1 results match your criteria: "School of Biomedical Sciences Brisbane QLD 4072 Australia richard.clark@uq.edu.au j.rosengren@uq.edu.au.[Affiliation]"
Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues.
Chem Sci
August 2024
The University of Queensland, School of Biomedical Sciences Brisbane QLD 4072 Australia
Article Synopsis
- Recifin A is a newly discovered peptide characterized by a distinctive "tyrosine-lock" structure that includes a four-stranded β-sheet stabilized by disulfide bonds.
- Researchers successfully synthesized recifin A using native chemical ligation of two fragments, finding that even in its linear form, it can adopt the complex fold easily.
- Five analogues of recifin A were created to study the importance of the central tyrosine residue and its role in inhibiting the cancer-related enzyme tyrosyl-DNA phosphodiesterase I.