152 results match your criteria: "Saveetha Institute of Medical and Technical Sciences (SIMATS) (Deemed to be University)[Affiliation]"

Comorbidities related to cardiovascular disease (CVD) and environmental pollution have emerged as serious concerns. The exposome concept underscores the cumulative impact of environmental factors, including climate change, air pollution, chemicals like PFAS, and heavy metals, on cardiovascular health. Chronic exposure to these pollutants contributes to inflammation, oxidative stress, and endothelial dysfunction, further exacerbating the global burden of CVDs.

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TiO-sodium alginate core-shell nanosystem for higher antimicrobial wound healing application.

Int J Biol Macromol

January 2025

Department of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa Vidyapeetham, Coimbatore 641112, India; Functional Materials Laboratory, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore 641112, India.

Wounds that are not properly managed can cause complications. Prompt and proper care is essential, to prevent microbial infection. Growing interest in metal oxide nanoparticles (NPs) for innovative wound treatments targeting healing and microbial infections.

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Bougainvillea glabra-mediated synthesis of Zr₃O and chitosan-coated zirconium oxide nanoparticles: Multifunctional antibacterial and anticancer agents with enhanced biocompatibility.

Int J Biol Macromol

January 2025

Department of Chemistry, Amrita School of Physical Sciences, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India; Functional Materials Laboratory, Amrita School of Engineering, Coimbatore, Amrita Vishwa Vidyapeetham, 641112, India. Electronic address:

The effectiveness and safety of nanomaterials (NMs) are essential for their use in healthcare. This study focuses on creating NPs with multifunctional antibacterial and anticancer properties to combat bacterial infections and cancer disease more effectively than traditional antibiotics. This study investigates the synthesis of ZrO and chitosan (ch) coated zirconium oxide nanoparticles (chZrO NPs) using Bougainvillea glabra (B.

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Signature of collagen alpha-1(x) gene expression in human cancers and their therapeutic implications.

Pathol Res Pract

January 2025

Department of Electric and Electronic Engineering, Dr. M.G.R Educational and Research Institute, Deemed to Be University, Chennai, Tamil Nadu 600 095, India.

Cancers are a class of disorders that entail uncontrollably unwanted cell development with dissemination. One in six fatalities globally is attributed to cancer, a global health issue. The analysis of the entire DNA sequence and how it expresses itself in tumor cells is known as cancer genomics.

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Historically the physiological or pathological loss of tooth structure in situ was deemed to be due to the 'absorption' of tooth structure due to the removal of the inorganic components of dentin and cementum by osteoclastic (dentinoclastic) cellular activity. This nomenclature and the activity that it represented was considered by almost all dental researchers and clinicians in the 1800s and early 1900s. The shift to the concept of 'resorption' occurred in the first half of the 20th century, with clarity emanating from significant research activity on the pathology of osseous structures, origin of osteoclastic cell types, and the function of periodontal ligament cells.

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Barotrauma is a medical condition caused by sudden pressure changes in the body causing damage to multiple parts of the body. However, it is an infrequent occurrence when it comes to Colo-rectal perforation, wherein the trauma occurs due to the insufflation of compressed air through the anus. Several factors influence the outcome of a patient with colonic perforation due to barotrauma such as the severity of the injury, hemodynamic status of the patient, the patient's general health and well-being, the time taken for active medical/ surgical intervention since the injury, aggressive intravenous antibiotics administration to prevent sepsis, post-operative complications like surgical site infection, post-op ileus, anastomotic leak, etc.

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Visual loss following secondary retinitis pigmentosa (RP) is a rare complication of cytotoxic chemotherapy. Few cases of docetaxel- and/or platinum-induced retinal toxicity have been reported. Routine ocular examination of patients undergoing chemotherapy is required for early recognition and intervention of ocular toxicity.

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Ocular toxoplasmosis is the leading cause of infectious retinochoroiditis in both adults and children. It is caused by the obligate intracellular parasite, Toxoplasma gondii. It is a common cause of posterior uveitis and focal retinitis, typically seen in immunocompetent individuals as a primary infection or in immunocompromised individuals as reactivation of latent infection.

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Tamoxifen, an oral medication that blocks estrogen activity, is frequently prescribed for the treatment of advanced breast cancer and as an additional therapy following surgical removal of early stage disease. A 45-year-old female with a history of breast carcinoma treated with tamoxifen presented with sudden onset bilateral visual impairment for 4 days. On ocular examination, the patient exhibited optic disc edema with hyperemia and bilateral anterior pathway defects in visual evoked potentials.

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Targeting Pseudomonas aeruginosa PAO1 pathogenicity: The role of Glycyrrhiza glabra in inhibiting virulence factors and biofilms.

Diagn Microbiol Infect Dis

December 2024

Department of Microbiology, Centre for infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai 600 077, Tamil Nadu, India. Electronic address:

Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen posing serious risks to immunocompromised individuals due to its virulence factors and biofilm formation. This study evaluated the efficacy of methanol extract of Glycyrrhiza glabra (G.

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3-Hydroxybenzoic acid inhibits the virulence attributes and disrupts biofilm production in clinical isolates of Acinetobacter baumannii.

Eur J Clin Microbiol Infect Dis

December 2024

Infection and Inflammation, Department of Biotechnology, School of Integrative Biology, Central University of Tamil Nadu, Thiruvarur, Tamil Nadu, 610 005, India.

Purpose: Acinetobacter baumannii (A. baumannii) is an emerging global public health threat owing to its ability to form biofilms. Here, we evaluated 3-hydroxybenzoic acid (3-HBA), a promising organic compound, for its ability to disrupt biofilm formation and virulence attributes in clinical isolates of A.

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Soil temperature estimation at different depths using machine learning paradigms based on meteorological data.

Environ Monit Assess

December 2024

Department of VLSI Microelectronics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, 602105, Tamil Nadu, India.

Knowledge of soil temperature (ST) is important for analysing environmental conditions and climate change. Moreover, ST is a vital element of soil that impacts crop growth as well as the germination of the seeds. In this study, four machine-learning (ML) paradigms including random forest (RF), radial basis neural network (RBNN), multi-layer perceptron neural network (MLPNN), and co-active neuro-fuzzy inference system (CANFIS) were used for estimation of daily ST at different soil depths (i.

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Etched CoFe Prussian blue analog nanozymes with superior peroxidase activity for colorimetric biosensing of hydrogen peroxide and dopamine.

Int J Biol Macromol

February 2025

Centre for Research in Functional Materials (CRFM), JAIN (Deemed-to-be University), Jain Global Campus, Bengaluru 562112, Karnataka, India. Electronic address:

Nanozymes represent a compelling alternative to natural enzymes due to their exceptional stability and cost-efficiency in diagnostic and therapeutic applications. In this work, a nanozyme etched CoFe Prussian blue analog (etched PBA) was designed and fabricated by a simple approach involving first synthesizing CoFe PBA and then chemical etching. The fabricated etched PBA acts as a peroxidase mimic catalyst.

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Comparison of Modified NeoPutty MTA, Biodentine, and Calcium Hydroxide in Indirect Pulp Therapy in Deciduous Teeth: An Clinical Study.

Int J Clin Pediatr Dent

September 2024

Department of Dental Research, CGHR, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

Background: Pulp capping is a vital dental procedure used to preserve the vitality of teeth affected by deep caries lesions without irreversible pulpitis. The use of modern bioceramic materials has enhanced the predictability of vital pulp therapy (VPT).

Aim: This study aimed to assess the clinical success of Biodentine, modified NeoPutty mineral trioxide aggregate (MTA), and calcium hydroxide (Ca(OH)2) as pulp capping materials for indirect pulp capping in carious primary teeth.

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Assessment of sleep bruxism and its association with sleep quality, stress levels, and dental health in pediatric population: a multifactorial analysis.

Eur Arch Paediatr Dent

December 2024

Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, 600077, Chennai, India.

Article Synopsis
  • - The study aimed to examine the connection between sleep bruxism (unconscious teeth grinding) and factors like sleep quality, stress, and dental health in children aged 6-12.
  • - A total of 384 children participated, with parents providing reports on bruxism, sleep quality, and stress levels; certain children were excluded based on health conditions or lack of consent.
  • - Results indicated that sleep bruxism in children is significantly related to poor sleep quality and higher stress levels, suggesting it may impact their overall dental health.
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Small molecule targeted inhibitor therapies often have several drawbacks, including limited oral bioavailability, quick metabolism, toxic effects that limit dosage, and poor water solubility. This study aims to develop a nanodrug self-delivery system that does not require a carrier by utilizing the self-assembly of camptothecin (CPT) and dihydroartemisinin (DHA). CPT/DHA nanoparticles (NPs) with varying diameters can be synthesized without requiring further carrier materials or chemical modifications by changing the CPT-to-DHA ratio (10:1, 5:1, 2:1, 1:1).

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Microbiome interactions: Acinetobacter baumannii biofilms as a co-factor in oral cancer progression.

World J Microbiol Biotechnol

November 2024

Department of Microbiology, Centre for infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Poonamallee, High Road Chennai, 600 077, Tamil Nadu, India.

Acinetobacter baumannii (A. baumannii) has long been recognized primarily as a hospital-acquired pathogen. However, recent studies have uncovered a potential link between this bacterium and oral cancer, necessitating a deeper exploration of this relationship.

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Letter to the Editor regarding, "An up to thirty-year retrospective study on the success and survival of single unit and splinted implant-supported crowns in a dental school setting".

J Prosthet Dent

November 2024

Assistant Professor, Department of Microbiology, Centre for Infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, Tamil Nadu, India.

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Enhancing microbiome-based biomarkers: challenges and opportunities.

Lancet Microbe

November 2024

Department of Microbiology, Centre for Infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai 600077, India.

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Potential health, environmental implication of microplastics: A review on its detection.

J Contam Hydrol

January 2025

Marwadi University Research Center, Department of Civil Engineering, Faculty of Engineering & Technology, Marwadi University, Gujarat, Rajkot, 360003, India.

Microplastic contamination of terrestrial and aquatic environment has gained immense research attention due to their potential ecotoxicity and biomagnification property when enterer into food chain. Heterogenous nature of microplastics coupled with their ability to combine with other emerging pollutants have increased the severity of this crisis. Existing detection methods often fails to accurately quantify the amount of microplastic components present in environmental and biological samples.

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Article Synopsis
  • Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting synovial joints, often linked to environmental factors and genetics, characterized by both joint and extra-articular symptoms.
  • The review explores the therapeutic potential of natural products in managing arthritis through three methodologies: in-silico analysis identifies molecular targets, in-vivo studies assess safety and effectiveness in reducing inflammation, and in-vitro studies examine cellular interactions and signaling pathways.
  • Overall, the study suggests that natural compounds could serve as valuable adjuncts to traditional RA treatments, highlighting their anti-inflammatory properties and the need for further research to enhance their therapeutic benefits.
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Correspondence to the Editor: Performance of Multimodal Artificial Intelligence Chatbots Evaluated on Clinical Oncology Cases.

Clin Oncol (R Coll Radiol)

January 2025

Department of Microbiology, Centre for Infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, Tamil Nadu, 600077, India.

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Letter to the Editor Regarding the Article "The Impact of COVID-19 on Breast Cancer Care: A Qualitative Analysis of Surgeons' Perspectives".

Clin Breast Cancer

January 2025

Department of Microbiology, Centre for infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, Tamil Nadu, India.

The COVID-19 pandemic exposed significant challenges in breast cancer care including healthcare inequities, limited access to surgeries, and difficulties in delivering virtual care. This letter builds upon the findings from the article "The Impact of COVID-19 on Breast Cancer Care" and proposes innovative solutions to address these challenges. Key suggestions include the use of AI-powered digital platforms for remote monitoring, robotic-assisted surgery for enhanced precision, mobile health applications for marginalized populations, and 3D printing for personalized breast reconstruction.

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Synergistic Interplay of Diet, Gut Microbiota, and Insulin Resistance: Unraveling the Molecular Nexus.

Mol Nutr Food Res

December 2024

Department of Microbiology, Centre for Infectious Diseases, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, Tamil Nadu, 600077, India.

This comprehensive review explores the intricate relationship between gut microbiota, diet, and insulin resistance, emphasizing the novel roles of diet-induced microbial changes in influencing metabolic health. It highlights how diet significantly influences gut microbiota composition, with different dietary patterns fostering diverse microbial communities. These diet-induced changes in the microbiome impact human metabolism by affecting inflammation, energy balance, and insulin sensitivity, particularly through microbial metabolites like short-chain fatty acids (SCFAs).

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