1,171 results match your criteria: "Scheuermann Kyphosis"
Ponte osteotomies for treatment of spinal deformities: they are not all made equal.
Eur Spine J
July 2024
Department of Orthopaedics, Azienda Ospedaliera Universitaria "Luigi Vanvitelli", Università degli Studi della Campania "Luigi Vanvitelli" School of Medicine, Piazza Luigi Miraglia 2, Padiglione 3 Est, 1° Piano, 80138, Naples, Italy.
Article Synopsis
- The study compares surgical outcomes of Ponte's osteotomies in treating adolescent idiopathic scoliosis (AIS), Scheuermann's kyphosis (SK), and adult scoliosis (AdS) in patients who underwent posterior spinal instrumented fusion from 2019 to 2022.
- A total of 80 patients were included, revealing that the average number of osteotomies performed was higher in AIS patients, and SK patients experienced significantly less blood loss and shorter execution time per osteotomy compared to the other groups.
- Results indicate that Ponte's osteotomies are safe and effective across all groups, with no significant differences in complications observed.
Validation of a new method for the radiological measurement of rod curvature in patients with spine deformity.
Spine Deform
November 2024
Spine Surgery Unit 1, Bordeaux University Pellegrin Hospital, Bordeaux, France.
Article Synopsis
- The study investigates the relationship between rod curvature and postoperative outcomes, aiming to provide a validated method for measuring rod curvature using X-rays and a regression algorithm to minimize manual errors.
- Data from 20 adolescent and 35 adult patients with spine deformities were analyzed, involving the marking of rod points on X-rays and applying a polynomial regression to determine rod curvature equations.
- Results show high reliability of the new measurement method, with intra-observer intraclass correlation coefficients exceeding 0.85 and excellent inter-observer reliability (0.98) particularly noted in the adolescent idiopathic scoliosis/Scheuermann kyphosis group.
Flexible posterior vertebral tethering for the management of Scheuermann's kyphosis: correction by using growth modulation-clinical and radiographic outcomes of the first 10 patients with at least 3 years of follow-up.
Eur Spine J
July 2024
Department of Orthopaedic Surgery and Traumatology, Emsey Advanced Spine Surgery Center, Surgical Spine Center of Excellence Certified By EUROSPINE, Emsey Hospital, Çamlık Mahallesi, Selçuklu Caddesi; No:22, Pendik, 34912, Istanbul, Turkey.
Article Synopsis
- The study aimed to evaluate the outcomes of flexible posterior vertebral tethering (PVT) over a minimum of three years in 10 skeletally immature patients with Scheuermann’s kyphosis (SK), questioning its effectiveness as an alternative to spinal fusion.
- Ten patients aged 11 to 15 were monitored for an average of 47.6 months, with PVT showing significant improvements in thoracic kyphosis and overall spinal alignment while maintaining mobility at the tethered vertebrae.
- The findings suggest that flexible PVT can gradually correct kyphosis in growing patients, providing successful clinical results and positioning it as a viable option over traditional fusion methods in treating SK.
Discovery of optimal cell type classification marker genes from single cell RNA sequencing data.
bioRxiv
June 2024
Department of Informatics, J. Craig Venter Institute, La Jolla, CA, United States of America.
Article Synopsis
- The use of single cell RNA sequencing (scRNA-seq) is transforming our knowledge of cell biology, particularly in identifying cell types, understanding disease, and advancing drug development.
- The growth of scRNA-seq data presents challenges in classifying cell types and finding key marker genes, leading to the adoption of machine learning strategies, such as the NS-Forest algorithm.
- NS-Forest v4.0 improves upon earlier versions by efficiently selecting marker gene combinations, introducing a new metric called On-Target Fraction to measure the exclusivity of marker gene expression, and enabling comparisons between user and algorithm-derived marker genes.
Natural Killer Cells Do Not Attenuate a Mouse-Adapted SARS-CoV-2-Induced Disease in Mice.
Viruses
April 2024
Division of Comparative Pathology, Tulane National Primate Research Center, Health Sciences Campus, 18703 Three Rivers Road, Covington, LA 70433, USA.
Article Synopsis
- * MA30-infected C57BL/6 mice showed severe lung inflammation and edema, similar to what severe COVID-19 patients experience, while K18-ACE2 mice had different inflammation patterns.
- * The research highlights the importance of T and B cells for an effective immune response against SARS-CoV-2, as their depletion led to worse infection outcomes, whereas NK cells had a minimal effect during the acute phase.
Health-Related Quality of Life of Patients with Postural Kyphosis Compared to Spinal Deformities in Adolescence: A Cross-Sectional Study.
Turk Neurosurg
May 2024
Health Sciences University, Gulhane School of Medicine, Department of Orthopedics and Traumatology, Ankara, Türkiye.
Article Synopsis
- The study aimed to compare the health-related quality of life (HRQoL) of adolescents with postural kyphosis (PK) to those with adolescent idiopathic scoliosis (AIS) and Scheuermann kyphosis (SK).
- Researchers utilized the Scoliosis Research Society-22 (SRS-22) questionnaire to assess the patients' HRQoL and measured their spinal deformities.
- Findings indicated that while patients with PK reported lower HRQoL overall, they experienced less pain compared to those with AIS and SK, highlighting the need for better awareness and treatment for PK's impact on adolescents.
Application efficacy of multi-segment posterior osteotomy in improving adolescent Scheuermann kyphosis deformity.
Panminerva Med
April 2024
Department of Spine Surgery, Sixth Affiliated Hospital of Jinan University, Dongguan, China -
Vitamin D deficiency in Scheuermann's disease is associated with increased adverse outcomes.
SICOT J
April 2024
Department of Orthopaedic Surgery, Louisiana State University, New Orleans, LA 70112, USA.
Article Synopsis
- Scheuermann's disease is a condition often seen in children that leads to hyperkyphosis, and this study investigates whether vitamin D deficiency affects health outcomes in these patients.
- Using the TriNetX database, researchers analyzed data from 11,277 U.S. patients with Scheuermann's disease, finding that 9.08% had vitamin D deficiency.
- The study revealed that vitamin D deficiency correlated with higher rates of pain, depression, and emergency room visits, while notably showing lower odds for surgical interventions on the spine.
Using Proximal Hooks as a Soft-Landing Strategy to Prevent Proximal Junctional Kyphosis in the Surgical Treatment of Scheuermann's Kyphosis.
Turk Neurosurg
May 2024
Gazi University Faculty of Medicine, Department of Orthopaedics and Traumatology, Ankara, Türkiye.
Article Synopsis
- The study aimed to assess the frequency of proximal junctional kyphosis (PJK) and the outcomes of surgeries for Scheuermann’s Kyphosis (SK) using either only pedicle screws or a mix of hooks and screws.
- Researchers evaluated 37 SK patients retrospectively, dividing them into two groups: one with only pedicle screws (22 patients) and the other with a mix of proximal hooks and pedicle screws (15 patients), tracking their clinical and radiological progress for at least 2 years.
- Results showed no significant differences in overall scores between the two groups; however, the pedicle screws group had larger increases in PJK angles, suggesting that using hooks may help reduce the risk of PJK.
A Novel Surgical Indication for Scheuermann's Kyphosis.
J Am Acad Orthop Surg Glob Res Rev
March 2024
From the The Department of Orthopedic Surgery (Dr. Haselhuhn, Dr. Odland, Dr. Soriano, Dr. Jones, and Dr. Polly), and the The Department of Neurosurgery (Dr. Jones and Dr. Polly), University of Minnesota, Minneapolis, MN.
Article Synopsis
- Scheuermann kyphosis, characterized by a thoracic curvature greater than 70°, can be surgically treated to improve spinal alignment, especially when compensatory lumbar hyperlordosis is insufficient.
- To assess if a patient is at risk for degeneration, doctors compare lumbar lordosis through radiographs in different positions; minimal changes indicate maximum compensation.
- A case study of an adolescent boy with Scheuermann kyphosis illustrates a successful surgical intervention involving spinal fusion and osteotomies, leading to a smooth recovery and return to normal activities after five months.
Distal Junctional Failures in Degenerative Thoracolumbar Hyperkyphosis.
Orthop Surg
April 2024
Department of Orthopedics, Peking University Third Hospital, Beijing, China.
Article Synopsis
- The study investigates Distal Junctional Failures (DJF) in patients with Degenerative Thoracolumbar Hyperkyphosis (DTH) who underwent surgery, aiming to improve surgical decision-making and patient outcomes.
- A total of 78 cases were reviewed, showing significant improvements in health-related quality of life measures and a correction of thoracolumbar kyphosis, despite a DJF occurrence in 16.7% of patients.
- Factors associated with DJF include older age, lower bone density (measured by CT HU), prolonged follow-up duration, increased blood loss during surgery, and poor postoperative outcomes.
Short-Term Risk Factors for Distal Junctional Kyphosis after Spinal Reconstruction Surgery in Patients with Osteoporotic Vertebrae.
Asian Spine J
February 2024
Department of Orthopaedics, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Article Synopsis
- This study examined risk factors for distal junctional kyphosis (DJK) in patients with osteoporosis undergoing spinal reconstruction, focusing on the importance of the sagittal stable vertebra.
- Researchers analyzed data from 46 patients post-surgery, finding that instability in the distal adjacent lower instrumented vertebra (LIV) disc and exclusion of the sagittal stable vertebra from fixation are significant risk factors for developing DJK.
- The findings suggest careful consideration of these factors during surgical planning to potentially reduce the risk of DJK in similar patients.
Coordinating virus research: The Virus Infectious Disease Ontology.
PLoS One
January 2024
Department of Philosophy, University at Buffalo, Buffalo, NY, United States of America.
Article Synopsis
- - The COVID-19 pandemic led to a surge in research focused on the SARS-CoV-2 virus, emphasizing the need for standardized interpretation of data to avoid data silos; ontologies play a crucial role in achieving this consistency.
- - The paper discusses the development of the Virus Infectious Disease Ontology (VIDO) as an extension of the Infectious Disease Ontology (IDO), aiming to provide a structured vocabulary for viral infectious diseases, including a connection to existing ontologies like the Coronavirus Infectious Disease Ontology (CIDO).
- - Future work includes developing reference ontologies for bacterial and fungal infections, with VIDO and CIDO being utilized in various applications such as host-pathogen data analysis, electronic health record
Is sagittal spinopelvic alignment a cause of low back pain in pediatric spine pathologies? A review.
J Child Orthop
December 2023
Department of Spine Disorders and Orthopaedics, Centre of Postgraduate Medical Education, Gruca Orthopaedic and Trauma Teaching Hospital, Otwock, Poland.
Article Synopsis
- The study investigates how changes in spinopelvic structure during growth may affect pain in pediatric spine issues, focusing on conditions like spondylolysis, spondylolisthesis, scoliosis, and kypho.
- A detailed search of literature from 1965 to 2023 was conducted using specific keywords related to these spine conditions and their development in children and adolescents.
- Findings indicate that idiopathic scoliosis shows the most varied sagittal alignment patterns, but overall, sagittal alignment does not correlate with pain in most conditions, highlighting the importance of understanding these mechanisms for diagnosis and treatment.
Management of low back pain accompanying sagittal plane pathologies in children: Spondylolysis/spondylolisthesis and Scheuermann's disease.
J Child Orthop
December 2023
Department of Orthopedics and Traumatology, Hacettepe University Hospitals, Ankara, Turkey.
Background: Low back pain in childhood was underappreciated for a long time, but recent studies report higher prevalences, up to 70%. Two of the common causes are spondylolyis/spondylolisthesis and Scheuermann's disease. These disorders are relevant in a way they both cause significant back pain, and may disrupt the sagittal spinal balance.
View Article and Find Full Text PDFArticle Synopsis
- * A pilot study involved two pigtail macaques infected with SIV (a simian version of HIV), which were exposed to SARS-CoV-2 and monitored to observe clinical disease and viral behavior over six weeks, compared to non-SIV-infected macaques.
- * Despite lacking robust immune responses, the SIV-infected macaques showed similar patterns of viral replication and clearance as non-infected macaques, suggesting that their immunodeficiency didn't affect the progression or evolution of SARS-CoV-2. *
Long-Term Health-Related Quality of Life (QOL) after Paediatric Spinal Deformity Surgery and Comparison with the General Population.
J Clin Med
November 2023
Scottish National Spine Deformity Centre, Royal Hospital for Children and Young People, Edinburgh EH16 4TJ, UK.
QOL questionnaires assess patients' perception on surgical outcomes. We reviewed 1354 patients with spinal deformity. Four hundred and twenty-eight patients had >10 years of follow-up.
View Article and Find Full Text PDFHow to determine the optimal proximal fusion level for Scheuermann kyphosis.
Eur Spine J
March 2024
Department of Orthopedic Surgery, Columbia University/New York-Presbyterian-Spine Hospital, New York, NY, USA.
Article Synopsis
- The study aimed to find the best fusion levels for spinal surgery in patients with Scheuermann kyphosis by analyzing outcomes from 86 patients.
- Out of these patients, 32% developed proximal junctional kyphosis (PJK), yet there were no significant differences in preoperative characteristics between those with and without PJK.
- The research concluded that to minimize PJK and maintain better surgical results, surgeons should position the uppermost instrumented vertebra at T2 or higher, especially in cases where the C7 plumb line to sacrum distance is 50 mm or more.
Article Synopsis
- Cerebral small vessel disease (cSVD) is linked to ischemic stroke and dementia, and this systematic review aims to clarify its relationship with cerebrovascular reactivity (CVR), cerebral autoregulation, and arterial stiffness (AS).
- The review analyzed 142 studies and conducted meta-analyses on 60 of them, revealing that CVR, cerebral autoregulation, and AS were significantly associated with cSVD in a majority of cases.
- The findings indicate a borderline association between impaired CVR and cSVD, and a strong link between increased AS and cSVD, suggesting that further research into these vascular factors as potential risk contributors is necessary.
Development of a molecular marker for the Pi1 gene based on the association of the SNAP protocol with the touch-up gradient amplification method.
J Microbiol Methods
November 2023
Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina, Estação Experimental de Itajaí - Epagri-EEI. C.P. 277, Itajaí, SC CEP 88318-112, Brazil.
Genetic resistance is the most effective and eco-friendly approach to combat rice blast. The application of resistance genes may be facilitated by the availability of molecular markers that allow marker-assisted selection during the breeding process. The Pi1 gene, considered to be a broad-spectrum resistance gene, might contribute to enhancing resistance to rice blast, but it lacks a suitable marker that can be used.
View Article and Find Full Text PDFScheuermann's Disease.
Semin Musculoskelet Radiol
October 2023
Department of Radiology, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, Shropshire, United Kingdom.
Article Synopsis
- - Scheuermann's disease is a condition that leads to progressive curvature of the spine (kyphosis) in adolescents, primarily causing back pain and postural issues.
- - The disease is linked to abnormal growth of the spinal end plates, potentially due to mechanical stress, but its exact causes are not fully understood and are likely influenced by multiple factors.
- - Treatment typically starts with conservative methods like physiotherapy and bracing to manage symptoms and prevent worsening, while surgery is reserved for severe cases or when conservative methods fail.
Real-Time Analysis of SARS-CoV-2-Induced Cytolysis Reveals Distinct Variant-Specific Replication Profiles.
Viruses
September 2023
Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA.
The ability of each new SARS-CoV-2 variant to evade host humoral immunity is the focus of intense research. Each variant may also harbor unique replication capabilities relevant for disease and transmission. Here, we demonstrate a new approach to assessing viral replication kinetics using real-time cell analysis (RTCA).
View Article and Find Full Text PDFA cell-level discriminative neural network model for diagnosis of blood cancers.
Bioinformatics
October 2023
Department of Informatics, J. Craig Venter Institute, La Jolla, CA 92037, United States.
Motivation: Precise identification of cancer cells in patient samples is essential for accurate diagnosis and clinical monitoring but has been a significant challenge in machine learning approaches for cancer precision medicine. In most scenarios, training data are only available with disease annotation at the subject or sample level. Traditional approaches separate the classification process into multiple steps that are optimized independently.
View Article and Find Full Text PDFLong-term outcome after brace treatment of Scheuermann's kyphosis: an observational controlled cohort study.
Eur J Phys Rehabil Med
August 2023
Unit of Orthopedics and Traumatology, Bambino Gesù Children's Hospital, Rome, Italy.
Background: In the literature, there are several papers on Scheuermann's kyphosis. It is a structural deformity of the spine that is characterized by anterior wedging of 5° or more of 3 adjacent thoracic vertebral bodies with kyphosis measuring greater than 45° between T5 and T12. Bracing treatment is able to obtain, during skeletal growth, remodeling of the deformed vertebrae.
View Article and Find Full Text PDFAuthor Correction: SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).
Nat Immunol
October 2023
Institute for Immunology and Immune Health, and Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School Medicine, Philadelphia, PA, USA.