Natural compounds as modulators of miRNAs: a new frontier in bladder cancer treatment.

Bladder cancer (BC) is a major global health issue with a high recurrence rate and limited effective treatments. Over the past few years, it has become evident that miRNAs play a role in the carcinogenesis process, particularly in regulating genes that promote cancer cell proliferation and invasion. This review focuses on the extent to which natural products can act as potential miRNA modulators for the management of bladder cancer.

Utility of MRI in NMIBC and feasibility of avoiding Re-TURB in carefully selected patients: a systematic review.

Objective: This systematic review was conducted to synthesize current research on the role of repeated transurethral resection of the bladder (re-TURB) and the emerging use of magnetic resonance imaging (MRI) in discerning patient suitability for safely foregoing this procedure.

Evidence Acquisition: Employing a methodical literature search, we consulted several bibliographic databases including PubMed, Science Direct, Scopus, and Embase. The review process adhered strictly to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines.

Transcriptomic analysis reveals potential roles of polyamine and proline metabolism in waterlogged peach roots inoculated with Funneliformis mosseae and Serendipita indica.

Root-associated endophytic fungi can create symbiotic relationships with trees to enhance stress tolerance, but the underlying mechanisms, especially with regard to waterlogging tolerance, remain unclear. This study aimed to elucidate the effects of Funneliformis mosseae and Serendipita indica on the growth, root cross-section structure, and root transcriptional responses of peach under waterlogging stress, with a focus on polyamine and proline metabolism. Genes and transcription factors associated with secondary cell wall biosynthesis were selected, and their expression profiles were analyzed.

Validation of a Pretransplant Risk Prediction Model for Early Allograft Dysfunction After Living-donor Liver Transplantation.

Background: Early allograft dysfunction (EAD) affects outcomes in liver transplantation (LT). Existing risk models developed for deceased-donor LT depend on posttransplant factors and fall short in living-donor LT (LDLT), where pretransplant evaluations are crucial for preventing EAD and justifying the donor's risks.

Methods: This retrospective study analyzed data from 2944 adult patients who underwent LDLT at 17 centers between 2016 and 2020.

Wastewater biotreatment and bioaugmentation for remediation of contaminated sites at an oil recycling plant.

This work focused on the biotreatment of wastewater and contaminated soil in a used oil recycling plant located in Bizerte. A continuous stirred tank reactor (CSTR) and a trickling filter (TF) were used to treat stripped and collected wastewater, respectively. The CSTR was started up and stabilized for 90 days.

Parental knowledge, awareness, and attitudes towards children's oral habits: a descriptive cross-sectional study.

Background: Oral health is fundamental to children's health and well-being. Parental knowledge, awareness, and practices towards oral habits significantly influence children's oral health. Early diagnosis and intervention to break abnormal oral habits are vital to prevent long-term detrimental effects on oral and facial development.

Wastewater microbiology: occurrence and prevalence of antibiotic-resistant extended-spectrum -lactamase-producing Enterobacteriaceae in the district wastewater system.

Extended spectrum -lactamase (ESBL)-producing Enterobacteriaceae, including and , pose a serious risk to human health because of antibiotic resistance. Wastewater serves as a reservoir for these bacteria, contributing to the evolution and transmission of antibiotic-resistant strains. The research aims to identify ESBL bacterium in wastewater samples from District Kohat.

Geochemical assessment of groundwater quality using Nemerov's pollution index: a micro-level study in the groundwater critical zone of western Rajasthan, India.

The pollution index is a helpful tool for assessing the quality of groundwater. To assess the water quality in the southern segment of Barmer District (Rajasthan), India, we collected 20 samples of groundwater from the post-monsoon 2021 and pre-monsoon 2022 periods. Physicochemical parameters such as pH, electrical conductivity (EC), total hardness, Cl, SO, F, NO, total dissolved solids, Ca, and Mg were analyzed.

Ventral Rectopexy: An International Expert Panel Consensus and Review of Contemporary Literature.

Background: Ventral rectopexy has become increasingly utilized in the surgical management of rectal prolapse. There is a need for a contemporary evaluation of the role of the procedure and description of its use in clinical practice.

Objective: To create an international consensus on ventral rectopexy.

Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis, activity and computational studies.

Background: Due to the divers biological applications of Cu(II) complexes, we in this study reports the various Cu(II) complexes. The study aims to synthesize and assess new Cu(II) complexes as powerful β-glucuronidase inhibitors.

Methods: Five Schiff base ligands and their complexes were synthesized, characterized, and screened against β-glucuronidase inhibitory activity.

Patent ductus arteriosus closure in infants weighing less than 1500 g via a tiny microcatheter: a simple technique with zero-contrast exposure.

Background: Despite patent ductus arteriosus closure in premature infants is a relatively fast procedure, it involves specific steps for equipment exchange and the use of a 4-Fr catheter, which may be large for tiny infants, potentially causing haemodynamic instability or tricuspid valve regurgitation.

Objectives: This study aims to describe the early experience with a new technique designed to simplify transcatheter patent ductus arteriosus closure in premature infants. It enables the closure using the KA micro plug device via a single microcatheter without equipment exchanges and contrast exposure.

On some integral inequalities of Grüss type involving the generalized fractional Saigo -integral operator.

Using the generalized Saigo fractional integral operator, the authors of this study prove several novel fractional integral inequalities of the Grüss type. By fixing the values of functions, specific situations derived from previously established findings are shown. The ultimate purpose of this work is to investigate the Grüss-type integral inequalities with the Saigo -integral operator, a more generalized integral operator.

Large annotated ultrasound dataset of non-alcoholic fatty liver from Saudi hospitals for analysis and applications.

This study presents a comprehensive ultrasound image dataset for Non-Alcoholic Fatty Liver Disease (NAFLD), addressing the critical need for standardized resources in AI-assisted diagnosis. The dataset comprises 10,352 high-resolution ultrasound images from 384 patients collected at King Saud University Medical City and National Guard Health Affairs in Saudi Arabia. Each image is meticulously annotated with NAFLD Activity Score (NAS) fibrosis staging and steatosis grading based on corresponding liver biopsy results.

A cross-sectional study of parental perspectives on children about COVID-19 and classification using machine learning models.

Background And Objective: This study delves into the parenting cognition perspectives on COVID-19 in children, exploring symptoms, transmission modes, and protective measures. It aims to correlate these perspectives with sociodemographic factors and employ advanced machine-learning techniques for comprehensive analysis.

Method: Data collection involved a semi-structured questionnaire covering parental knowledge and attitude on COVID-19 symptoms, transmission, protective measures, and government satisfaction.

Biophysics-guided uncertainty-aware deep learning uncovers high-affinity plastic-binding peptides.

Plastic pollution, particularly microplastics (MPs), poses a significant global threat to ecosystems and human health, necessitating innovative remediation strategies. Biocompatible and biodegradable plastic-binding peptides (PBPs) offer a potential solution through targeted adsorption and subsequent MP detection or removal from the environment. A challenge in discovering plastic-binding peptides is the vast combinatorial space of possible peptides (, over 10 for 12-mer peptides), which far exceeds the sample sizes typically reachable by experiments or biophysics-based computational methods.

The Knowledge, Attitudes, and Practices of Emergency Department Staff to Preparedness of Disaster and Emergency in Saudi Arabia: Multicenter Cross-sectional Study.

Aim: Disasters worldwide are increasing, impacting millions annually. In Saudi Arabia, disaster planning is crucial for emergency department (ED) staff, who must be trained in disaster management plans and operational strategies to handle disasters such as epidemics and Hajj overcrowding.

Methodology: A cross-sectional study targeting ED staff in 92 hospitals all over Saudi Arabia.

Comparison of Medical Students' Peer Evaluation and Teaching Staff Evaluation of Community Health Projects: Perceptions and Experiences.

Background: Public health education increasingly emphasizes experiential learning and community engagement. Peer review complements traditional staff evaluation, enhancing learning outcomes and refining teaching strategies. This study aims to investigate the perceptions and experiences of medical students with peer evaluation of community health projects.

Effect of polishing on the morphology of Zircaloy-4 nanostructure: formation of a novel hexagonal nanoscale pattern.

Zircaloy-4 (Zr-4) is widely used as the cladding material in nuclear power plants (NPPs) due to its excellent corrosion resistance and low neutron absorption cross-section. Under Loss of Coolant Accident (LOCA) conditions, oxidation of Zr-4 can compromise the safety of the NPPs by accelerating hydrogen production. Therefore, enhancing the oxidation resistance of Zr-4 is a critical research focus.

CD44-Receptors-Mediated Multiprong Targeting Strategy Against Breast Cancer and Tumor-Associated Macrophages: Design, Optimization, Characterization, and Cytologic Evaluation.

Introduction: Owing to its high prevalence, colossal potential of chemoresistance, metastasis, and relapse, breast cancer (BC) is the second leading cause of cancer-related fatalities in women. Several treatments (eg, chemotherapy, surgery, radiations, hormonal therapy, etc.) are conventionally prescribed for the treatment of BC; however, these are associated with serious systemic aftermaths.

The Creation of the Arabic Version of the Hyperhidrosis Quality of Life Index (HidroQoL©) with Validation and Cross-Cultural Adaptation.

Purpose: Hyperhidrosis (HH) is characterized by excessive sweating, which can significantly affect quality of life. The Hyperhidrosis Quality of Life Index (HidroQoL©) is the latest tool that has been developed and validated for assessing the quality of life of patients with HH. Because of the absence of an Arabic version of the HidroQoL©, this research aimed to create, validate, and adapt the HidroQoL© into Arabic.

Attribution theory of poverty and beliefs about charity in Malaysia: an inter-ethnic comparison.

Introduction: Malaysia as an ethnically diverse country has a history of interethnic inequality and poverty which led to the development of different views about the existence of poverty. Among these ethnic groups, some sympathize with the poor and help them through different charity organizations. However, these charity organizations are mostly unaware of the target donors that can aid their charity funds.

Electrochemical Cyclization-Desulfurization Approach for the Synthesis of 1,3-Benzoxazines Using Cascade C-O and C-N Bond Formation.

A cost-effective, eco-friendly, and highly efficient one-pot electrochemical process has been described for the synthesis of 4-1,3-benzoxazine and 4,5-dihydro-1,3-benzoxazepine derivatives by employing 2-aminobenzyl alcohols, 2-(2-aminophenyl)ethan-1-ol, isothiocyanate derivatives, and TBAPF as an electrolyte. The developed method is accomplished at 25 °C with a constant current of 20 mA. Utilizing a graphite anode and a platinum cathode in a dimethyl sulfoxide solvent, the devised metal-free electrochemical approach minimizes the production of waste and eliminates the need for external oxidizing agents.

Effect of Multiple Firing Cycles on Shear Bond Strength Between Zirconia and Lithium Disilicate.

BACKGROUND Indirect ceramic restorations often need multiple firings to match the shade of natural teeth or need after-correction and ceramic addition during the clinical trial stage. Many studies have examined how multiple firings affect the mechanical characteristics of zirconia-veneered prostheses. The effect of firing number on adhesion between these core and heat-pressed lithium disilicate veneering ceramics is unclear.

Parents' awareness towards preventive and interceptive orthodontic treatment.

Objectives: This study aims to assess the awareness and acceptance of preventive and interceptive orthodontic treatment among Saudi perents.

Methods: The study used a 29-question questionnaire, covering parents' demographic data, parents' awareness of malocclusion and habits, and parents' acceptance of treatment. It included visuals of different malocclusions, normal occlusion, and specific habits.