Synthesis of a novel β-cyclodextrin-functionalized FeO/BaMoO:Dy magnetic luminescent hybrid nanomaterial and its application as a drug carrier.

Magnetic luminescent hybrid nanoparticles Fe3O4/BaMoO4:Dy3+ (MLHNPs) were successfully synthesized by the co-precipitation method using ethylene glycol. The MLHNPs are functionalized with β-cyclodextrin (CD) using 3-aminopropyl triethoxysilane (APTES). The surface functionalization of nanoparticles and their conjugation have been confirmed via powder XRD, FTIR, HRTEM, and PL analyses.

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles.

Fluorescent dye labeling is a common strategy to analyze the fate of administered nanoparticles in living organisms. However, to which extent the labeling processes can alter the original nanoparticle biodistribution has been so far neglected. In this work, two widely used fluorescent dye molecules, namely, ATTO488 (ATTO) and Sulfo-Cy5 (S-Cy5), have been covalently attached to a well-characterized CXCR4-targeted self-assembling protein nanoparticle (known as T22-GFP-H6).

Moving through cancer: Setting the agenda to make exercise standard in oncology practice.

International evidence-based guidelines support the prescription of exercise for all individuals living with and beyond cancer. This article describes the agenda of the newly formed Moving Through Cancer initiative, which has a primary objective of making exercise standard practice in oncology by 2029.

Sampling of explosive residues: The use of a gelatine-based medium for the recovery of ammonium nitrate.

Forensic scientists must be able to recover traces of any original explosive materials not consumed in the detonation, in a careful controlled manner to aid a crime reconstruction. In current sampling techniques, the collection efficiency of post-blast residue is highly variable and often dependent on the swabbing materials and solvent systems used. To address these method limitations, this study presents a gelatine-based sampling medium and assesses its capabilities for the collection of ammonium nitrate.

A study on China's economic growth, green energy technology, and carbon emissions based on the Kuznets curve (EKC).

China's rapid economic development is unavoidably characterized by environmental pitfalls, especially the carbon dioxide emissions of greenhouse gases from the use of energy. Since there is a relationship between economic growth, energy consumption, and carbon emission, it is important to note that the continuous improvement and application of solar energy technology will play an active role in carbon emission reduction. Therefore, this paper uses the Kuznets curve to probe the relationship between economic growth, solar energy technology, and carbon emissions.

Inflammatory Bowel Disease: Are Symptoms and Diet Linked?

New Zealand (NZ) has one of the world's highest incidence rates of Inflammatory Bowel Disease (IBD), a group of chronic inflammatory conditions that affect the gastrointestinal tract. Patients with IBD often believe certain foods influence their disease symptoms and consequently may alter their diet considerably. The objective of this study was to determine foods, additives, and cooking methods (dietary elements) that NZ IBD patients identify in the onset, exacerbation, or reduction of their symptoms.

A multi-stimuli responsive ruthenium complex for catalytic water oxidation.

A ruthenium complex showing multi-stimuli-responsive isomerization was synthesized. The catalytic activity of this complex toward water oxidation showed responses to visible-light irradiation and heat due to photoisomerization and thermal back-isomerization, respectively. DFT calculations suggested that a pendant moiety in the complex was key to controlling the catalytic activity.

Time-dependent study of graphene oxide-trypsin adsorption interface and visualization of nano-protein corona.

Understanding of interactions of nanomaterials with biomolecules (especially proteins) is of great importance to the area of nanobiotechnology. Graphene and its derivative such as graphene oxide (GO), are two-dimensional (2-D) nanomaterials with remarkable physical and chemical properties and have been broadly explored in biotechnology and biomedical application. Here, we have reported the nature of adsorption of trypsin on the GO surface, considering its biomedical implications.

Strategic design of precautionary measures for airport passengers in times of global health crisis Covid 19: Parametric modelling and processing algorithms.

Presently, the negative results of a pandemic loom in a threatening manner on an international scale. Facilities such as airports have contributed significantly to the global spread of the COVID-19 virus. Therefore, in order to address this challenge, studies on sanitary risk management and the proper application of countermeasures should be carried out.

Electronic nose dataset for pork adulteration in beef.

This article provides a dataset of several weight combinations from the adulteration of pork in beef using an electronic nose (e-nose). Seven combinations mixtures have been built, they were 100% pure beef, 10% mixed with pork, 25% mixed with pork, 50% mixed with pork, 75% mixed with pork, 90% mixed with pork, and 100% pure pork. By using this combination, a minimum of 10% of a mixture of pork or beef can be detected.

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance.

Nonalcoholic fatty liver disease is strongly associated with hepatic insulin resistance (HIR); however, the key lipid species and molecular mechanisms linking these conditions are widely debated. We developed a subcellular fractionation method to quantify diacylglycerol (DAG) stereoisomers and ceramides in the endoplasmic reticulum (ER), mitochondria, plasma membrane (PM), lipid droplets, and cytosol. Acute knockdown (KD) of diacylglycerol acyltransferase-2 in liver induced HIR in rats.

Population- and sex-specific sensitivity of the marine amphipod Allorchestes compressa to metal exposure.

The sensitivity to contaminants of natural populations varies greatly depending on their historical exposure and on the sex of the individual. These factors result in great uncertainty in ecotoxicological risk assessments and challenge the protection of marine biodiversity. This study investigated the role of background pollution in the environment in shaping the sensitivity of males and females of the common marine amphipod Allorchestes compressa to the common trace marine pollutant, copper (Cu).

Ablation of Peroxiredoxin V Exacerbates Ischemia/Reperfusion-Induced Kidney Injury in Mice.

Ischemia/reperfusion (I/R) is one of the major causes of acute kidney injury (AKI) and associated with increased mortality and progression to chronic kidney injury (CKI). Molecular mechanisms underlying I/R injury involve the production and excessive accumulation of reactive oxygen species (ROS). Peroxiredoxin (Prx) V, a cysteine-dependent peroxidase, is located in the cytosol, mitochondria, and peroxisome and has an intensive ROS scavenging activity.

Metabolomics reveals chemical changes in Acer saccharum sap over a maple syrup production season.

Maple syrup, made by boiling the sap of Acer saccharum, is an important agriculture commodity in eastern Canada and New England. Although the collection season is relatively short, a rich progression in the sensory qualities of maple syrup can occur throughout the season. A risk associated with maple syrup production at the end of a season is the development of off-flavors that result in syrup with little to no commercial value.

Intramolecular Hydrogen Bonding: A Key Factor Controlling the Photosubstitution of Ruthenium Complexes.

Photosubstitution reactions of ruthenium complexes with pyrazole ligands, [Ru(bpy)(pzH)] (), [Ru(bpy)(pz)(pzH)] (), and [Ru(bpy)(pz)] () (pzH = pyrazole, bpy = 2,2'-bipyridine), were investigated. Dicationic complex was deprotonated to using moderate base (p = 15.2, MeCN), while the second deprotonation to give required more severe conditions (p = 26.

Timing of tracheal intubation on mortality and duration of mechanical ventilation in critically ill children: A propensity score analysis.

Objective: We aimed to investigate whether early tracheal intubation (TI) is associated with a reduced risk of mortality and increased ventilator-free days (VFD).

Methods: We performed a retrospective cohort study of children 0 to 18 years old in a pediatric intensive care unit (PICU), between 2008 and 2017. Patient demographics, vital signs, and laboratory findings were extracted.

In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases.

Background: COVID-19 is a life-threatening novel corona viral infection to our civilization and spreading rapidly. Tremendousefforts have been made by the researchers to search for a drug to control SARS-CoV-2.

Methods: Here, a series of arsenical derivatives were optimized and analyzed with in silico study to search the inhibitor of RNA dependent RNA polymerase (RdRp), the major replication factor of SARS-CoV-2.

A Mendelian randomization study of telomere length and blood-cell traits.

Whether telomere attrition reducing proliferative reserve in blood-cell progenitors is causal has important public-health implications. Mendelian randomization (MR) is an analytic technique using germline genetic variants as instrumental variables. If certain assumptions are met, estimates from MR should be free from most environmental sources of confounding and reverse causation.

Perfusion decellularization of porcine esophagus: Study of two processing factors affecting the folded mucosal structure of the esophageal scaffold.

Acellular scaffolds from decellularized donor organs are showing promising clinical results in tissue and organ repair and regeneration. A successful decellularization process is determined by (a) its capability to decellularize complete organs of large animals, (b) retention of the extracellular matrix (ECM) structures and morphologies, and (c) minimal loss of ECM proteins. In this study, porcine esophagi were perfused in full thickness with 0.

Cancer Cell Metabolites: Updates on Current Tracing Methods.

Cancer is the second leading cause of death-1 in 6 deaths globally is due to cancer. Cancer metabolism is a complex and one of the most actively researched area in cancer biology. Metabolic reprogramming in cancer cells entails activities that involve several enzymes and metabolites to convert nutrient into building blocks that alter energy metabolism to fuel rapid cell division.

Application of Artificial Intelligence in COVID-19 drug repurposing.

Background And Aim: COVID-19 outbreak has created havoc and a quick cure for the disease will be a therapeutic medicine that has usage history in patients to resolve the current pandemic. With technological advancements in Artificial Intelligence (AI) coupled with increased computational power, the AI-empowered drug repurposing can prove beneficial in the COVID-19 scenario.

Methods: The recent literature is studied and analyzed from various sources such as Scopus, Google Scholar, PubMed, and IEEE Xplore databases.

Transcriptomic Analysis of Gill and Kidney from Asian Seabass () Acclimated to Different Salinities Reveals Pathways Involved with Euryhalinity.

Asian seabass (or commonly known as barramundi), is a bony euryhaline teleost from the Family , inhabiting nearshore, estuarine, and marine connected freshwaters throughout the tropical Indo-West Pacific region. The species is catadromous, whereby adults spawn in salinities between 28 and 34 ppt at the mouth of estuaries, with resultant juveniles usually moving into brackish and freshwater systems to mature, before returning to the sea to spawn again as adults. The species lives in both marine and freshwater habitats and can move quickly between the two; thus, the species' ability to tolerate changes in salinity makes it a good candidate for studying the salinity acclimation response in teleosts.

Application of cognitive Internet of Medical Things for COVID-19 pandemic.

Background And Aim: In the age of advanced digital technology, smart healthcare based on the Internet of Things (IoT) is gaining importance to deal with the current COVID-19 pandemic. In this paper, the novel application of cognitive radio (CR) based IoT specific for the medical domain referred to as Cognitive Internet of Medical Things (CIoMT) is explored to tackle the global challenge. This concept of CIoT is best suited to this pandemic as every person is to be connected and monitored through a massive network that requires efficient spectrum management.

Rationally designed C/CoS@SnS nanocomposite as a highly efficient anode for lithium-ion batteries.

Nanostructured transition metal sulfides are promising anode materials for lithium-ion batteries. Nevertheless, it is still a great challenge to prepare capacity-improved electrodes without reducing their rate capability and cycle stability. In this paper, we present a C/CoS@SnS composite material by loading SnS nanocrystals onto MOF-derived C/CoS nanostructures.

Reducing toxic reactive carbonyl species in e-cigarette emissions: testing a harm-reduction strategy based on dicarbonyl trapping.

Reducing the concentration of reactive carbonyl species (RCS) in e-cigarette emissions represents a major goal to control their potentially harmful effects. Here, we adopted a novel strategy of trapping carbonyls present in e-cigarette emissions by adding polyphenols in e-liquid formulations. Our work showed that the addition of gallic acid, hydroxytyrosol and epigallocatechin gallate reduced the levels of carbonyls formed in the aerosols of vaped e-cigarettes, including formaldehyde, methylglyoxal and glyoxal.