Chemical constituents and antibacterial activities of Cameroonian dark brown propolis against potential biofilm-forming bacteria.

Propolis is a resinous material collected by different bee species from various plant exudates and used to seal holes in honeycombs, smoothen the internal walls, embalm intruders, improve health and prevent diseases. From its -hexane extract, eight compounds were isolated and characterised as: mangiferonic acid (); 1-hydroxymangiferonic acid (), new natural product; mangiferolic acid(); 27-hydroxymangiferolic acid (), reported here for the first time as propolis constituent; 27-hydroxymangiferonic acid (); -amyrin (); -amyrin () and lupeol (). The chemical structures of the isolated compounds were elucidated using spectroscopic methods, such as 1D and 2D-NMR, mass spectrometry and comparison with previous published reports.

Evaluation of HPLC Profile, Antioxidant, Quorum Sensing, Biofilm, Swarming Motility, and Enzyme Inhibition Activities of Conventional and Green Extracts of .

The current study aims to prepare a green extract using a new method in addition to conventional extraction methods including; methanolic and ultrasonic extraction of , to compare their phenolic composition utilizing high-performance liquid chromatograph equipped with a diode array detector (HPLC-DAD), anti-bacterial, anti-oxidant, and enzyme inhibition activities. The results of HPLC-DAD analysis showed that Rosmarinic acid was found the highest amount in the methanolic extract followed by ultrasonic and green extracts as 169.7 ± 0.

Flavonoids and other constituents from Jacaranda mimosifolia: In vitro analysis, molecular docking, and molecular dynamic simulations of antioxidant and anti-inflammatory activities.

The investigation of the methanol extract of the flowers of Jacaranda mimosifolia led to the isolation and characterisation of fourteen secondary metabolites (1-14) by the means of chromatographic and spectroscopic analysis. These compounds include eight flavonoids sorted as two flavonols (1-2), three flavones (3, 7-8), and three isoflavones (4, 9-10), two glucoiridoids (5-6), and four triterpenoids sorted as one oleanane (11), one hopane (12), and two lupane (13-14). The in vitro antioxidant potential of all the isolated compounds was evaluated using the ABTS- and FRAP- methods, which demonstrated concentration-dependent activity.

Triterpenoid saponins from the fruit pulp of (Fabaceae).

fruit, used as spice in West Africa was studied chemically; five previously undescribed triterpenoid saponins - and four known compounds - were isolated from the -Butanol fraction. The chemical structures of all nine isolates were determined by comprehensive analysis of HRMS, 1D & 2D NMR experiments and by comparison with data in the literature. All nine compounds were evaluated for antibacterial activity by the broth microdilution through the rapid -iodonitrotetrazolium chloride (INT) colorimetric technique.

Two new flavonoids from the leaves of Garcinia smeathmannii, in vitro and in silico anti-inflammatory potentials.

Garcinia smeathmannii is a well-known plant for its uses in the effective treatment of intestinal parasites, skin eruptions and skin burns. The dichloromethane-methanol (2:3) crude extract of the leaves of G. smeathmannii led to the isolation and characterization of twenty compounds (1-20) using chromatographic and spectroscopic techniques.

Dioctylsulfosuccinate Functionalized NiAl-Layered Double Hydroxide for Sensitive Fenuron Electroanalysis Using a Carbon Paste Electrode.

Environmental pollution resulting from the use of pesticides such as fenuron poses significant health risks due to the carcinogenic and teratogenic properties of these compounds. There is an urgent need to develop rapid and cost-effective detection methods for quantifying fenuron. In this study, an inorganic-organic composite material was obtained by intercalating sodium dioctylsulfosuccinate (DSS) within the interlayer space of a nickel-aluminum-layered double hydroxide (NiAl-LDH).

Dechlorination of PCBs in oil transformers by microwaves catalysed by Fe, glycerol, and NaOH.

Dechlorination of Polychlorinated Biphenyls (PCBs), carcinogenic substances used as oil in electrical transformers, remains an environmental challenge. This study aims to investigate the dechlorination of PCBs-contaminated transformer oils using microwave catalytic (Fe, glycerol) pyrolysis and to study the kinetics of PCBs dechlorination. After determining the composition of PCBs-contaminated oil using Gas Chromatography with an Electron Capture Detector (GC-ECD), response surface methodology through a central composite design was used to optimize dechlorination factors (irradiation time, microwave power, NaOH).

Nanosorbent based on coprecipitation of ZnO in goethite for competitive sorption of Cd(II)-Pb(II) and Cd(II)-Pb(II)-Ni(II) systems.

Amongst the various water pollutants, heavy metal ions require special attention because of their toxic nature and effects on humans and the environment. Preserving natural resources will have positive impacts on living conditions by reducing diseases and water treatment by nanotechnology is effective in solving this problem owing to the properties of nanomaterials. In this study, a goethite nanoparticle was prepared by hydrothermal method, while ZnO/goethite nanocomposite by co-precipitation was developed.

Comparative assessment of phenolic composition profile and biological activities of green extract and conventional extracts of Salvia sclarea.

In recent years, there have been an attempt to develop safe and environmental friendly solvents to replace conventional solvents, and use for extraction bioactive compounds from natural sources. A current investigation involved the preparation of green, methanolic, and ultrasonic extracts of S. sclarea, and compared their phenolic profiling using HPLC-DAD, antibacterial, antioxidant, and enzyme inhibition activities.

Potassium Amyl Xanthate (PAX) as an alternative organic reactive for mercury removal from cyanidation process of amalgamation tailing.

Mercury is the heavy metal that is most difficult to remove from cyanide solution. This situation brings with it many environmental, health and economic problems. This study aims to effectively utilize xanthate by presenting a new strategy for purifying mercury in the cyanidation process of amalgamation residues.

Assessment of Chemical Composition and In Vitro Antioxidant, Antidiabetic, Anticholinesterase and Microbial Virulence-Quenching Effects of Salad Burnet ( L.) Harvested from Algeria.

is a medicinal vegetable used in seasoning desserts, juices, and beverages. An evaluation of the total flavonoid, phenolic, tannin and anthocyanin contents indicated that these classes of compounds are distributed variably in the different fractions. In summary, the HPLC-DAD analyses enabled the identification and quantification of thirteen phenolic compounds in an ethyl acetate extract (EAE), nine in a dichloromethane extract (DCME), seven in an aqueous extract (AQE) and four in a butanol extract (BE).

Inhibition of biofilm, quorum-sensing, and swarming motility in pathogenic bacteria by magnetite, manganese ferrite, and nickel ferrite nanoparticles.

Resistance to antibiotics by pathogenic bacteria constitutes a health burden and nanoparticles (NPs) are being developed as alternative and multipurpose antimicrobial substances. Magnetite (FeO np), manganese ferrite (MnFeO np) and nickel ferrite (NiFeO np) NPs were synthesized and characterized using thermogravimetric analysis, transmission electron microscopy, Fourier transformed infra-red, and X-ray diffraction. The minimal inhibitory concentrations (MIC) ranged from 0.

The Influence of the Thermal Treatment of Copper Slag on the Microstructure and Performance of Phosphate Cements.

In general, phosphate cements have a very rapid setting reaction at room temperature. The same holds for copper slag-based phosphate cements. This means that using them as a binder, for instance as mortar, is always possible on a small scale, but very difficult on a large scale.

Efficient adsorption of tartrazine from an aqueous solution using a low-cost orange peel powder.

Orange peel powder was activated using different methods and was used to remove tartrazine (E102) from an aqueous solution. The following three adsorbents were synthethized: orange peel powder activated thermally (POAT), orange peel powder activated with sulfuric acid (POAA), orange peel powder activated with soda (POAS). These adsorbents were then characterized by Fourier Transform Infra-Red Spectrometry (FTIR), Raman spectroscopy, powder X-Ray Diffraction (XRD), and point-of-zero charge.

Evaluation of anti-quorum sensing and antibiofilm effects of secondary metabolites from Gambeya lacourtiana (De Wild) Aubr. & Pellegr against selected pathogens.

Background: Microbial infections cause serious health problems especially with the rising antibiotic resistance which accounts for about 700,000 human deaths annually. Antibiotics which target bacterial death encounter microbial resistance with time, hence, there is an urgent need for the search of antimicrobial substances which target disruption of virulence factors such as biofilm and quorum sensing (QS) with selective pressure on the pathogens so as to avoid resistance.

Methods: Natural products are suitable leads for antimicrobial drugs that can inhibit bacterial biofilms and QS.

and Evaluation of Anticholinesterase and Antidiabetic Effects of Furanolabdanes and Other Constituents from (Linn.) Griffith.

is a tropical plant noticeable for its variegated leaves and exploited for various medicinal purposes. In this study, seven compounds, including three furanolabdane diterpenoids, i.e.

Disruption of Biofilm Formation and Quorum Sensing in Pathogenic Bacteria by Compounds from Zanthoxylum Gilletti (De Wild) P.G. Waterman.

Microbial resistance is facilitated by biofilm formation and quorum-sensing mediated processes. In this work, the stem bark (ZM) and fruit extracts (ZMFT) of Zanthoxylum gilletii were subjected to column chromatography and afforded lupeol (1), 2,3-epoxy-6,7-methylenedioxyconiferyl alcohol (3), nitidine chloride (4), nitidine (7), sucrose (6) and sitosterol-β-D-glucopyranoside (2). The compounds were characterized using MS and NMR spectral data.

Bioactive constituents from Hook.f. (Flacourtiaceae).

The chemical investigation of the methanolic root extract of led to the isolation of a new arylbenzoate derivative, vogelinal (), together with thirteen known compounds (). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities.

Cholinesterase, α-glucosidase, tyrosinase and urease inhibitory activities of compounds from fruits of C.H. Wright (Violaceae).

From fruits, 3-Nor-4β-friedelan-24-ol () and 3-decyl-6,7,8-trimethoxy-2H,5H-furo[4,3,2-de]isochromene-2,5-dione (), new derivatives alongside, 28-hydroxyfriedelan-3-one (), friedelin (), 3,3',4,4',5'-pentamethylcoruleoellagic acid (), hexamethylcoruleoellagic acid (), 3',4,4',5,5'-pentamethylcoruleoellagic acid (), and fatty compounds were isolated and characterized using HRESIMS, EIMS, 1D and 2D NMR. enzyme inhibition of compounds and were evaluated on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glucosidase, urease and tyrosinase. Against AChE and BChE, the phenolic compounds and had good activity probably due to the phenolic nature and methoxy substituents.

Chronic Gastric Ulcer Healing Actions of the Aqueous Extracts of Staple Plant Foods of the North-West, Adamawa, and West Regions of Cameroon.

Aim: This study is aimed at establishing phenolic compound profile and assessing the possible antiulcer activities of aqueous extracts of some staple plant foods from the West and North-West regions of Cameroon against chronic gastric ulcer models in rats.

Materials And Methods: Phenolic constituents of extracts were evaluated using HPLC-DAD. Aqueous extracts of , , , , "nkui" spices, and "yellow soup" spices were tested at two doses (200 and 400 mg/kg).