mohamad Zin'.

Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach.

Natural products continue to play an important role as a source of biologically active substances for the development of new drug. , Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria.

Identification of Neuroprotective Factors Associated with Successful Ageing and Risk of Cognitive Impairment among Malaysia Older Adults.

The increase of ageing population has raised public attention on the concept of successful ageing. Studies have shown that vitamin D, telomere length, and brain-derived neurotrophic factor (BDNF) have been associated with cognitive function. Therefore, this study aimed to identify neuroprotective factors for cognitive decline in different ageing groups.