- Conventional chemotherapy struggles with targeting and retention, potentially leading to immune suppression, making it less effective for cancer treatment.
- Researchers developed Pep1, a polypeptide that changes shape in response to an enzyme (MMP-2), which helps improve how drugs are delivered and retained in tumor cells.
- By using a drug delivery system (DI/Pep1) that carries doxorubicin and indomethacin, the study showed increased immune response and reduced breast cancer growth, aiming to improve cancer treatment effectiveness.