A Synthetic Route to a Ruthenium Complex via Successive Photosubstitution Reactions.

Photosubstitution reactions of -[Ru(bpy)(MeCN)] with a pyrazole ligand (pzH) were studied under various conditions toward the development of a photochemical synthetic route to polypyridyl ruthenium complexes (bpy = 2,2'-bipyridine). In the absence of a base, light irradiation of an acetonitrile solution of pyrazole and -[Ru(bpy)(MeCN)] gave a mixture of the reactant and -[Ru(bpy)(pzH)(MeCN)]. In the presence of a mild base such as ,-dimethylaminopyridine, a second photosubstitution from -[Ru(bpy)(pzH)(MeCN)] to -[Ru(bpy)(pz)(pzH)] () was greatly enhanced, as confirmed by UV-vis and H nuclear magnetic resonance spectroscopy.

Design and Development Armband Vital Sign Monitor for Health-Care Monitoring.

Background: One of the vital organs that require regular check is heart. The representation of heart health can be identified through electrocardiogram (ECG) signals, blood pressure (BP), heart rate, and oxygen saturation (SpO2). Monitoring the heart condition needs to be regularly done to prevent heart attack that can occur suddenly and very quickly particularly for someone who has had a heart attack before.

Chondroitin Sulfate-Based Cryogels for Biomedical Applications.

Cryogels attained from natural materials offer exceptional properties in applications such as tissue engineering. Moreover, Halloysite Nanotubes (HNT) at 1:0.5 weight ratio were embedded into CS cryogels to render additional biomedical properties.

SafeFit Trial: virtual clinics to deliver a multimodal intervention to improve psychological and physical well-being in people with cancer. Protocol of a COVID-19 targeted non-randomised phase III trial.

Introduction: The impact of the COVID-19 pandemic (caused by the SARS-CoV-2 virus) on individuals with cancer has been profound. It has led to increased anxiety, distress and deconditioning due to reduced physical activity. We aim to investigate whether SafeFit, a multimodal intervention of physical activity, nutrition and psychological support delivered virtually by cancer exercise specialists (CES), can improve physical and emotional functionings during the COVID-19 pandemic.

Resolution-Enhancing Structure for the Electric Field Microsensor Chip.

Electrostatic voltage is a vital parameter in industrial production lines, for reducing electrostatic discharge harms and improving yields. Due to such drawbacks as package shielding and low resolution, previously reported electric field microsensors are still not applicable for industrial static monitoring uses. In this paper, we introduce a newly designed microsensor package structure, which enhances the field strength inside the package cavity remarkably.

Photovoltaic transistor of atoms due to spin-orbit coupling in three optical traps.

In this paper, spin-orbit coupling induced photovoltaic effect of cold atoms has been studied in a three-trap system which is an two-dimensional extension of a two-trap system reported previously. It is proposed here that atom coherent length is one of the important influences to the resistance of this photovoltaic battery. Current properties of the system for different geometrical structures of the trapping potentials are discussed.

Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti-biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities.

Nanostructured fluorescent particles derived from natural molecules were prepared by a green synthesis technique employing a microwave method. The precursors citric acid (CA) and cysteine (Cys) were used in the preparation of S- and N-doped Cys carbon dots (Cys CDs). Synthesis was completed in 3 min.

Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology.

Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. This review presents a comprehensive update on nanoparticles' toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced.

"Light modulates transcriptomic dynamics upregulating astaxanthin accumulation in Haematococcus: A review".

Haematococcus pluvialis is a green alga that can accumulate high astaxanthin content, a commercially demanding market keto food. Due to its high predicted market value of about 3.4 billion USD in 2027, it is essential to increase its production.

Investor Sentiment and Stock Returns During the COVID-19 Pandemic.

In this paper, we regard the Baidu index as an indicator of investors' attention to China's epidemic stocks. We believe that when seeking information to guide investment decisions, investor sentiment is usually affected by the information provided by the Baidu search engine, which may cause stock prices to fluctuate. Therefore, we constructed a GARCH extended model including the Baidu index to predict the return of epidemic stocks and compared it with the benchmark model.

Transition Metal-Catalyzed Hydroalkoxylation of Alkynes: An Overview.

Oxygen-bearing motifs, mainly the congener heterocycles are ubiquitous due to their presence in various natural products and bioactive scaffolds. Although in literature, several strategies have been developed for their synthesis, hydroalkoxylation of alkynes has come forward as a method of choice and has been used extensively. In particular, hydroalkoxylation of alkynes has gained enormous attention from the synthetic community due to the rapid access to a very useful and reactive synthetic intermediate like 'enol ether'.

Impacts of Metabolism and Organic Acids on Cell Wall Composition and Susceptibility to Membrane Active Antimicrobials.

Reliable antimicrobial susceptibility testing is essential in informing both clinical antibiotic therapy decisions and the development of new antibiotics. Mammalian cell culture media have been proposed as an alternative to bacteriological media, potentially representing some critical aspects of the infection environment more accurately. Here, we use a combination of NMR metabolomics and electron microscopy to investigate the response of and to growth in differing rich media to determine whether and how this determines metabolic strategies, the composition of the cell wall, and consequently susceptibility to membrane active antimicrobials including colistin and tobramycin.

Evaluating the post-discharge cost of healthcare-associated infection in NHS Scotland.

Background: Whereas the cost burden of healthcare-associated infection (HAI) extends beyond the inpatient stay into the post-discharge period, few studies have focused on post-discharge costs.

Aim: To investigate the impact of all types of HAI on the magnitude and distribution of post-discharge costs observed in acute and community services for patients who developed HAI during their inpatient stay.

Methods: Using data from the Evaluation of Cost of Nosocomial Infection (ECONI) study and regression methods, this study identifies the marginal effect of HAI on the 90-daypost-discharge resource use and costs.

Bed-days and costs associated with the inpatient burden of healthcare-associated infection in the UK.

Background: Healthcare-associated infection (HAI) is associated with increased morbidity and mortality resulting in excess costs.

Aim: To investigate the impact of all types of HAI on the inpatient cost of HAI using different approaches.

Methods: The incidence, types of HAI, and excess length of stay were estimated using data collected as part of the Evaluation of Cost of Nosocomial Infection (ECONI) study.

Personalized infection prevention and control: identifying patients at risk of healthcare-associated infection.

Background: Few healthcare-associated infection (HAI) studies focus on risk of HAI at the point of admission. Understanding this will enable planning and management of care with infection prevention at the heart of the patient journey from the point of admission.

Aim: To determine intrinsic characteristics of patients at hospital admission and extrinsic events, during the two years preceding admission, that increase risk of developing HAI.

Impact of healthcare-associated infection on length of stay.

Background: Increased length of stay (LOS) for patients is an important measure of the burden of healthcare-associated infection (HAI).

Aim: To estimate the excess LOS attributable to HAI.

Methods: This was a one-year prospective incidence study of HAI observed in one teaching hospital and one general hospital in NHS Scotland as part of the Evaluation of Cost of Nosocomial Infection (ECONI) study.

Evaluation of different packaging methods and storage temperature on MPs abundance and fillet quality of rainbow trout.

There are many studies on microplastics (MPs) about the aquatic ecosystems and its components. However, there is limited study on the MPs abundance, identification and sources in processed seafood products which are manufactured for direct human consumption. In this study, rainbow trout (Oncorhynchus mykiss) fillets were packed with different packaging techniques and stored at two different temperatures (+4 and -20°C) for 21 days.

Evaluating the optimization of the use of sedating antihistamines in a community pharmacy: a retrospective quality improvement study in Singapore.

Objectives: This study aimed to retrospectively assess whether community pharmacy customers accepted the pharmacist's recommendations for the selection of an antihistamine based on medicine optimization guidelines.

Methods: A retrospective study was conducted on the implementation of an antihistamine use optimization guide for patients who were seeking first-generation antihistamines between July and December 2019 across forty-five community pharmacies in Singapore. The primary outcome measure was the acceptance rate of ceasing or substituting first-generation antihistamine with a second-generation antihistamine.

A non-intrusive voltage measurement scheme based on MEMS electric field sensors: Theoretical analysis and experimental verification of AC power lines.

A non-interference AC voltage measurement system based on a resonant electric field microsensor is proposed. The equivalent circuit of the proposed system is established, which shows that the frequency response function is only related to the capacitances of the system structure in the kHz low-frequency range. Furthermore, the sensitivity analysis and experiments demonstrate that the amplitude sensitivity is independent of the frequency of an unknown AC voltage.

Insights into diatom microalgal farming for treatment of wastewater and pretreatment of algal cells by ultrasonication for value creation.

Wastewater management and its treatment have revolutionized the industry sector into many innovative techniques. However, the cost of recycling via chemical treatment has major issues especially in economically poor sectors. On the offset, one of the most viable and economical techniques to clean wastewater is by growing microalgae in it.

Scale Drop Disease Virus (SDDV) and Herpes Virus (LCHV) Coinfection Downregulate Immune-Relevant Pathways and Cause Splenic and Kidney Necrosis in Barramundi Under Commercial Farming Conditions.

Marine farming of barramundi () in Southeast Asia is currently severely affected by viral diseases. To better understand the biological implications and gene expression response of barramundi in commercial farming conditions during a disease outbreak, the presence of pathogens, comparative RNAseq, and histopathology targeting multiple organs of clinically "sick" and "healthy" juveniles were investigated. Coinfection of scale drop disease virus (SDDV) and herpes virus (LCHV) were detected in all sampled fish, with higher SDDV viral loads in sick than in healthy fish.

Modern computational intelligence based drug repurposing for diabetes epidemic.

Background And Aim: Objectives are to explore recent advances in discovery of new antidiabetic agents using repurposing strategies and to discuss modern technologies used for drug repurposing highlighting diabetic specific web portal.

Methods: Recent literature were studied and analyzed from various sources such as Scopus, PubMed, and IEEE Xplore databases.

Results: Drugs like Niclosamideethanolamine, Methazolamide, Diacerein, Berberine, Clobetasol, etc.

A single transcript CRISPR/Cas9 mediated mutagenesis of CaERF28 confers anthracnose resistance in chilli pepper (Capsicum annuum L.).

T-DNA-free homozygous mutant lines developed through a single transcript CRISPR/Cas9 system harboring the desired modification in the CaERF28 locus exhibited significantly enhanced resistance to the anthracnose pathogen Colletotrichum truncatum coupled with the improved expression of defense responsive genes. Anthracnose, caused by Colletotrichum species, is a major disease of chilli (Capsicum annuum) accounting for significant pre- and post-harvest yield losses across the tropical and subtropical regions of the world. Management of chilli anthracnose using traditional methods have not met with noticeable success.

Reviews on mechanisms of in vitro antioxidant, antibacterial and anticancer activities of water-soluble plant polysaccharides.

Degenerative diseases such as cancer and cardiovascular diseases, and antimicrobial resistance are becoming prominent health problems needing utmost public health attention. Curative interventions such as the use of pharmaceutical drugs and alternative plant medicines are increasingly being explored. Plant polysaccharides have gained attention for their promising bioactivities such as antioxidant, antimicrobial and anticancer activities.

Process Mining of Disease Trajectories: A Literature Review.

Disease trajectories model patterns of disease over time and can be mined by extracting diagnosis codes from electronic health records (EHR). Process mining provides a mature set of methods and tools that has been used to mine care pathways using event data from EHRs and could be applied to disease trajectories. This paper presents a literature review on process mining related to mining disease trajectories using EHRs.