Understanding capacity fading from structural degradation in Prussian blue analogues for wide-temperature sodium-ion cylindrical battery.

Low-cost Fe-based Prussian blue analogues often suffer from capacity degradation, resulting in continuous energy loss, impeding commercialization for practical sodium-ion batteries. The underlying cause of capacity decrease remains mysterious. Herein, we show that irreversible phase transitions, structural degradation, deactivation of surface redox centres, and dissolution of transition metal ions in Prussian blue analogues accumulate continuously during cycling.

A novel smartphone-mediated ratiometric fluorescence imprinting sensor based on boric acid-functionalized Eu-MOF for the detection of horseradish peroxidase.

Horseradish peroxidase (HRP) was used as a model glycoprotein, and a molecularly imprinted ratiometric fluorescence sensor based on a smartphone (NEB@MIP) was constructed using the sol-gel method for the fluorescence and visual detection of HRP. The sensor consisted of boronic acid-functionalized metal-organic frameworks (Eu-MOF-B(OH)) and nitrogen-doped carbon dots (N-CDs). The Eu-MOF-B(OH) surface can not only load abundant N-CDs but also covalently bind with HRP through its boronic acid groups.

Ascorbic Acid Encapsulated in Apoferritin as Improved Protoporphyrin-Sensitized TiO Nanoarrays of a Photoelectrochemical Nanobody-Based Microfluidic Biosensor for Immunoassay.

In this work, a nanobody-based microfluidic photoelectrochemical sensor utilizing protoporphyrin-sensitized TiO nanoarrays as signal transducer was developed for the detection of thymic stromal lymphopoietin (TSLP), a typical biomarker of asthma. The TiO nanoarrays were fabricated on ITO substrates via magnetron sputtering and in situ oxidation, and their visible light absorption and photogenerated carrier properties were improved upon sensitization with protoporphyrin dye. The electron donor ascorbic acid (AA) was encapsulated within apoferritin (ApoFt) and coupled directly to the target TSLP to obtain the ApoFt@AA-TSLP bioconjugate, which was subsequently mixed with different concentrations of TSLP and added to the electrode surface, enabling the quantitative release of AA dependent on the disassembly/reassembly properties of the ferritin shell.

3D printed eutectogel dissolving microneedles patch loaded with chitosan-based nanoparticles for diabetic wound management.

Dissolving microneedles (DMNs) represent promising platforms for painless transdermal drug delivery and biosensing, yet integrating multifunctionality with sustainable recyclability via photo-curable additive manufacturing strategy remains challenging. Here we report a multifunctional, pioneering 3D-printed DMNs patch combining a ternary polymerizable deep eutectic solvent (PDES) system with a recyclable eutectogel backing layer. DMNs, formulated with biocompatible choline chloride, itaconic acid, and N-vinyl-2-pyrrolidone, enable rapid photopolymerization and excellent mechanical strength for effective skin penetration.

Amidoxime-functionalized carboxymethylcellulose based porous hydrogels adsorbent fabricated from oyster shell stabilized Pickering emulsions for enhanced adsorption of Gd and Er.

Rare earth elements are strategic resources with diverse applications. However, during mining, wastewater rich in these elements is generated, leading to the loss of valuable rare-earth resources and poses a significant environmental threat. Therefore, a sustainable strategy for recycling rare earth elements from secondary sources is essential.

Curcumin@ graphene oxide/chitosan/arginine hydrogel: A novel approach to treat Candida periprosthetic joint infections.

Candida albicans, responsible for nearly 70 % of fungal infections, is a leading cause of life-threatening invasive infections, particularly in healthcare settings, with a mortality rate approaching 40 % even after medical treatment. This study introduces a novel antifungal agent such as Curcumin@Graphene Oxide/Chitosan/Arginine nanocomposite hydrogel (Cur@GO/CS/Arg), targeting Candida albicans, a primary cause of periprosthetic joint infections (PJIs). The hydrogel exhibited remarkable antifungal efficacy, characterized by a 17 mm inhibition zone, a minimum inhibitory concentration (MIC) of 1.

Preparation of mitochondrial targeted near-infrared ratio fluorescent probe and its dual response detection for viscosity and ONOO and cell imaging.

The changes in viscosity and the concentration of ONOO in mitochondria can effectively reflect the physiological and pathological status of cells. Therefore, the development of effective fluorescent probes for the sensing of viscosity and the concentration of ONOO in mitochondria has great significance. In this article, a mitochondrial targeted fluorescent probe named Mito-RP was synthesized for the dual responsive sensing of viscosity and ONOO by introducing pyridine ring and phenylboronic acid ester structure into 4-dimethylamino-cinnamaldehyde with long conjugated chain structure as the parent material.

An electrochemical quinine detection approach based on small molecule promoted split aptamer click ligation reaction.

Quinine is a natural antimalarial drug that also serves as a food additive; however, excessive consumption can result in harmful side effects. Here, we propose a simple and cost-effective electrochemical strategy for quinine detection based on the small molecule-templated split aptamer click ligation (SMT-SpA-CLR), where the integrity of the aptamer is restored through the template-promoted proximity effect. We first investigate the effects of two splitting sites on the affinity of quinine aptamer and find that the loop of the stem with more Watson-Crick base pairs is more suitable for splitting, which can maintain the affinity to a great extent.

Optimizing Peptide-Conjugated Lipid Nanoparticles for Efficient siRNA Delivery across the Blood-Brain Barrier and Treatment of Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) is a WHO grade 4 glioma and the most common malignant primary brain tumor. Addressing the clinical management of GBM presents an exceptionally daunting and intricate challenge, particularly in overcoming the blood-brain barrier (BBB) to deliver effective therapies to the brain. Nanotechnology-based drug delivery systems have exhibited considerable promise in tackling this aggressive brain cancer.

Photoredox Site-Selective C(sp)-H Alkylation of 1-(-Iodoaryl)-alkan-1-ones with Activated Alkenes Enabled by Hydrogen Atom Transfer.

A visible-light-mediated photoredox catalysis for β-C(sp)-H alkylation of 1-(-iodoaryl)alkan-1-ones with alkenes via 1,5-hydrogen atom transfer and alkene alkylarylation to produce diverse β-alkyl arylalkanones containing a quaternary carbon center is presented. This method is applicable to a wide range of 1-(-iodoaryl)alkan-1-ones and activated alkenes. Mechanistic studies suggest that the reaction involves a radical process.

Selective C(sp)-P Cross-Coupling of Alkenylsulfonium Salts with P(O)H Compounds: Divergent Synthesis of Alkenylphosphorus Compounds.

Herein, we report a both regioselective and stereoselective method for the formation of C(sp)-P bonds using alkenylsulfonium salts and >P(O)-H compounds. By employing a palladium catalyst or KCO, a variety of ()-alkenylphosphorus compounds and terminal alkenylphosphorus compounds were successfully synthesized with high selectivity. Notably, trisubstituted ()-alkenylphosphorus compounds were synthesized for the first time under metal-free conditions.

A water-soluble cationic [2]biphenyl-extended pillar[6]arene: synthesis, host-guest interaction with hemin and application in chemodynamic/photodynamic cancer therapy.

A water-soluble cationic [2]biphenyl-extended pillar[6]arene (CBpExP) was designed and synthesized successfully. It could form a stable 1 : 1 complex with hemin, thereby enhancing the stability of hemin in water, and can be further applied in cancer CDT and PDT.

A sensitive electrochemical biosensor based on Exo III cyclic amplification strategy for Phaeocystis globosa detection.

Phaeocystis globosa (P. globosa), a main culprit of harmful algal blooms (HABs), is highly prone to blocking the inlet filter screens of nuclear power cold sources, thus posing a significant threat to nuclear power safety. However, existing methods for P.

Structural Stabilization and Activity Enhancement of Glucoamylase via the Machine-Learning Technique and Immobilization.

Glucoamylases (GLL) hydrolyze starch to glucose syrup without yielding intermediate oligosaccharides, but their lack of stability under industrial conditions poses a major limiting factor. Using consensus- and ancestral-based machine-learning tools, a functional GLL with six mutations (GLL) was constructed that exhibited superior hydrolytic activity relative to the wild-type (WT-GLL). An oxidized multi-walled carbon nanotube (oMW-CNT) was used as a solid support to immobilize the WT-GLL with an immobilization capacity of 211.

Intrinsic stimuli-responsive main-chain supramolecular polymers driven by dative B ← N bonds.

Novel main-chain supramolecular polymers (MCSPs) with intrinsic stimuli-responsiveness were developed using dative B ← N bonds. By separately fluoridating/defluoridating boron and protonating/deprotonating nitrogen, the resultant MCSPs show reversible intrinsic response.

Enantioselective Synthesis of 1-Dihydrobenzazepines through Rh(II)-Catalyzed Cycloisomerization of 1,6-Enyne.

The 1-dihydrobenzazepine skeleton has emerged as a privileged structural motif in bioactive molecules. However, due to a lack of asymmetric methodology, access to chiral 1-dihydrobenzazepines has remained limited. Herein, we report the first intermolecular asymmetric cycloisomerization of benzo-fused enynes for the synthesis of chiral 1-dihydrobenzazepines via dirhodium catalysis.

-Nitration of Boronic Esters Enabled by Ferric Nitrate Nonahydrate (Fe(NO)·9HO) in HFIP.

We describe in this work an operationally facile and generally applicable -nitration of boronic esters by Fe(NO)·9HO in hexafluoroisopropanol (HFIP), allowing us fast access to various nitroarenes that are currently difficult to obtain via traditional electrophilic C-H nitrations. In contrast to previous deborylative -nitrations, this new protocol utilized less reactive and more stable organoboron reagents and therefore had significantly improved substrate scope and functional group tolerance, which was exemplified in the late-stage -nitration of various natural products, pharmaceuticals, and biologically active molecules.

Total Synthesis of Lugdunomycin via Sequential Photoinduced Spiroketalization and Isobenzofuran Diels-Alder Reactions.

The presence of sterically rigid contiguous quaternary stereocenters in natural products imposes conformational constraints with significant effects on their biological activities. However, achieving the direct synthesis of multiple contiguous quaternary stereocenters in a single step remains a formidable challenge. Here, we present the total synthesis of the antibacterial metabolite lugdunomycin (1) in thirteen steps via a sequence of photochemical transformations.

MXene-induced construction of SnS2 nano-arrays with sulfur vacancies for high-efficiency photocatalytic CO2 reduction.

Solar-driven CO2 reduction has gained significant attention as a sustainable approach for CO2 utilization, enabling the selective production of fuels and chemicals. SnS2, a non-precious metal sulfide semiconductor, has great potential in photocatalytic CO2 reduction due to its unique physicochemical properties. However, low electrical conductivity and susceptibility to aggregation of pure SnS2 lead to a high charge recombination rate and hinder the photocatalytic efficiency.

Atroposelective Synthesis of Pyridoindolones Bearing Two Remote Distinct C-N Axes through Cobalt-Catalyzed Enantioselective C-H Activation.

C-N axially chiral compounds represent an important class of atropisomers that are prevalent in bioactive and material molecules. Despite recent advances in synthetic methodologies, the asymmetric construction of atropisomers featuring multiple C-N axes has been rarely explored, significantly limiting their further applications. Herein, we report a novel atroposelective synthesis of diaxially chiral pyridoindolones featuring both six-five and six-six C-N axes through cobalt-catalyzed asymmetric C-H annulation.

Photocatalytic Regioselective Alkoxycarbonylation/Cyclization of 3-Aza-1,5-dienes: Access to Ester-Containing Pyrrolin-2-ones.

A direct alkoxycarbonyl radical-induced cascade reaction of 3-aza-1,5-dienes with alkyl chlorooxoacetates is reported. With this approach, an extensive range of ester-containing pyrrolin-2-ones are synthesized through photocatalyzed alkoxycarbonylation/cyclization with 3-aza-1,5-dienes under mild conditions. Moreover, dehydrogenative aromatization can proceed with the same photocatalytic system.

Anion-Regulated Solvation Structure and Electrode Interface toward Rechargeable Magnesium Batteries.

Developing chlorine-free electrolytes enabling fast Mg transport through a solid/cathode-electrolyte interphase (SEI/CEI) remains critical for rechargeable magnesium batteries (RMBs). However, single-anion electrolytes often lack the necessary redox properties for this requirement. Here, we propose a dual-anion electrolyte combining magnesium bis(trifluoromethanesulfonyl)imide and 1-butyl-1-methylpiperidinium trifluoromethylsulfonate (PPCFSO) in diglyme and 2-methoxyethylamine (MOEA) solvent, achieving efficient Mg plating/stripping, cathode compatibility, and high anodic stability.

Correction: Two-step spin transition around room temperature in a Fe complex.

Correction for 'Two-step spin transition around room temperature in a Fe complex' by Jianfeng Wu , , 2025, , 1231-1238, https://doi.org/10.1039/D4DT02736A.

Electrosynthesis of Atomically Precise Au Nanoclusters.

Innovation in synthesis methodologies is crucial for advancing the discovery of new materials. This work reports the electrosynthesis of a [Au(4-BuPhC≡C)(Dppe)]Cl nanocluster (Au NC) protected by alkynyl and phosphine ligands. From simple precursor, HAuCl and ligands, the whole synthesis is driven by a constant potential in single electrolytic cell.