2 results match your criteria: "School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK.[Affiliation]"
Mass Spectrometry Detection and Imaging of a Non-Covalent Protein-Drug Complex in Tissue from Orally Dosed Rats.
Angew Chem Weinheim Bergstr Ger
September 2022
School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK.
Article Synopsis
- Researchers used mass spectrometry to detect an intact protein-drug complex in rat liver tissue after the rats were given the drug bezafibrate.
- The complex involved fatty acid binding protein 1 (FABP1) non-covalently bonded with bezafibrate.
- This study represents the first successful analysis of non-covalent protein-drug complexes, which could significantly aid early drug discovery by allowing for direct characterization in a physiological context.
The untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets for the development of broad spectrum anti-virals. We combine in vitro RNA analysis with molecular dynamics simulations to build the first 3D models of the structure and dynamics of key regions of the 5' UTR of the SARS-CoV-2 genome. Furthermore, we determine the binding of metallo-supramolecular helicates (cylinders) to this RNA structure.
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