Defect-rich Co/N-doped hierarchically porous carbons for rapid and highly efficient adsorption of organophosphorus pesticides from environmental water.

Organophosphorus pesticides (OPPs) severely pollute various environmental water due to their excessive use, and it is extremely urgent to develop novel adsorbents with high adsorption capacities, rapid removal rate and easily recovery for the removal of OPPs. In this study, defect-rich Co/N-doped hierarchically porous carbons (Co/N-DHPCs) were constructed by pyrolyzing acid-etched ZIF-67 precursor. The developed Co/N-DHPCs possessed rich defects, well-developed hierarchical porous structure, high specific surface area and excellent magnetic property, and exhibited large adsorption capacities of 103.

Global, regional and national burden of neuroblastoma and other peripheral nervous system tumors, 1990 to 2021 and predictions to 2035: visualizing epidemiological characteristics based on GBD 2021.

Background: Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children, accounting for >15 % of cancer-related deaths in children. We analyzed the epidemiological statistical indicators of neuroblastoma and other peripheral nervous system tumors patients from 1990 to 2021 in Global Burden of Disease (GBD) 2021 database, aiming to provide valuable insights for public health interventions and clinical practices.

Methods: Based on the GBD 2021 database, this study analyzed the incidence, mortality, prevalence, and Disability-Adjusted Life-Years (DALYs) of neuroblastoma and other peripheral nervous system tumors from 1990 to 2021, stratified by sociodemographic development index (SDI) and geographic regions.

Construction of P450 scaffold biocatalysts for the biodegradation of five chloroanilines.

Chloroanilines represent a class of persistent and highly toxic environmental pollutants, posing significant challenges for green remediation strategies. While P450BM3 monooxygenases are renowned for their ability to catalyze the monooxidation of inert C-H bonds, costly NAD(P)H and complex electron transport systems required for P450BM3 catalysis limit their practical applications. This study pioneers the development of innovative artificial biocatalysts by strategically engineering the active site of P450BM3.

Design, synthesis, and evaluation of carboxylic acid-substituted celecoxib isosteres as potential anti-inflammatory agents.

A library comprising twenty-four isosteric derivatives of celecoxib substituted with carboxylic acid (labeled as 5a-5x), was synthesized and characterized through H NMR, C NMR, HRMS, and elemental analysis. Molecular docking studies revealed that all compounds successfully docked into the binding pocket of COX-2, and the introduction of carboxyl group enhances the interaction between the derivatives and COX-2. The compounds were further evaluated for cell toxicity, and in vitro anti-inflammatory activity.

Print-Light-Synthesis of ruthenium oxide thin film electrodes for electrochemical sensing applications.

Print-Light-Synthesis (PLS) combines the inkjet printing of a ruthenium precursor ink with the simultaneous photo-induced generation of ruthenium oxide films. During PLS, inkjet-printing generates on conductive as well as insulating substrates micrometer-thin reaction volumes that contain with high precision defined precursor loadings. Upon direct UV light irradiation, the Ru precursor converts to RuO while all other ink components escape in the gas phase.

Comparative analysis of certified emission reduction methodologies for methane emission reduction in China.

As one of the top emitters of methane (CH), China must take action to achieve its carbon neutrality goal. Programs to reduce CH emissions would benefit from the establishment of the China Certified Emission Reduction (CCER) trading market. However, studies investigating the impact of the CCER trading market on CH reduction remain limited.

Large-scale protein extraction from oat hulls using two hydrodynamic cavitation techniques: A comparison of extraction efficiency and protein nutritional properties.

This study explored large-scale protein extraction from oat hulls using two hydrodynamic cavitation (HDC) devices, assessing extraction efficiency and protein nutritional qualities. The extraction methods HDC 50 (NaOH) and HDC 20 (NaOH) were shown to be 10.8 and 3.

A Second Near-Infrared Window-Responsive Metal-Organic-Framework-Based Photosensitizer for Tumor Immunotherapy via Synergistic Ferroptosis and STING Activation.

Photodynamic therapy (PDT) holds promise as a cancer treatment modality due to its potential for enhanced therapy precision and safety. To enhance deep tissue penetration and minimize tissue adsorption and phototoxicity, developing photosensitizers activated by second near-infrared window (NIR-II) light shows significant potential. However, the efficacy of PDT is often impeded by tumor microenvironment hypoxia, primarily caused by irregular tumor vasculature.

Low-Cost Preparation of Wafer-Scale Au(111) Single Crystals for the Epitaxy of Two-Dimensional Layered Materials.

Single-crystal Au(111), renowned for its chemically inert surface, long-range "herringbone" reconstruction, and high electrical conductivity, has long served as an exemplary template in diverse fields, , crystal epitaxy, electronics, and electrocatalysis. However, commercial Au(111) products are high-priced and limited to centimeter sizes, largely restricting their broad applications. Herein, a low-cost, high-reproducible method is developed to produce 4 in.

Precision Metal Nanoclusters Meet Proteins: Crafting Next-Gen Hybrid Materials.

Metal nanoclusters (NCs), owing to their atomic precision and unique molecule-like properties, have gained widespread attention for applications ranging from catalysis to bioimaging. In recent years, proteins, with their hierarchical structures and diverse functionalities, have emerged as good candidates for functionalizing metal NCs, rendering metal NC-protein conjugates with combined and even synergistically enhanced properties featured by both components. In this Perspective, we explore key questions regarding why proteins serve as complementary partners for metal NCs, the methodologies available for conjugating proteins with metal NCs, and the characterization techniques necessary to elucidate the structures and interactions within this emerging bionano system.

Chalcogen Substitution-Modulated Molecule-Electrode Coupling in Single-Molecule Junctions.

Molecule-electrode interfaces play a pivotal role in defining the electron transport properties of molecular electronic devices. While extensive research has concentrated on optimizing molecule-electrode coupling (MEC) involving electrode materials and molecular anchoring groups, the role of the molecular backbone structure in modulating MEC is equally vital. Additionally, it is known that the incorporation of heteroatoms into the molecular backbone notably influences factors such as energy levels and conductive characteristics.

Salt-welding strategy for the design of repairable impact-resistant and wear-resistant hydrogels.

Self-healing hydrogels can autonomously repair damage, enhancing their performance stability and broadening their applications as soft devices. Although the incorporation of dynamic interactions enhances self-healing capabilities, it simultaneously weakens the hydrogels' strength. External stimuli such as heating, while accelerating the healing process, may also lead to dehydration.

Regioselective Suzuki-Miyarua Cross-Coupling for Substituted 2,4-Dibromopyridines Catalyzed by -Symmetric Tripalladium Clusters.

Multipalladium clusters possess peculiar structures and synergistic effects for reactivity and selectivity. Herein, -symmetric tripalladium clusters (, 0.5 mol %) afford C-regioselective SMCC of 2,4-dibromopyridine with phenylboronic acids or pinacol esters (C:C up to 98:1), in contrast to Pd(OAc) in ligand-free conditions.

Reference Values for Water-Specific T1, Intermuscular and Intramuscular Fat Content in Skeletal Muscle at 2.89 T.

Background: MRI offers quantification of proton density fat fraction (PDFF) and tissue characteristics with T1 mapping. The influence of age, sex, and the potential confounding effects of fat on T1 values in skeletal muscle in healthy adults are insufficiently known.

Purpose: To determine the accuracy and repeatability of a saturation-recovery chemical-shift encoded multiparametric approach (SR-CSE) for quantification of T1 and muscle fat content, and establish normative values (age, sex) from a healthy cohort.

Electron Microscopy Reveals Inhomogeneous Adsorption of Iodine and Concurrent Defect Formation in a Metal-Organic Framework.

Adsorption behaviors are typically examined through adsorption isotherms, which measure the average adsorption amount as a function of partial pressure or time. However, this method is incapable of identifying inhomogeneities across the adsorbent, which may occur in the presence of strong intermolecular interactions of the adsorbate. In this study, we visualize the adsorption of molecular iodine (I) in the metal-organic framework material MFM-300(Sc) using high-resolution scanning transmission electron microscopy (STEM).

The ligninolytic catalytic network reveals the importance of auxiliary enzymes in lignin biocatalysts.

Lignin degradation by biocatalysts is a key strategy to develop a plant-based sustainable carbon economy and thus alleviate global climate change. This process involves synergy between ligninases and auxiliary enzymes. However, auxiliary enzymes within secretomes, which are composed of thousands of enzymes, remain enigmatic, although several ligninolytic enzymes have been well characterized.

Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live cells.

The crowded bacterial cytoplasm is composed of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich spatial organization and apparent anomalous diffusion of intracellular components, although this has not been tested directly. Here, we use biplane microscopy to track the 3D motion of self-assembled bacterial genetically encoded multimeric nanoparticles (bGEMs) with tunable size (20 to 50 nm) and charge (-3,240 to +2,700 e) in live cells.

Metalgel Fiber with Excellent Electrical and Mechanical Properties.

With the rapid advancement of soft electronics, particularly the rise of fiber electronics and smart textiles, there is an urgent need to develop high-performance fiber materials with both excellent electrical and mechanical properties. However, existing fiber materials including metal fibers, carbon-based fibers, intrinsically conductive polymer fibers, and composite fibers struggle to simultaneously meet the requirements. Here, we introduce a metalgel fiber with a unique structure.

Endoplasmic Reticulum-Targeted Polymer-Manganese Nanocomplexes for Tumor Immunotherapy.

Manganese ions (Mn) are an immune activator that enhances the activation of both cGAS and STING proteins. The STING signaling activation and subsequential immune responses are predominantly associated with endoplasmic reticulum (ER). Therefore, ER targeting of Mn in the subcellular compartments would promote the activation of STING signaling pathways.

Inulin Dehydration to 5-HMF in Deep Eutectic Solvents Catalyzed by Acidic Ionic Liquids Under Mild Conditions.

Valorization of carbohydrate-rich biomass by conversion into industrially relevant products is at the forefront of research in sustainable chemistry. In this work, we studied the inulin conversion into 5-hydroxymethylfurfural, in deep eutectic solvents, in the presence of acidic task-specific ionic liquids as catalysts. We employed aliphatic and aromatic ionic liquids as catalysts, and choline chloride-based deep eutectic solvents bearing glycols or carboxylic acids, as solvents.

Regulating Charge Distribution in Porphyrin-Based Polymer for Achieving Photocatalytic CO Conversion to CH or CH.

The photocatalytic conversion of CO into products such as CH and CH poses a significant challenge due to the lengthy reaction steps and the high energy barrier involved. In this study, both benzothiadiazole (BTD) and hydroxyl groups (-OH) are introduced into cobalt-based polymerized porphyrinic network (PPN) through a C-C coupling reaction. This modification of orbital energy levels that strengthens the ability of gain electrons and facilitates the charge transfer in PPN.

Controlling the J- and H-Aggregates and Supramolecular Polymerization Pathways of Anthanthrene by Tuning the Hydrogen Bonding Sites.

Exploration of new π-conjugated building blocks for construction of supramolecular polymers is at the forefront of self-assembly. Herein, we incorporate a highly planar anthanthrene skeleton into the design of two supramolecular monomers 1 and 2. Their supramolecular polymerization have been comprehensively investigated by spectroscopic studies.

Cellular uptake and transport mechanism of lycopene-loaded nanomicelles formed by amphiphilic peptide self-assembly in the intestinal epithelium.

Background: This study aimed to elucidate the transport mechanism of lycopene-loaded nanomicelles to improve intestinal absorption of lycopene. The interactive mechanism between lycopene and nanomicelles was investigated through isothermal titration calorimetry (ITC). The cytotoxicity, cellular uptake, endocytosis, and intracellular transport pathways of lycopene-loaded nanomicelles were investigated using the Caco-2 cell model.

Synthesis of Benzazepines Bearing Three Contiguous Carbon Stereocenters through Pd(II)-Catalyzed [3 + 2] Cycloaddition of -Aryl Nitrones with Allenoates.

A cascade reaction of Pd(II)/dppben-catalyzed [3 + 2] cycloaddition of -aryl nitrones with allenoates and sequential reduction has been developed for the synthesis of functionalized benzazepines bearing three contiguous carbon stereocenters in moderate to good yields ranging from 15 to 82% and high diastereoselectivity. The obtained benzazepines could be converted into various benzazepine scaffolds, and an estrone-derived benzazepine scaffold was prepared over four steps from estrone. More importantly, chiral benzazepine bearing three contiguous carbon stereocenters could be obtained in 88% ee value with chiral auxiliary.

Coordination Self-Assembly Induced Hot Exciton Fluorescence and Multi-Source Excitation Long Afterglow.

Metal-organic complexes with long afterglow luminescence have attracted extensive attention due to potential applications in display, sensing and information security. However, most of the metal-organic complex long afterglow materials reported so far are limited to the use of UV light as the excitation source, and the ambiguity of the structure-activity relationship makes the development of metal-organic complexes extremely limited. Herein, a series of metal-organic complexes with ultralong emission lifetime is constructed by coordination assembly of Zn(II) with three isomers.