Beyond templates: exploring uncharted territory in anisotropic gold nanostructure-oligomer composites synthesis and electrocatalytic performance towards environmental pollutants.

The synthesis of polymer/oligomer-stabilized metal nanostructures (MNS) opens up a wide range of possibilities, from fundamental materials science to practical applications in domains such as medicine, catalysis, sensing, and energy. Because of the versatility of this synthetic approach, it is a dynamic and ever-changing field of study. These polymers/oligomers have precise control over the nucleation and growth kinetics, allowing the production of mono-disperse MNS with well-defined properties.

Inhibition of Oral Biofilms and Enhancement of Anticancer Activity on Oral Squamous Carcinoma Cells Using Caffeine-Coated Titanium Oxide Nanoparticles.

The fungus Candida albicans is a prominent cariogenic fungal agent that works in association with Streptococcus mutans to accelerate the formation of oral cancer and tooth decay. This study evaluates caffeine-encapsulated titanium oxide nanoparticles (CF-TiO NPs) for their potential to prevent biofilm formation on teeth and enhance oral anticancer treatment by influencing apoptotic gene regulation. The synthesized CF-TiO NPs were characterized using ultraviolet, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Fourier-transform infrared spectroscopy analyses, and their antioxidant activity was confirmed through free radical quenching studies.

Coleus vettiveroides Root Extract Protects Against Thioacetamide-Induced Chronic Liver Injury by Inhibiting NF-κB Signaling Pathway.

The roots of Coleus vettiveroides (CV) have been traditionally used in Indian medicinal systems such as Ayurveda and Siddha for its antioxidant, anti-inflammatory, and antidiabetic effects. This study examines the antifibrotic potential of CV ethanolic root extract (CVERE) against thioacetamide (TAA)-induced liver fibrosis in Wistar rats. TAA was administered via i.

Hydrogel-antimicrobial peptide association: A novel and promising strategy to combat resistant infections.

Infections from multi-drug resistant bacteria (MDRB) have raised a worldwide concern, with projections indicating that fatalities from these infections could surpass those from cancer by 2050. This troubling trend is influenced by several factors, including the scarcity of new antibiotics to tackle challenging infections, the prohibitive costs of last-resort antibiotics, the inappropriate use of antimicrobial agents in agriculture and aquaculture, and the over-prescription of antibiotics in community settings. One promising alternative treatment is the application of antimicrobial peptides (AMPs) against MDRB.

Nano-bio-encapsulation of phyto-vaccines: a breakthrough in targeted cancer immunotherapy.

Nano bio-encapsulation of phyto-vaccines for cancer has marked a cutting-edge strategy that brings together nanotechnology with plant-derived vaccines to enhance cancer therapy. Phyto-vaccines, isolated from bioactive compounds found in plants called protein bodies, have been shown to potentially stimulate the immune system to recognise and destroy cancer cells. However, challenges such as poor stability, rapid degradation, and limited bioavailability in the body have hindered their clinical application.

Enhanced Photocatalytic Degradation of Reactive Dyes Under Visible Light Using ZnO/CdS/Co Nanocomposites: A Step Toward Advanced Environmental Remediation.

In this study, ZnO, CdS, ZnO/CdS, and ZnO/CdS/Co nanostructures were successfully synthesized using a simple chemical precipitation method. The formation of these nanostructures was confirmed through x-ray diffraction (XRD), but their morphological properties were analyzed using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Their optical properties were investigated using UV-visible diffuse reflectance spectroscopy (UV-DRS) and photoluminescence spectroscopy (PL).

AI-powered decision making for road safety optimization under probabilistic linguistic Sugeno-Weber aggregation information.

Traffic accidents, a global concern, pose threats to lives and carry substantial economic and societal burdens. This paper explores the innovative integration of artificial intelligence (AI) into the ambiance of Multi Criteria Decision Making (MCDM) to address the challenge. We investigate AI's potential to enhance road safety globally, utilizing data analysis, predictive modeling, and intelligent traffic management systems.

Bismuth-based nanoparticles and nanocomposites: synthesis and applications.

In the vast landscape of materials science, bismuth emerges as a compelling element with unique properties and diverse applications. Its intriguing characteristics and advancements in nanotechnology have propelled bismuth-based nanoparticles to the forefront of scientific exploration, promising breakthroughs in various disciplines. This comprehensive review explores diverse methods for synthesizing bismuth-based nanoparticles and nanocomposites, ranging from conventional approaches such as hydrothermal and sol-gel to innovative techniques such as microwave-assisted, microemulsion, and green synthesis.

Isolation, structural characterization, and molecular docking studies on the bioactive compound from n-Hexane extract of (L.) DC against the pancreatic cancer target Aurora 2 Kinase.

Objectives: Natural flora historically has played a substantial part in drug development since they serve as active ingredients in medications and templates for the synthesis of novel pharmaceuticals. is a conventionally utilised therapeutic flora in Indian pharmacopoeia. Therefore, the current study is intended to separate, structurally describe and analyse the anti-pancreatic cancer potential of isolated natural bio-constituents from (L.

Interplay between lncRNAs and microrNAs in hypertension.

The interplay between long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in regulating hypertension modulate gene expression through different mechanisms, influencing key physiological and pathological processes. Specifically, interactions between lncRNAs and miRNAs affect various molecular pathways, including the renin-angiotensin-aldosterone system, which plays a critical role in blood pressure regulation. The lncRNA MALAT1 is particularly noted for its role in inflammation and oxidative stress regulation, suggesting potential targets for hypertension treatment and diagnostics.

Is global health truly global? A hashtag analysis of #GlobalHealth disparities on X.

Background: X (Formerly known as Twitter) healthcare hashtags are a popular healthcare informatics and educational tool among medical professionals. #Globalhealth is one such widely used hashtag with extensive engagement. This study analyses #GlobalHealth to understand its pattern, global digital distribution, and other parameters during the COVID-19 pandemic on X.

Etched CoFe Prussian blue analog nanozymes with superior peroxidase activity for colorimetric biosensing of hydrogen peroxide and dopamine.

Nanozymes represent a compelling alternative to natural enzymes due to their exceptional stability and cost-efficiency in diagnostic and therapeutic applications. In this work, a nanozyme etched CoFe Prussian blue analog (etched PBA) was designed and fabricated by a simple approach involving first synthesizing CoFe PBA and then chemical etching. The fabricated etched PBA acts as a peroxidase mimic catalyst.

Exploring the wound healing potential of and formulation: integrating experimental and computational approaches.

Background: Wound healing is a complex biological process involving numerous cellular and molecular events. and flowers have been traditionally used for their medicinal properties, prompting an investigation into their combined effects on wound healing using both and in silico approaches.

Methods: and flowers were processed in a 1:1 ratio using an ethanolic solvent.

Pluronic F-127 coated zinc oxide nanoparticles from : a comprehensive assessment of antibacterial, and anticancer activities.

The study synthesized Pluronic F-127 coated zinc oxide nanoparticles (PF-127ZnO NPs) using leaf extract and evaluated their antibacterial, antioxidant, and anticancer properties using various characterization methods such as UV-Vis, Fourier Transform Infra-Red, Photoluminescence spectroscopy, FESEM, EDAX, TEM, SAED, XRD, and DLS. The disc diffusion technique was used to evaluate the antibacterial properties of synthesized Pluronic F-127 coated zinc oxide nanoparticles against various pathogens and significant anticancer activity was noticed. The study examined the cytotoxicity of PF127ZnO nanoparticles to Hep3B cells .

Development and characterization of polyvinyl alcohol/gelatin/chitosan hydrogel for tissue engineering and wound healing applications using a fish cell line model.

Chitosan-based hydrogels have gained considerable attention in biomedical research due to their inherent biocompatibility, biodegradability, and non-toxicity. When combined with polyvinyl alcohol (PVA), the resulting hydrogels exhibit superior mechanical strength, elasticity, and swelling capacity, making them highly suitable for a range of applications, including wound healing, tissue engineering, and controlled drug delivery. In this study, we synthesized and characterized a novel PVA/gelatin/chitosan (PVA/G/C) hydrogel composite using a series of analytical techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray analysis (EDAX).

Biocontrol toxicity of Trichoderma harzianum (Hypocreales: Hypocreaceae) derived chemical molecules against malarial mosquito Anopheles stephensi with molecular docking studies.

In this study, the crude chemical constituents extracted from Trichoderma harzianum and their toxicity were evaluated against the larvae, pupae, and adults of Anopheles stephensi at 24 and 48 h post-treatment. Additionally, the chemical constituents of the crude extracts were identified using gas chromatography-mass spectrometry (GC-MS) analysis, and their ability to bind with target proteins was confirmed through molecular docking studies. The results clearly demonstrated that the chemical compounds from T.

Comprehensive study of Biginelli's compounds show antibacterial activity against Vibrio parahaemolyticus of two strains: In vitro and computational approaches.

This study addresses the critical challenges faced by global aquatic industries such as overfishing, habitat destruction, pollution, climate change, and unsustainable aquaculture practices. It focuses on developing effective solutions by synthesizing potent inhibitors against Vibrio parahaemolyticus of two strains namely: MTCC-451 (A) and Vp-S14 (B). Biginelli's compounds (B1-4) were identified as promising inhibitors with confirmed antibacterial activity through in silico and in vitro studies.

Undifferentiated Pleomorphic Sarcoma: A Case Report.

Undifferentiated pleomorphic sarcoma (UPS) is an uncommon and aggressive soft tissue tumor primarily affecting older adults, often presenting as a rapidly enlarging, painless mass in the extremities or other deep-seated locations. This case involves a 55-year-old woman who experienced a rapidly progressive and painful swelling in her right thigh following trauma. Imaging studies identified a large, lobulated tumor in the adductor muscles, close to the femur and pubic ramus, with no bone involvement or evidence of distant metastasis.

Study of Subcutaneous Pressure in Lower Limb Cellulitis and its Correlation With Surgical Intervention.

Introduction Cellulitis is a prevalent bacterial skin infection, particularly affecting the lower limbs and often necessitating clinical intervention due to its considerable incidence rate. Factors like venous insufficiency, lymphedema, and recurring episodes increase the risk of relapse, complicating treatment strategies. Although antibiotics and limb elevation are standard care, severe cases may require surgical intervention.

Chemical contaminants and environmental stressors induced teratogenic effect in aquatic ecosystem - A comprehensive review.

Aquatic environments, including marine and freshwater ecosystems, are vital for ecological balance and biodiversity. The rising global demand for aquaculture products necessitates increased production, with intensified aquaculture practices posing significant environmental risks. This review explores the pathways through which chemical pollutants, heavy metals, pharmaceuticals, and environmental stressors induce teratogenic effects in aquatic species.