Pyrene Based Schiff Base for Cascade Fluorescent "On-Off" Detection of Aluminium(III) and Fluoride Ions and its Applications in Live Cells Imaging.

An easy-to-prepare pyrene-based Schiff base PNZ was synthesized by condensing equimolar amount of 1-pyrenebutyric hydrazide with 2-hydroxy-naphthaldehyde, and employed as a fluorescent chemosensor for in-situ cascade detection of aluminium (Al) and fluoride (F) ions. In DMSO:HO (1 : 1, v/v), the weakly emissive PNZ showed a significant fluorescence enhancement at 455 nm selectively upon the addition of Al due to the complexation-induced formation of a pyrene excimer. Schiff base PNZ and Al formed a complex in 2 : 1 binding ratio with the estimated binding constants of K=9826.

Recent Development of Transition Metal Complexes as Chemotherapeutic Hypoxia Activated Prodrug (HAP).

Hypoxia is a state characterized by low concentration of Oxygen. Hypoxic state is often found in the central region of solid tumors. Hypoxia is associated with abnormal neovascularization resulted in poor blood flow in tissues and increased proliferation of tumor cells, imbalance between O supply and O consumption in tumor cells, high concentration of proton and strong reducibility.

Shape and Phase-Controlled One-Pot Synthesis of Air Stable Cationic AgCdS Nanocrystals, Optoelectronic and Electrochemical Hydrogen Evolution Studies.

CdS-based materials are extensively studied for photocatalytic water splitting. By incorporating Ag into CdS nanomaterials, the catalyst's charge carrier dynamic can be tuned for photo-electrochemical devices. However, photo-corrosion and air-stability of the heterostructures limit the photocatalytic device's performance.

Aggregation-induced Emission Active Naphthalimide Derived Schiff Base for Detecting Cu and Its Applications.

Herein, an aggregation-induced emission (AIE) active Schiff base (NHS) was synthesized by condensing naphthalimide hydrazide with salicylaldehyde. The non-fluorescent solution of NHS in DMSO turned to emissive NHS upon increasing the HEPES fraction in DMSO from 70 to 95%. The UV-Vis absorption and DLS studies supported the self-aggregation of NHS that restricted the intramolecular rotation and activated the ESIPT process.

Fluorescence Sensing of pH and p-Nitrophenol Using an AIEE Active Pyridoxal Derived Schiff Base.

An easy-to-prepare aggregation-induced emission enhancement (AIEE) active Schiff base NPY was synthesized by condensing vitamin B cofactor pyridoxal with 3-hydroxy-2-naphthoic hydrazide, and employed for the fluorescent sensing of pH and p-nitrophenol (p-NP). The AIEE phenomenon of NPY was investigated in mixed DMSO/HO medium. The weakly yellow-fluorescent NPY (λ = 535 nm) in pure DMSO turned to a bright cyan-fluorescent NPY (λ = 490 nm) upon addition of poor solvent water.

Pyridoxal Derived AIEgen for Fluorescence Turn-off Sensing of Cu and Fe Ions and Fluorescence Imaging of Latent Fingerprints.

Schiff base 4-((E)-((E)-(2-hydroxybenzylidene)hydrazono)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol (HSP) was synthesized by condensing vitamin B cofactor pyridoxal with salicylaldehyde hydrazone, and characterized by standard spectroscopic techniques (FT-IR, H NMR, C NMR, and ESI-MS). The solution of HSP in DMSO/HEPES (10 mM, pH = 7.4) mixed solvents with varying HEPES fractions (f) from 0 to 95% showed aggregation-induced emission (AIE).

Exploring potential of C band synthetic aperture radar imagery to investigate rice crop growth mechanism and productivity.

Development of satellite technology over decades established unique approach to analyze rice crop phenological parameters and supervise growth and production. Advancement in technology leads to the development of microwave remote sensing that is operational round the clock irrespective of weather conditions. An attempt has been carried out in the present study to classify and map phenological stages, namely, transplanting stage, heading stage, and harvesting stage of rice crop using Sentinel-1, MODIS Enhanced vegetation index (EVI) data.

Anti-bacterial Effects of MnO on the Enrichment of Manganese-oxidizing Bacteria in Downflow Hanging Sponge Reactors.

We focused on the use of abiotic MnO to develop reactors for enriching manganese-oxidizing bacteria (MnOB), which may then be used to treat harmful heavy metal-containing wastewater and in the recovery of useful minor metals. Downflow hanging sponge (DHS) reactors were used under aerobic and open conditions to investigate the potential for MnOB enrichment. The results of an experiment that required a continuous supply of organic feed solution containing Mn(II) demonstrated that MnOB enrichment and Mn(II) removal were unsuccessful in the DHS reactor when plain sponge cubes were used.

Remarkable Effect of Jacalin in Diminishing the Protein Corona Interference in the Antibacterial Activity of Pectin-Capped Copper Sulfide Nanoparticles.

Herein, we report a new strategy based on jacalin functionalization to diminish the impact of biological fluids in the antibacterial applications of nanoparticles (NPs). Precoating pectin-capped copper sulfide NPs (pCuS) with bovine serum albumin produced a protein corona, which affects the antibacterial activity of pCuS. It was found that the minimum inhibitory concentration (MIC) increases fourfold because of the formation of the protein corona.

In Vitro Measurement of Sphingolipid Intermembrane Transport Illustrated by GLTP Superfamily Members.

Herein, we describe methodological approaches for measuring in vitro transfer of sphingolipids (SLs) between membranes. The approaches rely on direct tracking of the lipid. Typically, direct tracking involves lipid labeling via attachment of fluorophores or introduction of radioactivity.

Characterization, recellularization, and transplantation of rat decellularized testis scaffold with bone marrow-derived mesenchymal stem cells.

Background: Regenerative medicine potentially offers the opportunity for curing male infertility. Native extracellular matrix (ECM) creates a reconstruction platform to replace the organs. In this study, we aimed to evaluate the efficiency of the testis decellularized scaffold as a proper niche for stem cell differentiation toward testis-specific cell lineages.

Proposal of degradation pathway with toxicity prediction for hydrolytic and photolytic degradation products of timolol.

Timolol (TIM) is a potent β-adrenergic blocker, useful in treatment of ocular hypertension or open-angle glaucoma. Development and validation of stability indicating LCMS assay method for TIM was accomplished coherent with ICH guideline. Successful chromatographic separation of TIM with its four degradation products was attained by using gradient elution mode on reverse phase column using ammonium acetate buffer, pH 4.

Down regulation of ITGA4 and ITGA5 genes after formation of 3D spherules by human Wharton's jelly stem cells (hWJSCs).

Human Wharton's jelly mesenchymal stem cells (hWJSCs) are multipotent stem cells that could be aggregated into 3D spherules. ITGA4 and ITGA5 genes encode α4 and α5 subunits of integrins, respectively. In this study, we analyzed expression levels of ITGA4 and ITGA5 gene mRNAs in undifferentiated and 3D spherules forming hWJSCs in order to determine their expression pattern for possible future treatment of cancer cells in a co-culture fashion.

A stability-indicating LC-MS/MS method for zidovudine: Identification, characterization and toxicity prediction of two major acid degradation products.

Zidvovudine (AZT) is a nucleoside analogue reverse transcriptase inhibitor (NRTI), a class of anti-retroviral drug. A stability-indicating assay method for AZT was developed in line with ICH guideline. Successful separation of AZT and its degradation products was achieved by gradient elution mode on reverse phase C column using 10 mM ammonium acetate: acetonitrile as the mobile phase at 0.

Cancer-meter: measure and cure.

This paper presents a theory and system on "Cancer-Meter'. This idea came through the statement that "cancer is curable if it is measurable". The Cancer-Meter proves that it is possible.

Synthesis and characterization of zinc sulfide quantum dots and their interaction with snake gourd (Trichosanthes anguina) seed lectin.

Owing to the use of quantum dots in biological labeling, and the specific interaction of lectins with tumor cells, studies on lectin-QDs interaction are of potential interest. Herein, we report a facile method to prepare zinc sulfide quantum dots (ZnS QDs) using pectin as a capping agent and studied their interaction with snake gourd seed lectin (SGSL) by fluorescence spectroscopy. The QDs were characterized by X-ray diffraction, high-resolution transmission electron microscopy, UV-Vis absorption and fluorescence spectroscopy.

An efficient synthesis and in vitro antibacterial evaluation of ruthenium-quinolinol complexes.

A series of ruthenium-quinolinol complexes were synthesized using a simple and effective pathway and their in vitro antibacterial activity against various resistant gram-positive and gram-negative bacteria were evaluated. It was established that compound [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) & [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3e) were significantly active against Staphylococcus aureus, Escherichia coli, Bacillus subtilis &Salmonella sp. The structures of the new compounds were elucidated by the analysis of spectroscopic data.

Cardiomyocyte marker expression in mouse embryonic fibroblasts by cell-free cardiomyocyte extract and epigenetic manipulation.

Background: The regenerative capacity of the mammalian heart is quite limited. Recent reports have focused on reprogramming mesenchymal stem cells into cardiomyocytes. We investigated whether fibroblasts could transdifferentiate into myocardium.