Design, Synthesis, Biocompatibility, molecular docking and molecular dynamics studies of novel Benzo[b]thiophene-2-carbaldehyde derivatives targeting human IgM Fc Domains.

In this study, three novel derivatives of benzo[b]thiophene-2-carbaldehyde (BTAP1, BTAP2, and BTAP3) were successfully synthesized and comprehensively characterized using spectroscopic techniques including FTIR, UV-VIS, HNMR, and CNMR. Thermal analysis through TGA and DTA demonstrated remarkable thermal stability with a maximum threshold at 270 °C. Spectroscopic investigations revealed π → π* transitions in all compounds, attributed to the conjugated system comprising benzothiophene rings connected to bromophenyl/ aminophenyl/phenol rings via α, β-unsaturated ketone bridges.

Street-scale black carbon modelling over the West Midlands, United Kingdom: Sensitivity test of traffic emission factor adjustments.

Black carbon is harmful for climate, environment, and human health. Road traffic is one of the major sources for black carbon in urban areas. This study develops a street scale air quality model configuration for the dispersion of black carbon concentrations across the West Midlands, UK, incorporating updated road traffic emission factors.

Formulation and biological evaluation of sodium alginate-based films blended with watercress oil: A Promising solution for combating foodborne pathogens and potential food packaging applications.

The main objective of this study is to prepare sodium alginate (SA)-based biofilms incorporated with watercress oil (WCO) as an antimicrobial material for sustainable food packaging. The physicochemical, antioxidant, and antibacterial properties of the prepared bio-based films were investigated. The antioxidant activity showed a remarkable increase, with DPPH inhibition increasing from 13.

Unveiling the interplay between knowledge, self-efficacy, and pro-environmental behavior about climate change in a sample of rural community-dwelling older adults: A national correlational study.

Background: Climate change is a global health concern that affects all of humanity, but it disproportionately impacts older adults, particularly those living in rural communities. Older adults lack the ability to actively engage in pro-environmental actions aimed at adapting to and mitigating the harmful effects of climate change.

Aim: To investigate the relationship between knowledge, self-efficacy, and pro-environmental behavior regarding climate change, as well as to identify the factors that predict pro-environmental behavior in a sample of rural community-dwelling older adults.

Spectrophotometric and computational characterization of charge transfer complex of selumetinib with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and its utilization in developing an innovative green and high throughput microwell assay for analysis of bulk form and pharmaceutical formulation.

For paediatric patients suffering from neurofibromatosis, Selumetinib (SEL) is the only approved drug. Here an original ecofriendly and high pace method is introduced using 96- microwell spectrophotometric assay (MW-SPA) to measure SEL content in bulk and commercial pharmaceutical formulation (Koselugo capsules). This assay was relied on in-microwell formation of a coloured charge transfer complex (CTC) upon interaction of SEL with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).

The efficacy of novel biomarkers for the early detection and management of acute kidney injury: A systematic review.

Acute kidney injury (AKI) is a frequent clinical complication lacking early diagnostic tests and effective treatments. Novel biomarkers have shown promise for enabling earlier detection, risk stratification, and guiding management of AKI. We conducted a systematic review to synthesize evidence on the efficacy of novel biomarkers for AKI detection and management.

From preparation to success: assessing the effectiveness of Saudi Pharmacists Licensure Examination (SPLE) preparation strategies in Saudi Arabia.

Aim: This study aimed to identify the most commonly used tools by recent pharmacy graduates who successfully passed the Saudi Pharmacists Licensure Examination (SPLE). It also sought to evaluate which tools were perceived as the most useful and representative of the exam content, while considering their monetary value and offering recommendations for future candidates.

Methods: A cross-sectional design was used, involving licensed pharmacists who graduated in 2019 or later and had successfully passed the SPLE.

Nephrotoxic effect of cypermethrin ameliorated by nanocurcumin through antioxidative mechanism.

Cypermethrin is a pyrethroid showing nephrotoxicity by generating ROS-impaired oxidative stress and changes in inflammatory and apoptotic markers. The harmful consequences are intended to be mitigated by the imbalance between oxidants and antioxidants. The anti-inflammatory and antioxidant possessions of nanocurcumin (NC) with improved bioavailability ameliorate Cyp toxicity in rat kidneys.

The protective efficacy of omega-3 polyunsaturated fatty acids on oxidative stress, inflammation, neurotransmitter perturbations, and apoptosis induced by monosodium glutamate in the brain of male rats.

Exaggerated neuronal excitation by glutamate is a well-known cause of excitotoxicity, a key factor in numerous neurodegenerative disorders. This study examined the neurotoxic effect of monosodium glutamate (MSG) in the brain cortex of rats and focused on assessing the potential neuroprotective effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). Four groups of adult male rats (n = 10) were assigned as follows; normal control, ω-3 PUFAs (400 mg/kg) alone, MSG (4 mg/g) alone, and MSG plus ω-3 PUFAs (4 mg/g MSG plus 400 mg/kg ω-3 PUFAs).

Prioritizing questions and topics for the development of guidelines and consensus-based recommendations supported by ILAE: A scoping review and proposal of prioritization criteria.

Clinical practice guidelines (CPGs) and consensus-based recommendations (CBRs) require considerable effort, collaboration, and time-all within the constraints of finite resources. Professional societies, such as the International League Against Epilepsy (ILAE), must prioritize what topics and questions to address. Implementing evidence-based care remains a crucial challenge in clinical practice.

Fine-Tuning NIR-Absorbing BODIPYs for Photoacoustic Detection of Hypochlorous Ion (OCl⁻).

Highly reactive oxygen and nitrogen species (ROS/RNS) play crucial roles in various pathological conditions. Among them, hypochlorous ion (OCl⁻), a potent ROS, is associated in numerous oxidative stress-related disorders. Elevated levels of OCl⁻ are thus recognized as a biomarker for diagnosing inflammatory conditions.

Exploring Pyridine-Based Schemes: A Comprehensive Review on their Synthesis and Therapeutic Applications.

Pyridine and its derivatives are six-membered aromatic rings containing nitrogen, which are abundant in nature and indispensable in studying heterocyclic chemistry. They constitute significant chemical substances with numerous applications. The application of pyridine derivatives by incorporating metals in modern medicine is growing in relevance.

Antileishmanial and Antitrypanosomal Trends of Synthetic Tetralone Derivatives.

Leishmaniasis and trypanosomiasis are parasitic diseases that are closely linked to poverty, pose significant local burdens, and are common in tropical and subtropical regions. Various synthetic tetralone derivatives were studied as potential scaffolds for antileishmanial and antitrypanosomal activities. The compounds were studied for their effectiveness against multiple kinetoplastid protozoan pathogens: Leishmania major, Leishmania mexicana, and bloodstream trypomastigotes of Trypanosoma brucei brucei.

Abnormalities in Blood Parameters in Athletes Taking Anabolic Androgenic Steroidal Agents; an Observational Clinical Study.

Background: Many studies indicate that high and multiple doses of anabolic-androgenic steroids (AAS) for athletic enhancement can result in serious and irreversible adverse effects. A study that includes laboratory blood testing to evaluate the direct effects of AAS agents among users has not been previously undertaken. The purpose of this study was to investigate the adverse effects of the use of AAS by athletes and to determine whether AAS use leads to changes in certain blood parameters.

Patterns and Outcomes of Acute Poisoning Among Children Presenting to Emergency Department in AlAhsa, Saudi Arabia.

Introduction Acute poisoning in children is still a global health concern that necessitates visiting the emergency department that might associated with morbidity and mortality. It has an impact on social, economic, and health issues, particularly for children under five who account for the majority of poisonings worldwide. Poisoning can result in mild cases, serious complications, or even death; oral ingestion is the most common way that poisoning occurs in children.

Preparation and pharmacokinetic evaluation of a sertraline-methylpropyphenazone prodrug: a comparative metabolic study on the plasma and brain tissues of rats using LC-MS/MS analysis.

A mutual prodrug of sertraline-methylpropyphenazone (SER-MP) was prepared and characterized using a spectral method. The yield of the prepared SER-MP was 90%, and its purity reached 98.8%.

Influence of variation in indium concentration and temperature on the threshold current density in In Ga As/GaAs QD laser diodes.

The influence of variations in indium concentration and temperature on threshold current density (J) in In Ga As/GaAs ( = 0, 0.8 and 0.16) quantum dot (QD) laser diodes - synthesized via molecular beam epitaxy (MBE) with three distinct indium concentrations on GaAs (001) substrates - was meticulously examined.

Challenges in Diagnosing Advanced Abdominal Ectopic Pregnancy in Low-Resource Settings: A Case from North Western Nigeria.

Abdominal ectopic pregnancy is a rare type of ectopic pregnancy associated with high maternal and perinatal mortality. We present a case of a 28-year-old now primipara who was misdiagnosed to have abruptio placentae and ruptured uterus on two different occasions from a primary health care center but was found to have an advanced abdominal ectopic gestation at 21 weeks gestational age. The patient was managed by exploratory laparotomy and is currently doing well.

BCOR abnormalities in endometrial stromal sarcoma.

Endometrial stromal tumors (ESTs) are uncommon mesenchymal tumors of the reproductive system associated with heterogeneous histomolecular features. According to the World Health Organization (WHO), ESTs are classified into benign endometrial stromal nodules (BESN) and endometrial stromal sarcomas (ESSs), which are further divided into low-grade and high-grade subtypes. High-grade ESS is frequently associated with YWHAE-NUTM2 gene fusions, while a newly recognized subtype with BCOR rearrangements, including fusions, alterations, and internal tandem duplications (ITDs), has recently been incorporated into the molecular classification of ESS.

Kinematic and muscle co-activation patterns in the dominant arm across forehand stroke phases in wheelchair tennis.

Objective: This study investigated upper limb kinematics and muscle co-activation in wheelchair tennis players during the forehand stroke. By analyzing linear and angular kinematic variables alongside muscle co-activation patterns, the study aimed to provide insights into the biomechanical mechanisms supporting forehand stroke performance.

Method: Fifteen professional male wheelchair tennis players (height: 163.

Health-promoting activities among Saudi Arabian parents of children with disabilities: A cross-sectional study.

Background: Engaging in health-promoting activities is crucial for maintaining overall well-being. However, parents of children with disabilities often face unique challenges that can impact their ability to engage in such activities. These challenges may include increased caregiving responsibilities, limited access to resources, and emotional and physical burdens, which may hinder their involvement in health-promoting behaviors.

Parental Acceptance of Moderate Sedation and Associated Techniques for Behavior Management in Saudi Arabia: A Cross-Sectional Study.

Purpose: This study aimed to evaluate the acceptance of moderate sedation (MS) as a behavior guidance technique (BGT) method among Saudi parents, and also assess their acceptance of other BGTs, including parental separation, papoose board (PB), and nitrous oxide (NO), used in conjunction with MS.

Patients And Methods: This cross-sectional study was conducted at the Dental University Hospital, King Saud University, Riyadh, Saudi Arabia. It involved Saudi parents of children aged 3-5 years undergoing dental treatment with MS, alongside additional BGTs such as parental separation, PB, and NO.

Intelligent Standalone Eye Blinking Monitoring System for Computer Users.

: Working on computers for long hours has become a regular task for millions of people around the world. This has led to the increase of eye and vision issues related to prolonged computer use, known as computer vision syndrome (CVS). A main contributor to CVS caused by dry eyes is the reduction of blinking rates.

Mathematical model and stability of SWCNT- and MWCNT-based nanofluid flow with thermal and chemically reactive effects inside a porous vertical cone.

This study investigates the significance of single-walled (SWCNTs) and multi-walled (MWCNTs) carbon nanotubes with a convectional fluid (water) over a vertical cone under the influences of chemical reaction, magnetic field, thermal radiation and saturated porous media. The impact of heat sources is also examined. Based on the flow assumptions, the fundamental flow equations are modeled as partial differential equations (PDEs).