Prevent and Reverse Metabolic Dysfunction-Associated Steatohepatitis and Hepatic Fibrosis via mRNA-Mediated Liver-Specific Antibody Therapy.

Chronic exposure of the liver to multiple insults culminates in the development of metabolic dysfunctionassociated steatohepatitis (MASH), a complicated metabolic syndrome characterized by hepatic steatosis and inflammation, typically accompanied by progressive fibrosis. Despite extensive clinical evaluation, there remain challenges in MASH drug development, which are primarily due to unsatisfactory efficacy and limited specificity. Strategies to address the unmet medical need for MASH with fibrosis before it reaches the irreversible stage of decompensated cirrhosis are critically needed.

Two-step sintering suppresses grain growth and improves flexural strength of dental zirconia.

Objectives: This study aimed to elucidate the effect of various two-step sintering (TSS) protocols on the physical, mechanical, and optical properties of partially stabilized zirconia with different yttria dopant concentrations (Y-PSZ).

Methods: Disc-shaped specimens were obtained from most widely used commercial dental zirconia powders of various Y contents (Tosoh Corp.) by uniaxial pressing followed by cold-isostatic pressing.

Letter to the editor in response to "Microbial colonization in the partially exposed nonabsorbable membrane during alveolar ridge preservation" (Braz et al., clinical oral Investigations, https://doi.org/10.1007/s00784-024-05763-7.).

Objective: This letter addresses the recent study by Braz et al. published in Clinical Oral Investigations in 2024 ( https://doi.org/10.

Challenges of Motherhood for Anesthesiologists: A Scoping Review.

Despite advancements in gender representation, female anesthesiologists continue to encounter challenges in career advancement that may be further impacted by motherhood. This scoping review examines personal and systemic barriers and facilitators to career advancement for anesthesiologists facing infertility, pregnancy, and childcare. The review identified 22 relevant studies across five themes: the timing of pregnancy and parental leave, breastfeeding and lactation needs, childcare and gender norms, job reentry and career advancement opportunities, and work-life balance and physician well-being.

Participant Experience of Taking Part in Periodontal Experimental Studies.

Despite the plethora of published periodontal interventional and experimental studies, there are no reports evaluating the experience of the participants as a research subject or their willingness for repeat participation in a similar study. This study aimed to determine the participants' experience and willingness to participate again in periodontal experimental studies and to explore factors that affect the participants' research experience. Questionnaires from four completed experimental wound healing studies with 76 total participants were extracted and analyzed.

Cone beam computed tomography findings as prognostic factors for maxillary sinus membrane perforation during maxillary sinus augmentation.

Background: Maxillary Schneiderian membrane (SM) perforation is one of the complications of maxillary sinus (MS) augmentation. The aim of the present study was to analyse cone beam computed tomography (CBCT) findings to identify prognostic factors for SM perforation.

Materials And Methods: 50 CBCT scans were recruit for the analysis, 39 were suitable for analysis and met the inclusion criteria.

Dental profiling in the archaeological sample of the Illyrian population in Southern Dalmatia, Croatia.

Dental profiling is the process of analyzing teeth to identify a victim or skeletal remains when no antemortem data are available. Using dental profiling techniques, we can determine the age, sex, and population of the individual and gather data about their socio-economic status, personal habits, oral and systemic health, occupation, nutrition, family relationships, and psychological characteristics. The research aims to gain insights into the diet, health, socio-economic status, and demography of the Late Iron Age inhabitants of Illyrian origin who lived on the Croatian island of Korcula.

A clinical comparative analysis using an optical tracking device versus conventional tracking device in the production of occlusal appliances.

Purpose: Optical tracking devices (OTDs) hold promise for enhancing patient-centered prostheses, but their efficacy remains underexplored. This clinical study aimed to comprehensively evaluate differences in static and dynamic occlusions among occlusal appliances fabricated using optical tracking, conventional tracking, and average articulator values (AAVs), providing insights into their efficacy in clinical and research-based practices.

Materials And Methods: Twelve dentate participants aged over 25 years, with Angle Class I and II occlusal relationships, were enrolled.

Impact of edentulism on community-dwelling adults in low-income, middle-income and high-income countries: a systematic review.

Objectives: This study aims to comprehensively explore the consequences of edentulism on community-dwelling adults in low-income, middle-income and high-income countries.

Design: Systematic review and Synthesis Without Meta-Analysis (SWiM).

Data Sources: MEDLINE, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from inception to 21 March 2023, in addition to grey literature searches, reference cross-checking and study recommendations.

Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner.

Bone is a frequent site for breast cancer metastasis. The vast majority of breast cancer-associated metastasis is osteolytic in nature, and RANKL (receptor activator for nuclear factor κB)-induced differentiation of bone marrow-derived macrophages to osteoclasts (OCLs) is a key requirement for osteolytic metastatic growth of cancer cells. In this study, we demonstrate that Myocardin-related transcription factor (MRTF) in breast cancer cells plays an important role in paracrine modulation of RANKL-induced OCL differentiation.

Histological assessments for anabolic effects in teriparatide/abaloparatide administered rodent models.

Parathyroid hormone (PTH) is thought to induce remodeling-based bone formation by promoting osteoclastic activity, a process known as cellular coupling. Our research has shown that the frequency of PTH administration affects trabecular number and thickness. High-frequency PTH administration induced remodeling-based bone formation, while less frequent administration induced both remodeling-based and modeling-based bone formation.

PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking.

Signaling through the platelet-derived growth factor receptor alpha (PDGFRα) plays a critical role in craniofacial development. Phosphatidylinositol 3-kinase (PI3K)/Akt is the primary effector of PDGFRα signaling during mouse skeletal development. We previously demonstrated that Akt phosphorylates the RNA-binding protein serine/arginine-rich splicing factor 3 (Srsf3) downstream of PI3K-mediated PDGFRα signaling in mouse embryonic palatal mesenchyme (MEPM) cells, leading to its nuclear translocation.

Oral Health, Inflammation, and Cardiometabolic Factors in the VA Million Veteran Program.

Introduction: Associations between cardiometabolic comorbidities and self-reported oral health (OH) are often underexplored in large biobank datasets. While these associations are unaffected by dental care access, they could be mediated by immune responses and inflammation.

Objectives: This study assessed the associations between cardiometabolic comorbidities and self-reported OH, periodontitis, and tooth loss using the (ICD) codes in participants from the U.

Big Data and Oral Health Disparities: A Critical Appraisal.

Big data has emerged as a pivotal asset in addressing oral health disparities in recent years. Big data encompasses the vast pool of health care-related biomedical information sourced from diverse channels, such as claims data, patient registries, and electronic health records (EHRs). This study is a critical review that synthesizes the evidence, identifies gaps in knowledge, and discusses future implications regarding big data analytics and oral health disparities.

DNA and RNA Methylation in Periodontal and Peri-implant Diseases.

Periodontal and peri-implant diseases are primarily biofilm-induced pathologies in susceptible hosts affecting the periodontium and dental implants. Differences in disease susceptibility, severity, and patterns of progression have been attributed to immune regulatory mechanisms such as epigenetics. DNA methylation is an essential epigenetic mechanism governing gene expression that plays pivotal roles in genomic imprinting, chromosomal stability, apoptosis, and aging.

Correlates and Comparability of Two Devices for Measuring Bite Force in Dentate Health Volunteers.

Objective: This study aimed to correlate the bite/occlusal force measurements obtained through two methods: a hydraulic pressure gauge with a biting transducer (GM-10), and a computer-assisted device that records occlusal force on a pressure-sensitive film (Prescale II).

Methods: Healthy, dentate volunteers were recruited. Participants' demographic data included age, sex, number of teeth present, presence of oral pain, history of prior orthodontic treatment and presence of parafunction.

Targeting Tumor Endothelial Cells by EGCG Using Specific Liposome Delivery System Inhibits Vascular Inflammation and Thrombosis.

Background: Inflammation is one of the hallmarks of cancer and is associated with tumor growth. Tumor endothelial cells (TECs) demonstrate inflamed phenotypes. Endothelial inflammation initiates thrombus formation, which is the second cause of cancer-related deaths.

Revised consensus guidelines for the use of cone-beam computed tomography/ digital volume tomography.

Cone beam computed tomography (CBCT) is established in dentistry for about 20 years. Technique evolved and indications clarified since then and since the Swiss consensus guidelines regarding CBCT were published in 2014 and 2015. Therefore, the Swiss association of dentomaxillofacial radiology decided to initiate the process of updating these guidelines by forming a consensus group divided into a core group responsible for the whole process and an approval group responsible for specific clinical matters.

Beneficial effects of non-invasive physical plasma on human periodontal ligament cells .

Introduction: Periodontitis is a chronic inflammatory disease of the periodontium that can lead to the loss of affected teeth if left untreated. It is induced by a multifactorial process centered on microbial pathogens such as Fusobacterium nucleatum . Non-invasive physical plasma (NIPP), a highly reactive gas, has become a focus of research, not only for its hemostatic, proliferation-enhancing and apoptotic properties, but also for its antimicrobial potential.

Early Initiative of Structured Mentoring and Research for Social Disadvantage Trainees to Increase Diversity and Inclusion among Clinician Scientists.

Background: There is a significant lag in integrating ethnically diverse healthcare trainees as clinician scientists. Although this gap is acknowledged, it is mostly focused physician scientists with a marked lag in dental scientists and the other healthcare fields such as the physician assistant program. We report on the outcome of three cohorts of underserved and economically disadvantaged trainees from a National Institute of Health Heart and Lung Blood Institute R25 summer training program with participants from four Rutgers Health Science schools.

Cultivation and molecular characterization of viable Helicobacter pylori from the root canal of 170 deciduous teeth of children.

Background: Helicobacter pylori is a persistent pathogen in the human stomach. However, the proposed transmission route via the oral cavity is not understood and under intense debate. While dozens of studies have shown by PCR that H.