4 results match your criteria: "Save Sight Institute University of Sydney[Affiliation]"
A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: Successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber's hereditary optic neuropathy.
Clin Case Rep
July 2024
Department of Medical Oncology Chris O'Brien Lifehouse Sydney New South Wales Australia.
We report on the successful use of chemotherapy for treatment of stage 2B testicular seminoma in a carrier of the Leber's hereditary optic neuropathy 11778 mitochondrial mutation. Neurotoxic chemotherapy may not prompt disease conversion.
View Article and Find Full Text PDFArticle Synopsis
- Updated data on chronic respiratory diseases (CRDs) are essential for preventing and controlling these conditions as part of achieving the UN's goal of reducing premature mortality from non-communicable diseases by 2030.
- From 1990 to 2019, global, regional, and national estimates were analyzed for various CRDs, including COPD and asthma, to assess their impact on mortality, disability, and overall prevalence.
- In 2019, CRDs resulted in 4 million deaths and 454.6 million cases worldwide, with conditions like COPD being the leading cause of death among CRDs, despite a decline in age-standardized rates for most diseases over the period analyzed.
Objective: There is currently an urgent need for reliable clinical biomarkers of remyelination to be used in Phase 2 and Phase 3 clinical trials. Low contrast visual acuity (LCVA) has been suggested as a functional measure of the integrity of the visual pathway. Therefore, the aim of this study was to elucidate the potential contribution of axonal loss and demyelination to LCVA loss in MS patients.
View Article and Find Full Text PDFAtypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.
Invest Ophthalmol Vis Sci
June 2015
Save Sight Institute University of Sydney, Sydney, New South Wales, Australia.
Purpose: The Fat family of atypical cadherins, originally identified in Drosophila, play diverse roles during embryogenesis and adult tissue maintenance. Among four mammalian members, Fat1 is essential for kidney and muscle organization, and is also essential for eye development; Fat1 knockout causes partial penetrant microphthalmia or anophthalmia. To account for the partial penetrance of the Fat1 phenotype, involvement of Fat4 in eye development was assessed.
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