Dynamic hydrogen-bonding enables high-performance and mechanically robust organic solar cells processed with non-halogenated solvent.

Developing active-layer systems with both high performance and mechanical robustness is a crucial step towards achieving future commercialization of flexible and stretchable organic solar cells (OSCs). Herein, we design and synthesize a series of acceptors BTA-C6, BTA-E3, BTA-E6, and BTA-E9, featuring the side chains of hexyl, and 3, 6, and 9 carbon-chain with ethyl ester end groups respectively. Benefiting from suitable phase separation and vertical phase distribution, the PM6:BTA-E3-based OSCs processed by o-xylene exhibit lower energy loss and improved charge transport characteristic and achieve a power conversion efficiency of 19.

Perovskite-Based Smart Eyeglasses as Noncontact Human-Computer Interaction.

More than 70% of human information comes from vision. The eye is one of the most attractive sensing sites to collect biological parameters. However, it is urgent to develop a cost-effective and easy-to-use approach to monitor eyeball information in a minimally invasive way instead of current smart contact lenses or camera-based eyeglasses.

Scalable synthesis of (±)-gregatin A a 1,3-dipolar cycloaddition strategy.

A 6-step gram-scale synthesis of the fungal polyketide (±)-gregatin A is described. The synthetic route features an intermolecular 1,3-dipolar cycloaddition, a Mo-mediated disconnection of the isoxazole skeleton, and an acid-mediated deprotection/enamine hydrolysis and hemiketalization cascade.

Metabolites, Biotransformation, and Plant-Growth Dual Regulatory Activity from Uncovered by the Fermentation Interaction with a Host.

One new azaphilone derivative () from in ordinary medium, one new phthalide derivative (), a microbial transformation product of ingredients by , a pair of new austdiol enantiomers (+)- and (-)-, one new epsilon-caprolactone derivative (), and one new ophiobolin-type sesterterpenoid () from the in host medium were reported. The structures were determined by spectroscopic analysis and single-crystal X-ray diffraction. Compounds - could completely inhibit the germination of rice seeds at 50 μg/mL, which is higher than that of the positive control.

Natural Kaurane-class of Diterpenoid Alkaloids: Structure, Distribution, and Bioactivities.

Kaurane-class diterpenoid alkaloids (DAs), an important group of C20-DAs, include mainly veatchine-, napelline-, anopterine- and tricalysiamide-type DAs and several types of DAs with novel skeletons discovered in recent years. To date, approximately 81 compounds belonging to this class of DAs have been isolated from plants in 5 families and 7 genera. Among them, Aconitum is the most important source of this class of DAs.

Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy.

Reactive oxygen species (ROS)-mediated anticancer modalities, which disturb the redox balance of cancer cells through multi-pathway simulations, hold great promise for effective cancer management. Among these, cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability, low toxicity, and high therapeutic efficacy. Herein, we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase (CPO) into gold nanorod (AuNR)-based nanogels (ANGs) for cascade-amplifying photothermal-enzymatic synergistic tumor therapy.

A responsive cocktail nano-strategy breaking the immune excluded state enhances immunotherapy for triple negative breast cancer.

The exclusion of immune cells from the tumor can limit the effectiveness of immunotherapy in triple negative breast cancer (TNBC). The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway plays a crucial role in priming adaptive anti-tumor immunity through the production of type I interferons (IFNs), facilitating the maturation of dendritic cells (DCs) and the function of T cells. Although the increased expression of programmed death-ligand 1 (PD-L1) upon STING activation is favorable for amplifying the efficacy of immune checkpoint inhibitors (ICIs) and realizing combination therapy, the penetration barrier remains a major obstacle.

A Highly Selective Probe for Real-Time Monitoring of Ethylenediamine with Ratiometric Luminescent and Colorimetric Dual-Mode Responses.

Ethylenediamine (EDA), as an important chemical raw material and fine chemical intermediate, has been widely applied in various industries. Real-time monitoring of EDA is highly desirable in daily life due to its potential threat to human health. Herein, we report a molecular probe named 4,4'-(9-carbazole-3,6-diyl)bis(1-(naphthalen-2-ylmethyl)pyridin-1-ium) iodide (p-N-DPC·I) with ratiometric luminescent and colorimetric dual-mode responses toward EDA, endowing a highly sensitive and selective detection method for its real-time monitoring.

Comparison of chemical constituents in species and their antimicrobial activity for extending the shelf life of foods.

Food spoilage causes significant economic losses and endangers human health. Developing novel antimicrobial agents and preservatives is urgently needed for anti-foodborne diseases and improving food storage. Zhen Zhu Cai () species are well-known edible plants among the East Asian populace that clear heat and anti-aging.

Engineered Microneedle System Enables the Smart Regulation of Nanodynamic Sterilization and Tissue Regeneration for Wound Management.

The healing of bacterial biofilm-infected wounds is a complex process, and the construction of emerging therapeutic modalities that regulate the microenvironment to magnify therapeutic effects and reduce biotoxicity is still highly challenging. Herein, an engineered microneedle (MN) patch is reported to mediate the efficient delivery of black phosphorus nanosheets (BP NSs) and copper peroxide nanodots (CP NDs) for dual nanodynamic sterilization and methicillin-resistant staphylococcus aureus (MRSA)-infected wound healing. Results demonstrate that the system can eliminate biofilm, reduce cytotoxicity, promote angiogenesis and tissue regeneration by the multiple advantages of chemodynamic therapy (CDT), enhanced photodynamic therapy (PDT), and improved degradation process from BP NSs to phosphate for promoting cell proliferation.

Luminescent Metal-Organic Framework with Outstanding "Turn-On" Hg Sensing Ability First Constructed by an AIE Ligand.

Hg is highly toxic and can cause serious harm to the environment and humans. Thus, it is vital to develop efficient Hg sensors. In this work, a LMOF-based (LMOF = luminescent metal-organic framework) "turn-on" Hg sensor () is first developed by an aggregation-induced emission (AIE) functional ligand.

Bionic Luminescent Sensors Based on Covalent Organic Frameworks: Auditory, Gustatory, and Olfactory Information Monitoring for Multimode Perception.

The synthesis of covalent organic frameworks (COFs) with excellent luminescent properties and their effective application in the field of bionic sensing remain a formidable challenge. Herein, a series of COFs with different numbers of hydroxyl groups are successfully synthesized, and the number of hydroxyl groups on the benzene-1,3,5-tricarbaldehyde (BTA) linker influences the properties of the final COFs. The COF (HHBTA-OH) prepared with hydrazine hydrate (HH) and BTA containing one hydroxyl group as the ligands exhibits the best fluorescent performance.

Terpenes from and the evaluation of their potential anti-inflammatory activity.

Two undescribed compounds, including one monoterpene () and one sesquiterpene (), together with eleven known compounds were isolated from . The structures of the isolated compounds were determined by comprehensive spectroscopic analysis; the absolute configurations of these compounds were determined by ECD calculation. Some of the compounds were tested for anti-inflammatory activity.

Four Alkaloids from with Antitumor Activity via Disturbing Glutathione Homeostasis.

Alstoschoquinolines A-D (-) representing three unprecedented scaffolds were isolated from the leaves of through direct separation by LC/MS detection. and consisted of a 5/6/5-coupled quinoline architecture containing six consecutive chiral carbons, while and possessed a bridged ring featuring 6/6/6/6 and 6/6/8/6 skeletons, respectively. They might be derived from the corynantheine-type indole alkaloid via sequential oxidation and rearrangement.

Stereoselective Vinylogous Aza-Pummerer Reaction of β,β-Disubstituted Enesulfinamides.

Treatment of multisubstituted NH-enesulfinamides with tosyl isocyanate (TsNCO) at room temperature results in the formation of α-tosylcarbamoyloxy -sulfenyl ketimines with high enantioselectivity. This process is believed to proceed via a vinylogous aza-Pummerer-type reaction pathway in which the sulfinyl oxygen atom in the enesulfinamides undergoes nucleophilic attack on tosyl isocyanate, triggering the subsequent transformations that enable the transfer of chirality from sulfur to carbon.

Synthesis of anisotropic silica nanoparticles by organic amine with diverse structures.

Herein, we synthesized anisotropic silica nanoparticles (AISNPs) with organic amines with different structures. Monoamines and diamines with distance between amine groups shorter than4 Å have been observed to facilitate the formation of isotropic silica nanoparticles (ISNPs). AISNPs were synthesized with diamines with distance between amine groups longer than4 Å and linear structures of triamines.

Two novel lanthanide metal-organic frameworks based on tetraphenylethylene for ultra-high proton conduction.

Two novel isostructural anionic lanthanide metal-organic frameworks, (MeNH)[Ln(HTCBPE-F)·(HCOO)·DMF]·4.5DMF·2HO (Eu-MOF and Dy-MOF), based on tetraphenylethylene carboxylate ligands were successfully constructed and characterized. These two MOFs possess porous structures and water stabilities with uncoordinated carboxylate groups and dimethyl ammonium cations, which allow for high proton conductivities (5.

NIR-Activated Hydrogel with Dual-Enhanced Antibiotic Effectiveness for Thorough Elimination of Antibiotic-Resistant Bacteria.

Antibiotic resistance has become a critical health crisis globally. Traditional strategies using antibiotics can lead to drug-resistance, while inorganic antimicrobial agents can cause severe systemic toxicity. Here, we have developed a dual-antibiotic hydrogel delivery system (PDA-Ag@Levo/CMCS), which can achieve controlled release of clinical antibiotics levofloxacin (Levo) and classic nanoscale antibiotic silver nanoparticles (AgNPs), effectively eliminating drug-resistant .

Amino acid modified copper-based metal organic polyhedral with higher peroxidase activity for potassium guaiacol sulfonate detection.

It has been reported some nanozymes could be used as a substitute for natural enzyme to detect HO to some extent. However, the low catalytic effect of these materials limited their further application fields. Hence, to increase the catalytic activity of nanozymes was a hot research topic and many methods have been reported.

Fluorine-expedited nitridation of layered perovskite SrTiO for visible-light-driven photocatalytic overall water splitting.

Photocatalytic overall water splitting is a promising approach for a sustainable hydrogen provision using solar energy. For sufficient solar energy utilization, this reaction ought to be operated based on visible-light-active semiconductors, which is very challenging. In this work, an F-expedited nitridation strategy is applied to modify the wide-bandgap semiconductor SrTiO for visible-light-driven photocatalytic overall water splitting.

Autocatalytic Interfacial Synthesis of Self-Standing Amide-Linked Covalent Organic Framework Membranes.

The synthesis of crystalline covalent organic frameworks (COFs) has in principle relied on reversible dynamic chemistry. A general method to synthesize irreversibly bonded COFs is urgently demanded for driving the COF chemistry to a new era. Here we report a universal two-step method for the straightforward synthesis of irreversibly amide-linked COF (AmCOF) membranes by autocatalytic interfacial polymerization (AIP).

Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas.

Penetrating orocutaneous or oropharyngeal fistulas (POFs), severe complications following unsuccessful oral or oropharyngeal reconstruction, remain complex clinical challenges due to lack of supportive tissue, contamination with saliva and chewed food, and dynamic oral environment. Here, we present a Janus hydrogel adhesive (JHA) with asymmetric functions on opposite sides fabricated via a facile surface enzyme-initiated polymerization (SEIP) approach, which self-entraps surface water and blood within an in-situ formed hydrogel layer (RL) to effectively bridge biological tissues with a supporting hydrogel (SL), achieving superior wet-adhesion and seamless wound plugging. The tough SL hydrogel interlocked with RL dissipates energy to withstand external mechanical stimuli from continuous oral motions like chewing and swallowing, thus reducing stress-induced damage.

Spin-polarized lasing in manganese doped perovskite microcrystals.

Spin-polarized lasers have demonstrated many superiorities over conventional lasers in both performance and functionalities. Hybrid organic-inorganic perovskites are emerging spintronic materials with great potential for advancing spin-polarized laser technology. However, the rapid carrier spin relaxation process in hybrid perovskites presents a major bottleneck for spin-polarized lasing.

Anti-Candida albicans effect and mechanism of Pachysandra axillaris Franch.

Ethnopharmacological Relevance: Pachysandra axillaris Franch., a traditional herbal medicine in Yunnan, has been used to treat traumatic injuries and stomach ailments, some of which were related to microbial infections in conventional applications, but, to the best of our knowledge, the antifungal bioactivity of this plant and its main antifungal components have not been previously reported.

Aim Of The Study: To identify the antifungal compounds of P.