Changes in Walking Stability at Different Percentages of Preferred Walking Speed in Healthy Young and Older Adults: Insights From Movement Component Analysis.

Walking instability increases the risk of falls and compromises mobility safety. This study aimed to explore the impact of various percentages of preferred walking speed (PWS)-specifically, 40%, 55%, 70%, 85%, 100%, 115%, 130%, and 145%-along with age-related changes, on walking stability during treadmill walking. Kinematic marker data from all walking speed trials were pooled for analysis, involving a total of 26 participants (13 young adults aged 24.

The effect of computer use on pain, grip strength, and upper limb neural tension in female undergraduate students: A matched-pair study.

Background: Female university students frequently complain of computer-related neck pain after one hour of use, which may cause changes in grip strength and nerve tension in the upper extremity.

Objective: The purpose of this study was to compare neck pain intensity, grip strength and upper limb neural tension, before and after an hour of computer use between female students with and without neck pain.

Method: There were 36 female students recruited, which were then divided into the neck pain group (n = 18) and the asymptomatic group (n = 18).

Association of pre-admission exercise habit with post-discharge outcomes for older patients with heart failure.

Aims: The benefits of exercise in patients with heart failure are well documented. However, to date, the association between exercise habits and prognosis is yet to be evaluated. In this study, we investigated the association between pre-hospital exercise habits and post-discharge prognosis in older adult patients with heart failure.

Profiling antimalarial drug-resistant haplotypes in , 1, and genes in causing malaria in the Central Region of Ghana: a multicentre cross-sectional study.

Background: The proliferation of parasites resistant to antimalarial drugs poses a serious threat to human life and remains an obstacle to managing and eradicating . The surveillance of molecular markers has become necessary to monitor the spread of resistant haplotypes and discover emerging mutations.

Objective: This molecular epidemiological study aimed to evaluate the prevalence of known mutations in the drug resistance genes , 1, and in the Central Region of Ghana.

Effect of honey, as a natural deep eutectic solvent, on the phytochemical stability and anti-inflammatory activity of Jack.

The use of Jack (EL) in combination with honey is widely recognized in conventional medicine because of its aphrodisiac and pyretic properties. However, the effects of honey, a natural deep eutectic solvent (NADES), on the phytochemical stability and anti-inflammatory activity of EL remain unknown. This study aimed to investigate the effect of honey on phytochemical and anti-inflammatory effects of EL.

Insight into the principles and advanced construction strategies of nanoprobe based multi-targets sensing in food safety.

In real-world food safety incidents, hazards are often diverse and coexist simultaneously. Mature single-target detection technologies, while effective, are insufficient for comprehensively evaluating the overall quality and safety of food. As a result, multi-target detection, which enables a more comprehensive assessment of multiple hazards in food, has emerged as a prominent research focus.

Influencing hair regrowth with EGCG by targeting glycogen synthase kinase-3β activity: a molecular dynamics study.

Hair follicle growth process through several well-organized stages with specific input by several signaling pathways including Wnt/β-catenin and Sonic Hedgehog with GSK3β in this process. As such, this research focus on investigating the efficacy of molecules that are able to inhibit GSK3β action in inducing hair regrowth. Applying computational techniques, three compounds NMN, Resveratrol and EGCG were analyzed for their GSK3β inhibition.

The role of pharmacological interventions in managing urological complications during pregnancy and childbirth: A review.

Pregnancy leads to a number of structural and functional changes in the urinary system, which makes females susceptible to urological complications. This review aims to discuss the epidemiology, complications and prevention and management of urinary tract infections (UTIs), kidney stones and bladder dysfunction in pregnancy. UTIs are the most common urological problem presenting in 10% of pregnant women; Escherichia coli is the most common causative organism.

Sustainable development goals (SDGs) and resilient healthcare systems: Addressing medicine and public health challenges in conflict zones.

This review explores the integration of sustainable development goals (SDGs) into healthcare organizations in conflict zones, with a specific focus on emergent models aimed at improving population health. The primary objective is to examine how innovative approaches such as telemedicine, mobile health clinics, and community health worker initiatives can be aligned with SDG targets, thereby enhancing healthcare outcomes in conflict-affected regions. The review focuses on the important areas of concern which encompasses technology, infrastructure, community engagement, and social/psychological factors.

Effect of Pilates Exercises on Pain, Endurance, Quality-of-Life, and Disability in Postmenopausal Women With Low Back Pain.

Purpose: To determine the effect of Pilates exercises on pain, endurance, quality-of-life, and disability in post-menopausal women with low back pain.

Methods: After obtaining signed written consent, 128 women in the post-menopausal stage were randomly allocated to two groups: group 'A' (experimental) and group 'B' (control-conventional). The participants underwent evaluations for disability using the Oswestry Disability Scale.

Unraveling thalassemia intermedia: Novel insights of a hemoglobin Jax [HBA2:c.44G>C] and deletional α-thalassemia interaction phenotype.

Objective: To elucidate the molecular basis, hematological features, and electrophoretic and chromatographic mobility behavior of an unstable α-globin chain variant, and to describe the diagnostic approach.

Methods: A Thai patient with unexplained chronic anemia and her daughter were investigated. Hematological data were analyzed using a standard automated cell counter.

Amebicidal and Antiadhesion Activities of Extract Against T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Against Beta-Tubulin.

Medicinal plants have been used as alternative agents for the treatment of infections. This study aimed to investigate bioactivities of medicinal plant extracts including extract (Kre) against T4 and . Anti- activities of 44 extracts from 5 plant species were determined.

The Effects of High-Intensity Laser Therapy vs. Low-Level Laser Therapy on Functional Ability and Quadriceps Architecture in Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial.

This study aimed to compare the effects of high-intensity laser therapy (HILT) and low-level laser therapy (LLLT) on the disability and architecture of the quadriceps in patients with knee osteoarthritis (OA). Ninety-eight patients with knee OA (KOA) were selected by convenience sampling and then divided into three groups: control, LLLT and HILT. Disability was determined using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).

Visual Performance and Satisfaction of Extended Depth of Focus Contact Lenses in Presbyopic Subjects.

The objective was to assess visual performance and the overall satisfaction of extended-depth-of-focus (EDOF) contact lenses (CLs) in a presbyopic population. We prospectively investigated visual acuity at all distances (0.3, 0.

Can consumption of finger millet diet improve mental health status in athletes: a possible link with modulation of cortisol levels.

Purpose: Despite the promising health benefits of finger millet, there is a notable lack of research specifically examining its effects on athletes' mental health. Therefore, the present narrative review aimed to explore the potential of finger millet (Eleusine coracana) in enhancing the mental health status of athletes.

Methods: For this narrative review databases like "PubMed," "SPORTDiscus," "Scopus," "ProQuest" and "Google Scholar" were referred to identify and analyze the studies to determine their relevance and findings.

Evaluating optimal height for hamstring activity in maximum-speed single-leg bridge test.

Hamstring strain injuries often occur during high-speed movements, yet no functional test reliably induces rapid hamstring contractions. This study aimed to determine the optimal platform height in the maximum-speed single-leg bridge test (MS-SLBT) to maximize hamstring activation. This cross-sectional study included 26 healthy male recreational athletes.

Plasma Soluble Progenitor Cell Receptors as Biomarkers for Severe Anemia Among Malaria-Infected Pediatrics: A Prospective Study in Ghana.

Background: Soluble forms of progenitor cell receptors may be implicated in the delayed erythropoietic response during severe anemia. In this study, plasma levels of soluble erythropoietin receptor (sEPO-R) and soluble granulocyte, macrophage-colony stimulating factor receptor (sGM-CSFR) were assessed in infected children in Ghana.

Methods: This case-control study was conducted at Tamale Teaching Hospital, Ghana.

Assessing the quality of life among African medical and health science students using the WHOQOL-BREF tool.

Background: The quality of life (QoL) among health professional students is available in the literature, yet there is a paucity of information concerning QoL among African students. The study aimed to measure the QoL with the World Health Organization Quality of Life-BREF (WHOQOL-BREF) tool among African medical and health science students.

Methods: A cross-sectional study was conducted involving 349 African medical and health science students from various disciplines at the International African University in May 2024.

Predictors of hearing loss disability: a multinational study using the ICF core set.

Purpose: Objective audiological assessments provide valuable insights on physiological dimensions of hearing loss (HL), but not on lived experiences and functional limitations perceived by individuals. This study employed the multidimensional ICF framework to explore how demographic and diagnostic variables predict self-reported disability in adults with HL.

Method: This cross-sectional study included 571 participants from India (94), South Africa (79), Sweden (219), and the USA (179).

Intraoperative Diagnosis: Imprint Cytology and Frozen Section in Ovarian Tumor, Averting Additional Surgery.

A granulosa cell tumor (GCT) is a type of ovarian cancer that constitutes approximately 10% of all ovarian malignancies. In this case, a female patient with hypothyroidism and a history of irregular periods was diagnosed with polycystic ovarian disease (PCOD) after a radiological examination, which subsequently recommended surgery. Frozen section analysis and imprint cytology assisted in the intraoperative diagnosis of the tumor.

The Role of GnRH Agonist Therapy and Hysterosalpingography (HSG) in Diagnosing and Treating Tubal Factor Infertility.

The paper describes the treatment of a 27-year-old woman with a history of infertility, heavy menstrual periods, and severe endometriosis with bilateral hydrosalpinx. The patient received hormonal treatment with triptorelin acetate, a GnRH agonist, to treat her endometriosis and regulate her menstruation. Hysterosalpingography confirmed the presence of bilateral hydrosalpinx, thus suggesting IVF as the most suitable method to conceive.

Menarche and pubertal progression: a cross-sectional analysis of timing and influencing factors in North-Eastern Ghana.

Menarche and pubertal onset vary across populations but understanding age-at-menarche (AAM) and pubertal growth tempo is limited in low-income settings. Identifying factors influencing pubertal development is vital for creating targeted health and education programmes supporting adolescent girls' well-being. Baseline data ( = 1045) from the Ten2Twenty-Ghana study were analysed to examine menarche attainment, pubertal development, AAM, and the associated factors among girls aged 10-17 years in the Mion district, Ghana.

Role of OX/OXR cascade in insomnia and sleep deprivation link Alzheimer's disease and Parkinson's disease: Therapeutic avenue of Dual OXR Antagonist (DORA).

Sleep plays a role in the elimination of neurotoxic metabolites that are accumulated in the waking brain as a result of neuronal activity. Long-term insomnia and sleep deprivation are associated with oxidative stress, neuroinflammation, amyloid beta (Aβ) deposition, and Lewy body formation, which are known to increase the risk of mild cognitive impairment (MCI) and dementia. Orexin A (OXA) and orexin B (OXB), two neuropeptides produced in the lateral hypothalamus, are known to influence the sleep-wake cycle and the stress responses through their interactions with OX receptor 1 (OX1R) and OX receptor 2 (OX2R), respectively.

Confirmation Bias in Sport Science: Understanding and Mitigating Its Impact.

Purpose: Confirmation bias, a cognitive phenomenon deeply ingrained in human thinking, shapes our perception of reality. It leads individuals to favor information that aligns with their preexisting beliefs while dismissing or undervaluing the contrary evidence. In sport science, where precision and evidence-based practices are critical aspects to optimize performance, confirmation bias can decisively impact decision-making processes.