2,825 results match your criteria: "School of Chemical and Biomolecular Engineering[Affiliation]"
Sci Adv
January 2025
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Designing binders to target undruggable proteins presents a formidable challenge in drug discovery. In this work, we provide an algorithmic framework to design short, target-binding linear peptides, requiring only the amino acid sequence of the target protein. To do this, we propose a process to generate naturalistic peptide candidates through Gaussian perturbation of the peptidic latent space of the ESM-2 protein language model and subsequently screen these novel sequences for target-selective interaction activity via a contrastive language-image pretraining (CLIP)-based contrastive learning architecture.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.
Orthopedic, maxillofacial, and complex dentoalveolar bone grafting procedures that require donor-site bone harvesting can be associated with post-surgical complications. There has been widespread adoption of exogenously sourced particulate bone graft materials (BGM) for bone regenerative procedures; however, the particulate nature of these materials may lead to compromised healing outcomes, mainly attributed to structural collapse of the BGM, prolonged tissue healing. In this study, a fully synthetic thermoresponsive hydrogel-based universal carrier matrix (TX) that forms flowable and shapable putties with different BGMs while spatially preserving the particles in a 3D scaffold at the implantation site is introduced.
View Article and Find Full Text PDFACS Catal
January 2025
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Partial oxidation of ethylene over silver catalysts produces more than 30 million metric tons of ethylene oxide (EO) annually. However, the form of active silver surfaces, reactive oxygen species, and dominant pathways of this chemical reaction remains controversial despite decades of research. Here, we use Raman spectroscopy and transient kinetic measurements to demonstrate that higher coverages of peroxide species, present only upon Ag oxide surfaces that form , correlate with greater selectivities to EO.
View Article and Find Full Text PDFNat Commun
January 2025
School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, Australia.
Regulating favorable assemblies of metallic atoms in the liquid state provides promise for catalyzing various chemical reactions. Expanding the selection of metallic solvents, especially those with unique properties and low cost, enables access to distinctive fluidic atomic structures on the surface of liquid alloys and offers economic feasibility. Here, Sn solvent, as a low-cost commodity, supports unique atomic assemblies at the interface of molten SnInCu, which are highly selective for H synthesis from hydrocarbons.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
College of Chemical and Material Engineering, Quzhou University, Quzhou, Zhejiang Province, 324000, People's Republic of China.
Background: Precise intraoperative tumor delineation is essential for successful surgical outcomes. However, conventional methods are often incompetent to provide intraoperative guidance due to lack specificity and sensitivity. Recently fluorescence-guided surgery for tumors to delineate between cancerous and healthy tissues has attracted widespread attention.
View Article and Find Full Text PDFCell Rep Methods
January 2025
Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address:
We develop a data harmonization approach for C. elegans volumetric microscopy data, consisting of a standardized format, pre-processing techniques, and human-in-the-loop machine-learning-based analysis tools. Using this approach, we unify a diverse collection of 118 whole-brain neural activity imaging datasets from five labs, storing these and accompanying tools in an online repository WormID (wormid.
View Article and Find Full Text PDFACS Energy Lett
January 2025
George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
The global lithium-ion battery recycling capacity needs to increase by a factor of 50 in the next decade to meet the projected adoption of electric vehicles. During this expansion of recycling capacity, it is unclear which technologies are most appropriate to reduce costs and environmental impacts. Here, we describe the current and future recycling capacity situation and summarize methods for quantifying costs and environmental impacts of battery recycling methods with a focus on cathode active materials.
View Article and Find Full Text PDFAdv Mater
January 2025
School of Chemical and Biomolecular Engineering, The University of Sydney, Darlington, New South Wales, 2006, Australia.
Oxygen evolution reaction (OER) is a cornerstone of various electrochemical energy conversion and storage systems, including water splitting, CO/N reduction, reversible fuel cells, and rechargeable metal-air batteries. OER typically proceeds through three primary mechanisms: adsorbate evolution mechanism (AEM), lattice oxygen oxidation mechanism (LOM), and oxide path mechanism (OPM). Unlike AEM and LOM, the OPM proceeds via direct oxygen-oxygen radical coupling that can bypass linear scaling relationships of reaction intermediates in AEM and avoid catalyst structural collapse in LOM, thereby enabling enhanced catalytic activity and stability.
View Article and Find Full Text PDFCommun Biol
January 2025
CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Lyon, France.
We have assessed antiviral activity and induction of protective immunity of fusion-inhibitory lipopeptides derived from the C-terminal heptad-repeat domain of SARS-CoV-2 spike glycoprotein in transgenic mice expressing human ACE2 (K18-hACE2). The lipopeptides block SARS-CoV-2 infection in cell lines and lung-derived organotypic cultures. Intranasal administration in mice allows the maintenance of homeostatic transcriptomic immune profile in lungs, prevents body-weight loss, decreases viral load and shedding, and protects mice from death caused by SARS-CoV-2 variants.
View Article and Find Full Text PDFJ Gastrointest Surg
January 2025
Thoracic Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Background: The benefit of pulmonary metastasectomy (PM) in patients with colorectal cancer (CRC) with isolated lung metastases remains unclear and failure to separate colon from rectal cancer may contribute. Utilizing a large national database, we investigate whether PM is associated with survival benefits in patients presenting with CRC with synchronous lung metastases based upon primary tumor location.
Methods: The Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015 was queried to identify patients with stage IV CRC with isolated synchronous lung metastases at initial diagnosis.
Water Res
December 2024
School of Chemical and Biomolecular Engineering, The University of Sydney, NSW 2006, Australia.
The escalating challenges posed by water resource contamination, especially exacerbated by health concerns associated with microbial fungi threats, necessitate advanced disinfection technologies. Within this context, non-thermal plasma generated within bubble column reactors emerges as a promising antifungal strategy. The effects of direct plasma bubbles within different discharge modes and thus-produced plasma activated water (PAW) on the inactivation of Saccharomyces cerevisiae are investigated.
View Article and Find Full Text PDFNat Commun
January 2025
School of Chemical and Biomolecular Engineering and The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW, Australia.
Science
January 2025
State Key Laboratory of Coordination Chemistry, MOE Key Laboratory of High-Performance Polymer Materials & Technology, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
We explored the potential for membrane materials to reduce energy and carbon requirements for the separation of aliphatic hydrocarbon feedstocks and products. We developed a series of fluorine-rich poly(arylene amine) polymer membranes that feature rigid polymer backbones with segregated perfluoroalkyl side chains. This combination imbues the polymers with resistance to dilation induced by hydrocarbon immersion without the loss of solution-based membrane fabrication techniques.
View Article and Find Full Text PDFAcc Chem Res
January 2025
Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, United States.
bioRxiv
December 2024
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Bone fracture repair initiates by periosteal expansion. The periosteum is typically quiescent, but upon fracture, periosteal cells proliferate and contribute to bone fracture repair. The expansion of the periosteum is regulated by gene transcription; however, the molecular mechanisms behind periosteal expansion are unclear.
View Article and Find Full Text PDFAAPS PharmSciTech
January 2025
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia, 30332-0100, U.S.A..
Delivery of therapies into skin is attractive for medical indications including vaccination and treatment of dermatoses but is highly constrained by the stratum corneum barrier. Microneedle (MN) patches have emerged as a promising technology to enable non-invasive, intuitive, and low-cost skin delivery. When combined with biodegradable polymer formulations, MN patches can further enable controlled-release drug delivery without injection.
View Article and Find Full Text PDFAcc Mater Res
December 2024
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States.
As a ubiquitous feature of the biological world, gradation, in either composition or structure, is essential to many functions and processes. Taking protein gradation as an example, it plays a pivotal role in the development and evolution of human bodies, including stimulation and direction of the outgrowth of peripheral nerves in a developing fetus. It is also critically involved in wound healing by attracting and guiding immune cells to the site of injury or infection.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing, 210037, China.
Suboptimal spatial utilization and inefficient access to internal porosity preclude porous carbon cathodes from delivering high energy density in zinc-ion hybrid capacitors (ZIHCs). Inspired by the function of capillaries in biological systems, this study proposes a facile coordination-pyrolysis method to fabricate thin-walled hollow carbon nanofibers (CNFs) with optimized pore structure and surface functional groups for ZIHCs. The capillary-like CNFs maximize the electrode/electrolyte interface area, facilitating the optimal utilization of energy storage sites.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
State Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Liquid fertilizers, particularly when integrated with precision irrigation systems, offer a more efficient and sustainable alternative to traditional solid nitrogen fertilizers. The industrial production of ammonium nitrate (NHNO) is environmentally detrimental due to its reliance on fossil fuels. This study introduces an innovative air-to-NOx-to-NHNO pathway for synthesizing liquid nitrogen fertilizer.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
Artificial photosynthesis of hydrogen peroxide (HO) from ambient air, water, and sunlight has attracted considerable attention recently. Despite being extremely challenging to synthesis, sp carbon-conjugated covalent organic frameworks (COFs) can be powerful and efficient materials for the photosynthesis of HO due to desirable properties. Herein, we report the designed synthesis of an sp carbon-conjugated COF, BTD-spc-COF, from benzothiadiazole and triazine units with high crystallinity and ultralarge mesopores (∼4 nm).
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48103, United States.
Sum frequency generation vibrational spectroscopy was applied to study the surface hydration and protein adsorption behavior on several polymer coatings based on pyridine, imidazole, and amine side groups along with vinyl or methacrylate backbones and their corresponding zwitterionic forms with carboxybetaine or sulfobetaine side chains, prepared by initiated chemical vapor deposition (iCVD). iCVD also enables facile tuning of the cross-linking density of the polymer coatings by blending in a cross-linker during the deposition, namely, 1,3,5,7-tetramethyl-1,3,5,7-tetravinyl cyclotetrasiloxane. Our results show that both the low- and high-cross-linking density zwitterionic polymers exhibit significantly better antifouling activities compared to those of the polymers without the zwitterionic side chains.
View Article and Find Full Text PDFWater Res
March 2025
Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China; Institute of Sun Yat-Sen University in Shenzhen, PR China. Electronic address:
Electrochemical oxidation process (EOP) is promising for micropollutant degradation in water treatment, where chloride ions (Cl) are inevitable in aqueous systems, leading to the EOP/Cl system. The oxidation of Cl at anodes generates reactive chlorine species (RCS), including heterogeneous chlorine species (Cl), homogeneous free available chlorine (FAC), chlorine dioxide (ClO), and chlorine radicals (CRs). This study developed a method to differentiate various RCS responsible for the removal of carbamazepine in EOP/Cl using the RuO/IrO-Ti anode.
View Article and Find Full Text PDFJ Mater Chem B
December 2024
School of Physics, University of Sydney, Sydney, NSW 2006, Australia.
Polymeric nanoparticles surface functionalised with fluorescent molecules hold significant potential for advancing diagnostics and therapeutic delivery. Despite their promise, challenges persist in achieving robust attachment of fluorescent molecules for real-time tracking. Weak physical adsorption, pH-dependent electrostatic capture, and hydrophobic interactions often fail to achieve stable attachment of fluorescent markers.
View Article and Find Full Text PDFSoft Matter
January 2025
Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.
Recent studies have reported that the overexpression of MUC1 glycoproteins on cell surfaces changes the morphology of cell plasma membranes and increases the blebbing of vesicles from them, supporting the hypothesis that entropic forces exerted by MUC1 change the spontaneous curvature of cell membranes. However, how MUC1 is incorporated into and influences the size and biophysical properties of plasma-membrane-blebbed vesicles is not understood. Here we report single-vesicle-level characterization of giant plasma membrane vesicles (GPMVs) derived from cells overexpressing MUC1, revealing a 40× variation in MUC1 density between GPMVs from a single preparation and a strong correlation between GPMV size and MUC1 density.
View Article and Find Full Text PDFACS Omega
December 2024
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30309, United States.
Efforts addressing sludge management, food security, and resource recovery have led to novel approaches in these areas. Electrically assisted conversion of sludge stands out as a promising technology for sewage sludge valorization, producing nitrogen and phosphorus-based fertilizers. The adoption of this technology, which could lead to a fertilizer circular economy, holds the potential to catalyze a transformative change in wastewater treatment facilities toward process intensification, innovation, and sustainability.
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