580 results match your criteria: "School of Biomedical and Laboratory Sciences[Affiliation]"

Background: Intestinal parasitic infections are a significant public health concern, especially among food handlers, who can transmit these infections to the public through food preparation and handling. This systematic review and meta-analysis aimed to determine the pooled prevalence and associated factors of intestinal parasitic infections among food handlers in the East African region.

Methods: A systematic review and meta-analysis on intestinal parasitic infections among food handlers involved a comprehensive search across various databases, including Scopus, PubMed, ScienceDirect, Google Scholar, and the institution's library registers.

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Prevalence of intestinal parasites and Helicobacter pylori co-infection in people with gastrointestinal symptoms in Africa: a systematic review and meta-analysis.

BMC Infect Dis

January 2025

Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Article Synopsis
  • Gastrointestinal infections from intestinal parasites and Helicobacter pylori are major health issues in Africa due to poor sanitation and limited healthcare access, prompting a review to determine their prevalence among symptomatic patients.
  • This review followed strict research protocols and analyzed data from multiple databases, revealing a combined prevalence of 31.03% for co-infections, with significant variability in results across different regions.
  • Results showed Egypt had the highest co-infection rate at 39.84%, while Ethiopia had the lowest at 5.86%, with no significant publication bias detected in the findings.
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Background: Hyperemesis gravidarum affects about 4.8% of pregnant women. It can lead to electrolyte imbalances and liver function disturbances, which may result in pregnancy complications.

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Article Synopsis
  • Malaria is a significant global health issue caused by the Plasmodium genus, with drug resistance, particularly to chloroquine in P. vivax and P. falciparum, being a pressing concern in endemic regions of Africa.
  • The study aimed to assess the prevalence of molecular markers indicating chloroquine resistance in malaria parasites across East Africa through a systematic review and meta-analysis of relevant studies.
  • A total of 20 studies were analyzed, focusing on key molecular markers associated with chloroquine resistance, ultimately providing insight into the prevalence of these markers in malaria parasites.
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Background: Malaria poses a significant public health threat globally, particularly in African regions, where asymptomatic malaria is a considerable logistic problem. Individuals with asymptomatic malaria do not seek treatment, and thus they are invisible to health facilities and represent a substantial hidden reservoir of Plasmodium species. This study aimed to determine the prevalence of asymptomatic malaria and its associated factors in Gorgora, western Dembia district, Northwest Ethiopia.

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Background: Hookworm infection is a common problem among schoolchildren and mothers in tropical and subtropical countries, causing cognitive impairment, growth retardation in children and anaemia, low birth weight, preterm birth, and intrauterine growth delay in susceptible mothers. Since schoolchildren generally have a higher prevalence due to behavioral and hygiene-related factors, our systematic review and meta-analysis aimed to determine the prevalence and risk factors for Hookworm infection among schoolchildren in Ethiopia.

Methods: Relevant studies were retrieved from several search databases.

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Background: Due to the overlapping endemic regions and the high burden of both infections, coinfection with Plasmodium falciparum and Schistosoma mansoni poses distinct public health concerns that require coordinated, multifaceted interventions. There are epidemiological studies on the coinfection of these two parasites in Ethiopia, and the results differ and are inconsistent from one region to another. Thus, the goal of this systematic review and meta-analysis was to ascertain Ethiopia's pooled prevalence of P.

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Dietary diversity and its associated factors among adolescent girls in Ethiopia: a systematic review and meta-analysis.

BMC Public Health

December 2024

Department of Human Nutrition, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Even though fragmented and inconsistent findings have been reported in Ethiopia, adolescence is a period of rapid growth following infancy and is severely affected by micronutrient deficiencies, food insecurity, and poor-quality diets. Therefore, the aim of this meta-analysis was to estimate the pooled prevalence of dietary diversity and its associated factors among adolescent girls in Ethiopia.

Methods: International databases such as EMBASE, Hinari, Scopus, PubMed, Google Scholar, and direct Google searches were systematically used to search for articles and reports.

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Prevalence, genotype diversity, and zoonotic potential of bovine rotavirus A in Amhara National Regional State, Ethiopia: A multicenter cross-sectional study.

Virus Res

December 2024

Center for Food Animal Health, Department of Animal Sciences, College of Food Agricultural and Environmental Sciences, The Ohio State University, Wooster, OH 44691, USA; Department of Veterinary Preventive Medicine, The College of Veterinary Medicine, The Ohio State University, Wooster, OH 44691, USA. Electronic address:

Article Synopsis
  • Rotavirus A (RVA) is a leading cause of gastroenteritis in calves and has the potential to spread to humans, making it a public health concern.
  • A study in Amhara, Ethiopia, involved 266 calves to assess the prevalence and genetic variety of RVA, finding a 15.4% infection rate with various G and P genotypes.
  • The research highlights the need for ongoing monitoring of RVA in calves due to its significant presence and possible zoonotic transmission risks.
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Asymptomatic nasopharyngeal carriage of multidrug resistant bacteria among children at University of Gondar Hospital Northwest Ethiopia Revealing Hidden Health Risks.

Sci Rep

November 2024

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Gram-negative bacteria in the nasopharynx can eventually invade bacteria-limited sites and cause serious illnesses such as meningitis, otitis media, and pneumonia. However, data related to the carriage of these bacteria in children attending outpatient departments in the study area are limited. To assess nasopharyngeal carriage, antibiotic susceptibility patterns, and associated factors of gram-negative bacteria among children attending the outpatient department at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

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Global prevalence of anemia in displaced and refugee children: A comprehensive systematic review and meta-analysis.

PLoS One

November 2024

Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Anemia due to living condition disproportionally affects the global refugee children. Nutritional deficiency particularly iron deficiency is the primary causes of anemia. Hence, we conducted a systemic review and meta-analysis on the prevalence of anemia among refugee children.

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Article Synopsis
  • Multidrug-resistant (MDR) bacteria are complicating wound infection treatment globally, with limited data on such bacteria in Ethiopia.
  • This study focused on identifying the prevalence of Gram-negative rods that produce extended-spectrum beta-lactamase (ESBL) among wound infection patients at the University of Gondar Comprehensive Specialized Hospital between May and July 2022.
  • Out of 228 participants, 71.1% tested positive for infections, predominantly featuring various strains of Gram-negative bacteria, including the most common ones as detailed in the study's findings.
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Hematological changes in women with cervical cancer before and after cancer treatment: retrospective cohort study.

Sci Rep

November 2024

Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Hematological changes is one of the most common complications occurred in cancer patients. Therefore, the current study aimed to assess the hematological toxicity of cervical cancer patients before and after the initiation of treatment. The retrospective cohort study was conducted from 2015 to 2022 at the University of Gondar Comprehensive Specialized Hospital.

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Glomerular injury may occur during pregnancy as a consequence of systemic disease and pregnancy-related medical complications. While urinary nephrin has been shown to provide early identification of preeclampsia (PE) in high-risk pregnancies, the role of urinary nephrin in determining glomerular injury in pregnant women is yet to be explored. This study aimed to investigate the use of urinary nephrin as a predictor for early glomerular injury in a study conducted at the Townville University Hospital.

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Background: The occurrence of potential drug‒drug interactions (pDDIs) is a serious global issue that affects all age groups, with the elderly population being the most vulnerable. This is due to their relatively high rates of comorbidity and polypharmacy, as well as physiological changes that can increase the potential for DDIs and the likelihood of adverse drug reactions. The aim of this study was to estimate the prevalence of pDDIs and associated factors among elderly patients in Ethiopia.

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Article Synopsis
  • * A community-based survey conducted with 390 participants revealed that 85.9% had poor knowledge, 88.2% held negative attitudes, and 88.2% practiced poorly regarding hepatitis prevention.
  • * The findings suggest a critical need for educational interventions, as having received hepatitis vaccination was linked to improved attitudes and practices about the infection.
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Background: Seventy percent of epileptic patients may not experience seizures if they receive proper treatment with antiepileptic drugs (AEDs). However, many children and adolescents face poor seizure control (PSC). Therefore, the purpose of this review is to systematically and quantitatively summarize the pooled prevalence of PSC and its predictors among children with epilepsy in Ethiopia.

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Background: Stroke is a leading cause of death and disability worldwide. While caregivers play a vital role in recovery, their long-term support can affect their mental well-being. This study aims to estimate the pooled prevalence of depression and associated factors among caregivers of stroke survivors in developing countries.

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genetic diversity; implications for malaria control in Ethiopia: Systematic review and meta-analysis.

Health Sci Rep

October 2024

Department of Epidemiology and Biostatistics, Institute of Public Health College of Medicine and Health Sciences, University of Gondar Gondar Ethiopia.

Background: In malaria endemic regions, infection is characterized by variable genetic diversity at different settings. The parasite's various forms are found at varied frequency in different geographic areas. Understanding malaria parasite diversity and transmission is vital to evaluate control interventions.

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Background: The severity of infectious disease outcomes is dependent on the virulence factors of the pathogen and the host immune response. CARD8 is a major regulator of the innate immune proinflammatory response and has been suggested to modulate the host response to common inflammatory diseases. In the present study, the C10X genetic polymorphism in the CARD8 gene was investigated in relation to bacterial meningitis.

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Prevalence and associated factors of norovirus infections among patients with diarrhea in the Amhara national regional state, Ethiopia.

BMC Infect Dis

September 2024

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Article Synopsis
  • Noroviruses (NoVs) are the top cause of diarrhea globally, especially in developing countries, and this study aimed to investigate their prevalence in Ethiopia, where data is scarce.
  • Conducted from May to November 2021, the study analyzed 550 participants with diarrhea, collecting fecal samples and using RT-PCR to test for NoV, while demographic information was gathered via questionnaires.
  • Results showed an 8.9% overall prevalence of NoV, with higher rates in the elderly (33.3%) and children under 5 (12.5%), particularly in certain areas like Debre Tabor and Bahir Dar; GII was the dominant genogroup found.
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A comparative study of hormonal contraceptive use and vitamin D levels at Gondar Town 2023.

Sci Rep

September 2024

Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia.

Vitamin D deficiency is an emerging public health problem globally, with devastating health consequences. Some studies suggest that exogenous sex hormones, found in hormonal contraceptives, may enhance vitamin D levels. However, the reasons for this association are not fully understood, as women using hormonal contraception may have different lifestyle habits affecting their vitamin D status.

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Isolation and antimicrobial susceptibility profile of Salmonella species from slaughtered cattle carcasses and abattoir personnel at Dessie, municipality Abattoir, Northeast Ethiopia.

BMC Microbiol

September 2024

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Article Synopsis
  • Antibiotic-resistant Salmonella poses a significant public health risk, with limited data on contamination rates of cattle carcasses in abattoirs, particularly in Northeast Ethiopia.* -
  • This study collected 336 carcass swabs and 24 stool samples from abattoir workers to analyze the presence and antibiotic resistance of Salmonella, finding an 8% prevalence rate in cattle and workers.* -
  • Results indicated that Salmonella was 100% resistant to ampicillin and demonstrated high levels of resistance to other antibiotics, with a significant number being resistant to multiple drug classes, highlighting poor hygiene practices in the slaughter process.*
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Seroprevalence of hepatitis B and hepatitis C virus among clinically suspected cases of viral hepatitis visiting Guhalla Primary Hospital, Northwest Ethiopia.

Sci Rep

September 2024

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.Box 196, Gondar, Ethiopia.

Article Synopsis
  • Hepatitis B and C viruses are major health threats, causing liver issues like cirrhosis and cancer, especially in low-resource countries.
  • A study at Guhalla Primary Hospital in Ethiopia analyzed data from 883 patients to determine the prevalence of these viruses, finding rates of 14% for HBV and nearly 20% for HCV.
  • The research highlighted that females and specific age groups (31-40 years for HBV; 21-30 and over 40 years for HCV) had significantly higher risks of infection.
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