Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon.

Aim: This study is aimed at establishing phenolic compound profile and assessing the possible antiulcer activities of aqueous extracts of some staple plant foods from the West and North-West regions of Cameroon against chronic gastric ulcer models in rats.

Materials And Methods: Phenolic constituents of extracts were evaluated using HPLC-DAD. Aqueous extracts of , , , , "nkui" spices, and "yellow soup" spices were tested at two doses (200 and 400 mg/kg).

glucosidase inhibitory activity of isolated compounds and semisynthetic derivative from aerial parts of DC.

The current study was conducted to isolate the phytoconstituents from leaves and stem bark and evaluate their inhibitory activity against α-glucosidase, digestive enzyme related to diabetes mellitus. Phytochemical investigation of the leaves resulted in the isolation of three saponins (3-5), two triterpenoids (7 and 8) and two steroids (10a and 10b) as inseparable mixture, while one saponin (6), one triterpenoid (9) and one mixture of two cinnamates (2a and 2b) were isolated from the stem bark. Except for compounds 2 b, 7, 8, 10a and 10 b all the isolated compounds are reported here for the first time from the genus .

In Vitro Evaluation of α-amylase and α-glucosidase Inhibition of 2,3-Epoxyprocyanidin C1 and Other Constituents from Poir.

Diabetes mellitus is a metabolic disorder which is one of the leading causes of mortality and morbidities in elderly humans. Chronic diabetes can lead to kidney failure, blindness, limb amputation, heart attack and stroke. Physical activity, healthy diets and medications can reduce the incidence of diabetes, so the search for more efficient antidiabetic therapies, most especially from natural products, is a necessity.

Euphol from Tapinanthus sp. Induces Apoptosis and Affects Signaling Proteins in Glioblastoma and Prostate Cancer Cells.

Background: Plants play an important role in cancer therapy. They are source of natural molecules which can induce apoptosis in cancer cells by affecting molecular mechanisms implicated in cancer progression. The MAP Kinase/ERK1/2 and PI3K/AKT signaling pathways are two classical signaling pathways implicated in cancer progression and constitute therapeutic targets against cancer.

A new flavonol derivative and other compounds from the leaves of Schum with activity against multidrug-resistant bacteria.

Investigation of the leaves of Schum led to the isolation and identification of a new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether () together with eleven known compounds (-), with two of them ( and ) obtained as a mixture. Their structures were established by extensive spectroscopic analyses. Antibacterial activity of compound as well as the reference antibiotic, ciprofloxacin was tested on Gram-negative multidrug-resistant bacteria overexpressing active efflux pumps, and against methicillin-resistant strains of (MRSA).

Antibiofilm and Anti-Quorum Sensing Potential of Cycloartane-Type Triterpene Acids from Cameroonian Grassland Propolis: Phenolic Profile and Antioxidant Activity of Crude Extract.

Propolis is very popular for its beneficial health properties, such as antimicrobial activity and antioxidant effects. It is one of the most long-serving traditional medicines to mankind due to its interesting chemical diversity and therapeutic properties. The detailed chemical information of propolis samples is very necessary to guarantee its safety and for it to be accepted into health care systems.

Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of L. Benth (Fabaceae).

Twenty-two compounds were isolated from the fruit of including one unprecedented, rare amino acid-derived zwitterionic and one new flavone derivative. The isolation was performed on repeated column chromatography over silica gel and their structures were determined by 1D-, 2D-NMR and HR-ESI-MS spectra together with reported data in the literature. The chemophenetic significance is also discussed.

Valorization of cricket, (Linnaeus, 1758), flour as a source of dietary protein in Japanese quail, (Temminck and Schlegel, 1849), farming.

Objective: Quail production is ranked as an important alternative animal protein source in Cameroon. One of the main constraints of this production is the quality of feed, which lacks protein that is regularly supplied by fish meal. To avoid disagreements due to the constant shortage of fish meal, alternative protein sources are needed, and among them are crickets ().

Chemical constituents from fruits of Vahl ex. DC (Connaraceae) and evaluation of their anticholinesterase and antiradical activities.

The phytochemical investigation of the DCM/MeOH (1:1) extract of the fruits of led to the isolation and characterization of one new quinic acid derivative, ferruginoic acid (), together with six known compounds . Compounds were reported for the first time from this species. The structures of compounds - were elucidated on the basis of 1 D and 2 D NMR spectroscopic data, mass spectrometry and by comparison of spectroscopic data with those from the literature.

Antibacterial and Antioxidant Activities of Isolated Compounds from Leaves.

(G. &Perr.) Taub (Mimosaceae) is a large tree native to dry tropical Africa and characteristic of dry leguminous forests.

In Vitro Antilipidic and Antithrombotic Activities of (Lamiaceae) Leaves Extracts and Fractions.

Objective: The present study investigated the effect of the leaves extracts and fractions of on the inhibition of pancreatic lipase, cholesterol esterase, adipocytes lipid uptake, and antithrombotic activity which may be important in atherosclerosis development.

Methods: Aqueous, ethanolic, and hydroethanolic extracts of were prepared by maceration. The hydroethanolic extract was fractionated into -hexane, ethylacetate, and butanol fractions and their inhibition of pancreatic lipase, cholesterol esterase, adipocytes lipid uptake, and antithrombotic activities measured.

A homochiral coordination polymer of cobalt(II) and L-serine.

A one-dimensional chiral cobalt(II) coordination polymer, namely, catena-poly[[[(S)-2-amino-3-hydroxypropanoato-κN,O]cobalt(II)]-μ-(S)-2-amino-3-hydroxypropanoato-κO,O:N,O], [Co(CHNO)] or Δ-[Co(L-Ser-κN,O)] (L-Ser = L-serine) (1), has been synthesized and characterized using elemental and thermal analyses, IR spectroscopy and single-crystal and powder X-ray diffraction techniques. The asymmetric unit of 1 consists of two serine anions which are coordinated to a Co ion to give three chelate rings. These extend the structure into a helical chain with pendant chelate rings which participate in interchain hydrogen bonding.

Peptide conjugates of 18β-glycyrrhetinic acid as potent inhibitors of α-glucosidase and AGEs-induced oxidation.

18β-Glycyrrhetinic acid (18β-GA) is known for several biological activities, and has been the focus of extensive research for the development of therapeutic agents. In the current study, 18β-GA-peptide conjugates 2-11 were evaluated for their in vitro α-glucosidase inhibitory and antiglycation activities. Structure-activity relationship (SAR) established and molecular interactions of active bioconjugates with the enzyme's binding sites were predicted through molecular modeling approach.

Effect of Sodium Disilicate and Metasilicate on the Microstructure and Mechanical Properties of One-Part Alkali-Activated Copper Slag/Ground Granulated Blast Furnace Slag.

Copper slag (CS) remains a challenging industrial by-product with a relatively small utilization fraction. The present study investigated the development of one-part alkali-activated cements based on CS, ground granulated blast furnace slag (GGBS) and a mixture of the two as a precursor. We investigated 5 to 15 wt% solid sodium metasilicate (NaSiO) and disilicate (NaSiO) as alkaline reagents.

One new constituent from the stem bark of De Wild. (sapotaceae).

The phytochemical investigation of the methanol extract of the stem bark of led to the isolation and characterization of one new secondary metabolite, lacourtianal (), together with eight known compounds. Compounds ; ; ; ; and were reported for the first time from genus. The structures of compounds - were elucidated on the basis of 1 D and 2 D NMR spectroscopic and mass spectrometric data as well as comparison with the literature.

Chemical Composition, Anti-Quorum Sensing, Enzyme Inhibitory, and Antioxidant Properties of Phenolic Extracts of L. Kuntze.

Phenolic extracts of were prepared and their preliminary phenolic profiles determined using HPLC-DAD with 26 phenolic standards. Apigenin (21.75 ± 0.

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources.

Alzheimer's disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient's daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies.

Asperpyrone, a rare -pyrone metabolite produced by an endophytic fungus sp. isolated from (Planch. & Triana) Oliv.

A new -pyrone, asperpyrone () and two known compounds, stigmasterol () and 7-hydroxy-3-(2,3-dihydroxybutyl)-1(3)-Isobenzofuranone () were isolated from the solid rice culture of the endophytic fungus sp., an endophytic fungus isolated from the fresh inner tissue of the barks of . Their structures were determined by extensive spectral analysis including 1 D and 2 D NMR, HRESIMS and single-crystal X-ray crystallographic analysis.

A Preliminary Study of Chemical Profiles of Honey, Cerumen, and Propolis of the African Stingless Bee .

Recently, the honey and propolis of stingless bees have been attracting growing attention because of their health-promoting properties. However, studies on these products of African Meliponini are still very scarce. In this preliminary study, we analyzed the chemical composition of honey, two cerumen, and two resin deposits (propolis) samples of from Tanzania.

Antibiofilm and Enzyme Inhibitory Potentials of Two Annonaceous Food Spices, African Pepper () and African Nutmeg ().

Food pathogens represent an important health threat, and it is relevant to study the effect of foodstuffs such as spices which can inhibit bacterial growth. This study reports the antimicrobial, antibiofilm, and enzyme (Acetylcholinesterase, Butyrylcholinesterase, urease, tyrosinase) inhibitory activities of two medicinal food spices belonging to the Annonaceae family, and . GC-MS (gas chromatography mass spectrometry) analysis of silylated samples of Methanol-Dicloromethane (50:50) extracts of both plants led to the identification of nine compounds in and seven compounds in .

Two new triterpenoid fatty acid esters from Harms (Araliaceae).

Two new fatty acid esters of triterpenoids (-) together with eleven known compounds (-) were obtained after investigation of the CHCl-MeOH (1:1) crude extract from the leaves of Harms. All these compounds (-) were isolated for the first time from this plant among which compounds , , and - were also isolated from the genus for the first time. The structures of the isolated compounds were elucidated by analyses of their spectroscopic data (1D and 2D NMR, and MS).

Antibiofilm and anti-quorum sensing activities of polyethylene imine coated magnetite and nickel ferrite nanoparticles.

This study was aimed at synthesizing polyethyleneimine-coated magnetic nanoparticles and evaluating their effect on pathogenic bacteria. Polyethyleneimine-coated magnetite (PEIMnF) and nickel ferrite (PEINF) nanoparticles were succesfully synthesized and their surface groups, morphology and chemical structures were characterized using ATR-FTIR (Attenuated Total Reflectance Fourrier Transformed Infra-Red) and SEM (Scanning Electron Microscopy). TGA (Thermogravimetric analysis) was used to analyse the thermal behaviour and stability of synthesized nanomaterials.

potentializes the PMSG-inducing effect on some physiological and biochemical parameters in PMSG-primed immature rats.

The present study evaluated the effect of the aqueous extract from leaves of E. speciosa on some physiological and biochemical parameters of reproduction and the onset of puberty in pregnant mare serum gonadotropin (PMSG)-primed immature female rats. High pressure liquid chromatography (HPLC) was used to quantify the phenolic compounds in the methanol/methylene chloride (1:1) extract, the ethanolic and ethyl acetate fractions and the aqueous residue of E.