Genome mining of albocandins A-E from sp. YINM00030.

The natural products of 2,5-diketopiperazines have attracted considerable attention due to their potent pharmacological activities. Guided by genome mining techniques, five albonoursin analogues, designated as albocandins A-E (1-5), were isolated from sp. YINM00030, an actinomycete sourced from the rhizosphere soil of medicinal plants.

A novel small molecule NJH-13 induces pyroptosis via the Ca driven AKT-FOXO1-GSDME signaling pathway in NSCLC by targeting TRPV5.

Introduction: Pyroptosis represents a mode of programmed necrotic cell death (PCD), mediated by members of gasdermin family (GSDMs), such as GSDME. It is emerging as a promising approach for combating cancer. Notably, GSDME is the key modulator for the switch between apoptosis and pyroptosis in cells.

Scalable synthesis of (±)-gregatin A a 1,3-dipolar cycloaddition strategy.

A 6-step gram-scale synthesis of the fungal polyketide (±)-gregatin A is described. The synthetic route features an intermolecular 1,3-dipolar cycloaddition, a Mo-mediated disconnection of the isoxazole skeleton, and an acid-mediated deprotection/enamine hydrolysis and hemiketalization cascade.

Metabolites, Biotransformation, and Plant-Growth Dual Regulatory Activity from Uncovered by the Fermentation Interaction with a Host.

One new azaphilone derivative () from in ordinary medium, one new phthalide derivative (), a microbial transformation product of ingredients by , a pair of new austdiol enantiomers (+)- and (-)-, one new epsilon-caprolactone derivative (), and one new ophiobolin-type sesterterpenoid () from the in host medium were reported. The structures were determined by spectroscopic analysis and single-crystal X-ray diffraction. Compounds - could completely inhibit the germination of rice seeds at 50 μg/mL, which is higher than that of the positive control.

A Highly Selective Probe for Real-Time Monitoring of Ethylenediamine with Ratiometric Luminescent and Colorimetric Dual-Mode Responses.

Ethylenediamine (EDA), as an important chemical raw material and fine chemical intermediate, has been widely applied in various industries. Real-time monitoring of EDA is highly desirable in daily life due to its potential threat to human health. Herein, we report a molecular probe named 4,4'-(9-carbazole-3,6-diyl)bis(1-(naphthalen-2-ylmethyl)pyridin-1-ium) iodide (p-N-DPC·I) with ratiometric luminescent and colorimetric dual-mode responses toward EDA, endowing a highly sensitive and selective detection method for its real-time monitoring.

Comparison of chemical constituents in species and their antimicrobial activity for extending the shelf life of foods.

Food spoilage causes significant economic losses and endangers human health. Developing novel antimicrobial agents and preservatives is urgently needed for anti-foodborne diseases and improving food storage. Zhen Zhu Cai () species are well-known edible plants among the East Asian populace that clear heat and anti-aging.

Terpenes from and the evaluation of their potential anti-inflammatory activity.

Two undescribed compounds, including one monoterpene () and one sesquiterpene (), together with eleven known compounds were isolated from . The structures of the isolated compounds were determined by comprehensive spectroscopic analysis; the absolute configurations of these compounds were determined by ECD calculation. Some of the compounds were tested for anti-inflammatory activity.

Four Alkaloids from with Antitumor Activity via Disturbing Glutathione Homeostasis.

Alstoschoquinolines A-D (-) representing three unprecedented scaffolds were isolated from the leaves of through direct separation by LC/MS detection. and consisted of a 5/6/5-coupled quinoline architecture containing six consecutive chiral carbons, while and possessed a bridged ring featuring 6/6/6/6 and 6/6/8/6 skeletons, respectively. They might be derived from the corynantheine-type indole alkaloid via sequential oxidation and rearrangement.

Stereoselective Vinylogous Aza-Pummerer Reaction of β,β-Disubstituted Enesulfinamides.

Treatment of multisubstituted NH-enesulfinamides with tosyl isocyanate (TsNCO) at room temperature results in the formation of α-tosylcarbamoyloxy -sulfenyl ketimines with high enantioselectivity. This process is believed to proceed via a vinylogous aza-Pummerer-type reaction pathway in which the sulfinyl oxygen atom in the enesulfinamides undergoes nucleophilic attack on tosyl isocyanate, triggering the subsequent transformations that enable the transfer of chirality from sulfur to carbon.

Two novel lanthanide metal-organic frameworks based on tetraphenylethylene for ultra-high proton conduction.

Two novel isostructural anionic lanthanide metal-organic frameworks, (MeNH)[Ln(HTCBPE-F)·(HCOO)·DMF]·4.5DMF·2HO (Eu-MOF and Dy-MOF), based on tetraphenylethylene carboxylate ligands were successfully constructed and characterized. These two MOFs possess porous structures and water stabilities with uncoordinated carboxylate groups and dimethyl ammonium cations, which allow for high proton conductivities (5.

Amino acid modified copper-based metal organic polyhedral with higher peroxidase activity for potassium guaiacol sulfonate detection.

It has been reported some nanozymes could be used as a substitute for natural enzyme to detect HO to some extent. However, the low catalytic effect of these materials limited their further application fields. Hence, to increase the catalytic activity of nanozymes was a hot research topic and many methods have been reported.

Anti-Candida albicans effect and mechanism of Pachysandra axillaris Franch.

Ethnopharmacological Relevance: Pachysandra axillaris Franch., a traditional herbal medicine in Yunnan, has been used to treat traumatic injuries and stomach ailments, some of which were related to microbial infections in conventional applications, but, to the best of our knowledge, the antifungal bioactivity of this plant and its main antifungal components have not been previously reported.

Aim Of The Study: To identify the antifungal compounds of P.

Dynamic Covalent Bonds-Mediated Color-Switchable Circularly Polarized Luminescence in Helical Assemblies of Achiral Liquid Crystal Block Copolymer Films.

Circularly polarized luminescence (CPL) film attracted considerable attention in information storage and encryption, three-dimensional display, and chiral recognition. However, due to the limited molecular mobility within thin film, achieving a high asymmetry factor and non-contact modulation of CPL remain challenging. In this work, color-switchable homochiral CPL films with high luminescence asymmetry factor (g~0.

Antioxidative Indole Diketopiperazine Alkaloids from Endophytic Fungi Aspergillus sp. JXC-5.

Three previously undescribed indole diketopiperazine alkaloids and seventeen known compounds were characterized by Aspergillus sp. JXC-5 by solid fermentation. Their structures were elucidated by spectroscopic methods and high-resolution electrospray ionization mass spectrometry, and the absolute configurations were further confirmed by electronic circular dichroism (ECD), induced CD spectra, and ML_J_DP4 methods.

Voagafries A-E, undescribed indole alkaloids with anti-glioma activity from Voacanga africana.

Voagafries A-E, five undescribed monoterpenoid indole alkaloids (MIAs), were isolated from the stem bark of Voacanga africana. Voagafrie A (1) has a unique 6/5/5/6/6 spiral ring skeleton with an indolone-fused 9-oxo-3-aza-tricyclo[6,3,1,0]-12-alkane-10-carbonyllactone. Voagafrie B (2) is a rare 5,6-seco diazine scaffold, whereas voagafrie C (3) possesses an octahydropyrrolo[2,3-b] pyrrole-fused 2,8-diazabicyclo[3.

Alstoscholarisine L, a novel caged monoterpenoid indole alkaloid with antifungal activity from Alstonia scholaris.

Alstoscholarisine L is an architecturally complex monoterpenoid indole alkaloid with a unique ring fusion pattern, isolated from the leaves of Alstonia scholaris. The 6/5/5/6/6/6-membered rings contain two lactonic rings and one aminal carbon and possess seven contiguous aligned stereocenters, three of which are quaternary. Its structure was elucidated by extensive spectroscopic data analyses, quantum chemical computations, and single-crystal X-ray diffraction.

Siegesoxylipin A‒J, previously undescribed phyto-oxylipins inhibition of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci from Sigesbeckia orientalis.

Ten previously undescribed phyto-oxylipins siegesoxylipin A‒J (1-10), along with four known analogs (11-14), were isolated from the aerial parts of Sigesbeckia orientalis. The elucidation of their structures was accomplished through spectroscopic analyses, base-catalyzed hydrolysis and X-ray diffraction. Moreover, unmethylesterified 4-methylpentanoic acid siegesoxylipins 1, 2, and 4-7 exhibited potent inhibitory bioactivity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) strains with MIC values of 8 μg/mL, in which siegesoxylipin A (1) inhibited bacteria by inducing membrane damage.

Podocarpane and cleistanthane diterpenoids from Strophioblachia glandulosa: structural elucidation, anti-hypertrophy activity and network pharmacology.

In the present investigation, fourteen unprecedented podocarpane diterpenoids strophiolosas A-J, L-N and P (1-10, 12-14, 16), two new cleistanthane derivatives strophiolosas Q-R (17-18), two new dibenzopyroan-ones and one new tetralone strophiolosas S-U (19-21), were isolated from the whole plant of Strophioblachia glandulosa. The structures were elucidated via various spectroscopic analysis, quantum chemistry calculations, and X-ray diffraction. Bioactivity test indicated that compounds 5 and 17 possessed promising anti-cardiac hypertrophy effect in vitro (IC values of 16.

Characterization of Spirobisnaphthalenes from an Endophytic Fungus sp. Associated with and Insights into Their Biological Activity.

Fungal secondary metabolites have been increasingly sought after as an alternative strategy to herbicides and a source of new medicines. Twenty spirobisnaphthalenes (SBNs) were isolated from the fermentation broth of sp. YUD20003 from the herb (L.

Stereoselective Enesulfinamide-Sulfinylimine Tautomerization of β,β-Disubstituted Enesulfinamides.

In the presence of cesium fluoride and organosilicon reagent, β,β-disubstituted NH-enesulfinamides undergo stereoselective enesulfinamide-sulfinylimine tautomerization at room temperature, resulting in the formation of α-branched -sulfinyl ketimines in good yields with high stereoselectivity. A variety of acyclic ketone surrogates α-substituted with two electronically and sterically similar groups (e.g.

TRIM4 enhances small-molecule-induced neddylated-degradation of CORO1A for triple negative breast cancer therapy.

As a critical member of the Coronin family, Coronin 1A (CORO1A) plays a crucial role in the progression of triple-negative breast cancer (TNBC). However, CORO1A is typically considered "undruggable" due to its smooth surface and complex protein-protein interactions (PPIs). Molecular glues have emerged as one of the most effective strategies to rapidly degrade such "undruggable" targets.

Native corncob-derived biosorbent with grafted 1,3,4-thiadiazole for enhanced adsorption of palladium in metallurgical wastewater.

The reuse of agricultural waste brings significant benefits but still faces a multitude of challenges. In this work, novel precious metal sorbents were constructed by grafting 1,3,4-thiadiazole-2-thiol (MTD) and 2,5-dithiadiazole-1,3,4-thiadiazole (DMTD) onto native corncob, which could rapidly and selectively recover palladium (Pd) from metallurgical wastewater. The characterization of the sorbents by powder X-ray diffraction indicated that introducing MTD or DMTD on native corncob did not alter the crystallinity and inherent structural framework.

Cascade Annulation for Synthesizing Chromenopyrrolones from -Hydroxyphenyl Enaminones and 2-Halo--alkyloxyacetamides.

A cascade cyclization reaction comprising two halogenation reactions and a Michael addition was developed for the synthesis of chromeno[2,3-]pyrrole-3-ones . Additionally, another cascade cyclization reaction, which involves a halogenation reaction followed by two intramolecular Michael additions, was established for the synthesis of chromeno[2,3-]pyrrole-2-ones . Both types of compounds were synthesized from -hydroxyphenyl enaminones and 2-halo--alkyloxyacetamides through a process that facilitated the intramolecular formation of C-C, C-O, and C-N bonds to effectively establish two fused rings in a single operation.