Early breast cancer detection and differentiation tool based on tissue impedance characteristics and machine learning.

During Basic screening, it is challenging, if not impossible to detect breast cancer especially in the earliest stage of tumor development. However, measuring the electrical impedance of biological tissue can detect abnormalities even before being palpable. Thus, we used impedance characteristics data of various breast tissue to develop a breast cancer screening tool guided and augmented by a deep learning (DL).

Performance of TiO-Based Tubular Membranes in the Photocatalytic Degradation of Organic Compounds.

This work presents the photocatalytic degradation of organic pollutants in water with TiO and TiO/Ag membranes prepared by immobilising photocatalysts on ceramic porous tubular supports. The permeation capacity of TiO and TiO/Ag membranes was checked before the photocatalytic application, showing high water fluxes (≈758 and 690 L m h bar, respectively) and <2% rejection against the model pollutants sodium dodecylbenzene sulfonate (DBS) and dichloroacetic acid (DCA). When the membranes were submerged in the aqueous solutions and irradiated with UV-A LEDs, the photocatalytic performance factors for the degradation of DCA were similar to those obtained with suspended TiO particles (1.

Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform.

Glioblastoma Multiforme (GBM) is the most aggressive and most common primary malignant brain tumor. The age of GBM patients is considered as one of the disease's negative prognostic factors and the mean age of diagnosis is 62 years. A promising approach to preventing both GBM and aging is to identify new potential therapeutic targets that are associated with both conditions as concurrent drivers.

Modulating Catalytic Activity and Stability of Atomically Precise Gold Nanoclusters as Peroxidase Mimics via Ligand Engineering.

Metal nanoclusters (NCs), composed of a metal core and protecting ligands, show promising potentials as enzyme mimics for producing fuels, pharmaceuticals, and valuable chemicals, etc. Herein, we explore the critical role of ligands in modulating the peroxidase mimic activity and stability of Au NCs. A series of Au(SR) NCs with various thiolate ligands [SR = -acetyl-l-cysteine (NAC), 3-mercaptopropionic acid (MPA), or 3-mercapto-2-methylpropanoic acid (MMPA)] are utilized as model catalysts.

Fabrication and enhanced visible-light photocatalytic Hproduction of B-doped N-deficient g-CN/CdS Hybrids with robust 2D/2D hetero-interface interaction.

2D layered photocatalysts with proper electronic structure have sparked much attention in the field of visible-light photocatalysis for Hproduction. Herein, by simply calcining the mixture of ultrathin g-CN(CNN) and NaBH, heteroatom B and N defect were simultaneously introduced into g-CN. The obtained modified g-CN(BDCNN) was further coupled with 2D flower-like CdS nanosheet.

Spontaneous Object Exploration in a Recessive Gene Knockout Model of Parkinson's Disease: Development and Progression of Object Recognition Memory Deficits in Male Rats.

Cognitive impairments appear at or before motor signs in about one third of patients with Parkinson's disease (PD) and have a cumulative prevalence of roughly 80% overall. These deficits exact an unrelenting toll on patients' quality and activities of daily life due in part to a lack of available treatments to ameliorate them. This study used three well-validated novel object recognition-based paradigms to explore the suitability of rats with knockout of the PTEN-induced putative kinase1 gene () for investigating factors that induce cognitive decline in PD and for testing new ways to mitigate them.

self-assembly fabrication of ultrathin sheet-like CuS modified g-CNheterojunction and its enhanced visible-light photocatalytic performance.

Photocatalysts with heterojunction structure have been widely used for organic degradation. In this study, CuS/g-CNheterojunction was formed byself-assembly via a simply hydrothermal method. A series of characterizations were applied to analyzing the morphology, structure, optical properties and photo-induced electron transfer of the samples.

Enhanced Hevolution performance by carbonized SiC/g-CNheterojunction under visible-light illumination.

In this study, carbonized silicon carbide/graphitic carbon nitride ((SiC/C)/g-CN) composites were fabricated via a facile calcination method. The optimal SiC/C/g-CNcomposite shows an excellent visible-light photocatalytic activity for water splitting, with the highest hydrogen evolution amount being 200.2mol, which is four times higher than that of pure g-CNwhen triethanolamine and platinum (1.

Three-in-One C H -Selectivity-Guided Adsorptive Separation across an Isoreticular Family of Cationic Square-Lattice MOFs.

Energy-efficient selective physisorption driven C H separation from industrial C2-C1 impurities such as C H , CO and CH is of great importance in the purification of downstream commodity chemicals. We address this challenge employing a series of isoreticular cationic metal-organic frameworks, namely iMOF-nC (n=5, 6, 7). All three square lattice topology MOFs registered higher C H uptakes versus the competing C2-C1 gases (C H , CO and CH ).

The music and social bonding hypothesis does require multilevel selection.

Is musicality an individual level adaptation? The authors of this target article reject the need for group selection within their model, yet their arguments do not fulfill the conceptual requirements for justifying such a rejection. Further analysis can highlight the explanatory value of embracing multilevel selection theory as a foundational element of the music and social bonding (MSB) hypothesis.

PPARα Agonist, MHY3200, Alleviates Renal Inflammation during Aging via Regulating ROS/Akt/FoxO1 Signaling.

PPARα is a ligand-dependent transcription factor and its activation is known to play an important role in cell defense through anti-inflammatory and antioxidant effects. MHY3200 (2-[4-(5-chlorobenzo[]thiazol-2-yl)phenoxy]-2,2-difluoroacetic acid), a novel benzothiazole-derived peroxisome proliferator-activated receptor α (PPARα) agonist, is a synthesized PPARα activator. This study examined the beneficial effects of MHY3200 on age-associated alterations in reactive oxygen species (ROS)/Akt/forkhead box (FoxO) 1 signaling in rat kidneys.

Effects of a non-caffeinated coffee substitute on functional dyspepsia.

Background: Functional dyspepsia (FD) is a debilitating functional gastrointestinal disorder characterized by early satiety, post-prandial fullness or epigastric pain related to meals. FD is diagnosed when organic etiology for the symptoms is not identified. It is widely believed that FD may be linked to the consumption of certain foods.

Complete mitochondrial DNA sequence of the East Asian minnow, (Actinopterygii: Cypriniformes).

Some populations of the East Asian minnow Herzenstein, 1892, which are naturally distributed in western Japan, have declined and are considered endangered. However, has become a domestic invasive species in eastern Japan. Thus, knowledge of genetic features and phylogenetic relationships of is important for conservation of this species and understanding its impact on ecosystems.

Interpretable multimodal deep learning for real-time pan-tissue pan-disease pathology search on social media.

Pathologists are responsible for rapidly providing a diagnosis on critical health issues. Challenging cases benefit from additional opinions of pathologist colleagues. In addition to on-site colleagues, there is an active worldwide community of pathologists on social media for complementary opinions.

A systematic review on anti-Alzheimer's disease activity of prescription Kangen-karyu.

Traditional Chinese and Japanese medicines have become prime sources of drug discovery and there is a pressing need to investigate the effectiveness of these traditional medicines for modern drug discovery. Recently, among various traditional formulations, studies on Kangen-karyu (Guan-Yuan-Ke-Li), a mixture of six medicinal herbs (Salviae Miltiorrhizae Radix, Cnidii Rhizoma, Paeoniae Radix, Carthami Flos, Aucklandiae Radix, and Cyperi Rhizoma), have been growing to assess its neuroprotective role. This prompted us to undertake a thorough review of various targets of Kangen-karyu regarding its effectiveness against Alzheimer's disease, particularly focusing on cholinesterases, beta-site amyloid precursor protein cleaving enzyme 1, and glycogen synthase kinase 3β.

Evaluation of phytotherapeutic activities and phytochemical content of Phormidium autumnale Gomont from natural freshwater sources.

The information available on microalgae-sourced compounds, especially antibiotics and other bioactive compounds, and their potential commercial applications is still insufficient. In this study, antibacterial activity, metabolites, and molecular characterization of Phormidium autumnale, which was isolated from samples collected from different natural freshwater sources in Ankara, Turkey, were investigated. Sequencing results of 16s rDNA confirmed the molecular identification of P.

Experimental evolution of gallium resistance in .

Background And Objectives: Metallic antimicrobial materials are of growing interest due to their potential to control pathogenic and multidrug-resistant bacteria. Yet we do not know if utilizing these materials can lead to genetic adaptations that produce even more dangerous bacterial varieties.

Methodology: Here we utilize experimental evolution to produce strains of K-12 MG1655 resistant to, the iron analog, gallium nitrate (Ga(NO)).

Difficulties in benchmarking ecological null models: an assessment of current methods.

Identifying species interactions and detecting when ecological communities are structured by them is an important problem in ecology and biogeography. Ecologists have developed specialized statistical hypothesis tests to detect patterns indicative of community-wide processes in their field data. In this respect, null model approaches have proved particularly popular.

Hybrids of Polymeric Capsules, Lipids, and Nanoparticles: Thermodynamics and Temperature Rise at the Nanoscale and Emerging Applications.

The importance of thermodynamics does not need to be emphasized. Indeed, elevated temperature processes govern not only industrial scale production but also self-assembly, chemical reaction, interaction between molecules, etc. Not surprisingly, biological processes typically take place at a specific temperature.

Illuminating the dark metabolome to advance the molecular characterisation of biological systems.

Background: The latest version of the Human Metabolome Database (v4.0) lists 114,100 individual entries. Typically, however, metabolomics studies identify only around 100 compounds and many features identified in mass spectra are listed only as 'unknown compounds'.

Implementation of the International Classification of Functioning, Disability, and Health (ICF) Core Sets for Children and Youth with Cerebral Palsy: Global Initiatives Promoting Optimal Functioning.

The International Classification of Functioning, Disability, and Health (ICF) Core Sets for children and youth with cerebral palsy (CP) offer service providers and stakeholders a specific framework to explore functioning and disability for assessment, treatment, evaluation, and policy purposes in a global context. Describe global initiatives applying the ICF Core Sets for children and youth with CP, with a focus on contributions to clinical practice and challenges in their implementation. This is a descriptive cross-sectional study.

Studying of Po and Pb Deposition in Some Lichen Species in Manisa, Turkey.

Lichens are very useful for monitoring of the radionuclide deposition because having a high efficiency capturing the radionuclides from the atmospheric fallout. In the present work, Po and Pb deposition in some lichen species were determined using an alpha spectrometer. Different lichens were collected around Demirci-Manisa and investigated their uses as biomonitor for Po and Pb deposition.

Coarsening and mechanics in the bubble model for wet foams.

Aqueous foams are an important model system that displays coarsening dynamics. Coarsening in dispersions and foams is well understood in the dilute and dry limits, where the gas fraction tends to zero and one, respectively. However, foams are known to undergo a jamming transition from a fluidlike to a solidlike state at an intermediate gas fraction ϕ_{c}.

Single Gas Permeance Performance of High Silica SSZ-13 Zeolite Membranes.

Continuous and high silica SSZ-13 zeolite membranes were prepared on porous mullite supports from high SiO₂/Al₂O₃ ratio or aluminum-free precursor synthesis gel. Single gas permeance (CO₂ and CH₄) of the high silica SSZ-13 zeolite membrane was decreased with the SiO₂/Al₂O₃ ratio in the precursor synthesis gel, while the ideal CO₂/CH₄ selectivity of the membrane was gradually increased. Moreover, effects of synthesis conditions (such as H₂O/SiO₂ and RNOH/SiO₂ ratios of precursor synthesis gel, crystallization time) on the single gas permeance performance of high silica SSZ-13 zeolite membranes were studied in detail.

Preparation and cathodoluminescence characteristics of rare earth activated BaAlO phosphors.

Undoped and Pr, Sm and Tb activated BaAlO phosphors have been synthesized by solid state reaction method and combustion method. The structure and morphological observation of the phosphor samples were monitored by X-ray powder diffraction (XRD) and environmental scanning electron microscope (ESEM) coupled to an energy dispersive X-ray spectrometer (EDS). The all diffraction peaks are well assigned to standard data card (PDF♯17-306).