Examining Heart Failure Informal Care Partners Using Person and System Levels and Domains: A Meta-Synthesis.

Background: Within the last decade, system and policy-level changes have driven substantial shifts in heart failure (HF) care from hospital to home, requiring greater support from informal care partners. What has not been examined is the state of the care partner science by person and system-level domains using qualitative studies to understand impact across multiple person and system levels.

Objectives: (1) Identify by person and system levels and domain what is known about informal care partners and (2) Identify gaps in the caregiving science and suggest ways to move forward.

Transition Metal Carbonitride MXenes Anchored with Pt Sub-Nanometer Clusters to Achieve High-Performance Hydrogen Evolution Reaction at All pH Range.

Transition metal carbides, known as MXenes, particularly TiCT, have been extensively explored as promising materials for electrochemical reactions. However, transition metal carbonitride MXenes with high nitrogen content for electrochemical reactions are rarely reported. In this work, transition metal carbonitride MXenes incorporated with Pt-based electrocatalysts, ranging from single atoms to sub-nanometer dimensions, are explored for hydrogen evolution reaction (HER).

From fatty liver to fibrosis: the impact of miRNAs on NAFLD and NASH.

Non-alcoholic fatty liver disease (NAFLD) is a disease with various levels varying from fatty liver steatosis to acute steatosis which is non-alcoholic steatohepatitis (NASH), which can develop into hepatic failure, as well as in some conditions it can develop into hepatocellular carcinoma (HCC). In the NAFLD and NASH context, aberrant microRNA (miRNA) expression has a thorough contribution to the incidence and development of these liver disorders by influencing key biological actions, involving lipid metabolism, inflammation, and fibrosis. Dysregulated miRNAs can disrupt the balance between lipid accumulation and clearance, exacerbate inflammatory responses, and promote fibrogenesis, thus advancing the severeness of the disorder from simple steatosis to more complex NASH.

Innovative approaches to large lower calyceal stones (10-20 mm): evaluating modified T-tilt position and lower calyx hydrodilatation techniques in flexible ureteroscopy versus hydrodilatation alone: prospective randomized controlled study.

Background: Managing lower calyceal stones poses significant challenges. Flexible ureteroscopy and laser lithotripsy (FURSL) are standard techniques for treating large stones (10-20 mm).

Objective: This study evaluates the role of the T-tilt position (45-degree Trendelenburg with a 45-degree lateral tilt against the side of the stone) and hydrodilatation of the lower calyx with 50 cc saline injection as needed in optimizing stone-free rates and safety during FURSL for lower calyceal stones.

Trends in insecticide resistance in natural populations of Culex quinquefasciatus and its impact on mosquito fitness in Dschang, West Cameroon.

Specific information about the dispersion of Culex quinquefasciatus from Dschang in western Cameroon is scarce, and evidence-based interventions are needed. Common use of larvicides and adulticides conduct to the development of vectors resistance which can lead to deep biological changes, including fitness costs. We assessed the profile of insecticide resistance in field populations of Cx.

Understanding the anatomical basis of anorectal fistulas and their surgical management: exploring different types for enhanced precision and safety.

Anorectal fistulas remain one of the most challenging conditions in colorectal surgery and require precise anatomical knowledge for successful management. This comprehensive review synthesizes the current evidence on the anatomical foundations of fistula development and treatment, particularly focusing on the cryptoglandular hypothesis and its clinical implications. A systematic analysis of the recent literature has examined the relationship between anatomical structures and fistula formation, classification systems, diagnostic modalities, and therapeutic approaches.

MRI features of hepatocellular adenomas in children: clinical and radiological review.

Background: Hepatocellular adenomas (HCAs) are rare, benign hepatic tumors in children, with limited imaging data available for pediatric cases.

Objective: To describe the magnetic resonance imaging (MRI) and clinical features of histologically proven HCAs in children.

Materials And Methods: Single-center retrospective review of pathology-proven HCA from January 2004 to February 2024.

Pomegranate as a natural remedy for gastric ulcers prevention: a review of its gastroprotective mechanisms and pharmacological benefits.

Gastric ulcers (GUs) represent a common gastrointestinal disorder characterized by mucosal damage and inflammation, often precipitated by factors such as Helicobacter pylori infection and the consumption of COX inhibitors. This comprehensive review investigates the role of oxidative stress and inflammation in the pathogenesis of GUs and assesses the potential therapeutic effects of Punica granatum (pomegranate, Pg) supplementation. Utilizing a series of experimental models, including indomethacin, aspirin, and alcohol-induced ulcers, we demonstrate that Pg extracts possess significant gastroprotective properties.

Molecular mechanisms of phytoconstituents from selected Egyptian plants against non-small cell lung cancer using integrated in vitro network pharmacology and molecular docking approach.

Non-small cell lung cancer (NSCLC) is a widespread highly malignant type of lung cancer. Conventional chemotherapeutic drugs may be accompanied by both drug resistance and serious side effects in patients. Therefore, safer and more effective medications are urgently needed for the treatment of NSCLC.

Exploring the Adsorption Features of Furan and 1,n-Dioxane as Environmental Toxins on Two-Dimensional RuC Nanosheet: A DFT Study.

The potential of the two-dimensional ruthenium carbide (RuC) nanosheet to detect highly toxic environmental compounds - namely, Furan (Fur) and 1,n-Dioxane (1,n-Diox) - was investigated utilizing the density functional theory (DFT) approach. The adsorption features of the Fur and 1,n-Diox molecules on the RuC nanosheet were evaluated in parallel and vertical configurations. From energetic manifestations, Fur and 1,n-Diox molecules preferred to be adsorbed in the parallel configuration rather than the vertical one on the RuC nanosheet with negative E values of -27.

Comparison of Cochlear Implant Efficacy in Pre- Versus Postsynaptic Auditory Neuropathy: A Systematic Review.

Etiological factors affecting outcomes of cochlear implants (Cis) are known; however, a direct comparison of efficacy based on lesion location is needed. We aimed to systematically examine the current evidence to compare the effectiveness of CIs in patients with presynaptic versus postsynaptic neuropathy. A comprehensive literature search was conducted across multiple databases, including MEDLINE (via PubMed), Embase, CENTRAL, Web of Science, Scopus, CINAHL, and PsycINFO.

Structural Elucidation of Photoluminescent Carbon Nanodots Through Quenching Kinetics with Molecular Electron Donors and Acceptors.

Photoluminescence (PL) quenching mechanism and dynamics of carbon nanodots (CNDs) with molecular electron donor and acceptor is investigated by means of time resolved emission spectroscopy. CNDs are prepared by direct pyrolysis from two different precursors, di-ammonium citrate and tri-ammonium citrate, and at two different temperatures 150 °C and 180 °C and 40 hours under ambient conditions. Despite the small changes in the pyrolysis temperature rather significant differences are observed in the structure, PL quantum yield, and hence observation of the important characteristics of PL quenching kinetics in the presence of benzophenone and dimethoxybenzene as an electron acceptor and donors, respectively.

Targeted Therapies: The Role of Monoclonal Antibodies in Disease Management.

Monoclonal antibodies (mAbs) are a key class of biotherapeutic medicines used to treat a wide range of diseases, such as cancer, infectious diseases, autoimmune disorders, cardiovascular diseases, and hemophilia. They can be engineered for greater effectiveness and specific applications while maintaining their structural elements for immune targeting. Traditional immunoglobulin treatments have limited therapeutic uses and various adverse effects.

Assessing the Quality of Life in Adult Lung Transplant Recipients Quality of Life Post-Lung Transplant.

Background: Significant limitations in daily life characterize end-stage lung diseases (ESLD) due to symptoms such as dyspnea, recurrent infections, side effects of immunosuppressive medication, and frequent need for hospitalizations. In addition to physical symptoms, ESLD is associated with emotional and social sources of distress such as depression, anxiety, fear of dying, financial concerns, and regular need for relocation. A transplant can significantly affect the recipients' life domains, from physical and emotional well-being to social relationships and roles.

Interventions for Compassion Fatigue, Burnout, and Secondary Traumatic Stress in Nurses: A Systematic Review and Network Meta-Analysis.

This study uses network meta-analysis to evaluate the relative effectiveness of different interventions (behavioral, psychological, and comprehensive) in alleviating compassion fatigue, burnout, and secondary traumatic stress, as well as in improving compassion satisfaction among nurses, aiming to provide evidence-based insights for enhancing nurses' mental health and care quality. Compassion fatigue in nurses negatively affects their mental health, patient care quality, and healthcare efficiency. Various interventions (psychological, behavioral, and integrated) target this issue, but evidence on their effectiveness is inconclusive.

Effect of panretinal photocoagulation on retinal oxygen metabolism and ocular blood flow in diabetic retinopathy.

Purpose: To investigate the effects of panretinal photocoagulation (PRP) on retinal oxygen metabolism, calibre of retinal vessels, and blood flow velocity in the optic nerve head (ONH) and choroid in patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR).

Methods: In this retrospective study, 37 patients (37 eyes) were studied. Retinal oximetry and laser speckle flowgraphy measurements were performed at baseline and after PRP.

Microscopic Characterization Based Synthesis of Silver Nanoparticles Using Merremia quinquefolia (L.) Hallier f. Leaf Extract: Their Biological Approaches and Degradation of Methylene Blue Dye.

The green methods for the synthesis of silver nanoparticles (AgNPs) has developed popularity recently due to the low preparation costs, environmental friendliness, and non-toxicity of the precursors. In this study, AgNPs were synthesized using leaf extract from Merremia quinquefolia. Spectroscopic techniques were used for analyzing the functional groups, morphology, crystalline phase, and elemental composition of nanomaterials.

Toward a Comprehensive Understanding of Nurses' Compassion Fatigue: A Meta-Integrative Qualitative Synthesis.

Aims: The study aims to conduct a thematic synthesis approach of existing qualitative research to synthesise the real experiences of nurses dealing with compassion fatigue. This integration seeks to provide a comprehensive overview, identify common themes, and offer theoretical support for developing effective intervention strategies to mitigate compassion fatigue in healthcare settings.

Design: A thematic synthesis approach was utilised, synthesising qualitative studies on nurses' experiences of compassion fatigue.

Advances in Scaffolds and Additives for Infection Control in Autologous Chondrocyte Transplantation.

Cartilage tissue engineering (CTE) has revolutionized the field of regenerative medicine, offering significant advancements in surgeries such as autologous chondrocyte transplantation. However, despite these advancements, infections associated with cartilage implants remain a persistent challenge, compromising the success of surgeries and patient recovery. To address these challenges, this review provides a comprehensive foundation for researchers interested in addressing infections in CTE.

Correction: Fahmy et al. Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells. 2021, , 20.

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Galegine, a Bioprivileged Alkaloid from Tithonia tubaeformis: Antipyretic Activity Insights.

Background: In continuation of our chemical and biological work on Tithonia tubaeformis, we evaluated the antipyretic activity of its extract which on fractionation gives a pure alkaloid galegine. Galegine a bioprivileged compound, is a hemiterpene bearing a guanidine group, which holds significant importance in medicinal chemistry. Biological activities such as antimicrobial, antidiabetic, anti-inflammatory, cardiovascular, anticancer, and antihypertensive, are often associated with guanidine-containing molecules.

Smart Stimuli-responsive Nanogels: A Potential Tool for Targeted Drug Delivery.

Nanogels (NGs) are presently the focus of extensive research because of their special qualities, including minimal particle size, excellent encapsulating efficacy, and minimizing the breakdown of active compounds. As a result, NGs are great candidates for drug delivery systems. Cross-linked nanoparticles (NPs) called stimulus-responsive NGs are comprised of synthetic, natural, or a combination of natural and synthetic polymers.

Clinicopathological and in Silico Insights into Male Infertility: Agerelated Trends and Anti-sperm Antibodies Post COVID-19 Vaccination.

Background: Infertility was often considered a female issue, but male infertility emerged significantly after the Covid-19 pandemic. Hence, assessments are crucial for planning policies on health care and family planning and reasons thereof post vaccinations.

Material And Methods: The present study was a case-control, dual-centers, prospective study with normal sperm parameters.

Refractive Results With EyeCryl Phakic Toric Intraocular Lens Implantation in a Hospital in Medina, Saudi Arabia: A Retrospective Study.

Objectives: To evaluate the efficacy, safety, and stability of EyeCryl Phakic intraocular lens (IOL) implantation.

Methodology: This retrospective study was conducted in Maghrabi Hospital in Medina to review 31 patients who underwent posterior chamber phakic IOL (EyeCryl Phakic IOL) for surgical correction of myopia or astigmatism. The data were collected from patient medical records after obtaining their consents.

The Relationship Between Mental Health and Periodontal Disease: Insights from NHANES Data.

Introduction And Aim: Periodontal disease, initiated by dental biofilm and influenced by various local and systemic factors, includes stress as a potential contributor to its progression. Despite associations with severe forms like acute necrotizing ulcerative gingivitis, a comprehensive large-sample study linking stress to periodontal disease is lacking. This study aims to investigate the relationship between mental health and periodontal disease.