Graph Neural Networks-Based Prediction of Drug Gene Interactions of RTK-VEGF4 Receptor Family in Periodontal Regeneration.

Background: The RTK-VEGF4 receptor family, which includes VEGFR-1, VEGFR-2, and VEGFR-3, plays a crucial role in tissue regeneration by promoting angiogenesis, the formation of new blood vessels, and recruiting stem cells and immune cells. Machine learning, particularly graph neural networks (GNNs), has shown high accuracy in predicting these interactions. This study aims to predict drug-gene interactions of the RTK-VEGF4 receptor family in periodontal regeneration using graph neural networks.

Green Synthesis of ZnO Nanoparticles Using Ficus benghalensis for Visible Light-Driven Photocatalytic Degradation of Crystal Violet and Antibacterial and Antibiofilm Activities.

Crystal Violet (CV) is a vibrant and harmful dye known for its toxicity to aquatic life and potential carcinogenic effects on humans. This study explores the removal of CV through photocatalysis driven by visible light, as well as examining the antibacterial and antibiofilm characteristics of zinc oxide nanoparticles (ZnO NPs) synthesized from the aerial roots of Ficus benghalensis. Various characterization techniques were employed to confirm the optical properties, crystal lattices, and morphology of ZnO NPs.

Utilization of refuse-derived fuel in industrial applications: Insights from Uttar Pradesh, India.

Urbanization and population growth in India have quickened, leading to an annual generation of around 62 million tonnes of municipal solid waste (MSW). Improper management of organic waste presents a major environmental problem due to air and water pollution, soil contamination and greenhouse gas production. This research aims to develop refuse-derived fuel (RDF) as a viable option, converting waste into a high-calorific energy carrier for industrial use.

Membrana preformativa: Unveiling the unexplored facets of dental development.

Aim: Odontogenesis is a complex and highly regulated biological process that involves a range of molecular mechanisms. Among these, Ki67 and Cyclin D1 are crucial cell cycle regulators that play pivotal roles in controlling cell proliferation during tooth development. This study aims to provide detailed insights into the expression patterns and functional significance of Ki67 and Cyclin D1 in tooth development.

Microplastic pollution in the marine environment: Distribution factors and mitigation strategies in different oceans.

As the COVID-19 pandemic began in 2020, plastic usage spiked, and microplastic (MP) generation has increased dramatically. It is documented that MP can transfer from the source to the ocean environment where they accumulate as the destination. Therefore, it is essential to understand their transferring pathways and effective environmental factors to determine the distribution of MPs in the marine environment.

Targeting necroptosis in MCF-7 breast cancer cells: In Silico insights into 8,12-dimethoxysanguinarine from Eomecon Chionantha through molecular docking, dynamics, DFT, and MEP studies.

Breast cancer remains a significant challenge in oncology, highlighting the need for alternative therapeutic strategies that target necroptosis to overcome resistance to conventional therapies. Recent investigations into natural compounds have identified 8,12-dimethoxysanguinarine (SG-A) from Eomecon chionantha as a potential necroptosis inducer. This study presents the first computational exploration of SG-A interactions with key necroptotic proteins-RIPK1, RIPK3, and MLKL-through molecular docking, molecular dynamics (MD), density functional theory (DFT), and molecular electrostatic potential (MEP) analyses.

Practices and preferences in the use of magnification among endodontists and restorative dentists: A multicentre study.

Background And Objectives: Aim of the current study was to assess the perception, preference, and practice of endodontists and restorative dentists at different locations around the world about dental magnification instruments.

Materials And Methods: A multicenter, cross-sectional study was ethically approved from the local committee of bioethics. After thorough literature search, a questionnaire was designed and validated.

Investigation of electrochromic performances of multicolor VO devices fabricated at low processing temperature.

In recent decades, poorly insulated windows have increased the energy consumption of heating and cooling systems, thus contributing to excessive carbon dioxide emissions and other related pollution issues. From this perspective, the electrochromic (EC) windows could be a tangible solution as the indoor conditions are highly controllable by these smart devices even at a low applied voltage. Literally, vanadium pentoxide (VO) is a renowned candidate for the EC application due to its multicolor appearance and substantial lithium insertion capacity.

Evaluating the feasibility of estimating particulate mass emissions of older-model diesel vehicle using smoke opacity measurements.

Real-world emissions of particulate matter (PM) and smoke opacity were studied for an older-model diesel pickup truck during four types of driving tests, namely fixed-point test, snap-acceleration test, road test, and hill road test (uphill/downhill). A portable emissions measurement system (PEMS) and an opacimeter were used to measure real-time concentrations of PM and smoke opacity, respectively, and simultaneously. Correlation analysis showed a significant positive association between PM and opacity, suggesting the feasibility of using an opacimeter to estimate PM mass emissions from diesel vehicles.

Navigating green synthesized metal-based nanoparticles as anti-inflammatory agent - Comprehensive review.

The biosynthesis of nanomaterials is a vast and expanding field of study due to their applications in a variety of fields, particularly the pharmaceutical and biomedical fields. Various synthetic routes, including physical and chemical methods, have been developed in order to generate metal nanoparticles (NPs) with definite shapes and sizes. In this review, focused on the recent advancements in the green synthetic methods for the generation of silver, zinc and copper NPs with simple and eco-friendly approaches and the potential of the biosynthesized metal and metal oxide NPs as alternative and therapeutic agent for the treatment of inflammatory diseases.

Inhibition of Oral Biofilms and Enhancement of Anticancer Activity on Oral Squamous Carcinoma Cells Using Caffeine-Coated Titanium Oxide Nanoparticles.

The fungus Candida albicans is a prominent cariogenic fungal agent that works in association with Streptococcus mutans to accelerate the formation of oral cancer and tooth decay. This study evaluates caffeine-encapsulated titanium oxide nanoparticles (CF-TiO NPs) for their potential to prevent biofilm formation on teeth and enhance oral anticancer treatment by influencing apoptotic gene regulation. The synthesized CF-TiO NPs were characterized using ultraviolet, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and Fourier-transform infrared spectroscopy analyses, and their antioxidant activity was confirmed through free radical quenching studies.

Ecofriendly Synthesis of Nickel Oxide Nanoparticles From Fissidens Species and Its Biological Applications.

The present study was performed to synthesize eco-friendly nickel oxide nanoparticles (NiONPs) from the aqueous extract of Fissidens species (FS) and explore its biological activities. Phytochemicals, namely, alkaloids, flavonoids, sterols, tannins, proteins, carbohydrates and phenols, were present in the aqueous extract of Fissidens sp. The UV-Vis and FT-IR analyses of FS-NiONPs revealed a prominent peak at 392 nm, along with functional groups that facilitate the formation of FS-NiONPs.

The role of combined problem-based learning (PBL) and case-based learning (CBL) teaching methodologies in dental education.

Background: Innovative methods of teaching such as problem-based learning (PBL) and case-based learning (CBL) have shown promising results in academic understanding and application and enable one to manage their patients in a better manner. The study aimed to analyze the role of a combination of PBL and CBL teaching methodologies in a dental teaching institute in India.

Materials And Methods: This prospective, cross-sectional randomized study comprised 500 students divided into two study groups, each consisting of 250 participants.

An unusual surgical complication: Slipped molar lodged in vocal cords and its anesthetic management.

Background: Extraction of wisdom tooth is one of the most common surgical interventions, as it is more prone for impaction. Due to the pain and anxiety associated with the procedure, it is common to do this procedure under conscious sedation. However unexpected events do occur during the procedure and one such complication along with the prompt management is discussed here.

Enhanced Photocatalytic Degradation of Reactive Dyes Under Visible Light Using ZnO/CdS/Co Nanocomposites: A Step Toward Advanced Environmental Remediation.

In this study, ZnO, CdS, ZnO/CdS, and ZnO/CdS/Co nanostructures were successfully synthesized using a simple chemical precipitation method. The formation of these nanostructures was confirmed through x-ray diffraction (XRD), but their morphological properties were analyzed using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Their optical properties were investigated using UV-visible diffuse reflectance spectroscopy (UV-DRS) and photoluminescence spectroscopy (PL).

MnCoO Nanostructure Anchored on Functionalized Carbon Black for the Enhanced Bifunctional Electrocatalytic Performance of OER and HER.

The electrocatalytic oxygen and hydrogen evolution reactions (OER and HER) are key processes used in energy storage and conversion. We have developed a highly efficient MnCoO nanostructure anchored with functionalized carbon black (MnCoO/f-CB), which has been characterized by XRD, FT-IR, Raman spectra, FE-SEM, and HR-TEM analyses as robust bifunctional electrocatalysts for both HER and OER. At a characteristic 10 mA cm current density, the MnCoO/f-CB composite ECs exhibit low overpotentials of 330 mV for OER and 360 mV for HER, respectively.