Flowable Oxygen-Release Hydrogel Inhibits Bacteria and Treats Periodontitis.

Periodontitis, the chronic inflammation of the periodontal tissues caused by bacteria in plaque, is the leading cause of tooth loss in adults in the world. Currently, periodontitis is effectively treated with mechanical cleaning and the use of antibiotics. However, these treatments only temporarily remove plaque, which can rapidly proliferate and multiply in periodontal pockets over time.

Recent progress in understanding the role of bacterial extracellular DNA: focus on dental biofilm.

Dental biofilm is a highly complicated and dynamic structure comprising not only microbial communities but also the surrounding matrix of extracellular polymeric substances (EPS), including polysaccharides, proteins, extracellular DNA (eDNA) and other biopolymers. In recent years, the important role of bacterial eDNA in dental biofilms has gradually attracted attention. In this review, we present recent studies on the presence, dynamic conformation and release of oral bacterial eDNA.

Preparation of CMC/ACP/PHMB nanocomposites and preliminary study on their antibacterial and remineralization functions.

Caries is a chronic oral disease causing a series of complications. This study aims to develop a material that could remineralize demineralized enamel and simultaneously exert antibacterial effects. A carboxymethyl chitosan (CMC)/amorphous calcium phosphate (ACP)/polyhexamethylene biguanide hydrochloride (PHMB) nanocomposite was synthesized for the first time, and its stability, remineralization ability, and antibacterial properties were investigated in this study.

CAD/CAM surgical guides and pre-bent distractors: Enhancing precision in MDO for severe dentofacial deformities secondary to TMJ ankylosis.

Background: This study aimed to compare the different outcomes of mandibular distraction osteogenesis (MDO) using computer-aided design and manufacturing (CAD/CAM) surgical guides accompanied by pre-bent distractors versus CAD/CAM surgical guides with commercial distractors.

Methods: Twenty-eight patients with severe dentofacial deformities secondary to unilateral temporomandibular joint ankylosis (TMJA) were retrospectively enrolled. Ten parameters associated with MDO were measured preoperatively, virtually, and postoperatively.

Silk-based biomaterials for promoting spinal cord regeneration: A review.

The management of neurological disorders is profoundly complicated by spinal cord injury (SCI), which leads to the impairment of motor and sensory functions. A major challenge in the treatment of SCI is the formation of a dysfunctional pathological microenvironment characterized by an excessive inflammatory response, deposition of inhibitory molecules, glial scarring, and vascular dysfunction. A thorough understanding of the pathological and physiological changes following SCI is essential to elucidate the mechanisms underlying functional recovery and to develop effective therapeutic interventions.

A review of self-healing hydrogels for bone repair and regeneration: Materials, mechanisms, and applications.

Bone defects, which arise from various factors such as trauma, tumor resection, and infection, present a significant clinical challenge. There is an urgent need to develop new biomaterials capable of repairing a wide array of damage and defects in bone tissue. Self-healing hydrogels, a groundbreaking advancement in the field of biomaterials, displaying remarkable ability to regenerate damaged connections after partial severing, thus offering a promising solution for bone defect repair.

Analysis of recurrence factors after radical mandibular resection for ameloblastoma.

Background: To analyze causes of recurrence following radical mandibular resection of ameloblastoma, and to propose surgical variation.

Methods: We conducted a retrospective analysis of patients treated for ameloblastoma from 2012 to 2024, specifically those who underwent radical mandibular resection followed by reconstruction with autologous bone flaps, focusing on cases of recurrence.

Results: Six patients were included in the study, all with primary tumors located in the mandible.

Effects of Fzd6 on intestinal flora and neuroinflammation in lipopolysaccharide-induced depression-like mice.

Background: The gut microbiome is critical for the pathophysiology of depression, and inflammation is one of the factors contributing to depression. Fzd6 has been implicated in depression. This study aimed to elucidate the effects of the Fzd6 mutation on gut microbiota structure and the possible regulatory mechanisms involved in depression-associated neuroinflammation.

Biomechanical analysis of stress distribution and failure risk in mandibular incisors restored with resin-bonded fixed partial dentures using CAD/CAM materials and restoration designs.

Background: Computer-aided design/manufacturing (CAD/CAM) materials are widely used in resin-bonded fixed partial dentures (RBFPDs), but their suitability across different designs has not been fully assessed. This study compares the stress distribution and failure probability of mandibular incisors restored by RBFPDs with various CAD/CAM materials.

Materials And Methods: Finite-element models of single- and double-ended RBFPDs were created using cone-beam computed tomography (CBCT) data.

Tumor-Derived GDF15 Induces Tumor Associated Fibroblast Transformation From BMSCs and Fibroblasts in Oral Squamous Cell Carcinoma.

Cancer associated fibroblasts (CAFs) are the predominant stromal cell-type in the solid tumor microenvironment, originating from various cell types and playing a crucial role in promoting tumor progression and metastasis The generation of CAFs is influenced by complex factors secreted by tumor cells, with particular emphasis on transforming growth factor-β (TGF-β). However, it remains largely unknown whether growth/differentiation factor-15 (GDF15), as a member of the TGF-β superfamily, exerts similar effects to TGF-β in oral squamous cell carcinoma (OSCC). In this study, we investigated the impact of GDF15 derived from tumor cells on CAF transformation and elucidated the underlying mechanisms.

Cone-beam computed tomographic evaluation of styloid process: a retrospective study of 498 patients with maxillofacial diseases.

Purpose: The purpose of this study was to assess the structural characteristics of the styloid process (SP) using cone-beam computed tomography (CBCT) examination in patients with maxillofacial diseases. The study aimed to determine the prevalence of elongated styloid process (ESP) and its relationship to gender in the study population. Radiographic records of 498 subjects were evaluated retrospectively.

Hyperlipidemia impairs bone repair and regeneration via miR-193a-3p/STMN1/PI3K/Akt axis.

Hyperlipidemia, a metabolic disease characterized by excessive blood lipid, disturbs bone metabolism by shifting cell fate of bone marrow stromal cells (BMSCs) towards adipogenic differentiation, thus resulting in poor bone regeneration and osseointegration of implants. Among numerous factors affecting hyperlipidemic bone metabolism, non-coding RNAs play an essential role in post-transcriptional regulation. Our previous study has shown that miR-193a-3p levels were elevated in hyperlipidemia, which hindered implant osseointegration and BMSCs function.

Case reports of oral appliance therapy on three young adults with Down syndrome and OSA.

Patients with Down syndrome (DS) have a high incidence of obstructive sleep apnea (OSA) due to hypotonia, weight, underdeveloped midface, and relative macroglossia. This article presents three cases of young adults with DS, who were diagnosed with mild to severe OSA and unable to tolerate positive airway pressure therapy. These patients have been successfully treated with a custom-made mandibular advancement device (MAD) or dual treatment with MAD and bi-level positive airway pressure (PAP) therapy.

Risk factors for poor outcomes in adult patients with lip through-and-through wounds.

Background: Risk factors associated with infection and traumatic lacerations affecting the face are still not fully understood. This study investigated risk factors for poor outcomes in adult patients with through-and-through lip wounds who underwent debridement and suturing.

Methods: Patients with through-and-through lip wounds who underwent debridement in our emergency department between January 1, 2017, and December 31, 2021, were included.

Impact of oral flora in tongue coating and saliva on oral cancer risk and the regulatory role of Interleukin-8.

Background: Oral flora and inflammatory factors play a crucial role in oral cancer, but the relationship between them and oral cancer has not been clearly established.

Methods: Oral flora served as exposure factor, oral cancer as outcome factor, and inflammatory factors as mediating factor. Mendelian randomization (MR) analysis was used to analyze the relationship between oral flora and oral cancer, and the potential mediating effect of inflammatory factors was explored through mediation analysis.

HS-Scavenging Hydrogel Alleviating Mitochondria Damage to Control Periodontitis.

HS, as a typical metabolite of periodontal pathogens, exhibits a clear positive correlation with the occurrence and development of periodontitis. HS at physiological concentrations can regulate many biological processes. However, excess HS in the periodontal pocket can trigger secretion of proinflammatory cytokines, cause oxidative stress, and result in mitochondrial damage and cell death in human gingival fibroblasts, exacerbating periodontitis development and periodontal tissue destruction.

Effect of Loading Angles on Abutment Screw Loosening: In Vitro Study.

Aim: Biomechanical performance is a critical factor in the long-term success of dental implants, with abutment screw loosening being a common clinical issue. This study aimed to examine the impact of abutment screw design and external load loading angles on abutment screw loosening.

Materials And Methods: Abutments and abutment screws with 30°, 60°, 90°, and 180° fitting tapers were fabricated and tested for preload and initial loosening torque.

Clinical evaluation of SonicFill bulk resin technique in the restoration of proximal deep caries of primary molars: a two-year randomized controlled trial.

Background/purpose: Traditional restorative composites require time-consuming incremental layering techniques which poses challenges in pediatric dentistry. SonicFill bulk resin allows for thicker layers to be placed efficiently, reducing treatment time and enhancing filling quality. This prospective, parallel, randomized, controlled clinical study aimed to compare the operative time and outcomes between SonicFill bulk resin and conventional restorative composite for deep proximal restorations in primary molars.

Exploring the dark side of diagnostic dyes with a focus on Indocyanine green's adverse reactions.

Indocyanine green (ICG) is a diagnostic dye commonly used in medical imaging and liver function monitoring. Given its widespread use, there is a need for detailed evaluations of its adverse drug reactions in real-world settings. As the comprehensive overview of its safety profile is very limited, this study aimed to analyze the adverse events (AEs) associated with ICG using data from the Food and Drug Administration Adverse Event Reporting System (FAERS).

Ubiquitin-Proteasome System in Periodontitis: Mechanisms and Clinical Implications.

The progression of periodontitis, a bacteria-driven inflammatory and bone-destructive disease, involves myriad cellular and molecular mechanisms. Protein regulation significantly influences the pathogenesis and management of periodontitis. However, research regarding its regulatory role in periodontitis remains relatively limited.