Synthesis of α,β-Unsaturated Carbonyl Compounds via Cu/TEMPO/O2 Aerobic Catalytic System.

An N,N,N-type Cu(Ⅱ) complex-catalyzed desaturation method for converting alcohols, ketones, lactones, and lactams to their α,β-unsaturated carbonyl compounds is reported. The dehydrogenation reaction can be conducted with a green terminal oxidant O2 without requiring strong acid/base or stoichiometric oxidants. The Cu(Ⅱ) complex/TEMPO/O2 system uses a non-noble catalyst, and a green terminal oxidant as well as demonstrates high activity and functional group tolerance.

Ultrafast enzyme-responsive hydrogel for real-time assessment and treatment optimization in infected wounds.

Monitoring wound infection and providing appropriate treatment are crucial for achieving favorable outcomes. However, the time-consuming nature of laboratory culture tests may delay timely intervention. To tackle this challenge, a simple yet effective HDG hydrogel, composed of hydrogen peroxide (H₂O₂), dopamine, and GelMA polymer, is developed for the ultrafast detection and treatment of Staphylococcus aureus (SA) infections.

Chemically Hydrophobic and Structurally Antireflective Nanocoatings in Butterflies.

Moth-eye nanostructures, known for their biological antireflective properties, are formed by a self-assembly mechanism. Understanding and replicating this mechanism on artificial surfaces open avenues for the engineering of bioinspired multifunctional nanomaterials. Analysis of corneal nanocoatings from butterflies of the genus reveals a variety of nanostructures with uniformly strong antiwetting properties accompanied by varying antireflective functionalities.

LiZrF-based electrolytes for durable lithium metal batteries.

Lithium (Li) metal batteries (LMBs) are promising for high-energy-density rechargeable batteries. However, Li dendrites formed by the reaction between highly active Li and non-aqueous electrolytes lead to safety concerns and rapid capacity decay. Developing a reliable solid-electrolyte interphase is critical for realizing high-rate and long-life LMBs, but remains technically challenging.

Dynamic supramolecular snub cubes.

Mimicking the superstructures and properties of spherical biological encapsulants such as viral capsids and ferritin offers viable pathways to understand their chiral assemblies and functional roles in living systems. However, stereospecific assembly of artificial polyhedra with mechanical properties and guest-binding attributes akin to biological encapsulants remains a formidable challenge. Here we report the stereospecific assembly of dynamic supramolecular snub cubes from 12 helical macrocycles, which are held together by 144 weak C-H hydrogen bonds.

Artificial metalloenzyme assembly in cellular compartments for enhanced catalysis.

Artificial metalloenzymes (ArMs) integrated within whole cells have emerged as promising catalysts; however, their sensitivity to metal centers remains a systematic challenge, resulting in diminished activity and turnover. Here we address this issue by inducing in cellulo liquid-liquid phase separation through a self-labeling fusion protein, HaloTag-SNAPTag. This strategy creates membraneless, isolated liquid condensates within Escherichia coli as protective compartments for the assembly of ArMs using the same fusion protein.

Biochar filtration of drug-resistant bacteria and active pharmaceutical ingredients to combat antimicrobial resistance.

Antimicrobial resistance (AMR) is a major cause of death worldwide, with 1.27 M direct deaths from bacterial drug-resistant infections as of 2019. Dissemination of multidrug-resistant (MDR) bacteria in the environment, in conjunction with pharmapollution by active pharmaceutical ingredients (APIs), create and foster an environmental reservoir of AMR.

Harnessing light-activated gallium porphyrins to combat intracellular Staphylococcus aureus using an in vitro keratinocyte infection model.

Staphylococcus aureus (S. aureus) can survive inside nonprofessional phagocytes such as keratinocytes, enabling it to evade antibiotics and cause recurrent infections once treatment stops. New antibacterial strategies to eliminate intracellular, multidrug-resistant bacteria are needed.

MoS-confined Rh-Zn atomic pair boosts photo-driven methane carbonylation to acetic acid.

Direct carbonylation of CH to CHCOOH provides a promising pathway for upgrading of natural gas to transportable liquid chemicals, in which high-efficiency CH activation and controllable C-C coupling are both critical but challenging. Herein, we report that highly efficient photo-driven carbonylation of CH with CO and O to CHCOOH is achieved over MoS-confined Rh-Zn atomic-pair in conjunction with TiO. It delivers a high CHCOOH productivity of 152.

YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution.

Tumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally controlled oncogene activation and tumor suppressor inhibition together with multiomics to unveil the processes underlying oral epithelial progenitor cell reprogramming into tumor initiating cells at single cell resolution.

Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules.

Helicene-shaped molecules are compelling chemical structures with unique twisted helical chirality and remarkable properties. Although progress occurs in the catalytic asymmetric synthesis of helicene (-like) molecules, the enantioselective synthesis of multiple helicenes, especially four or higher helicity, is still challenging and has yet to be achieved. Herein, we report an organocatalytic [4 + 2] cycloadditions to achieve double S-shaped quadruple helicene-like molecules with high enantioselectivity (up to 96% e.

Dual targeting of HSP90 and BCL-2 in breast cancer cells using inhibitors BIIB021 and ABT-263.

Purpose: The incidence of breast cancer has been increasing in recent years, and monotherapy approaches are not sufficient alone in the treatment of breast cancer. In the combined therapy approach, combining two or three different agents in lower doses can mitigate the side effects on living cells and tissues caused by high doses of chemical agents used alone. ABT-263 (navitoclax), a clinically tested Bcl-2 family protein inhibitor, has shown limited success in clinical trials due to the development of resistance to monotherapy in breast cancer cells.

Rational designing of ZIF-67-derived CoO nanocomposite with hierarchical porous structure and extensive peroxidase mimetic activities for highly sensitive colorimetric detection of nitrite in drinking water.

A simple, fast, and cost-effective colorimetric nitrite (NO) sensor based on ZIF-67-derived CoO nanocomposite (ZCo-2 NC) structure has been developed. The prepared colorimetric sensor (ZCo-2 NC) was employed to sensitively detect NO in drinking water system by the exhibition of promising peroxidase-mimicking nanozyme-like features. The sensor manifest well-determined sensing response with excellent linear and wide range of NO sensitivity (0.

A Review on Medicinal Approaches of Novel Imatinib Derivatives.

Phenyl amino pyrimidine attracts researchers due to its versatile scaffold and medicinal significance. This significant moiety present in the Imatinib contributed to medicinal chemistry. In this manuscript, we reviewed various derivatives of Imatinib containing 2-phenylaminopyrimidine, which has a variety of roles, especially in the anti-cancer category.

Synergistic transformation of Cr(VI) in lubricant degradation by bacterial consortium.

In recent years, it has become widely acknowledged that heavy metals are often present in oil-contaminated sites. This study utilized three specific types of microorganisms with different functions to construct a composite bacterial consortium for treating lubricant-Cr(VI) composite pollutants. The selected strains were Lysinbacillus fusiformis and Bacillus tropicus.

Design and Construction of a Porphyrin-Based Samarium(III)-Metal-Organic Framework for Antibiotic Detection.

Porphyrins bearing the unique 18π electron tetrapyrrolic macrocycles exhibit interesting photophysical and photochemical properties and have been considered as promising ligands for the construction of functionalized metal-organic frameworks (MOFs). The combination of porphyrin-type ligands with lanthanide metals featured with diverse coordination environments to realize the novel functions as well as the diversity of the MOF is thus attractive but challenging. Herein, an unprecedented porphyrin-based samarium MOF (Sm-BCPP) composed of a 5,10-bis(4-carboxyphenyl)-10,20-diphenyl porphyrin (HBCPP) ligand and samarium-formed one-dimensional clusters has been constructed via a solvothermal approach, and the synthesized Sm-BCPP has excellent chemical stabilities, exhibiting red luminescence.

Eutectic Solvents Based on Matrine and Fatty Acids as Solubility and Stability Enhancers of Curcumin.

Eutectic solvents (ESs) have shown great efficiency on increasing the solubility, stability, and bioactivity of active pharmaceutical ingredients (APIs) in recent research studies. Curcumin is an important API driven from natural plants, which displayed a series of biofunctions like antibacterials, anti-inflammatory, and anticancer activities etc. However, its poor water solubility and stability hindered its further clinic application.

Living Cell-Mediated Self-Assembly: From Monomer Design and Morphology Regulation to Biomedical Applications.

The self-assembly of molecules into highly ordered architectures is a ubiquitous and natural process, wherein molecules spontaneously organize into large structures to perform diverse functions. Drawing inspiration from the formation of natural nanostructures, cell-mediated self-assembly has been developed to create functional assemblies both inside and outside living cells. These techniques have been employed to regulate the cellular world by leveraging the dynamic intracellular and extracellular microenvironment.

Leveraging Multivalent Assembly towards High-Temperature Liquid-Phase Phosphorescence.

High-temperature phosphorescence (HTP) materials have attracted considerable attention owing to their expanded application prospects, whereas they still suffer from severe deactivation in polar media, limiting their reliability and utility. Here, we present an efficient multivalent assembly strategy to achieve high-temperature liquid-phase phosphorescence (HTLP). The supramolecular assembly of multivalent modules leads to extremely robust hydrogen-bonding networks, which firmly immobilize the organic phosphors and protect triplet excitons from annihilation in high-temperature polar media, resulting in excellent HTLP emission.

Covalent Adaptable Poly[2]rotaxane Networks via Dynamic C-N Bond Transalkylation.

Covalent adaptable networks (CANs), a novel class of crosslinked polymers with dynamic covalent bonds, have gained significant attention for combining the durability of thermosets with the reprocessability of thermoplastics, making them promising for emerging applications. Here, we report the first example of poly[2]rotaxane-type CANs (PRCANs), in which oligo[2]rotaxane backbones characterized by densely packed mechanical bonds, are cross-linked through dynamic C-N bond. Oligo[2]rotaxane backbones could guarantee the mechanical properties of CANs.

Targeting Synthesis of Diatomic Catalysts by Selective Etching and Sequential Adsorption of Metal Atom.

Diatomic catalysts featuring a tunable structure and synergetic effects hold great promise for various reactions. However, their precise construction with specific configurations and diverse metal combinations is still challenging. Here, a selective etching and metal ion adsorption strategy is proposed to accurately assign a second metal atom (M) geminal to the single atom site (M-N) for constructing diatomic sites (e.

Assessment of the chemical solubility of experimental and commercial lithium silicate glass-ceramics.

Objective: This study aimed to evaluate the chemical solubility (CS) and conduct a comprehensive physicochemical characterization of several experimental and commercial lithium silicate-based glass-ceramics towards an understanding of the chemical processes governing dissolution in these glass-ceramics.

Methodology: Glass-ceramic (GC) samples were categorized into two groups: experimental materials featuring lithium metasilicate crystals (GCE1 and GCE2); and five commercial brands relying mostly on lithium disilicate (Celtra®Duo, IPS e.max®CAD, Straumann®n!ce®, CEREC Tessera™, and VITA Suprinity®).

Single Precursor-Derived Sub-1 nm MoCo Bimetallic Particles Decorated on Phosphide-Carbon Nitride Framework for Sustainable Hydrogen Generation.

The strategic design and fabrication of efficient electrocatalysts are pivotal for advancing the field of electrochemical water splitting (EWS). To enhance EWS performance, integrating non-noble transition metal catalysts through a cooperative double metal incorporation strategy is important and offers a compelling alternative to conventional precious metal-based materials. This study introduces a novel, straightforward, single-step process for fabricating a bimetallic MoCo catalyst integrated within a three-dimensional (3D) nanoporous network of N, P-doped carbon nitride derived from a self-contained precursor.

Toxicity of nickel, copper, and selenium in medaka embryos (oryzias latipes): a comparative study.

The indispensability of biometals nickel, copper, and selenium in pharmaceutical, agricultural, and other industrial applications, coupled with their release from mining processes, has made them potent environmental contaminants, especially when present in aquatic ecosystems at levels above the essential range. The toxicity of these biometals in fish embryogenesis, including their toxicity levels, was studied using medaka embryos. Test solutions (0.