A Review on Microbial Products and Their Perspective Application as Antimicrobial Agents.

Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and microalgae are an auspicious source of vital bioactive compounds. In this review, the existing research regarding antimicrobial molecules from microorganisms is summarized. The potential antimicrobial compounds from actinomycetes, particularly spp.

Contaminant dispersion with axial input sources in soil media under non-linear sorption.

Contaminant transport in a soil formation is described by advection dispersion equation. In this study, a horizontal and transversal contaminant transport along transient groundwater flow under non-linear sorption is solved numerically to examine the contaminant distribution profiles in finite soil media. The horizontal and transversal pore-water seepage velocities are defined as varying exponentially with time.

A comparative study of chiral separation of proton pump inhibitors by supercritical fluid chromatography and high-performance liquid chromatography.

A comparative study of chiral separation of pantoprazole and rabeprazole is carried out using supercritical fluid chromatography and high-performance liquid chromatography. The columns used were Chiralpak IA and Chiralpak IE. The best mobile phase in supercritical fluid chromatography was carbon dioxide-0.

L-cysteine functionalized graphene quantum dots for sub-ppb detection of As (III).

Here, we report functionalized graphene quantum dots (GQDs) for the optical detection of arsenic at room temperature. GQDs with the fluorescence of three fundamental colors (red, green, and blue) were synthesized and functionally capped with L-cysteine (L-cys) to impart selectively towards As (III) by exploiting the affinity of L-cys towards arsenite. The optical characterization of GQDs was carried out using UV-vis absorption spectroscopy, Fourier transform infrared spectroscopy, and fluorescence spectrometry, and the structural characterizations were performed using transmission electron microscopy.

Efficiency analysis in the management of COVID-19 pandemic in India based on data envelopment analysis.

This article measured the performance of 32 states and union territories (UTs) of India against COVID-19 disease using efficiency score which was calculated by data envelopment analysis (DEA) and compared the efficiency score with the different models which are used in many articles to evaluate the efficiency of healthcare system. Here the input parameters are taken as public health expenditure in a million, number of hospitals, number of hospital beds, percentage of health workers, population density, and number of infected, and output parameters divided into good and bad categories such as the number of recovered are taken as good output. The number of death is taken as bad outputs.

Drug Repurposing to Identify Nilotinib as a Potential SARS-CoV-2 Main Protease Inhibitor: Insights from a Computational and Study.

COVID-19, an acute viral pneumonia, has emerged as a devastating pandemic. Drug repurposing allows researchers to find different indications of FDA-approved or investigational drugs. In this current study, a sequence of pharmacophore and molecular modeling-based screening against COVID-19 M (PDB: 6LU7) suggested a subset of drugs, from the Drug Bank database, which may have antiviral activity.

Identification of cancer stemness related miRNA(s) using integrated bioinformatics analysis and in vitro validation.

Unlabelled: The stemness property of cells allows them to sustain their lineage, differentiation, proliferation, and regeneration. MicroRNAs are small non-coding RNAs known to regulate the stemness property of cells by regulating the expression of stem cell signaling pathway proteins at mRNA level. Dysregulated miRNA expression and associated stem cell signaling pathways in normal stem cells give rise to cancer stem cells.

A mathematical model to study the COVID-19 pandemic in India.

In this paper, a compartmental model is proposed to study the dynamics of COVID-19 pandemic caused by the coronavirus SARS-CoV-2 and the role of media in controlling this ongoing infection. Model includes implementation of media awareness as a control measure to mitigate the spread of the disease. In the proposed model, we have divided the total human population into four sub-classes, namely susceptibles, asymtomatic infectives, aware susceptibles and symptomatic infectives (or Isolated infectives which are under treatment/hospitalized) incorporating classes representing cumulative density of virus and media alert.

Exploration of novel TOSMIC tethered imidazo[1,2-a]pyridine compounds for the development of potential antifungal drug candidate.

New candidates of imidazo[1,2-a]pyridine were designed by combining 2-amino pyridine, TOSMIC and various assorted aldehydes to explore their antioxidant and antifungal potential. The design of these derivatives was based on utilizing the antifungal potential of azoles and TOSMIC moiety. These derivatives were synthesized by adopting multi-component reaction methodology, as it serves as a rapid and efficient tool to target structurally diverse heterocyclic compounds in quantitative yield.

The non-canonical mechanism of ER stress-mediated progression of prostate cancer.

Background: The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing. Also, alcohol is a physiological ER stress inducer, and the link between alcoholism and progression of prostate cancer (PCa) is well documented but not well characterized. According to the canonical model, the mediator of ER stress, ATF6, is cleaved sequentially in the Golgi by S1P and S2P proteases; thereafter, the genes responsible for unfolded protein response (UPR) undergo transactivation.

Novel Strategy for Gallium-Substituted Hydroxyapatite/ Fiber Extract/Poly(-vinylcarbazole) Biocomposite Coating on Titanium for Biomedical Applications.

The current work mainly focuses on the innovative nature of nano-gallium-substituted hydroxyapatite (nGa-HAp)/ fiber extract (PDFE)/poly(-vinylcarbazole) (PVK) biocomposite coating on titanium (Ti) metal in an eco-friendly and low-cost way through electrophoretic deposition for metallic implant applications. Detailed analysis of this nGa-HAp/PDFE/PVK biocomposite coating revealed many encouraging functional properties like structure and uniformity of the coating. Furthermore, gallium and fruit extract of PDFE-incorporated biocomposite enhance the antimicrobial, cell viability, and bioactivity studies.

Interplay of KNDy and nNOS neurons: A new possible mechanism of GnRH secretion in the adult brain.

Reproduction in mammals is favoured when there is sufficient energy available to permit the survival of offspring. Neuronal nitric oxide synthase expressing neurons produce nitric oxide in the proximity of the gonadotropin-releasing hormone neurons in the preoptic region. nNOS neurons are an integral part of the neuronal network controlling ovarian cyclicity and ovulation.

Phase transformation and enhanced blue photoluminescence of zirconium oxide poly-crystalline thin film induced by Ni ion beam irradiation.

Swift heavy ions (SHI) irradiation of Nickel (Ni) beam with different ions fluence bring the modifications in the functional properties of radio frequency (RF) grown zirconium oxide (ZrO) nanocrystalline thin films. X-ray diffraction analysis affirms the monoclinic to tetragonal phase transformation and diminishing of peak at higher fluence 1 × 10 and 2 × 10 ions/cm induced by electronic excitation caused by SHI. Zirconium oxide thin films exhibit the same thickness (195 nm) of virgin and irradiated samples and whereas the nanocrystalline thin films have the elemental composition in proper stoichiometry (1:2) as analyzed by rutherford backscattering spectroscopy (RBS).

A cross-sectional study on prevalence of menstrual problems, lifestyle, mental health, and PCOS awareness among rural and urban population of Punjab, India.

Introduction: Menstrual cycle gets affected by various modifiable risk factors. To assess prevalence of various types of menstrual problems, lifestyle and mental health status, identification of variables as predictors for menstrual problems and level of polycystic ovary syndrome (PCOS) awareness among rural and urban population of Punjab, the present study has been carried out.

Methods: The study was conducted from November 2019 to July 2020 in the Malwa region of Punjab, India, with 2673 participants (15-25 years).

Imaging application and radiosensitivity enhancement of pectin decorated multifunctional magnetic nanoparticles in cancer therapy.

In this contribution, we report the fabrication of multifunctional nanoparticles with gold shell over an iron oxide nanoparticles (INPs) core. The fabricated system combines the magnetic property of INPs and the surface plasmon resonance of gold. The developed nanoparticles are coated with thiolated pectin (TPGINs), which provides stability to the nanoparticles dispersion and allows the loading of hydrophobic anticancer drugs.

Structural and binding studies of cyclin-dependent kinase 2 with NU6140 inhibitor.

Cyclin-dependent kinase 2 (CDK2) is an established target protein for therapeutic intervention in various diseases, including cancer. Reported inhibitors of CDK2 target the ATP-binding pocket to inhibit the kinase activity. Many small molecule CDK2 inhibitors have been discovered, and their crystal structure with CDK2 or CDK2-cyclin A complex has been published.

Activation of defense response in common bean against stem rot disease triggered by Trichoderma erinaceum and Trichoderma viride.

White mold and stem rot is a common disease of Phaseolus vulgaris caused by Sclerotinia sclerotiorum. Biological control is a promising alternative for the control of this disease. In the present study, two Trichoderma spp.

Pyrolysis of sewage sludge for sustainable biofuels and value-added biochar production.

The study deals with the pyrolysis of sewage sludge to produce eco-friendly and sustainable fuels along with value-added biochar products. The experiments were conducted in a fixed-bed cylindrical glass reactor in the temperature range of 250-700 °C and achieved the product yield of 22.4 wt% bio-oil, 18.

Integrated 3D-QSAR, molecular docking, and molecular dynamics simulation studies on 1,2,3-triazole based derivatives for designing new acetylcholinesterase inhibitors.

Alzheimer's disease (AD) is a multifactorial and polygenic disease. It is the most prevalent reason for dementia in the aging population. A dataset of twenty-six 1,2,3-triazole-based derivatives previously synthetized and evaluated for acetylcholinesterase inhibitory activity were subjected to the three-dimensional quantitative structure-activity relationship (3D-QSAR) study.

Potential of herbal cocktail of medicinal plant extracts against 'big four' snake venoms from India.

Background: Venomous snake bites cause acute medical emergencies and are fatal. India accounts for large proportion of snake-bite deaths globally. Medically important 'BIG FOUR' snakes of India are Bungarus caeruleus (krait), Naja naja (cobra), Echis carinatus (saw-scaled viper) and Daboia russelii (Russell's viper).

A case study of 2019-nCOV cases in Argentina with the real data based on daily cases from March 03, 2020 to March 29, 2021 using classical and fractional derivatives.

In this study, our aim is to explore the dynamics of COVID-19 or 2019-nCOV in Argentina considering the parameter values based on the real data of this virus from  03, 2020 to  29, 2021 which is a data range of more than one complete year. We propose a Atangana-Baleanu type fractional-order model and simulate it by using predictor-corrector (P-C) method. First we introduce the biological nature of this virus in theoretical way and then formulate a mathematical model to define its dynamics.

Investigating functional performance and substituent effect in modelling molecular structure, UV-visible spectra, and optical properties of D-π-A conjugated organic dye molecules: a DFT and TD-DFT study.

The molecular structure, UV-visible spectra, and optical properties of D-π-A conjugated organic dye molecules (Disperse Red 1 (DR1) and Disperse Red 73 (DR73)) were analyzed using density functional theory (DFT) and time-dependent density functional theory (TD-DFT) and compared with azobenzene molecule to study the effect of donor and acceptor substituents on the molecular properties. The performance of DFT functionals is investigated using B3LYP hybrid functional and three long-range corrected functionals (CAM-B3LYP, LC-ω PBE, and ω B97XD) in conjunction with 6-31G(d,p) basis set. Using TD-DFT, we calculate the vertical excitation energies and transition dipole moment values for 100 excited states.

Recent advances in the carbon-phosphorus (C-P) bond formation from unsaturated compounds by s- and p-block metals.

Researchers around the globe have witnessed several breakthroughs in s- and p-block metal chemistry. Over the past few years, several applications in catalysis associated with these main group metals have been established, and owing to their abundance and low cost and they have proved to be essential alternatives to transition metal catalysts. In this review, we present a detailed discussion on the catalytic addition of P-H bonds from various phosphine reagents to multiple bonds of unsaturated substrates for the synthesis of organophosphorus compounds with C-P bonds promoted by various s- and p-block metal catalysts, as published in the last decade.

Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade.

Unlike mammals, two kisspeptins genes encoding, kiss1 and kiss2 are detected in fishes with highly varied and contradictory difference in their reproductive activities. The present study was undertaken to examine the direct action of kisspeptin-10 and its role in gonadal activities in the gonadally quiescent Asian catfish using native mammalian kisspeptin decapeptide (KP-10) involving in vivo and in vitro approaches. The in vivo KP-10 treatment caused precocious onset of gametogenesis and its rapid progression, as was evident from the appearance of advanced stages of ovarian follicles in ovary, and advanced germ cells (spermatocytes/ spermatids) in the testis of the treated Clarias batrachus in comparison to the control gonads.