Response to dapsone (DDS) monotherapy in leprosy patients of Gudiyatham Taluk, South India: comparison between the 1960s and the 1970s.

At the Schieffelin Leprosy Research and Training Centre, Karagiri, India, 148 lepromatous (LL) and borderline lepromatous (BL) leprosy patients registered for treatment in the years 1971 to 1973 were found to respond as well to dapsone (DDS) monotherapy as 391 LL and BL patients registered in 1964 to 1966, as indicated by clearance of Mycobacterium leprae from skin smears during the initial seven years of therapy in each patient. Apparently, the efficacy of DDS monotherapy has not been progressively diminishing since the introduction of DDS monotherapy into the area.

DDS-resistant infection among leprosy patients in the population of Gudiyatham Taluk, South India. Part 3. Prevalence, incidence, risk factors, and interpretation of mouse foot pad test results.

At the Schieffelin Leprosy Research and Training Centre, Karigiri, India, a study of the population of Gudiyatham Taluk revealed that the prevalence of dapsone (DDS)-resistant infection among lepromatous (LL) and borderline lepromatous (BL) leprosy patients treated for a minimum of three years was 3.3% (33 per 1000), with an average annual incidence of 0.28% per year.

The results of lumbrical replacement by extensor to flexor many tail operation--a retrospective study.

A follow-up study was carried out on sixty one (61) leprosy patients who had extensor to Flexor Many tail surgery at Schieffelin Leprosy Research and Training Centre, Karigiri from 1975 to 1976. After analysing the data, it was noticed that the amount of clawing reduced considerably. Secondly the over all assessment was good for 70% of the hands.

A clinico-pathological study of primary neuritic leprosy.

Normally neural involvement in leprosy is an ascending neuritis from the nerve involvement in the dermal lesions. However, in some cases neural involvement is seen in the absence of any dermal lesions. In some of these pure neuritic cases, dermal lesions appear sometime later.

Effects of fingers of leprosy patients having surgical removal of sublimus tendons.

A retrospective study was carried out by the analysis of 212 charts of leprosy patients attending the Schieffelin Leprosy Research and Training Centre for the period 1964 to 1974. The purpose was to determine what changes were evident in postoperative fingers after their sublimus tendons were surgically removed for some other purposes such as for use as a motor tendon for opponens replacement etc. At the conclusion of the analysis it was found that there were five negative and two positive effects for these fingers.

Prevalence of secondary dapsone resistance in Gudiyattam Taluk, the leprosy control area of the Schieffelin Leprosy Research and Training Centre, Karigiri. 1. Preliminary report.

A preliminary study of the prevalence rate of secondary dapsone resistance among leprosy patients in Gudiyattam Taluk, Tamil Nadu, was undertaken. During the period March 1978 to February 1979, there were 1580 lepromatous and borderline lepromatous patients considered to be at risk of developing secondary resistance. Of them, 1431 were examined clinically, and reactivation and/or relapse was found in 114 patients.