7,689 results match your criteria: "Saveetha Medical College & Hospital[Affiliation]"

In this study, ZnO, CdS, ZnO/CdS, and ZnO/CdS/Co nanostructures were successfully synthesized using a simple chemical precipitation method. The formation of these nanostructures was confirmed through x-ray diffraction (XRD), but their morphological properties were analyzed using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Their optical properties were investigated using UV-visible diffuse reflectance spectroscopy (UV-DRS) and photoluminescence spectroscopy (PL).

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Detection of Enterococcus faecalis and the red complex bacteria analyzed by the Checkerboard technique for DNA-DNA hybridization in endodontic infections: A systematic review and meta-analysis.

Diagn Microbiol Infect Dis

December 2024

Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia; Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Article Synopsis
  • Endodontic infections include issues like pulp necrosis and abscesses, where identifying harmful bacteria like Enterococcus faecalis and others is crucial for proper diagnosis and treatment.
  • A systematic review analyzed the prevalence of these bacteria using the Checkerboard DNA-DNA hybridization technique across 17 studies, evaluating 620 samples, finding high prevalence rates (74% for E. faecalis, 63% for P. gingivalis, etc.).
  • The presence of these bacteria can hamper endodontic therapy effectiveness and is often linked to recurring infections, making DNA-DNA hybridization a valuable and efficient tool for tailored endodontic treatments.
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Traffic accidents, a global concern, pose threats to lives and carry substantial economic and societal burdens. This paper explores the innovative integration of artificial intelligence (AI) into the ambiance of Multi Criteria Decision Making (MCDM) to address the challenge. We investigate AI's potential to enhance road safety globally, utilizing data analysis, predictive modeling, and intelligent traffic management systems.

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In the vast landscape of materials science, bismuth emerges as a compelling element with unique properties and diverse applications. Its intriguing characteristics and advancements in nanotechnology have propelled bismuth-based nanoparticles to the forefront of scientific exploration, promising breakthroughs in various disciplines. This comprehensive review explores diverse methods for synthesizing bismuth-based nanoparticles and nanocomposites, ranging from conventional approaches such as hydrothermal and sol-gel to innovative techniques such as microwave-assisted, microemulsion, and green synthesis.

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Objectives: Natural flora historically has played a substantial part in drug development since they serve as active ingredients in medications and templates for the synthesis of novel pharmaceuticals. is a conventionally utilised therapeutic flora in Indian pharmacopoeia. Therefore, the current study is intended to separate, structurally describe and analyse the anti-pancreatic cancer potential of isolated natural bio-constituents from (L.

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Liquid mosquito repellent induces toxic effects in zebrafish.

Drug Chem Toxicol

December 2024

Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu, India.

Mosquitoes serve as vectors for life-threatening parasitic diseases, presenting a continuous threat throughout human history. This has resulted in the extensive utilization of various mosquito repellents, including liquid mosquito repellents (LMRs), roll-ons, and topical creams. While these products demonstrate significant efficacy, the toxicological implications associated with their use are not yet fully understood and continue to be a subject of debate.

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Apigenin (APG) is being investigated for its potential in treating different forms of cancer. It can regulate many cellular processes, such as cell proliferation, apoptosis, cell cycle arrest, invasion, metastasis, and autophagy, via controlling multiple cellular signaling pathways. In addition, this chemical demonstrates a significant preference for cancer cells over healthy cells.

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Heterogeneous photocatalysis has been widely explored as a promising solution for dye degradation due to its cost-effectiveness, ease of recovery, and use of green technology. Precisely, iron-doped cadmium sulfide (CdS) exhibits greater efficiency because of its higher charge separation, more electron transfer efficiency, and adsorption under visible region. In this study, two different ratios of iron-doped cadmium sulfide (CdFeS/GO) nanocomposites such as CdFeS/GO and CdFeS/GO were synthesized using the coprecipitation method and characterized with UV-Vis DRS, XRD, FT-IR, Raman, XPS, and HR-TEM.

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The electrocatalytic oxygen and hydrogen evolution reactions (OER and HER) are key processes used in energy storage and conversion. We have developed a highly efficient MnCoO nanostructure anchored with functionalized carbon black (MnCoO/f-CB), which has been characterized by XRD, FT-IR, Raman spectra, FE-SEM, and HR-TEM analyses as robust bifunctional electrocatalysts for both HER and OER. At a characteristic 10 mA cm current density, the MnCoO/f-CB composite ECs exhibit low overpotentials of 330 mV for OER and 360 mV for HER, respectively.

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Interplay between lncRNAs and microrNAs in hypertension.

Hypertens Res

December 2024

Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Tamil Nadu, India.

The interplay between long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in regulating hypertension modulate gene expression through different mechanisms, influencing key physiological and pathological processes. Specifically, interactions between lncRNAs and miRNAs affect various molecular pathways, including the renin-angiotensin-aldosterone system, which plays a critical role in blood pressure regulation. The lncRNA MALAT1 is particularly noted for its role in inflammation and oxidative stress regulation, suggesting potential targets for hypertension treatment and diagnostics.

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Impact of statin therapy on CD40:CD40L signaling: mechanistic insights and therapeutic opportunities.

Pharmacol Rep

February 2025

Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Statins are widely utilized to reduce cholesterol levels, particularly in cardiovascular diseases. They interface with cholesterol synthesis by inhibiting the 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase enzyme. Besides their primary effect, statins demonstrate anti-inflammatory and immune-modulating properties in various diseases, highlighting the pleiotropic effect of these drugs.

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Unlabelled: The emergence of multidrug resistance in pathogenic organisms has caused growing concern, especially among healthcare providers, necessitating the development of new antimicrobial compounds. Resistance to metal nanoparticles is more challenging for any pathogen and thus paved a new avenue of research to formulate a new line of drugs combined with metal nanoparticles to treat microbial resistance. In this present investigation, green synthesised silver (AgNP), gold (AuNP), and platinum (PtNP) nanoparticles using the rind extract of the fruit of Garcinia mangostana L.

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Is global health truly global? A hashtag analysis of #GlobalHealth disparities on X.

Front Public Health

December 2024

Global Remote Research Scholars Program, St. Paul, MN, United States.

Background: X (Formerly known as Twitter) healthcare hashtags are a popular healthcare informatics and educational tool among medical professionals. #Globalhealth is one such widely used hashtag with extensive engagement. This study analyses #GlobalHealth to understand its pattern, global digital distribution, and other parameters during the COVID-19 pandemic on X.

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Unlabelled: We present the chemical synthesis of polyethyleneimine-conjugated silver sulfide nanoparticles (PEI/AS) utilizing an economical solvothermal synthesis method, aimed at developing effective alternative antibacterial agents. The antibacterial efficacy of the synthesized materials, both with and without the application of near-infrared (NIR) laser irradiation, was evaluated in vitro against two distinct clinically relevant multi-drug-resistant (MDR) uropathogenic strains: and . The bactericidal effects induced by NIR light indicate that the PEI/AS nanoparticles possess an efficiency that is five times greater than that of AgS alone.

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This study explores the therapeutic potential of curcumin (CUR) in cancer therapy, specifically examining its targeted transport through folate receptors and its interaction with certain proteins in breast cancer cell lines. We employed molecular docking technique to assess the binding affinities of CUR with proteins 1H1Q, 1UOM, 4JDD, 5U2D and MCF10A normal breast epithelial cell line protein 5UGB. Out of these, the CUR-1H1Q complex exhibited the greatest binding affinity.

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Etched CoFe Prussian blue analog nanozymes with superior peroxidase activity for colorimetric biosensing of hydrogen peroxide and dopamine.

Int J Biol Macromol

February 2025

Centre for Research in Functional Materials (CRFM), JAIN (Deemed-to-be University), Jain Global Campus, Bengaluru 562112, Karnataka, India. Electronic address:

Nanozymes represent a compelling alternative to natural enzymes due to their exceptional stability and cost-efficiency in diagnostic and therapeutic applications. In this work, a nanozyme etched CoFe Prussian blue analog (etched PBA) was designed and fabricated by a simple approach involving first synthesizing CoFe PBA and then chemical etching. The fabricated etched PBA acts as a peroxidase mimic catalyst.

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Exploring the wound healing potential of and formulation: integrating experimental and computational approaches.

J Complement Integr Med

December 2024

Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu.

Background: Wound healing is a complex biological process involving numerous cellular and molecular events. and flowers have been traditionally used for their medicinal properties, prompting an investigation into their combined effects on wound healing using both and in silico approaches.

Methods: and flowers were processed in a 1:1 ratio using an ethanolic solvent.

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This study aimed to investigate the impact of a lubricant derived from trimethylolpropane trioleate on power consumption and surface roughness during high-speed drilling of Al-6061, with the goal of developing an environmentally friendly cutting fluid. The study investigated the impact of additive concentration, spindle speed, and feed rate on energy consumption and surface roughness using a Taguchi L27 orthogonal array. Through analysis of the Taguchi experimental outcomes and single-to-noise ratios, the parameters were ranked accordingly.

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