Enhanced targeted treatment of cervical cancer using nanoparticle-based doxycycline delivery system.

This study investigates a nanoparticle-based doxycycline (DOX) delivery system targeting cervical cancer cells via the CD44 receptor. Molecular docking revealed a strong binding affinity between hyaluronic acid (HA) and CD44 (binding energy: -7.2 kJ/mol).

Investigating the impact of Multiwalled Carbon Nanotubes exposure on enzymatic activities and histopathological variations in Swiss albino mice.

Present study was conducted to evaluate the detrimental impacts of exposure of Multi-walled Carbon Nanotubes (MWCNT-NP) on enzymatic activities and tissue structures in Swiss albino mice. The experimental groups of mice received MWCNT-NP for specific time period (seven or fourteen days). Two distinct doses of the MWCNT-NP solution were given orally: 0.

AlphaFold and what is next: bridging functional, systems and structural biology.

Introduction: The DeepMind's AlphaFold (AF) has revolutionized biomedical research by providing both experts and non-experts with an invaluable tool for predicting protein structures. However, while AF is highly effective for predicting structures of rigid and globular proteins, it is not able to fully capture the dynamics, conformational variability, and interactions of proteins with ligands and other biomacromolecules.

Areas Covered: In this review, we present a comprehensive overview of the latest advancements in 3D model predictions for biomacromolecules using AF.

Guidance on the assessment of the functionality of biomaterials for periodontal tissue regeneration: Methodologies and testing procedures.

Innovative biomaterials and tissue engineering strategies show great promise in regenerating periodontal tissues. This guidance provides an overview and detailed recommendations for evaluating the biological functionality of these new biomaterials in vitro, focusing on mineralization, immunomodulatory effects, cellular differentiation, and angiogenesis. Additionally, it discusses the use of in vivo experimental models that mimic periodontitis and scrutinizes methods such as osteogenic differentiation, immunomodulation, and anti-inflammatory responses to assess the effectiveness of these biomaterials in promoting periodontal tissue reconstruction.

Mapping the Energy Carrier Diffusion Tensor in Perovskite Semiconductors.

Understanding energy transport in semiconductors is critical for the design of electronic and optoelectronic devices. Semiconductor material properties, such as charge carrier mobility or diffusion length, are commonly measured in bulk crystals and determined using models that describe transport behavior in homogeneous media, where structural boundary effects are minimal. However, most emerging semiconductors exhibit nano- and microscale heterogeneity.

Claude, ChatGPT, Copilot, and Gemini Performance versus Students in Different Topics of Neuroscience.

Despite extensive studies on large language models and their capability to respond to questions from various licensed exams, there has been limited focus on employing chatbots for specific subjects within the medical curriculum, specifically medical neuroscience. This research compared the performances of Claude 3.5 Sonnet (Anthropic), GPT-3.

Bio-fabrication of chitosan-stabilized magnesium oxide nanomaterials: Investigation of photocatalytic, in vitro cytotoxicity activities and apoptosis in oral squamous carcinoma cells.

A bio-fabrication approach is a novel way to develop chitosan-stabilized magnesium oxide nanomaterials (cMgO-NMs). The process involves utilizing polymeric chitosan as the reducing and stabilizing agent. The characteristics of the developed cMgO-NMs were determined using various spectroscopical techniques.

TiO-sodium alginate core-shell nanosystem for higher antimicrobial wound healing application.

Wounds that are not properly managed can cause complications. Prompt and proper care is essential, to prevent microbial infection. Growing interest in metal oxide nanoparticles (NPs) for innovative wound treatments targeting healing and microbial infections.

Non-coding RNAs in urinary bladder cancer microenvironment: Diagnostic, therapeutic, and prognostic perspective.

Urinary bladder cancer (UBC) is the ninth most common cancer worldwide. Despite the reliance of UBC therapy on definite pathological grading and classifications, the clinical response among patients varies widely. The molecular basis of this type of cancer appeals to considerable research; hence, new diagnostic and therapeutic options are introduced.

Excellent acetone sensing enabled by tunable metal organic framework derived TiO nanodisks.

Annealing plays a crucial role for in enhancing the gas sensing properties of MOF-derived TiO (MIL-125). Generally, TiO transforms into different polymorphs (anatase, rutile, and brookite) during annealing, each with unique crystal structures and gas sensing properties. The aim of this research was to investigate the impact of annealing (500-650 °C) on the properties of MIL-125, which had not been previously studied.

Unveiling next-generation organic photovoltaics: Quantum mechanical insights into non-fullerene donor-acceptor compounds.

Organic photovoltaics (OPVs) have improved greatly in recent years in pursuit for efficient and sustainable energy conversion methods. Specifically, utilizing quantum chemistry approaches such as density functional theory (DFT), the electronic structures, energy levels, and charge transport characteristics of donor-π-acceptor (D-π-A) systems based on non-fullerene donor and acceptor molecules have been examined and synthesized. Non-fullerene acceptors offer several advantages over traditional fullerene-based materials, such as enhanced light absorption, modifiable energy levels, and reduced recombination losses.

Migraine among King Khaled University students; prevalence, determinants, and impact on academic life.

Background: Migraine is a common primary headache disorder that significantly affects academic life and is often associated with stress, depression, anxiety, and irregular sleep patterns among university students. This study aimed to assess the prevalence of migraine among King Khalid University (KKU) students, identify its determinants, and evaluate the impact of migraine and other headaches on academic life and performance.

Methods: An analytical cross-sectional study was conducted among 732 students from Colleges of Medicine, Pharmacy, Engineering, and Computer science.

Design and synthesis of new 1,2,3-triazole derivatives as VEGFR-2/telomerase downregulatory candidates endowed with apoptotic potential for cancer treatment.

In this current work, we dedicated efforts to designing and synthesizing new 1,2,3-triazole-analogues (5a-d), (6a-d), and (7a-c) to act as dual VEGFR-2 and telomerase inhibitors with promising apoptotic potential. The synthesized analogues were examined against eleven diverse types of cancer cells and two normal cells to assess their ability to inhibit cell growth (GI%). Obviously, compound 7b showed the best average GI% (75.

Morin Mitigates 5-Fluorouracil-Induced Nephrotoxicity by Activating Nrf2/HO-1 and FXR, and Suppressing ERK/VCAM-1 and NF-κB Pathways.

5-Fluorouracil (5-FU) is a DNA analog used in chemotherapy to treat various tumors. However, the clinical use of 5-FU is limited due to its severe adverse effects, particularly its nephrotoxicity. Morin (MRN) is a flavanol found in many different plants, including those in the Moraceae family, and has anti-inflammatory and antioxidant bioactivities.

Palliative potential of genistein to counteract endosulfan instigated colon toxicity via regulating TLR4/MyD88, JAK1/STAT3 and NF-κB pathway: A biochemical and histological approach.

Endosulfan (ESN) is an organophosphate insecticidal agent that is documented to induce various organ toxicities. Genistein (GEN) is a plant derived polyphenolic compound with excellent biological as well as pharmacological properties. This research was planned to assess the palliative potential of GEN to avert ENS prompted colonic toxicity.

Life Cycle Economic and Environmental Assessment for Emerging Heavy-Duty Truck Powertrain Technologies in China: A Comparative Study of Battery Electric, Fuel Cell Electric, and Hydrogen Combustion Engine Trucks.

Amid ambitious net-zero goals and growing demands for freight logistics, addressing the climate challenges posed by the heavy-duty truck (HDT) sector is an urgent and pivotal task. This study develops an integrated HDT model by incorporating vehicle dynamic simulation and life cycle analysis to quantify energy consumption, greenhouse gas (GHG) emissions, and total cost of ownership associated with three emerging powertrain technologies in various truck use scenarios in China, including battery electric, fuel cell electric, and hydrogen combustion engine trucks. The results reveal varying levels of economic suitability for these powertrain alternatives depending on required driving ranges and duty cycles: the battery electric for regional-haul applications, the hydrogen fuel cell for longer-haul and low-load driving conditions, and the hydrogen combustion engine to meet high power requirements.

Optimization of HIV drugs through MCDM technique Analytic Hierarchy Process(AHP).

Topological indices are crucial tools for predicting the physicochemical and biological features of different drugs. They are numerical values obtained from the structure of chemical molecules. These indices, particularly the degree-based TIs are a useful tools for evaluating the connection between a compound's structure and its attributes.

Development and laboratory evaluation of a novel IoT-based electric-driven metering system for high precision garlic planter.

In order to address many issues, such as the inconsistent and unreliable seeding process in traditional mechanical garlic seed metering systems (SMS), as well as the lack of ability to monitor the effectiveness of the seeding, a highly accurate electric-driven metering system (EDMS) was developed and created specifically for garlic seed planters. This study provided a description of the overall structure and functioning principle, as well as an analysis of the mechanism for smooth transit and delivery. A combination of an infrared (IR) sensor, Arduino Mega board, stepper motor, speed sensor, and a Wi-Fi module was employed to operate the EDMS, as well as monitor and count the quantity of garlic seeds during the planting process and determine the qualified rate (QR) and missing rate (MR).

Economic impact and clinical benefits of clinical pharmacy interventions: A six-year multi-center study using an innovative medication management tool.

Background: Increasing healthcare costs, particularly in Low- and Middle-Income Countries (LMICs) like Egypt, highlight the need for rational economic strategies. Clinical pharmacy interventions offer potential benefits by reducing drug therapy problems and associated costs, thereby supporting healthcare system sustainability.

Objective: This study evaluates the economic impact and clinical benefits of clinical pharmacy interventions in four tertiary hospitals in Egypt by implementing an innovative tool for medication management, focusing on cost avoidance and return on investment (ROI), while accounting for case severity and drug therapy problem (DTP) resolution.

Evaluating and upgrading the performance of a bridge network structure with Rayleigh distribution lifetimes.

In this work, bridge network model with Rayleigh distribution lifetimes is used. Two main techniques are calculated to upgrade this model: reduction and redundancy techniques. In order to compare the effectiveness of the various approaches, the survival function, the mean time to failure and gamma-fractiles for the original and upgraded model are calculated.

Inherent differential microbial assemblages and functions associated with corals exhibiting different thermal phenotypes.

Certain coral individuals exhibit enhanced resistance to thermal bleaching, yet the specific microbial assemblages and their roles in these phenotypes remain unclear. We compared the microbial communities of thermal bleaching-resistant (TBR) and thermal bleaching-sensitive (TBS) corals using metabarcoding and metagenomics. Our multidomain approach revealed stable distinct microbial compositions between thermal phenotypes.

Evaluating the In Vitro Anthelmintic Activity of Zinc Oxide Nanoparticles (ZnO-NPs) Against the Adult Stages of Fasciola hepatica.

Background: Fascioliasis represents one of the most significant parasitic and foodborne zoonotic diseases in the world. Resistance to currently deployed human and veterinary flukicides is a growing health problem. Zinc oxide nanoparticles (ZnO-NPs) have developed enormous importance in nanomedicine.

Effectiveness of behavioural and psychological interventions for managing obesity in children and adolescents: A systematic review and meta-analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline.

Objective: Conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) of behavioural and psychological interventions for managing paediatric obesity.

Methods: Eligible studies, published between 1985 and 2022, included 0 to 18 year olds with outcomes reported ≥3 months post-baseline, including patient-reported outcome measures (PROMs), cardiometabolic and anthropometric outcomes, and adverse events (AEs). We pooled data using a random effects model and assessed certainty of evidence (CoE) related to minimally important difference estimates for outcomes using GRADE.