Categorising reported errors and incidents from morbidity and mortality meetings (M&Ms) in a small animal multi-specialty veterinary teaching hospital.

Background: Errors in veterinary clinical settings can lead to patient harm. Morbidity and mortality meetings (M&Ms) are forums to discuss errors and incidents that can lead or have led to adverse outcomes, potential harm or unsafe conditions, with the purpose of improving patient safety in future. Despite growing implementation of M&Ms in veterinary medicine, their effectiveness in improving future patient safety may be constrained by the need for absolute confidentiality during meetings.

CCN5 suppresses injury-induced vascular restenosis by inhibiting smooth muscle cell proliferation and facilitating endothelial repair via thymosin β4 and Cd9 pathway.

Background And Aims: Members of the CCN matricellular protein family are crucial in various biological processes. This study aimed to characterize vascular cell-specific effects of CCN5 on neointimal formation and its role in preventing in-stent restenosis (ISR) after percutaneous coronary intervention (PCI).

Methods: Stent-implanted porcine coronary artery RNA-seq and mouse injury-induced femoral artery neointima single-cell RNA sequencing were performed.

A review of international clinical guidelines that inform the use of assistive technology to support adults living with progressive or complex conditions.

Methods: A published review protocol guided searches of four electronic databases and 11 CPG portals. CPGs published between January 2012 and September 2023 in English for adults with progressive or complex conditions were included. Recommendations were catalogued according to: author, year and country of publication; grading of recommendations made; number of recommendations made overall and number pertaining to AT; target condition and/or population; age group/s recommendations related to (if specified); type of AT (categorised into "cognition", "communication", "vision", "hearing", "self-care", "mobility", "combination" or "other"); target professions to apply recommendations; evidence grading; and reference to supporting evidence.

PrP Glycoprotein Is Indispensable for Maintenance of Skeletal Muscle Homeostasis During Aging.

Background: The cellular prion protein (PrP), a glycoprotein encoded by the PRNP gene, is known to modulate muscle mass and exercise capacity. However, the role of PrP in the maintenance and regeneration of skeletal muscle during ageing remains unclear.

Methods: This study investigated the change in PrP expression during muscle formation using C2C12 cells and evaluated muscle function in Prnp wild-type (WT) and knock-out (KO) mice at different ages (1, 9 and 15 months).

Model construction and clinical therapeutic potential of engineered cardiac organoids for cardiovascular diseases.

Cardiovascular diseases cause significant morbidity and mortality worldwide. Engineered cardiac organoids are being developed and used to replicate cardiac tissues supporting cardiac morphogenesis and development. These organoids have applications in drug screening, cardiac disease models and regenerative medicine.

Defining and responding to the contextual drivers for implementation of antimicrobial stewardship in 14 neonatal units in South Africa.

Background: Research on the contextual drivers of antimicrobial stewardship (AMS) programme interventions in neonatal units is limited.

Methods: As part of a prospective mixed-methods multidisciplinary neonatal AMS (NeoAMS) interventional study in 14 South African hospitals, we applied a three-phased process to assess implementation barriers and contextual drivers experienced by participating health professionals. The study included: (Phase one; P1) a survey of pre-intervention barriers and enablers; (P2) written feedback during the study intervention phase; and (P3) semi-structured exit interviews.

Monkey multi-organ cell atlas exposed to estrogen.

Awareness of estrogen's effects on health is broadening rapidly. The effects of long-term high levels of estrogen on the body involve multiple organs. Here, we used both single-cell chromatin accessibility and RNA sequencing data to analyze the potential effect of estrogen on major organs.

Temporal Anomaly Detection in Attention-Deficit/Hyperactivity Disorder Using Recurrent Neural Networks.

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition marked by movement hyperactivity, often persisting into adulthood. Understanding the movement patterns associated with ADHD is crucial for improving diagnostic precision and tailoring interventions. This study leverages the HYPERAKTIV dataset, which includes high-resolution temporal data on motor activity from people diagnosed with ADHD.

L. (Anacardiaceae) fruits flours at different maturation stages: Drying kinetics, mathematical modelling, characterization and correlation analysis.

The aim of this study was to examine the drying kinetics of L. fruits at various maturation stages (I to V) using a range of mathematical models (Henderson and Pabis, Lewis, Logarithmic, Midilli, and Page). Additionally, an assessment of the resulting flours' quality was conducted.

Deciphering the dynamic single-cell transcriptional landscape in the ocular surface ectoderm differentiation system.

The ocular surface ectoderm (OSE) is essential for the development of the ocular surface, yet the molecular mechanisms driving its differentiation are not fully understood. In this study, we used single-cell transcriptomic analysis to explore the dynamic cellular trajectories and regulatory networks during the differentiation of embryonic stem cells (ESCs) into the OSE lineage. We identified nine distinct cell subpopulations undergoing differentiation along three main developmental branches: neural crest, neuroectodermal, and surface ectodermal lineages.

Ginseng as a therapeutic target to alleviate gut and brain diseases via microbiome regulation.

The human gut, which contains a diverse microbiome, plays an important role in maintaining physiological balance and preserving the immune system. The complex interplay between the central nervous system (CNS) and the gut microbiome has gained significant attention due to its profound implications for overall health, particularly for gut and brain disorders. There is emerging evidence that the gut-brain axis (GBA) represents a bidirectional communication system between the CNS and the gastrointestinal tract and plays a pivotal role in regulating many aspects of human health.

Assessment of Patient Awareness Regarding Chronic Kidney Disease Management in Santhal Parganas.

Background: Chronic kidney disease (CKD) is a global health challenge, and effective self-management is crucial for optimal outcomes. Assessing the prevailing knowledge about CKD in patients can help strategies information education communication program to better manage the disease. This study evaluated the current knowledge of self-management of CKD among patients suffering from CKD in Santhal Parganas of Jharkhand state in India.

Single-cell RNA sequencing reveals the intercellular crosstalk and the regulatory landscape of stromal cells during the whole life of the mouse ovary.

The heterogeneity of ovarian mesenchymal/stromal cells has just been revealed in both mice and humans. However, it remains unclear about the cellular development trace and the intercellular communication network in the whole life of the ovary. In the study, we integrated ours and published single-cell RNA sequencing data from E11.

The environmental health literacy level was effectively improved of residents in Shaanxi Province, China, 2022.

Background: Environmental health literacy (EHL) aims to enable individuals to make informed choices to reduce health risks and protect the environment.

Objectives: To assess the EHL of residents in Shaanxi Province, China in 2022 and analyze the influencing factors.

Methods: This study was a 2022 cross-sectional survey in Shaanxi Province, China, involving 2,237 residents aged 15 to 69.

Hearing Performance and Soft-Tissue Outcomes of Minimally Invasive Ponto Surgery and Local Anesthesia in Children with Unilateral Craniofacial Malformation.

 Minimally invasive Ponto surgery (MIPS) enables the installation of percutaneous bone-anchored hearing implants (BAHIs) with a drill guide through a hole punch incision. Despite being well established for adults, there is a lack of studies in the literature regarding its use in pediatric patients.  The aim of the present study was to investigate the hearing performance and soft-tissue outcomes of the use of MIPS under local anesthesia in children with unilateral craniofacial malformation (UCM).

Research Best Practices for Eye Stroke Vision Rehabilitation: A Qualitative Study.

Purpose: Central retinal artery occlusion, also known as an eye stroke, results in visual impairment and functional challenges. Our study objectives were to identify meaningful measures and factors that indicate or enable successful recovery after eye stroke and to determine optimal processes to support research, including exploring barriers and facilitators to successful research participation.

Methods: We used qualitative methods including the 5Ts Framework (target population identification, team composition, time considerations, tips to accommodate older adults, tools for inclusive enrollment of older adults) to provide a guide to the development of the semi-structured interviews and to help facilitate the research process such as the set-up of interviews.

": A Photovoice Exploration of Diabetes Self-Management for Older Persons in Rural Ontario, Canada.

Objective: To explore diabetes self-management for older adults in rural Ontario.

Methods: Fourteen adults, 65 and older, with diabetes, participated in this study using a participatory, art-based approach involving photovoice and semi-structured interviews. Data underwent hermeneutic phenomenology analysis.

Polymer-Layered Optical Wearable (PLOW) for Healthcare Applications: Temperature and Stretching Monitoring.

Thermal and stretching characteristics are crucial variables in healthcare, robotics, and human-machine interaction applications. Here, we present a single-mode fiber-based, balloon-shaped, single- and dual polymer-layered optical wearable (PLOW) system that can sense both temperature and stretching. These two types of PLOWs are compared in terms of their detection performance across all criteria.

Meeting Parents' Health Literacy Needs-Designing and Feasibility Testing of a Three-Step Intervention in the Childhood Epilepsy Context.

Aims: (1) To codesign a health literacy intervention within a specialist healthcare setting to help the parents of children with epilepsy access, comprehend, use and communicate information and (2) to assess the intervention's feasibility by exploring stakeholders' perspectives on its usefulness, ease of use of trial methods and contextual factors impacting its execution.

Design: A codesign participatory approach followed by a feasibility approach inspired by the OPtimising HEalth LIteracy and Access to Health Services (Ophelia) process for health literacy intervention development.

Methods: (1) The codesign approach included workshops with (a) multidisciplinary personnel (n = 9) and (b) parents (n = 12), along with (c) an interview with one regional epilepsy specialist nurse (n = 1).

Role of the Veterans Health Administration's LGBTQ+ Veteran Care Coordinators in Facilitating Care for Transgender and Gender-Diverse Veterans.

Introduction: Transgender and gender-diverse (TGD) individuals frequently encounter discrimination in health care settings. The Veterans Health Administration (VA) is committed to addressing the health disparities experienced by TGD veterans. The purpose of this study was to explore the experiences of TGD veterans with LGBTQ+ veteran care coordinators.

Enablers and inhibitors of nursing and midwifery leadership in Pacific Island collectivist cultures.

Aim: To identify and explore inhibitors and enablers of nursing and midwifery leadership in the Pacific; to develop context-specific recommendations for policy and practice.

Background: Many Pacific Island countries experience poor health outcomes and are vulnerable to climate-related health emergencies. Nursing and midwifery leadership is essential to improve regional health outcomes through influencing policy decisions, strengthening health systems and ensuring optimal health workforce utilisation.

The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer's disease mice.

Background: Specific genetic variants in the ATP-binding cassette transporter A7 locus (ABCA7) are associated with an increased risk of Alzheimer's disease (AD). ABCA7 transports lipids from/across cell membranes, regulates Aβ peptide processing and clearance, and modulates microglial and T-cell functions to maintain immune homeostasis in the brain. During AD pathogenesis, neuroinflammation is one of the key mechanisms involved.

Driving job satisfaction through inclusive knowledge management: a focus on learning and communication in diverse workplaces.

Background: This study examines the impact of knowledge management practices (KMP) on job satisfaction, focusing on the mediating roles of learning opportunities and communication quality. It aims to provide insights into how effectively KMP can enhance employee satisfaction in Pakistan's IT sector.

Method: The research utilizes cross-sectional data collected from 345 IT sector employees in Pakistan.

Cell signaling communication within papillary craniopharyngioma revealed by an integrated analysis of single-cell RNA sequencing and bulk RNA sequencing.

Objective: This study aims to elucidate the primary signaling communication among papillary craniopharyngioma (PCP) tumor cells.

Methods: Five samples of PCP were utilized for single-cell RNA sequencing. The most relevant ligand and receptor interactions among different cells were calculated using the CellChat package in R software.

Which factors influence the transition towards a healthy and sustainable food environment in Dutch hospitals? A qualitative view from stakeholders.

Background: Hospitals fulfill an important exemplary role in promoting health and well-being. It is therefore crucial to have a supportive food environment that stimulates healthy and sustainable food choices of patients, staff, and visitors. This qualitative study aimed to identify factors influencing the implementation of long-lasting actions to enhance the healthiness and sustainability of the food environment in the hospital setting in the Netherlands, from the perspective of different stakeholders.