1,241 results match your criteria: "School of Dental Science[Affiliation]"

Taste Preference and Metabolic Rate of Trehalose in Chickens.

J Poult Sci

January 2025

Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.

Trehalose (Tre) is composed of two molecules of D-glucose joined by an α,α-1,1 glucosidic linkage. Because Tre is utilized by the gut microbiome and enhances gut immunity in chickens, it is used as a feed ingredient. However, taste preference and metabolic dynamics of Tre in chickens are not fully understood.

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Template for positioning miniplates (PUNPLAPOT-M) on mandibular symphysis: Novel innovation.

Natl J Maxillofac Surg

November 2024

Fellow of International Association of Oral and Maxillofacial Surgeons, Chicago, USA.

Purpose: This study was conducted to check the efficacy of PUNPLAPOT-innovative Template for positioning of the bone miniplate for fracture fixation.

Material And Methods: Twenty dried mandible specimens were used in this study. The specimens were then divided into two groups using random sampling.

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Purpose: The purpose of this study was to analyze the association between the number of medications and oral functions.

Methods: The study participants were selected from individuals who were attending regular follow-up as hospital outpatients. Patient profiles, the number of medications used, and measured values of oral function were extracted.

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Apexification is a crucial procedure for achieving apical healing in non-vital teeth with open apices. Traditionally, calcium hydroxide has been used for this purpose, but it has significant drawbacks, including prolonged treatment duration, increased risk of root fracture, and the potential for porous barrier formation. Mineral trioxide aggregate (MTA) has emerged as a superior alternative due to its biocompatibility, faster setting time, and better sealing properties.

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Dental fluorosis (DF) is a condition affecting tooth enamel that occurs during the development of permanent teeth, resulting from excessive fluoride consumption. Based on the severity, the tooth surface exhibits discoloration or structural anomalies. The range of colors varies from mild discoloration to severe dark brown lesions.

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Background: Community- and evidence-based approaches are essential for improving dental public health. We evaluated the effectiveness of sending vouchers in a community-based oral screening program to encourage dental visits and improve oral health among adults.

Methods: We analyzed the data from April 2014 to March 2019 obtained from administrative claims and screening program databases in Tsukuba City, Japan.

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Knowledge, attitudes, and behaviours of Irish preschool teachers regarding the oral health of preschool children.

Eur Arch Paediatr Dent

December 2024

Department of Public and Child Dental Health, School of Dental Science, Trinity College Dublin, Lincoln Place, Dublin 2, Ireland.

Article Synopsis
  • The study aimed to evaluate Irish preschool teachers' knowledge, attitudes, and behaviors regarding the oral health of children aged 3-5 years old.
  • A questionnaire and guided interviews with 90 teachers revealed that while some implemented oral health education, many lacked adequate training and resources, with a mean correct response rate of only 5.32 out of 9.
  • The findings indicate a significant need for improved oral health training and resources for preschool teachers to better educate young children on oral health.
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Management of traumatic dental injuries (TDI) is very complex, even under ideal circumstances. Children in the primary dentition have unique needs, and it is important that the diagnosis and treatment choices are offered to parents. The prevalence of TDI in the primary dentition is far greater than for any other age group.

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Does intubation while observing the glottis with a fiberoptic scope reduce postoperative sore throat?

BMC Anesthesiol

November 2024

Department of Dental Anesthesiology, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan.

Introduction: In oral maxillofacial surgery, the nasal tracheal tube is mostly used to provide a better surgical field for oral, head and neck operations. Postoperative sore throat and hoarseness are common following tracheal intubation, with an incidence of 11-55%. Then, we previously reported advantage technique of fiberoptic scope to decrease the risk which the tip of the tube is visualized as the tube is advanced which helps avoid impingement of the tube.

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Are orofacial pain assessment tools for adults who cannot self-report pain suitable for dental practice? A scoping review.

Spec Care Dentist

December 2024

Department of Child and Public Dental Health, Dublin Dental University Hospital and School of Dental Science, Trinity College Dublin, Dublin, Ireland.

Introduction: This study aims to identify and appraise orofacial pain assessment tools designed to score pain in adults who cannot self-report and rate their suitability for dental practice.

Methods: A protocolled systematic scoping review, in accordance with Joanna Briggs Institute methods was completed. A development panel (n = 7) reviewed attributes of each tool for suitability for use in dental practice, using predefined criteria.

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The European Union (EU)-funded KitNewCare consortium aims to create and manage a comprehensive EU-wide programme focusing on sustainability in Kidney Care. Around 850 million people have chronic kidney disease (CKD) worldwide and by 2030, 6 million will need kidney replacement therapy, mainly haemodialysis. As the world population gets older, projections for the end of the century worsen.

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Reporting MRONJ as an adverse drug reaction: an oral surgery survey.

Br Dent J

October 2024

Specialty Dentist in Oral Surgery, Department of Oral Surgery, Birmingham Dental Hospital, Birmingham Community Healthcare NHS Foundation Trust, United Kingdom.

Introduction Medication-related osteonecrosis of the jaw (MRONJ) is a significant adverse drug reaction associated with anti-angiogenic and anti-resorptive medications. The aim of this survey was to highlight the importance of reporting adverse drug reactions, including MRONJ.Methodology An electronic survey was disseminated to dentists working in the oral surgery department Birmingham Community Healthcare Trust in November 2021.

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Virtual clinics in oral surgery: an equitable service for all?

Br Dent J

October 2024

Consultant Oral Surgeon, Department of Oral Surgery, Birmingham Dental Hospital, Birmingham Community Healthcare NHS Foundation Trust, UK.

Introduction Teledentistry has become more prevalent in the provision of oral healthcare since the COVID-19 pandemic. Virtual consultation clinics were introduced at Birmingham Dental Hospital as an adjunct to face-to-face (F2F) consultation clinics. This service evaluation compares virtual and F2F consultation clinics in oral surgery, with particular focus on 'did not attend' (DNA) rates.

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Objective This study aimed to evaluate the effects of different solvents on the microhardness of mineral trioxide aggregate (MTA) and Biodentine, which are used in endodontic therapy for their biocompatibility and ability to create a hermetic seal. Methods A total of 150 extracted human single-rooted teeth were selected and sectioned into 4 mm slices. The samples were divided into two groups according to the material used: MTA and Biodentine.

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Oral syphilis - the great imitator: a series of six cases.

Br Dent J

October 2024

Division of Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Dublin Dental University Hospital, School of Dental Science, Trinity College Dublin, Dublin 2, Ireland.

Article Synopsis
  • Syphilis is known as the 'great mimicker' due to its ability to show non-specific symptoms and can affect various organs, with the oral cavity often involved in the early stages.
  • The rise in syphilis cases worldwide, reflected in recent clinical observations, emphasizes the importance of recognizing its diverse presentations for timely diagnosis and treatment.
  • Dentists play a crucial role in identifying oral syphilis manifestations, which can help prevent serious complications and reduce the spread of the infection.
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induces invasive growth and angiogenic responses in malignant oral keratinocytes that are cell line- and bacterial strain-specific.

Front Cell Infect Microbiol

September 2024

Division of Oral Biosciences, Dublin Dental University Hospital and School of Dental Science, Trinity College Dublin, Dublin, Ireland.

Article Synopsis
  • The study explores how different strains of an anaerobic bacterium found in the mouth impact oral cells, especially in relation to oral cancers, using two distinct cancer cell lines from varying stages of a specific type of oral cancer (OSCC).
  • Findings show that bacteria adhered more strongly to advanced-stage OSCC cells, triggered responses linked to cancer cell movement and growth, and influenced levels of important proteins that promote cancer progression and blood vessel formation.
  • The research highlights that different bacterial strains and host cell types significantly affect how invasive growth occurs in oral cells, suggesting that treatment strategies could be tailored based on these factors.
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The role of orthodontics in the prevention and management of gingival recession.

Br Dent J

September 2024

Specialist in Orthodontics, Perth, Western Australia, Australia.

Careful management of orthodontic patients presenting with thin periodontal phenotype is paramount. Combined orthodontic-periodontal input is helpful both in terms of diagnosis and stabilisation but also to coordinate care. Well-executed orthodontics offers the potential to safeguard periodontal health but also to induce significant aesthetic improvement either in isolation or combined with increasingly predictable muco-gingival procedures.

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Periodontitis: orthodontic implications and management.

Br Dent J

September 2024

Specialist in Orthodontics, Perth, Western Australia, Australia.

Orthodontics is increasingly ingrained in the overall management of patients with periodontitis. Advanced periodontitis is often characterised by pathological tooth migration, loss of posterior support and incisal proclination. Orthodontics may therefore offer both aesthetic and therapeutic benefit.

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Non-excitable cells express sodium voltage-gated channel alpha subunit 1 gene and protein (known as SCN1A and NaV1.1, respectively); however, the functions of NaV1.1 are unclear.

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The role of GABA in modulation of taste signaling within the taste bud.

Pflugers Arch

November 2024

Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Taste buds contain 2 types of GABA-producing cells: sour-responsive Type III cells and glial-like Type I cells. The physiological role of GABA, released by Type III cells is not fully understood. Here, we investigated the role of GABA released from Type III cells using transgenic mice lacking the expression of GAD67 in taste bud cells (Gad67-cKO mice).

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Development of resistance and tolerance to antifungal drugs in Candida albicans can compromise treatment of infections caused by this pathogenic yeast species. The uniquely expanded C. albicans TLO gene family is comprised of 14 paralogous genes which encode Med2, a subunit of the multiprotein Mediator complex which is involved in the global control of transcription.

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Article Synopsis
  • Chikungunya virus (CHIKV), transmitted by Aedes mosquitoes, is a major global health concern, with complications exacerbated in vulnerable populations; the current vaccine (IXCHIQ) is inadequate for controlling the disease.
  • The article explores various vaccine candidates, including RNA vaccines, which show promise due to their quick development and safety, while highlighting the E1 and E2 proteins as key targets for immune response.
  • It also examines monoclonal antibodies and other innovative strategies for vaccine development, discussing both potential antiviral therapies and immune system mechanisms involved in the response to CHIKV.
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Gnao1 is a molecular switch that regulates the Rho signaling pathway in differentiating neurons.

Sci Rep

July 2024

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Highashi-ku, Fukuoka, 812-8582, Japan.

Article Synopsis
  • GNAO1 encodes a protein involved in brain development, and its mutations lead to serious neurological issues such as developmental delays and seizures in infants.
  • Research shows that reducing Gnao1 levels disrupts important signaling pathways and affects neuron growth, particularly in cells from patients with specific mutations.
  • The study suggests that targeting the Rho GTPase pathway could be a potential therapeutic strategy for treating GNAO1-associated encephalopathy.
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Mechanisms and Functions of Sweet Reception in Oral and Extraoral Organs.

Int J Mol Sci

July 2024

Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan.

The oral detection of sugars relies on two types of receptor systems. The first is the G-protein-coupled receptor TAS1R2/TAS1R3. When activated, this receptor triggers a downstream signaling cascade involving gustducin, phospholipase Cβ2 (PLCβ2), and transient receptor potential channel M5 (TRPM5).

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Article Synopsis
  • The Shank3 gene, linked to autism, has several isoforms (Shank3a-f) and knockout mice lacking Shank3a/b show heightened seizure susceptibility.
  • Researchers conducted a proteomic analysis that identified 348 proteins interacting with the N-terminal and ankyrin repeat domains of Shank3a/b, highlighting significant associations with RNA-binding proteins and components involved in splicing and ribosomes.
  • The interaction between Shank3 and the protein Nono was validated, and knockout mice also displayed abnormal splicing of autism-related genes, suggesting Shank3 regulates RNA-binding protein interactions and gene expression in the developing brain.
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