6 results match your criteria: "School of Chemistry and Chemical Engineering. Henan Normal University[Affiliation]"
Inverse conjugate additions of acrylic amides and esters with F/Cl/O/N-nucleophiles and CF reagents.
Sci Adv
February 2025
Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering. Henan Normal University, 46 East of Construction Road, Xinxiang 453007, Henan, China.
The conjugate additions of nucleophiles to conjugate acceptors are among the most powerful hetero-carbon bond formation reactions. The conjugate addition normally occurs via a β-nucleophilic addition, resulting in the formation of a stabilized α-carbanion intermediate that can be subsequently quenched by electrophiles or protons. Nevertheless, the inverse conjugate addition involving an α-specific nucleophilic addition remains less explored because of the electronic mismatch.
View Article and Find Full Text PDFPhotoredox-Catalyzed Regioselective 1,3-Alkoxypyridylation of -Difluorocyclopropanes.
Org Lett
December 2024
Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, State Key Laboratory of Antiviral Drugs, School of Chemistry and Chemical Engineering Henan Normal University, Xinxiang, Henan 453007, China.
Difluoromethylene and pyridine cores are very important structural units in medicinal chemistry. Herein, we report the development of photoredox-catalyzed ring-opening and 1,3-alkoxypyridylation of -difluorinated cyclopropanes using 4-cyanopyrines and alcohols, employing cyclopropane radical cations as the key intermediate. The reaction exhibits high regioselectivity under mild conditions and can also be practiced on gram-scale synthesis, telescoped reaction, and late-stage functionalization of biological molecules.
View Article and Find Full Text PDFMapping of β3-Adrenergic Receptor in Living Cells with a Ligand-Guided Fluorescent Probe.
Anal Chem
November 2024
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, School of Chemistry and Materials Science, Nanjing Normal University, Wenyuan Road 1, Nanjing 210046, China.
Tracking the dynamic distribution of native proteins in living cells or tissues in real time is essential for understanding the functional mechanisms involved in their physiological or pathological processes. The β3-adrenergic receptor (β3-AR) has important biological functions. It is expected to be a diagnostic indicator for aging, yet current probes for β-ARs are unable to dynamically monitor β3-AR in real time, which impedes the progress of β3-AR research.
View Article and Find Full Text PDFDynamically Favorable Ion Channels Enabled by a Hybrid Ionic-Electronic Conducting Film toward Highly Reversible Zinc Metal Anodes.
Adv Mater
November 2024
College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
Article Synopsis
- - Aqueous zinc ion batteries are promising for their safety and eco-friendliness, but issues like uneven dendrite growth and unwanted reactions on the Zn anode hinder their effectiveness.
- - A new hybrid ink combining graphene-like carbon nitride and conductive polymers is applied to the Zn anode, enhancing the distribution of the electric field and reducing resistance, which helps stabilize zinc flow.
- - With this innovative coating, the battery can achieve a high coulombic efficiency of 99.47% over 1500 cycles and maintain stable performance for over 3000 hours, indicating progress towards creating more reliable and sustainable Zn metal anodes.
Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator.
Cell Chem Biol
January 2021
Clinical Immunology Center & Epigenetics Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Electronic address:
Chimeric antigen receptor (CAR)-T-based therapeutics are a breakthrough in cancer treatment; however, they are hampered by constitutive activation, which leads to worrisome side effects. Engineering CAR-T cells to be as tightly controllable as possible remains a topic of ongoing investigation. Here, we report a photoswitchable approach that uses a mediator for the at-will regulation of CAR-T cells.
View Article and Find Full Text PDFADP-ribosyl-N₃: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds.
Molecules
August 2017
Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering Henan Normal University, Xinxiang 453007, Henan, China.
Article Synopsis
- ADP-ribose and its derivatives are essential for various physiological processes, making their artificial synthesis important for chemical biology and drug discovery.
- Creating ADP-ribosylated compounds is challenging due to their complex structure, fragile bonds, and high water affinity.
- This paper introduces the first synthesis of ADP-ribosyl-N₃, which serves as a precursor for a new strategy to produce different ADP-ribosylated compounds, including innovative nucleotides and peptides.