Salient Voice Symptoms in Primary Muscle Tension Dysphonia.

Introduction: Patients with primary muscle tension dysphonia (pMTD) commonly report symptoms of vocal effort, fatigue, discomfort, odynophonia, and aberrant vocal quality (eg, vocal strain, hoarseness). However, voice symptoms most salient to pMTD have not been identified. Furthermore, how standard vocal fatigue and vocal tract discomfort indices that capture persistent symptoms-like the Vocal Fatigue Index (VFI) and Vocal Tract Discomfort Scale (VTDS)-relate to acute symptoms experienced at the time of the voice evaluation is unclear.

Neuromodulation of risk and reward processing during decision making in individuals with general anxiety disorder (GAD).

Individuals with general anxiety disorder (GAD) have an impaired future-oriented processing and altered reward perception, which might involve the ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC). Twenty-nine adults with GAD performed the balloon analogue risk-taking task (BART) and delay discounting task (DDT) during five sessions of transcranial direct current stimulation (tDCS) with different stimulation conditions. The stimulation conditions were: anodal dlPFC (F3)/cathodal vmPFC (Fp2), anodal vmPFC (Fp2)/cathodal dlPFC (F3), anodal dlPFC (F3)/cathodal right shoulder, anodal vmPFC (Fp2)/cathodal left shoulder, and sham stimulation.

Self-reported Hearing Quality of Life for Adolescent Cochlear Implant Recipients: A Longitudinal Study.

Background:  Clinicians are increasingly interested in self-reported hearing-specific quality of life (HQoL) for cochlear implant (CI) recipients, including pediatric CI recipients.

Purpose:  (1) To compare HQoL of adolescent CI recipients to those of peers with typical hearing (TH); (2) to examine, longitudinally, HQoL for a set of CI recipients; and (3) to determine the effects of child, demographic, audiological, speech perception, and language variables on adolescent HQoL.

Research Design:  Hearing Environments and Reflections on Quality of Life (HEARQL) questionnaires were completed by children with CIs at elementary (HEARQL-26) and adolescent (HEARQL-28) ages.

NS2B-D55E and NS2B-E65D Variations Are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model.

Japanese encephalitis virus (JEV) NS2B-NS3 is a protein complex composed of NS3 proteases and an NS2B co-factor. The N-terminal protease domain (180 residues) of NS3 (NS3(pro)) interacts directly with a central 40-amino acid hydrophilic domain of NS2B (NS2B(H)) to form an active serine protease. In this study, the recombinant NS2B(H)-NS3(pro) proteases were prepared in and used to compare the enzymatic activity between genotype I (GI) and III (GIII) NS2B-NS3 proteases.

Researchers' agency and the boundaries of global mental health: perspectives from and about Latin America.

The decolonise global health movement has critically reassessed the field's historical and political underpinnings, urging researchers to recognise biases and power imbalances through reflexivity and action. Genuine change is seen as the outcome of the researcher's self-awareness, often leaving the underlying structures of global health-and global mental health (GMH)-in the background. Here, we problematise how expectations around agency and change have been mobilised in discussions around decolonisation, highlighting the gradual and contingent nature of international collaboration in GMH.

Do US quitsites present information related to providing services for LGBTQ individuals? An audit study.

Introduction: Most US quitlines have quitsites and websites designated to promote their services. Quitsites have the potential to encourage LGBTQ individuals to utilize quitline services by explicitly mentioning the provision of LGBTQ-competent services. The present study audited quitsites to determine the presence of information regarding services for LGBTQ individuals.

Response to ASNM intraoperative SSEP position statement.

This correspondence is in response to Dr. David Allison's comments to the Editor, regarding the American Society of Neurophysiological Monitoring's (ASNM) updated intraoperative somatosensory evoked potential (SEP) monitoring position statement.

Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition.

Dopamine (DA) signaling is critical for optimal cognitive aging, especially in prefrontal-parietal and fronto-striatal networks. Single nucleotide polymorphisms associated with dopamine regulation, COMTVal158Met and DRD2C957T, stand to exert influence on executive function performance via neural properties. The current study investigated whether longitudinal thinning of mesocortical regions is related to COMT and DRD2 genetic predisposition and associated with decline in executive function over four-years.

Infants' Social Evaluation of Helpers and Hinderers: A Large-Scale, Multi-Lab, Coordinated Replication Study.

Evaluating whether someone's behavior is praiseworthy or blameworthy is a fundamental human trait. A seminal study by Hamlin and colleagues in 2007 suggested that the ability to form social evaluations based on third-party interactions emerges within the first year of life: infants preferred a character who helped, over hindered, another who tried but failed to climb a hill. This sparked a new line of inquiry into the origins of social evaluations; however, replication attempts have yielded mixed results.

Sensory neuron LKB1 mediates ovarian and reproductive function.

Treatments for reproductive disorders in women consist of hormone replacement therapy, which have negative side effects that impact health, spurring the need to understand new mechanisms to employ new therapeutic strategies. Bidirectional communication between sensory neurons and the organs they innervate is an emerging area of interest in tissue physiology with a relevance in reproductive disorders. We hypothesized that the metabolic activity of sensory neurons has a profound effect on reproductive phenotypes.

A data integration method for new advances in development cognitive neuroscience.

Combining existing datasets to investigate key questions in developmental cognitive neuroscience brings exciting opportunities and unique challenges. However, many data pooling methods require identical or harmonized methodologies that are often not feasible. We propose Integrative Data Analysis (IDA) as a promising framework to advance developmental cognitive neuroscience with secondary data analysis.

A Real-Time Approach for Assessing Rodent Engagement in a Nose-Poking Go/No-Go Behavioral Task Using ArUco Markers.

Behavioral neuroscience requires precise and unbiased methods for animal behavior assessment to elucidate complex brain-behavior interactions. Traditional manual scoring methods are often labor-intensive and can be prone to error, necessitating advances in automated techniques. Recent innovations in computer vision have led to both marker- and markerless-based tracking systems.

Sex-dependent effects of early life sensory overstimulation on later life behavioral function in rats.

Children today are immersed in electronic technology shortly after birth as they now begin regularly watching television earlier than they did in the past. Many new programs geared towards infants contain lots of lights, color, and sounds, which may constitute a form of sensory overstimulation (SOS) that leads to cognitive and behavioral changes in children and adolescents. Here, we examined the impact of early life SOS exposure on later life behavioral and cognitive function in rodents by exposing developing male and female rats to excessive audiovisual stimulation from postnatal days (PND) 10-40 and assessing anxiety-like behavior, social motivation, compulsive behavior, and spatial learning/cognition from PND 50-60.

B-cell and plasma cell activation in a mouse model of chronic muscle pain.

Fibromyalgia (FM) is a complex chronic musculoskeletal pain disorder with an elusive pathogenesis, with a strong implication of immune interactions. We recently found that IL-5 and the adaptive immune system mediates pain outcomes in fibromyalgia (FM) patients and preclinical models of FM-like chronic widespread pain (CWP). However, there is an active debate if FM/CWP has an autoimmune etiology.

Deep convolutional neural networks are sensitive to face configuration.

Deep convolutional neural networks (DCNNs) are remarkably accurate models of human face recognition. However, less is known about whether these models generate face representations similar to those used by humans. Sensitivity to facial configuration has long been considered a marker of human perceptual expertise for faces.

Managing clinical heterogeneity in psychopathology: Perspectives from brain research.

Clinical heterogeneity is a significant factor to contend with when seeking to organize, understand, and treat psychopathology. In recent years, the field has prioritized efforts to minimize nonmeaningful heterogeneity and leverage meaningful heterogeneity to improve assessment and diagnostics, inform mechanistic understanding, and facilitate the development of novel treatments. Indeed, exciting developments such as the National Institute for Mental Health Research Domain Criteria and the Hierarchical Taxonomy of Psychopathology have provided powerful frameworks for facing clinical complexity.

Disentangling gender, sex, and biology: a mixed methods study of gender identity data collection tools.

Objectives: We used community-based mixed methods to test whether transgender and gender diverse (TGD) people preferred gender identity questions developed by community members over current questions in use and generate hypotheses about data collection preferences.

Methods: We interviewed twenty TGD adults in English and Spanish, asking them to rate and discuss their responses to questions. We analyzed quantitative data with descriptive statistics and qualitative data with template analysis, then integrated them.

The localization of coma.

Coma and disorders of consciousness (DoC) are common manifestations of acute severe brain injuries. Research into their neuroanatomical basis can be traced from Hippocrates to the present day. Lesions causing DoC have traditionally been conceptualized as decreasing "alertness" from damage to the ascending arousal system, and/or, reducing level of "awareness" due to structural or functional impairment of large-scale brain networks.

Nicotine-related beliefs induce dose-dependent responses in the human brain.

Beliefs have a powerful influence on our behavior, yet their neural mechanisms remain elusive. Here we investigate whether beliefs could impact brain activities in a way akin to pharmacological dose-dependent effects. Nicotine-dependent humans were told that nicotine strength in an electronic cigarette was either 'low', 'medium' or 'high', while nicotine content was held constant.

Compound Crises: The Impact of Emergencies and Disasters on Mental Health Services in Puerto Rico.

Background: Mental health in Puerto Rico is a complex and multifaceted issue that has been shaped by the island's unique history, culture, and political status. Recent challenges, including disasters, economic hardships, and political turmoil, have significantly affected the mental well-being of the population, coupled with the limitations in the accessibility of mental health services. Thus, Puerto Rico has fewer mental health professionals per capita than any other state or territory in the United States.

Vocal control and speech production in cochlear implant listeners: A review within auditory-motor processing framework.

A comprehensive literature review is conducted to summarize and discuss prior findings on how cochlear implants (CI) affect the users' abilities to produce and control vocal and articulatory movements within the auditory-motor integration framework of speech. Patterns of speech production pre- versus post-implantation, post-implantation adjustments, deviations from the typical ranges of speakers with normal hearing (NH), the effects of switching the CI on and off, as well as the impact of altered auditory feedback on vocal and articulatory speech control are discussed. Overall, findings indicate that CIs enhance the vocal and articulatory control aspects of speech production at both segmental and suprasegmental levels.